-
1
-
-
2942522878
-
Clinical classification of pulmonary hypertension
-
Simonneau, G., et al. 2004. Clinical classification of pulmonary hypertension. J. Am. Coll. Cardiol. 43:5S-12S.
-
(2004)
J. Am. Coll. Cardiol
, vol.43
-
-
Simonneau, G.1
-
2
-
-
33646269035
-
Pulmonary arterial hypertension in France: Results from a national registry
-
Humbert, M., et al. 2006. Pulmonary arterial hypertension in France: results from a national registry. Am. J. Respir. Crit. Care Med. 173:1023-1030.
-
(2006)
Am. J. Respir. Crit. Care Med
, vol.173
, pp. 1023-1030
-
-
Humbert, M.1
-
3
-
-
0019205876
-
Ultrastructural findings in lung biopsy material from children with congenital heart defects
-
Meyrick, B., and Reid, L. 1980. Ultrastructural findings in lung biopsy material from children with congenital heart defects. Am. J. Pathol. 101:527-537.
-
(1980)
Am. J. Pathol
, vol.101
, pp. 527-537
-
-
Meyrick, B.1
Reid, L.2
-
4
-
-
0030940521
-
Tenascin-C, proliferation and subendothelial fibro-nectin in progressive pulmonary vascular disease
-
Jones, P.L., Cowan, K.N., andRabinovitch, M. 1997. Tenascin-C, proliferation and subendothelial fibro-nectin in progressive pulmonary vascular disease. Am. J. Pathol. 150:1349-1360.
-
(1997)
Am. J. Pathol
, vol.150
, pp. 1349-1360
-
-
Jones, P.L.1
Cowan, K.N.2
andRabinovitch, M.3
-
5
-
-
12144288054
-
Hypoxia-induced pulmonary artery adventitial remodeling and neovascularization: Contribution of progenitor cells
-
Davie, N.J., et al. 2004. Hypoxia-induced pulmonary artery adventitial remodeling and neovascularization: contribution of progenitor cells. Am. J. Physiol. Lung Cell Mol. Physiol. 286:L668-L678.
-
(2004)
Am. J. Physiol. Lung Cell Mol. Physiol
, vol.286
-
-
Davie, N.J.1
-
6
-
-
0037076796
-
Mature vascular endothelium can give rise to smooth muscle cells via endothelial-mesenchymal transdifferentiation: In vitro analysis
-
Frid, M.G., Kale, V.A., and Stenmark, K.R. 2002. Mature vascular endothelium can give rise to smooth muscle cells via endothelial-mesenchymal transdifferentiation: in vitro analysis. Circ. Res. 90:1189-1196.
-
(2002)
Circ. Res
, vol.90
, pp. 1189-1196
-
-
Frid, M.G.1
Kale, V.A.2
Stenmark, K.R.3
-
7
-
-
0015970152
-
Primary pulmonary hypertension: A case report including electronmicroscopic study
-
Meyrick, B., Clarke, S.W., Symons, C., Woodgate, D.J., and Reid, L. 1974. Primary pulmonary hypertension: a case report including electronmicroscopic study. Br. J. Dis. Chest. 68:11-20.
-
(1974)
Br. J. Dis. Chest
, vol.68
, pp. 11-20
-
-
Meyrick, B.1
Clarke, S.W.2
Symons, C.3
Woodgate, D.J.4
Reid, L.5
-
8
-
-
0022853501
-
Pulmonary artery endothelial abnormalities in patients with congenital heart defects and pulmonary hypertension: A correlation of light with scanning electron microscopy and transmission electron microscopy
-
Rabinovitch, M., et al. 1986. Pulmonary artery endothelial abnormalities in patients with congenital heart defects and pulmonary hypertension: A correlation of light with scanning electron microscopy and transmission electron microscopy. Lab. Invest. 55:632-653.
-
(1986)
Lab. Invest
, vol.55
, pp. 632-653
-
-
Rabinovitch, M.1
-
9
-
-
0024245337
-
Endothelial injury and vascular reactivity in mono-crotaline pulmonary hypertension
-
Rosenberg, H.C., and Rabinovitch, M. 1988. Endothelial injury and vascular reactivity in mono-crotaline pulmonary hypertension. Am. J. Physiol. 255:H1484-H1491.
-
(1988)
Am. J. Physiol
, vol.255
-
-
Rosenberg, H.C.1
Rabinovitch, M.2
-
10
-
-
0029868471
-
Exogenous leukocyte and endogenous elastases can mediate mitogenic activity in pulmonary artery smooth muscle cells by release of extracellular-matrix bound basic fibroblast growth factor
-
Thompson, K., and Rabinovitch, M. 1996. Exogenous leukocyte and endogenous elastases can mediate mitogenic activity in pulmonary artery smooth muscle cells by release of extracellular-matrix bound basic fibroblast growth factor. J. Cell Physiol. 166:495-505.
