Predominant T-helper 1 cytokine profile of hepatitis B virus nucleocapsid-specific T cells in acute self-limited hepatitis B

Hepatology

Volumn 25, Issue 4, 1997, Pages 1022-1027

  Penna, Amalia ^a   Del Prete, Gianfranco ^b   Cavalli, Albertina ^a   Bertoletti, Antonio ^a   D'Elios, Mario M ^b   Sorrentino, Rosa ^c   D'Amato, Mauro ^d   Boni, Carolina ^a   Pilli, Massimo ^a   Fiaccadori, Franco ^a   Ferrari, Carlo ^a  

^a UNIVERSITY OF PARMA   (Italy)

^b UNIVERSITY OF FLORENCE   (Italy)

^c UNIVERSITY OF L'AQUILA   (Italy)

^d CNR   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 4; INTERLEUKIN 5; VIRUS ANTIGEN;

ADULT; ANTIGEN RECOGNITION; ANTIGEN SPECIFICITY; ARTICLE; CLINICAL ARTICLE; DISEASE COURSE; FEMALE; HELPER CELL; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; HUMAN CELL; MALE; PRIORITY JOURNAL; VIRUS NUCLEOCAPSID;

ACUTE DISEASE; ADULT; CELL LINE; CLONE CELLS; CYTOKINES; FEMALE; HEPATITIS B; HEPATITIS B VIRUS; HUMANS; MALE; MIDDLE AGED; NUCLEOCAPSID; TH1 CELLS;

EID: 20644471859     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.510250438     Document Type: Article

References (22)

1. Penna A, Chisari FV, Bertoletti A, Missale G, Fowler P, Giuberti T, Fiaccadori F, et al. Cytotoxic T lymphocytes recognize an HLA-A2-restricted epitope within the hepatitis B virus nucleocapsid antigen. J Exp Med 1991;174:1565-1570.
2. Nayersina R, Fowler P, Guilhot S, Missale G, Cerny A, Schlicht H-J, Vitiello A, et al. HLA-A2 restricted cytotoxic T lymphocyte responses to multiple hepatitis B surface antigen epitopes during hepatitis B virus infection. J Immunol 1993;150:4659-4671.
3. Rehermann B, Person J, Redeker A, Fowler P, Brown M, Sette A, Moss B, et al. The cytotoxic T lymphocyte response to multiple hepatitis B virus polymerase epitopes during and after acute viral hepatitis. J Exp Med 1995;181:1047-1058.
4. Ferrari C, Bertoletti A, Penna A, Cavalli A, Valli A, Missale G, Pilli M, et al. Identification of immunodominant T cell epitopes of the hepatitis B virus nucleocapsid antigen. J Clin Invest 1991;88:214-222.
5. + T cell population during seroconversion to anti-HBe and anti-HBs in hepatitis B virus infection. J Virol 1995;69:3358-3368.
6. Ferrari C, Penna A, Bertoletti A, Valli A, Degli Antoni A, Giuberti T, Cavalli A, et al. Cellular immune response to hepatitis B virus (HBV) encoded antigens in acute and chronic HBV infection. J Immunol 1990;145:3442-3449.
7. Jung MC, Spengler U, Schraut W, Hoffmann R, Zachoval R, Eisenburg J, Eichenlaub D, et al. Hepatitis B virus antigen specific T cell activation in patients with acute and chronic hepatitis B. J Hepatol 1991;13:310-317.
8. Chisari FV, Ferrari C. Hepatitis B virus immunopathogenesis. Annu Rev Immunol 1995;13:29-60.
9. Paul WE, Seder RA. Lymphocyte responses and cytokines. Cell 1994;76:241-251.
10. Sher A, Coffman RL. Regulation of immunity to parasites by T cells and T-cell derived cytokines. Annu Rev Immunol 1992;10:385-409.
11. Yamamura M, Uyemura K, Deans RJ, Weinberg K, Rea TH, Bloom BR, Modlin RL. Defining protective response to pathogens: cytokine profiles in leprosy lesions. Science 1991;254:277-279.
12. Scott P, Natovitz P, Coffman RL, Pearce E, Sher A. Immunoregulation of cutaneous leishmaniasis. T cell lines that transfer protective immunity or exacerbation belong to different T helper subsets and respond to distinct parasite antigens. J Exp Med 1988;168:1675-1684.
13. Heinzel FP, Sadick MD, Holaday BJ, Coffman RL, Locksley RM. Reciprocal expression of interferon γ or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expression of distinct helper T cell subset. J Exp Med 1989;169:59-72.
14. Carding SR, Allan W, McMickle A, Doherty PC. Activation of cytokine genes in T cells during primary and secondary murine influenza pneumonia. J Exp Med 1993;177:475-482.
15. Ramsay AJ, Ruby J, Ramshaw IA. A case for cytokines as effector molecules in the resolution of virus infection. Immunol Today 1993;14:155-157.
16. Urban JJ, Katona I, Paul WE, Finkelman FD. Interleukin-4 is important in protective immunity to a gastrointestinal nematode infection in mice. Proc Natl Acad Sci U S A 1991;88:5513-5517.
17. Pasek M, Goto T, Gilbert W, Zink B, Shaller H, Mackay P, Leadbetter G, et al. Hepatitis B virus genes and their expression in E. Coli. Nature 1979;282:575-579.
18. Milich DR, McLachlan A, Stahl S, Wingfield P, Thorton GB, Hughes JL, Jones JE. Comparative immunogenicity of hepatitis B virus core and e antigens. J Immunol 1988;141:3617-3624.
19. Lefkovits I, Waldmann H. Analysis of cells in the immune system. Cambridge, UK: Cambridge University Press, 1979:1-324.
20. Del Prete GF, De Carli M, Mastromauro C, Biagiotti R, Macchia D, Falagiani P, Ricci M, et al. Purified protein derivative of mycobacterium tuberculosis and excretory-secretory antigen(s) of Toxocara canis expand in vitro human T cells with stable and opposite (type 1 T helper or type 2 T helper) profile of cytokine production. J Clin Invest 1991;88:346-350.
21. Sinigaglia F, Guttinger M, Kilgus J, Doran DM, Matile H, Etlinger H, Trzeciak A, et al. A malaria T cell epitope recognized in association with most mouse and human MHC class II molecules. Nature 1988;336:778-780.
22. Panina P, Tan A, Termijtelen A, Demotz S, Corradin G, Lanzavecchia A. Universally immunogenic T cell epitopes: promiscuous binding to human class II and promiscuous recognition by T cells. Eur J Immunol 1989;19:2237-2242.