메뉴 건너뛰기




Volumn 1, Issue 11, 2002, Pages 911-916

Hepatitis C virus replicons: Potential role for drug development

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; ANTIVIRUS AGENT; RIBAVIRIN; VIRUS RNA;

EID: 0036835773     PISSN: 14741776     EISSN: None     Source Type: Journal    
DOI: 10.1038/nrd942     Document Type: Article
Times cited : (139)

References (46)
  • 1
    • 0035811625 scopus 로고    scopus 로고
    • Hepatitis C virus infection
    • Lauer, G. M. & Walker, B. D. Hepatitis C virus infection. N. Engl. J. Med. 345, 41-52 (2001).
    • (2001) N. Engl. J. Med. , vol.345 , pp. 41-52
    • Lauer, G.M.1    Walker, B.D.2
  • 2
    • 0033920795 scopus 로고    scopus 로고
    • Replication of hepatitis C virus
    • Bartenschlager, R. & Lohmann, V. Replication of hepatitis C virus. J. Gen. Virol. 81, 1631-1648 (2000).
    • (2000) J. Gen. Virol. , vol.81 , pp. 1631-1648
    • Bartenschlager, R.1    Lohmann, V.2
  • 3
    • 0035955558 scopus 로고    scopus 로고
    • Recent advances in the molecular biology of hepatitis C virus
    • Rosenberg, S. Recent advances in the molecular biology of hepatitis C virus. J. Mol. Biol. 313, 451-464 (2001).
    • (2001) J. Mol. Biol. , vol.313 , pp. 451-464
    • Rosenberg, S.1
  • 4
    • 0033992516 scopus 로고    scopus 로고
    • Overview of hepatitis C virus genome structure, polyprotein processing, and protein properties
    • Reed, K. E. & Rice, C. M. Overview of hepatitis C virus genome structure, polyprotein processing, and protein properties. Curr. Top. Microbiol. Immunol. 242, 55-84 (2000).
    • (2000) Curr. Top. Microbiol. Immunol. , vol.242 , pp. 55-84
    • Reed, K.E.1    Rice, C.M.2
  • 5
    • 0026513651 scopus 로고
    • Internal ribosome entry site within hepatitis C virus RNA
    • Tsukiyama-Kohara, K., Iizuka, N., Kohara, M. & Nomoto, A. Internal ribosome entry site within hepatitis C virus RNA. J. Virol. 66, 1476-1483 (1992).
    • (1992) J. Virol. , vol.66 , pp. 1476-1483
    • Tsukiyama-Kohara, K.1    Iizuka, N.2    Kohara, M.3    Nomoto, A.4
  • 6
    • 0027153210 scopus 로고
    • Translation of human hepatitis C virus RNA in cultured cells is mediated by an internal ribosome-binding mechanism
    • Wang, C., Sarnow, P. & Siddiqui, A. Translation of human hepatitis C virus RNA in cultured cells is mediated by an internal ribosome-binding mechanism. J. Virol. 67, 3338-3344 (1993).
    • (1993) J. Virol. , vol.67 , pp. 3338-3344
    • Wang, C.1    Sarnow, P.2    Siddiqui, A.3
  • 7
    • 0033673387 scopus 로고    scopus 로고
    • Structures of two RNA domains essential for hepatitis C virus internal ribosome entry site function
    • Lukavsky, P. J., Otto, G. A., Lancaster, A. M., Sarnow, P. & Puglisi, J. D. Structures of two RNA domains essential for hepatitis C virus internal ribosome entry site function. Nature Struct. Biol. 7, 1105-1110 (2000).
