Expression and immune response to hepatitis C virus core DNA-based vaccine constructs

Hepatology

Volumn 24, Issue 1, 1996, Pages 14-20

  Tokushige, Katsutoshi ^a   Wakita, Takaji ^a   Pachuk, Catherine ^b   Moradpour, Darius ^a   Weiner, David B ^c   Zurawski Jr , Vincent R ^b   Wands, Jack R ^a,d  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b Apollon Inc   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d MASSACHUSETTS GENERAL HOSPITAL CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CORE PROTEIN; HEPATITIS VACCINE; VIRUS DNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DRUG RESEARCH; FEMALE; HEPATITIS C; HUMAN; IMMUNIZATION; INFECTION PREVENTION; MOUSE; PRIORITY JOURNAL; PROTEIN EXPRESSION; VACCINATION; VIRUS EXPRESSION;

EID: 0029971032     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1053/jhep.1996.v24.pm0008707253     Document Type: Article

References (56)

1. Simmonds P, Holmes EC, Cha TA, Chan SW, McOmish F, Irvine B, Beall E, et al. Classification of hepatitis C virus into six major genotypes and a series of subtypes by phylogenic analysis of the NS5 region. J Gen Virol 1993;74:2391-2399.
2. Choo QL, Richman KH, Han JH, Berger K, Lee C, Dong C, Gallegos C, et al. Genetic organization and diversity of the hepatitis C virus. Proc Natl Acad Sci U S A 1991;88:2451-2455.
3. Inchauspe G, Zebedee S, Lee DH, Sugitani M, Nasoff M, Prince AM. Genomic structure of the human prototype strain H or hepatitis C virus: comparison with American and Japanese isolates. Proc Natl Acad Sci U S A 1991;88:10292-10296.
4. Kato N, Hijikata M, Ootsuyama Y, Nakagawa M, Ohkoshi S, Sugimura T, Shimotohno K. Molecular cloning of the human hepatitis C virus genome from Japanese patients with non-A, non-B hepatitis. Proc Natl Acad Sci U S A 1990;87:9524-9528.
5. Okamoto H, Okada S, Sugiyama Y, Kurai K, Iizuka H, Machida A, Miyakawa Y, et al. Nucleotide sequence of the genomic RNA of hepatitis C virus isolated from a human carrier: comparison with reported isolates for conserved and divergent regions. J Gen Virol 1991;72:2697-2704.
6. Takamizawa A, Mori C, Fuke I, Manabe S, Murakami S, Fujita J, Onishi E, et al. Structure and organization of the hepatitis C virus genome isolated from human carriers. J Virol 1991;65:1105-1113.
7. Bartenschlager R, Ahlborn-Laake L, Mous J, Jacobsen H. Nonstructural protein 3 of the hepatitis C virus encodes a serine-type proteinase required for cleavage at the NS3/4 and NS4/5 junctions. J Virol 1993;67:3835-3844.
8. Grakoui A, Wychowski C, Lin C, Feinstone SM, Rice C. Expression and identification of hepatitis C virus polyprotein. J Virol 1993;67:1385-1395.
9. Selby MJ, Choo QL, Berger K, Kuo G, Glazer E, Eckart M, Lee C, et al. Expression, identification and subcellular localization of the proteins encoded by the hepatitis C viral genome. J Gen Virol 1993;74:1103-1113.
10. Han JH, Shyamala V, Richmann KH, Brauer MJ, Irvine B, Urdea MS, Tekamp-Olsen P, et al. Characterization of the terminal regions of hepatitis C viral RNA: identification of conserved sequences in the 5′ untranslated region and poly(A) tails at the 3′ end. Proc Natl Acad Sci U S A 1991;88:1711-1715.
11. Bukh J, Purcell RH, Miller RH. Sequence analysis of the 5′ non-coding region of hepatitis C virus. Proc Natl Acad Sci U S A 1992;89:4942-4946.
12. Brown EA, Zhang H, Ping LH, Lemon SM. Secondary structure of the 5′ non-translated regions of hepatitis C virus and pestivirus genomic RNAs. Nucleic Acids Res 1992;20:5041-5045.
13. Tsukiyama-Kohara K, Iizuka N, Kohara M, Nomoto A. Internal ribosome entry site within hepatitis C virus RNA. J Virol 1992;66:1476-1483.
14. Wakita T, Wands, JR. Specific inhibition of hepatitis C virus expression by antisense oligodeoxynucleotides. J Biol Chem 1994;269:14205-14210.
15. Wang C, Sarnow P, Siddiqui A. Translation of human hepatitis C virus RNA in cultured cells is mediated by an internal ribosome-binding mechanism. J Virol 1993a;67:3338-3344.