-
(1996)
J. Cell Physiol
, vol.166
, pp. 495-505
-
-
Thompson, K.1
Rabinovitch, M.2
-
11
-
-
33750580874
-
Angiopoietin/Tie2 pathway influences smooth muscle hyperplasia in idiopathic pulmonary hypertension
-
Dewachter, L., et al. 2006. Angiopoietin/Tie2 pathway influences smooth muscle hyperplasia in idiopathic pulmonary hypertension. Am. J. Respir. Crit. Care Med. 174:1025-1033.
-
(2006)
Am. J. Respir. Crit. Care Med
, vol.174
, pp. 1025-1033
-
-
Dewachter, L.1
-
12
-
-
0036243337
-
Abradykinin antagonist and a caspase inhibitor prevent severe pulmonary hypertension in a rat model
-
Taraseviciene-Stewart, L., et al. 2002. Abradykinin antagonist and a caspase inhibitor prevent severe pulmonary hypertension in a rat model. Can. J. Physiol. Pharmacol. 80:269-274.
-
(2002)
Can. J. Physiol. Pharmacol
, vol.80
, pp. 269-274
-
-
Taraseviciene-Stewart, L.1
-
13
-
-
34548433880
-
Hyperproliferative apoptosis-resistant endothelial cells in idiopathic pulmonary arterial hypertension
-
Masri, F.A., et al. 2007. Hyperproliferative apoptosis-resistant endothelial cells in idiopathic pulmonary arterial hypertension. Am. J. Physiol. Lung Cell Mol. Physiol. 293:L548-L554.
-
(2007)
Am. J. Physiol. Lung Cell Mol. Physiol
, vol.293
-
-
Masri, F.A.1
-
14
-
-
9444220218
-
Increased arginase II and decreased NO synthesis in endothelial cells of patients with pulmonary arterial hypertension
-
Xu, W., et al. 2004. Increased arginase II and decreased NO synthesis in endothelial cells of patients with pulmonary arterial hypertension. FASEB J. 18:1746-1748.
-
(2004)
FASEB J
, vol.18
, pp. 1746-1748
-
-
Xu, W.1
-
15
-
-
33846614655
-
Alterations of cellular bioenergetics in pulmonary artery endothelial cells
-
Xu, W., et al. 2007. Alterations of cellular bioenergetics in pulmonary artery endothelial cells. Proc. Natl. Acad. Sci. U. S. A. 104:1342-1347
-
(2007)
Proc. Natl. Acad. Sci. U. S. A
, vol.104
, pp. 1342-1347
-
-
Xu, W.1
-
16
-
-
0028852955
-
Pulmonary artery adventitial changes and venous involvement in primary pulmonary hypertension
-
Chazova, I., et al. 1995. Pulmonary artery adventitial changes and venous involvement in primary pulmonary hypertension. Am. J. Pathol. 146:389-397
-
(1995)
Am. J. Pathol
, vol.146
, pp. 389-397
-
-
Chazova, I.1
-
17
-
-
0030940521
-
Progressive pulmonary vascular disease is characterized by a proliferative response related to deposition of tenascin-C and is preceded by subendo-thelial accumulation of fibronectin
-
Jones, P., Cowan, K., and Rabinovitch, M. 1997. Progressive pulmonary vascular disease is characterized by a proliferative response related to deposition of tenascin-C and is preceded by subendo-thelial accumulation of fibronectin. Am. J. Pathol. 150:1349-1360.
-
(1997)
Am. J. Pathol
, vol.150
, pp. 1349-1360
-
-
Jones, P.1
Cowan, K.2
Rabinovitch, M.3
-
18
-
-
0027400143
-
Neointimal macrophages colocalize with extracellular matrix gene expression in human atherosclerotic pulmonary arteries
-
Liptay, M.J., et al. 1993. Neointimal macrophages colocalize with extracellular matrix gene expression in human atherosclerotic pulmonary arteries. J. Clin. Invest. 91:588-594.
-
(1993)
J. Clin. Invest
, vol.91
, pp. 588-594
-
-
Liptay, M.J.1
-
19
-
-
1542784420
-
S100A4/Mts1 produces murine pulmonary artery changes resembling plexogenic arteriopathy and is increased in human plexogenic arteriopathy
-
Greenway, S., et al. 2004. S100A4/Mts1 produces murine pulmonary artery changes resembling plexogenic arteriopathy and is increased in human plexogenic arteriopathy. Am. J. Pathol. 164:253-262.