    • (2000) Nature Struct. Biol. , vol.7 , pp. 1105-1110
    • Lukavsky, P.J.1    Otto, G.A.2    Lancaster, A.M.3    Sarnow, P.4    Puglisi, J.D.5
  • 8
    • 0031905698 scopus 로고    scopus 로고
    • A prokaryotic-like mode of cytoplasmic eukaryotic rbosome binding to the initiation codon during internal translation initiation of hepatitis C and classical swine fever virus RNAs
    • Pestova, T. V., Shatsky, I. N., Fletcher, S. P., Jackson, R. J. & Hellen, C. U. A prokaryotic-like mode of cytoplasmic eukaryotic rbosome binding to the initiation codon during internal translation initiation of hepatitis C and classical swine fever virus RNAs. Genes Dev. 12, 67-83 (1998).
    • (1998) Genes Dev. , vol.12 , pp. 67-83
    • Pestova, T.V.1    Shatsky, I.N.2    Fletcher, S.P.3    Jackson, R.J.4    Hellen, C.U.5
  • 9
    • 0035898608 scopus 로고    scopus 로고
    • Synthesis of a novel hepatitis C virus protein by ribosomal frameshift
    • Xu, Z. et al. Synthesis of a novel hepatitis C virus protein by ribosomal frameshift. EMBO J. 20, 3840-3848 (2001).
    • (2001) EMBO J. , vol.20 , pp. 3840-3848
    • Xu, Z.1
  • 10
    • 0035050164 scopus 로고    scopus 로고
    • Evidence for a new hepatitis C virus antigen encoded in an overlapping reading frame
    • Walewski, J. L., Keller, T. R., Stump, D. D. & Branch, A. D. Evidence for a new hepatitis C virus antigen encoded in an overlapping reading frame. RNA 7, 710-721 (2001).
    • (2001) RNA , vol.7 , pp. 710-721
    • Walewski, J.L.1    Keller, T.R.2    Stump, D.D.3    Branch, A.D.4
  • 11
    • 0028817781 scopus 로고
    • C-terminal domain of the hepatitis C virus NS3 protein contains an RNA helicase activity
    • Kim, D. W., Gwack, Y., Han, J. H. & Choe, J. C-terminal domain of the hepatitis C virus NS3 protein contains an RNA helicase activity. Biochem. Biophys. Res. Commun. 215, 160-166 (1995).
    • (1995) Biochem. Biophys. Res. Commun. , vol.215 , pp. 160-166
    • Kim, D.W.1    Gwack, Y.2    Han, J.H.3    Choe, J.4
  • 12
    • 0027199917 scopus 로고
    • Hepatitis C virus NS3 protein polynucleotide-stimulated nucleoside triphosphatase and comparison with the related pestivirus and flavivirus enzymes
    • Suzich, J. A. et al. Hepatitis C virus NS3 protein polynucleotide-stimulated nucleoside triphosphatase and comparison with the related pestivirus and flavivirus enzymes. J. Virol. 67, 6152-6158 (1993).
    • (1993) J. Virol. , vol.67 , pp. 6152-6158
    • Suzich, J.A.1
  • 13
    • 0030583249 scopus 로고    scopus 로고
    • Characterization of RNA binding activity and RNA helicase activity of the hepatitis C virus NS3 protein
    • Gwack, Y, Kim, D. W., Han, J. H. & Choe, J. Characterization of RNA binding activity and RNA helicase activity of the hepatitis C virus NS3 protein. Biochem. Biophys. Res. Commun. 225, 654-659 (1996).
    • (1996) Biochem. Biophys. Res. Commun. , vol.225 , pp. 654-659
    • Gwack, Y.1    Kim, D.W.2    Han, J.H.3    Choe, J.4
  • 14
    • 0029970903 scopus 로고    scopus 로고
    • The helicase activity associated with hepatitis C virus nonstructural protein 3 (NS3)
    • Tai, C. L., Chi, W. K., Chen, D. S. & Hwang, L. H. The helicase activity associated with hepatitis C virus nonstructural protein 3 (NS3). J. Virol. 70, 8477-8484 (1996).