16. Alter MJ, Margolis HS, Krawczynski K, Judson FN, Mares A, Alexander WJ, Hu PY, et al. The natural history of community-acquired hepatitis C in the United States. N Engl J Med 1992;327:1899-1905.
17. Colombo M, Kuo G, Choo QL, Donato MF, Del Ninno E, Tommasini MA, Dioguardi N, et al. Prevalence of antibodies to hepatitis C virus in Italian patients with hepatocellular carcinoma. Lancet 1989;ii:1006-1008.
18. Saito I, Miyamura T, Ohbayashi A, Harada H, Katayama T, Kikuchi S, Watanabe Y, et al. Hepatitis C virus infection is associated with the development of hepatocellular carcinoma. Proc Natl Acad Sci U S A 1990;87: 6547-6549.
19. Simonetti RG, Cammá C, Fiorello F, Cottone M, Rapicetta M, Marino L, Fiorentino G, et al. Hepatitis C virus infection as a risk factor for hepatocellular carcinoma in patients with cirrhosis. Ann Intern Med 1992; 116:97-102.
20. Tsukuma H, Kawashima T. Risk factors for hepatocellular carcinoma among patients which chronic liver disease. N Engl J Med 1993;328:1797-1801.
21. Davis GL. Interferon treatment of chronic hepatitis C. Am J Med 1994; 96:41S-46S.
22. Di Bisceglie AM, Shindo M, Fong TL, Fried MW, Swain MG, Bergasa MV, Axiotis CA, et al. A pilot study of ribavirin therapy for chronic hepatitis C. HEPATOLOGY 1992;16:649-654.
23. Barry MA, Barry ME, Johnston SA. Production of monoclonal antibodies by genetic immunization. Biotechniques 1994;16:616-619.
24. Davis HL, Michel ML, Whalen RG. DNA-based immunization induces continuous secretion of hepatitis B surface antigen and high levels of circulating antibody. Hum Mol Genet 1993;11:1847-1851.
25. Tang DC, DeVit M, Johnston SA. Genetic immunization is a simple method for eliciting an immune response. Nature 1992;356:152-154.
26. Wolff JA, Malone RW, Williams P, Chong W, Acsadi G, Jani A, Felgner PL. Direct gene transfer into mouse muscle in vivo. Science 1990;247: 1465-1468.
27. Cox GJM, Zamb TJ, Babiuk LA. Bovine herpesvirus 1: immune responses in mice and cattle injected with plasmid DNA. J Virol 1993;67:5664-5667.
28. Fynan EF, Robinson HL, Webster RG. Use of DNA encoding influenza hemagglutinin as an avian influenza vaccine. DNA Cell Biol 1993;12:785-789.
29. Fynan EF, Webster RG, Fuller DH, Haynes JR, Santoro JC, Robinson HL. DNA vaccines: protective immunizations by parenteral, mucosal and genegun inoculations. Proc Natl Acad Sci U S A 1993;90:11478-11482.
30. Ulmer JB, Donnelly JJ, Parker SE, Rhodes GH, Felgner PL, Dwarki VJ, Gromkowski SH, et al. Heterologous protection against influenza by infection of DNA encoding a viral protein. Science 1993;259:1745-1749.
31. Xiang ZQ, Spitalnik S, Tran M, Wunner WH, Cheng J, Ertl HCJ. Vaccination with a plasmid vector carrying the rabies virus glycoprotein gene induces protective immunity against rabies virus. Virology 1994;199:132-140.
32. Wolff JA, Ludtke JJ, Acsadi G, Williams P, Jani A. Long-term persistence of plasmid DNA and foreign gene expression in mouse muscle. Hum Mol Genet 1992;1:363-369.
33. Manthorpe M, Cornefert-Jensen F, Hartikka J, Felgner J, Rundell A, Margalith M, Dwarki V. Gene therapy by intramuscular injection of plasmid DNA: studies on firefly luciferase gene expression in mice. Hum Gene Ther 1993;4:419-431.
34. Yankauckas MA, Morrow JE, Parker SE, Abai A, Rhodes GH, Dwarki VJ, Gromkowski SH. Long-term anti-nucleoprotein cellular and humoral immunity is induced by intramuscular injection of plasmid DNA containing NP gene. DNA Cell Biol 1993;12:777-783.
35. Montgomery DL, Shiver JW, Leander KR, Perry HC, Friedman A, Martinez D, Ulmer JB, et al. Heterologous and homologous protection against influenza A by DNA vaccination: optimization of DNA vectors. DNA Cell Biol 1993;12:777-783.
36. Martin LP, Lau L, Asano M, Ahmed R. DNA vaccination against persistent viral infection. J Virol 1995;69:2574-2582.
37. Wang B, Ugen KE, Srikantan V, Agadjanyan MG, Dang K, Refaeli Y, Sato AI, et al. Gene inoculation generates immune responses against human immunodeficiency virus type I. Proc Natl Acad Sci U S A 1993b;90:4156-4160.