-
(2004)
Am. J. Pathol
, vol.164
, pp. 253-262
-
-
Greenway, S.1
-
20
-
-
0037092565
-
CX(3)C chemokine fractalkine in pulmonary arterial hypertension
-
Balabanian, K., et al. 2002. CX(3)C chemokine fractalkine in pulmonary arterial hypertension. Am. J. Respir. Crit. Care Med. 165:1419-1425.
-
(2002)
Am. J. Respir. Crit. Care Med
, vol.165
, pp. 1419-1425
-
-
Balabanian, K.1
-
21
-
-
0026628265
-
An imbalance between the excretion of thromboxane and prostacyclin metabolites in pulmonary hypertension
-
Christman, B.W., et al. 1992. An imbalance between the excretion of thromboxane and prostacyclin metabolites in pulmonary hypertension. N. Engl J. Med. 327:70-75.
-
(1992)
N. Engl J. Med
, vol.327
, pp. 70-75
-
-
Christman, B.W.1
-
22
-
-
0030031888
-
A comparison of continuous intravenous epoprostenol (prostacyclin) with conventional therapy for primary pulmonary hypertension. The Primary Pulmonary Hypertension Study Group
-
Barst, R.J., et al. 1996. A comparison of continuous intravenous epoprostenol (prostacyclin) with conventional therapy for primary pulmonary hypertension. The Primary Pulmonary Hypertension Study Group. N. Engl J. Med. 334:296-301.
-
(1996)
N. Engl J. Med
, vol.334
, pp. 296-301
-
-
Barst, R.J.1
-
23
-
-
34249302372
-
A meta-analysis of trials of pulmonary hypertension: A clinical condition looking for drugs and research methodology
-
Macchia, A., et al. 2007. A meta-analysis of trials of pulmonary hypertension: a clinical condition looking for drugs and research methodology. Am. Heart J. 153:1037-1047
-
(2007)
Am. Heart J
, vol.153
, pp. 1037-1047
-
-
Macchia, A.1
-
24
-
-
34249294002
-
The value of approved therapies for pulmonary arterial hypertension
-
Rich, S. 2007. The value of approved therapies for pulmonary arterial hypertension. Am. Heart J. 153:889-890.
-
(2007)
Am. Heart J
, vol.153
, pp. 889-890
-
-
Rich, S.1
-
25
-
-
0028060499
-
Enhanced endothelin-1 and endothelin receptor gene expression in chronic hypoxia
-
Li, H., et al. 1994. Enhanced endothelin-1 and endothelin receptor gene expression in chronic hypoxia. J. Appl. Physiol. 77:1451-1459.
-
(1994)
J. Appl. Physiol
, vol.77
, pp. 1451-1459
-
-
Li, H.1
-
26
-
-
0027324745
-
Expression of endothelin-1 in the lungs of patients with pulmonary hypertension
-
Giaid, A., et al. 1993. Expression of endothelin-1 in the lungs of patients with pulmonary hypertension. New Engl J. Med. 328:1732-1739.
-
(1993)
New Engl J. Med
, vol.328
, pp. 1732-1739
-
-
Giaid, A.1
-
27
-
-
0037484589
-
Effects of the dual endothelin receptor antagonist bosentan in patients with pulmonary arterial hypertension: A 1-year follow-up study
-
Sitbon, O., et al. 2003. Effects of the dual endothelin receptor antagonist bosentan in patients with pulmonary arterial hypertension: a 1-year follow-up study. Chest. 124:247-254.
-
(2003)
Chest
, vol.124
, pp. 247-254
-
-
Sitbon, O.1
-
28
-
-
10744230817
-
Sitaxsentan therapy for pulmonary arterial hypertension
-
Barst, R.J., et al. 2004. Sitaxsentan therapy for pulmonary arterial hypertension. Am. J. Respir. Crit. Care Med. 169:441-447
-
(2004)
Am. J. Respir. Crit. Care Med
, vol.169
, pp. 441-447
-
-
Barst, R.J.1
-
29
-
-
0029055964
-
Reduced expression of endothelial nitric oxide synthase in the lungs of patients with pulmonary hypertension
-
Giaid, A., and Saleh, D. 1995. Reduced expression of endothelial nitric oxide synthase in the lungs of patients with pulmonary hypertension. New Engl J. Med. 333:214-221.