    • (1996) J. Virol. , vol.70 , pp. 8477-8484
    • Tai, C.L.1    Chi, W.K.2    Chen, D.S.3    Hwang, L.H.4
  • 15
    • 0030051777 scopus 로고    scopus 로고
    • Identification and properties of the RNA-dependent RNA polymerase of hepatitis C virus
    • Behrens, S. E., Tomei, L. & De, F. R. Identification and properties of the RNA-dependent RNA polymerase of hepatitis C virus. EMBO J. 15, 12-22 (1996).
    • (1996) EMBO J. , vol.15 , pp. 12-22
    • Behrens, S.E.1    Tomei, L.2    De, F.R.3
  • 16
    • 1842289764 scopus 로고    scopus 로고
    • Biochemical properties of hepatitis C virus NS5B RNA-dependent RNA polymerase and identification of amino acid sequence motifs essential for enzymatic activity
    • Lohmann, V., Körner, F., Herian, U. & Bartenschlager, R. Biochemical properties of hepatitis C virus NS5B RNA-dependent RNA polymerase and identification of amino acid sequence motifs essential for enzymatic activity. J. Virol. 71, 8416-8428 (1997).
    • (1997) J. Virol. , vol.71 , pp. 8416-8428
    • Lohmann, V.1    Körner, F.2    Herian, U.3    Bartenschlager, R.4
  • 17
    • 0036100578 scopus 로고    scopus 로고
    • Expression of hepatitis C virus proteins induces distinct membrane alterations including a candidate viral replication complex
    • Egger, D. et al. Expression of hepatitis C virus proteins induces distinct membrane alterations including a candidate viral replication complex. J. Virol. 76, 5974-5984 (2002).
    • (2002) J. Virol. , vol.76 , pp. 5974-5984
    • Egger, D.1
  • 18
    • 0034877411 scopus 로고    scopus 로고
    • Novel cell culture systems for the hepatitis C virus
    • Bartenschlager, R. & Lohmann, V. Novel cell culture systems for the hepatitis C virus. Antiviral Res. 52, 1-17 (2001).
    • (2001) Antiviral Res. , vol.52 , pp. 1-17
    • Bartenschlager, R.1    Lohmann, V.2
  • 20
    • 0031888265 scopus 로고    scopus 로고
    • Characterization of an autonomous subgenomic pestivirus RNA replicon
    • Behrens, S. E., Grassmann, C. W., Thiel, H. J., Meyers, G. & Tautz, N. Characterization of an autonomous subgenomic pestivirus RNA replicon. J. Virol. 72, 2364-2372 (1998).
    • (1998) J. Virol. , vol.72 , pp. 2364-2372
    • Behrens, S.E.1    Grassmann, C.W.2    Thiel, H.J.3    Meyers, G.4    Tautz, N.5
  • 21
    • 0031014022 scopus 로고    scopus 로고
    • Subgenomic replicons of the flavivirus Kunjin: Construction and applications
    • Khromykh, A. A. & Westaway, E. G. Subgenomic replicons of the flavivirus Kunjin: construction and applications. J. Virol. 71, 1497-1505 (1997).
    • (1997) J. Virol. , vol.71 , pp. 1497-1505
    • Khromykh, A.A.1    Westaway, E.G.2
  • 22
    • 0023945724 scopus 로고
    • Construction and characterization of poliovirus subgenomic replicons
    • Kaplan, G. & Racaniello, V. R. Construction and characterization of poliovirus subgenomic replicons. J. Virol. 62, 1687-1696 (1988).
    • (1988) J. Virol. , vol.62 , pp. 1687-1696
    • Kaplan, G.1    Racaniello, V.R.2
  • 23
    • 0345188811 scopus 로고    scopus 로고
    • Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line
    • Lohmann, V. et al. Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line. Science 285, 110-113 (1999).
    • (1999) Science , vol.285 , pp. 110-113
    • Lohmann, V.1
  • 24
    • 0034623816 scopus 로고    scopus 로고
    • Efficient initiation of HCV RNA replication in cell culture
    • Blight, K. J., Kolykhalov, A. A. & Rice, C. M. Efficient initiation of HCV RNA replication in cell culture. Science 290, 1972-1974 (2000).