38. Wang B, Boyer J, Srikantan V, Coney L, Carrano R, Phan C, Merva M, et al. DNA inoculation induces neutralizing immune responses against human immunodeficiency virus type 1 in mice and nonhuman primates. DNA Cell Biol 1993c;12:799-805.
39. Williams WV, Boyer JD, Merva M, Livolsi V, Wilson D, Wang B, Weiner DB. Genetic infection induces protective in vivo immune responses. DNA Cell Biol 1993;12:675-683.
40. Chen C, Okayama H. High efficiency transformation of mammalian cells by plasmid DNA. Mol Cell Biol 1987;7:2745-2752.
41. Moradpour D, Wakita T, Tokushige K, Carlson RI, Krawczynski K, Wands, JR. Characterization of three novel monoclonal antibodies against hepatitis C virus core protein. J Med Virol 1996;48:234-241.
42. Iwata K, Wakita T, Okumura A, Yoshioka K, Takayanagi M, Wands JR, Kakumu S. Interferon gamma production by peripheral blood lymphocytes to hepatitis C virus core protein in chronic hepatitis C infection. HEPATOLOGY 1995;22:1057-1064.
43. Kim DW, Harada T, Saito I, Miyamura T. An efficient expression vector for stable expression in human liver cells. Gene 1993;134:307-308.
44. Wang M, Merva M, Dang K, Ugen K, Boyer J, William W, Weiner DB. DNA inoculation induces protection in vitro immune response against cellular challenge with HIV-1 antigen-expressing cells. AIDS Res Hum Retroviruses 1994;10(suppl 2):S35-S41.
45. Weiner AJ, Geysen HM, Christopherson C, Hall JE, Mason TJ, Saracco G, Bonino F, et al. Evidence for immune selection of hepatitis C virus (HCV) putative envelope glycoprotein variants: potential role in chronic HCV infection. Proc Natl Acad Sci U S A 1992;89:3468-3472.
46. Kato N, Ootsuyama Y, Ohkoshi S, Nakazawa T, Sekiya H, Hijikata M, Shimotohno K. Characterization of hypervariable regions in the putative envelope protein of hepatitis C virus. Biochem Biophys Res Commun 1992; 189:119-127.
47. Koziel MJ, Dudley D, Afdhal N, Choo QL, Houghton M, Ralston R, Walker BD. Hepatitis C virus (HCV)-specific cytotoxic T lymphocytes recognize epitopes in the core and envelope proteins of HCV. J Virol 1993;67:7522-7532.
48. Koziel MJ, Dudley D, Wong JT, Dienstag J, Houghton M, Ralston R, Walker BD. Intrahepatic cytotoxic T lymphocytes specific for hepatitis C virus in persons with chronic hepatitis. J Immunol 1992;149:3339-3344.
49. Kita H, Moriyama T, Kaneko T, Harase I, Nomura M, Miura H, Nakamura I, et al. HLA B44 restricted cytotoxic T lymphocytes recognizing an epitope on hepatitis C virus nucleocapsid protein. HEPATOLOGY 1993;18:1039-1044.
50. Cerny CA, McHutchinson JG, Pasquinelli C, Brown ME, Brothers MA, Grabscheid B, Fowler P, et al. Cytotoxic T lymphocyte response to hepatitis C virus-derived peptides containing the HLA A2.1 binding motif. J Clin Invest 1995;95:521-530.
51. Botarelli P, Brunetto M, Minutello M, Calvo P, Unutmaz D, Weiner A, Choo QL, et al. T-lymphocyte response to hepatitis C virus in different clinical courses of infection. Gastroenterology 1993;104:580-587.
52. Ferrari C, Valli A, Galati L, Penna A, Scaccaglia P, Giuberti T, Schianti C, et al. T-cell response to structural and nonstructural hepatitis C virus antigens in persistent and self-limited hepatitis C virus infections. HEPATOLOGY 1994;19:286-295.
53. Schupper H, Hayashi P, Scheffel J, Aceituno S, Paglieroni T, Holland PV, Zeldis JB. Peripheral-blood mononuclear cell responses to recombinant hepatitis C virus antigens in patients with chronic hepatitis C. HEPATOLOGY 1993;18:1055-1060.
54. Lagging LM, Meyer K, Hoft D, Houghton M, Belshe RB, Ray R. Immune response to plasmid DNA encoding the hepatitis C virus core protein. J Virol 1995;69:5859-5863.
55. Yokoyama M, Zhang J, Whitton JL. DNA immunization confers protection against lethal lymphocytic choriomeningitis virus infection. J Virol 1995; 69:2684-2688.
56. Major ME, Vitvitski L, Mink MA, Schleef M, Whalen RG, Trepo C, Inchauspe G. DNA-based immunization with chimeric vectors for the induction of immune responses against the hepatitis C virus nucleocapsid. J Virol 1995;69:5798-5805.