-
(1995)
New Engl J. Med
, vol.333
, pp. 214-221
-
-
Giaid, A.1
Saleh, D.2
-
30
-
-
21044449937
-
Beneficial effect of oral sildenafil therapy on childhood pulmonary arterial hypertension: Twelve-month clinical trial of a single-drug, open-label, pilot study
-
Humpl, T., Reyes, J.T., Holtby, H., Stephens, D., and Adatia, I. 2005. Beneficial effect of oral sildenafil therapy on childhood pulmonary arterial hypertension: twelve-month clinical trial of a single-drug, open-label, pilot study. Circulation. 111:3274-3280.
-
(2005)
Circulation
, vol.111
, pp. 3274-3280
-
-
Humpl, T.1
Reyes, J.T.2
Holtby, H.3
Stephens, D.4
Adatia, I.5
-
31
-
-
29244449014
-
Successful treatment with sildenafil in systemic sclerosis patients with isolated pulmonary arterial hypertension: Two case reports
-
Hayakawa, I., et al. 2005. Successful treatment with sildenafil in systemic sclerosis patients with isolated pulmonary arterial hypertension: two case reports. Rheumatol Int. 26:270-273.
-
(2005)
Rheumatol Int
, vol.26
, pp. 270-273
-
-
Hayakawa, I.1
-
32
-
-
26444485467
-
Severe persistent pulmonary hypertension of the newborn in a setting where limited resources exclude the use of inhaled nitric oxide: Successful treatment with sildenafil
-
Juliana, A.E., and Abbad, F.C. 2005. Severe persistent pulmonary hypertension of the newborn in a setting where limited resources exclude the use of inhaled nitric oxide: successful treatment with sildenafil. Eur J. Pediatr. 164:626-629.
-
(2005)
Eur J. Pediatr
, vol.164
, pp. 626-629
-
-
Juliana, A.E.1
Abbad, F.C.2
-
33
-
-
24944476691
-
Sildenafil therapy in patients with sickle cell disease and pulmonary hypertension
-
Machado, R.F., et al. 2005. Sildenafil therapy in patients with sickle cell disease and pulmonary hypertension. Br. J. Haematol. 130:445-453.
-
(2005)
Br. J. Haematol
, vol.130
, pp. 445-453
-
-
Machado, R.F.1
-
34
-
-
84984585851
-
The effect of sildenafil on pulmonary embolism-induced oxidative stress and pulmonary hypertension
-
Dias-Junior, C.A., et al. 2005. The effect of sildenafil on pulmonary embolism-induced oxidative stress and pulmonary hypertension. Anesth. Analg 101:115-120.
-
(2005)
Anesth. Analg
, vol.101
, pp. 115-120
-
-
Dias-Junior, C.A.1
-
35
-
-
17044420569
-
Oral sildenafil improves primary pulmonary hypertension refractory to epoprostenol
-
Kataoka, M., et al. 2005. Oral sildenafil improves primary pulmonary hypertension refractory to epoprostenol. Circ. J. 69:461-465.
-
(2005)
Circ. J
, vol.69
, pp. 461-465
-
-
Kataoka, M.1
-
36
-
-
21144437393
-
Sildenafil versus endothelin receptor antagonist for pulmonary hypertension (SERAPH) study
-
Wilkins, M.R., et al. 2005. Sildenafil versus endothelin receptor antagonist for pulmonary hypertension (SERAPH) study. Am. J. Respir. Crit. Care Med. 171:1292-1297.
-
(2005)
Am. J. Respir. Crit. Care Med
, vol.171
, pp. 1292-1297
-
-
Wilkins, M.R.1
-
37
-
-
37549033243
-
A USA-based registry for pulmonary arterial hypertension:1982-2006
-
Thenappan, T., Shah, S.J., Rich, S., and Gomberg-Maitland, M. 2007. A USA-based registry for pulmonary arterial hypertension:1982-2006. Eur. Respir. J. 30:1103-1110.
-
(2007)
Eur. Respir. J
, vol.30
, pp. 1103-1110
-
-
Thenappan, T.1
Shah, S.J.2
Rich, S.3
Gomberg-Maitland, M.4
-
38
-
-
19344369605
-
Adrenomedullin: Angiogenesis and gene therapy
-
Nagaya, N., Mori, H., Murakami, S., Kangawa, K., and Kitamura, S. 2005. Adrenomedullin: angiogenesis and gene therapy. Am. J. Physiol. Regul Integr. Comp. Physiol. 288:R1432-R1437.