    • (2000) Science , vol.290 , pp. 1972-1974
    • Blight, K.J.1    Kolykhalov, A.A.2    Rice, C.M.3
  • 25
    • 0035032237 scopus 로고    scopus 로고
    • Enhancement of hepatitis C virus RNA replication by cell-culture-adaptive mutations
    • Krieger, N., Lohmann, V. & Bartenschlager, R. Enhancement of hepatitis C virus RNA replication by cell-culture-adaptive mutations. J. Virol. 75, 4614-4624 (2001).
    • (2001) J. Virol. , vol.75 , pp. 4614-4624
    • Krieger, N.1    Lohmann, V.2    Bartenschlager, R.3
  • 26
    • 0035157218 scopus 로고    scopus 로고
    • Mutations in hepatitis C virus RNAs conferring cell culture adaptation
    • Lohmann, V., Körner, F., Dobierzewska, A. & Bartenschlager, R. Mutations in hepatitis C virus RNAs conferring cell culture adaptation. J. Virol. 75, 1437-1449 (2001).
    • (2001) J. Virol. , vol.75 , pp. 1437-1449
    • Lohmann, V.1    Körner, F.2    Dobierzewska, A.3    Bartenschlager, R.4
  • 27
    • 0034888396 scopus 로고    scopus 로고
    • Effect of α-interferon on the hepatitis C virus replicon
    • Guo, J. T., Bichko, V. V. & Seeger, C. Effect of α-interferon on the hepatitis C virus replicon. J. Virol. 75, 8516-8523 (2001).
    • (2001) J. Virol. , vol.75 , pp. 8516-8523
    • Guo, J.T.1    Bichko, V.V.2    Seeger, C.3
  • 28
    • 0036190918 scopus 로고    scopus 로고
    • Selectable subgenomic and genome-length dicistronic RNAs derived from an infectious molecular clone of the HCV-N strain of hepatitis C virus replicate efficiently in cultured Huh7 cells
    • Ikeda, M., Yi, M., Li, K. & Lemon, S. M. Selectable subgenomic and genome-length dicistronic RNAs derived from an infectious molecular clone of the HCV-N strain of hepatitis C virus replicate efficiently in cultured Huh7 cells. J. Virol. 76, 2997-3006 (2002).
    • (2002) J. Virol. , vol.76 , pp. 2997-3006
    • Ikeda, M.1    Yi, M.2    Li, K.3    Lemon, S.M.4
  • 29
    • 0035065277 scopus 로고    scopus 로고
    • Interferon-α inhibits hepatitis C virus subgenomic RNA replication by an MxA-independent pathway
    • Frese, M., Pietschmann, T., Moradpour, D., Haller, O. & Bartenschlager, R. Interferon-α inhibits hepatitis C virus subgenomic RNA replication by an MxA-independent pathway. J. Gen. Virol. 82, 723-733 (2001).
    • (2001) J. Gen. Virol. , vol.82 , pp. 723-733
    • Frese, M.1    Pietschmann, T.2    Moradpour, D.3    Haller, O.4    Bartenschlager, R.5
  • 30
    • 0036196022 scopus 로고    scopus 로고
    • Persistent and transient replication of full-length hepatitis C virus genomes in cell culture
    • Pietschmann, T. et al. Persistent and transient replication of full-length hepatitis C virus genomes in cell culture. J. Virol. 76, 4008-4021 (2002).
    • (2002) J. Virol. , vol.76 , pp. 4008-4021
    • Pietschmann, T.1
  • 31
    • 0034747214 scopus 로고    scopus 로고
    • Sequences in the 5′ nontranslated region of hepatitis C virus required for RNA replication
    • Friebe, P., Lohmann, V., Krieger, N. & Bartenschlager, R. Sequences in the 5′ nontranslated region of hepatitis C virus required for RNA replication. J. Virol. 75, 12047-12057 (2001).
    • (2001) J. Virol. , vol.75 , pp. 12047-12057
    • Friebe, P.1    Lohmann, V.2    Krieger, N.3    Bartenschlager, R.4
  • 32
    • 0036094885 scopus 로고    scopus 로고
    • Genetic analysis of sequences in the 3′ nontranslated region of hepatitis C virus that are important for RNA replication
    • Friebe, P. & Bartenschlager, R. Genetic analysis of sequences in the 3′ nontranslated region of hepatitis C virus that are important for RNA replication. J. Virol. 76, 5326-5338 (2002).
    • (2002) J. Virol. , vol.76 , pp. 5326-5338
    • Friebe, P.1    Bartenschlager, R.2
  • 33
    • 0036305913 scopus 로고    scopus 로고
    • Mutations in NS5B polymerase of hepatitis C virus: Impacts on in vitro enzymatic activity and viral RNA replication in the subgenomic replicon cell culture
    • Cheney, I. W. et al. Mutations in NS5B polymerase of hepatitis C virus: impacts on in vitro enzymatic activity and viral RNA replication in the subgenomic replicon cell culture. Virology 297, 298-306 (2002).
    • (2002) Virology , vol.297 , pp. 298-306
    • Cheney, I.W.1
  • 34
    • 0036191172 scopus 로고    scopus 로고
    • Interferon-γ inhibits replication of subgenomic and genomic hepatitis C virus RNAs
    • Frese, M. et al. Interferon-γ inhibits replication of subgenomic and genomic hepatitis C virus RNAs. Hepatology 35, 694-703 (2002).
    • (2002) Hepatology , vol.35 , pp. 694-703
    • Frese, M.1
  • 35
    • 0036314483 scopus 로고    scopus 로고
    • Hepatitis C virus subgenomic replicons induce endoplasmic reticulum stress activating an intracellular signaling pathway
    • Tardif, K. D., Mori, K. & Siddiqui, A. Hepatitis C virus subgenomic replicons induce endoplasmic reticulum stress activating an intracellular signaling pathway. J. Virol. 76, 7453-7459 (2002).
    • (2002) J. Virol. , vol.76 , pp. 7453-7459
    • Tardif, K.D.1    Mori, K.2    Siddiqui, A.3
  • 36
    • 0037007105 scopus 로고    scopus 로고
    • Regulation of PKR and IRF-1 during hepatitis C virus RNA replication
    • Pflugheber, J. et al. Regulation of PKR and IRF-1 during hepatitis C virus RNA replication. Proc. Natl Acad. Sci. USA 99, 4650-4655 (2002).
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 4650-4655
    • Pflugheber, J.1
  • 37
    • 0242388690 scopus 로고    scopus 로고
    • Subgenomic hepatitis C virus (HCV) replicons inducing the expression of a secreted enzymatic reporter protein
    • (in the press)
    • Yi, M., Bodola, F. & Lemon, S. M. Subgenomic hepatitis C virus (HCV) replicons inducing the expression of a secreted enzymatic reporter protein. (in the press).
    • Yi, M.1    Bodola, F.2    Lemon, S.M.3
  • 38
    • 0035148546 scopus 로고    scopus 로고
    • Characterization of cell lines carrying self-replicating hepatitis C virus RNAs
    • Pietschmann, T., Lohmann, V., Rutter, G., Kurpanek, K. & Bartenschlager, R. Characterization of cell lines carrying self-replicating hepatitis C virus RNAs. J. Virol. 75, 1252-1264 (2001).
    • (2001) J. Virol. , vol.75 , pp. 1252-1264
    • Pietschmann, T.1    Lohmann, V.2    Rutter, G.3    Kurpanek, K.4    Bartenschlager, R.5
  • 39
    • 0034911386 scopus 로고    scopus 로고
    • Inhibition of HIV-1 integrase by small molecules: The potential for a new class of AIDS chemotherapeutics
    • Young, S. D. Inhibition of HIV-1 integrase by small molecules: the potential for a new class of AIDS chemotherapeutics. Curr. Opin. Drug Discov. Dev. 4, 402-410 (2001).
    • (2001) Curr. Opin. Drug Discov. Dev. , vol.4 , pp. 402-410
    • Young, S.D.1
  • 40
    • 0032884013 scopus 로고    scopus 로고
    • New antiviral agents for the therapy of chronic hepatitis B virus infection
    • Zoulim, F. & Trepo, C. New antiviral agents for the therapy of chronic hepatitis B virus infection. Intervirology 42, 125-144 (1999).
    • (1999) Intervirology , vol.42 , pp. 125-144
    • Zoulim, F.1    Trepo, C.2
  • 41
    • 0019966544 scopus 로고
    • Growth of human hepatoma cells lines with differentiated functions in chemically defined medium
    • Nakabayashi, H., Taketa, K., Miyano, K., Yamane, T. & Sato, J. Growth of human hepatoma cells lines with differentiated functions in chemically defined medium. Cancer Res. 42, 3858-3863 (1982).
    • (1982) Cancer Res. , vol.42 , pp. 3858-3863
    • Nakabayashi, H.1    Taketa, K.2    Miyano, K.3    Yamane, T.4    Sato, J.5
  • 42
    • 0036145482 scopus 로고    scopus 로고
    • Replication of subgenomic hepatitis A virus RNAs expressing firefly luciferase is enhanced by mutations associated with adaptation of virus to growth in cultured cells
    • Yi, M. & Lemon, S. M. Replication of subgenomic hepatitis A virus RNAs expressing firefly luciferase is enhanced by mutations associated with adaptation of virus to growth in cultured cells. J. Virol. 76, 1171-1180 (2002).
    • (2002) J. Virol. , vol.76 , pp. 1171-1180
    • Yi, M.1    Lemon, S.M.2
  • 43
    • 0036310498 scopus 로고    scopus 로고
    • Cell clones selected from the Huh7 human hepatoma cell line support efficient replication of a subgenomic GB virus B replicon
    • De Tomassi, A. et al. Cell clones selected from the Huh7 human hepatoma cell line support efficient replication of a subgenomic GB virus B replicon. J. Virol. 76, 7736-7746 (2002).
    • (2002) J. Virol. , vol.76 , pp. 7736-7746
    • De Tomassi, A.1
  • 44
    • 0036290504 scopus 로고    scopus 로고
    • Subgenomic replicon derived from a cell line infected with the hepatitis C virus
    • Kishine, H. et al. Subgenomic replicon derived from a cell line infected with the hepatitis C virus. Biochem. Biophys. Res. Commun. 293, 993-999 (2002).
    • (2002) Biochem. Biophys. Res. Commun. , vol.293 , pp. 993-999
    • Kishine, H.1
  • 45
    • 0023013770 scopus 로고
    • Production of hepatitis B virus by a differentiated human hepatoma cell line after transfection with cloned circular HBV DNA
    • Sureau, C., Romet-Lemonne, J. L., Mullins, J. I. & Essex, M. Production of hepatitis B virus by a differentiated human hepatoma cell line after transfection with cloned circular HBV DNA. Cell 47, 37-47 (1986).
    • (1986) Cell , vol.47 , pp. 37-47
    • Sureau, C.1    Romet-Lemonne, J.L.2    Mullins, J.I.3    Essex, M.4
  • 46
    • 4243284722 scopus 로고    scopus 로고
    • Successful HBV infection of a novel highly differentiated human hepatoma cell line
    • (in the press)
    • Gripon, P. et al. Successful HBV infection of a novel highly differentiated human hepatoma cell line. Proc. Natl Acad. Sci. USA (in the press).
    • Proc. Natl. Acad. Sci. USA
    • Gripon, P.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.