-
(2005)
Am. J. Physiol. Regul Integr. Comp. Physiol
, vol.288
-
-
Nagaya, N.1
Mori, H.2
Murakami, S.3
Kangawa, K.4
Kitamura, S.5
-
39
-
-
33947721196
-
Moderate pulmonary arterial hypertension in male mice lacking the vasoactive intestinal peptide gene
-
Said, S.I., et al. 2007. Moderate pulmonary arterial hypertension in male mice lacking the vasoactive intestinal peptide gene. Circulation. 115:1260-1268.
-
(2007)
Circulation
, vol.115
, pp. 1260-1268
-
-
Said, S.I.1
-
40
-
-
0035130447
-
Hemodynamic unloading leads to regression of pulmonary vascular disease in rats
-
O'Blenes, S.B., Fischer, S., McIntyre, B., Keshavjee, S., and Rabinovitch, M. 2001. Hemodynamic unloading leads to regression of pulmonary vascular disease in rats. J. Thorac. Cardiovasc. Surg. 121:279-289.
-
(2001)
J. Thorac. Cardiovasc. Surg
, vol.121
, pp. 279-289
-
-
O'Blenes, S.B.1
Fischer, S.2
McIntyre, B.3
Keshavjee, S.4
Rabinovitch, M.5
-
41
-
-
33746365848
-
Reversal of idiopathic pulmonary arterial hypertension and allograft pneumonectomy after single lung transplantation
-
Deb, S., et al. 2006. Reversal of idiopathic pulmonary arterial hypertension and allograft pneumonectomy after single lung transplantation. Chest. 130:214-217
-
(2006)
Chest
, vol.130
, pp. 214-217
-
-
Deb, S.1
-
42
-
-
0035131411
-
40-O-(2-hydroxyethyl)-rapamycin attenuates pulmonary arterial hypertension and neointimal formation in rats
-
Nishimura, T., et al. 2001. 40-O-(2-hydroxyethyl)-rapamycin attenuates pulmonary arterial hypertension and neointimal formation in rats. Am. J. Respir. Crit. Care Med. 163:498-502.
-
(2001)
Am. J. Respir. Crit. Care Med
, vol.163
, pp. 498-502
-
-
Nishimura, T.1
-
43
-
-
34147189502
-
Rho kinase-mediated vasoconstriction is important in severe occlusive pulmonary arterial hypertension in rats
-
Oka, M., et al. 2007. Rho kinase-mediated vasoconstriction is important in severe occlusive pulmonary arterial hypertension in rats. Circ. Res. 100:923-929.
-
(2007)
Circ. Res
, vol.100
, pp. 923-929
-
-
Oka, M.1
-
44
-
-
31644431508
-
Beneficial acute effects of rho-kinase inhibitor in patients with pulmonary arterial hypertension
-
Ishikura, K., et al. 2006. Beneficial acute effects of rho-kinase inhibitor in patients with pulmonary arterial hypertension. Circ. J. 70:174-178.
-
(2006)
Circ. J
, vol.70
, pp. 174-178
-
-
Ishikura, K.1
-
45
-
-
0033817459
-
Heterozygous germline mutations in BMPR2, encoding a TGF-beta receptor, cause familial primary pulmonary hypertension
-
Lane, K.B., et al. 2000. Heterozygous germline mutations in BMPR2, encoding a TGF-beta receptor, cause familial primary pulmonary hypertension. Nat. Genet. 26:81-84.
-
(2000)
Nat. Genet
, vol.26
, pp. 81-84
-
-
Lane, K.B.1
-
46
-
-
0033838125
-
Familial primary pulmonary hypertension (gene PPH1) is caused by mutations in the bone morphogenetic protein receptor-II gene
-
Deng, Z., et al. 2000. Familial primary pulmonary hypertension (gene PPH1) is caused by mutations in the bone morphogenetic protein receptor-II gene. Am. J. Hum. Genet. 67:737-744.
-
(2000)
Am. J. Hum. Genet
, vol.67
, pp. 737-744
-
-
Deng, Z.1
-
47
-
-
0037096836
-
Functional analysis of bone morphogenetic protein type II receptor mutations underlying primary pulmonary hypertension
-
Rudarakanchana, N., et al. 2002. Functional analysis of bone morphogenetic protein type II receptor mutations underlying primary pulmonary hypertension. Hum. Mol Genet. 11:1517-1525.
-
(2002)
Hum. Mol Genet
, vol.11
, pp. 1517-1525
-
-
Rudarakanchana, N.1
-
48
-
-
0037085287
-
The mode of bone morphogenetic protein (BMP) receptor oligomerization determines different BMP-2 signaling pathways
-
Nohe, A., et al. 2002. The mode of bone morphogenetic protein (BMP) receptor oligomerization determines different BMP-2 signaling pathways. J. Biol. Chem. 277:5330-5338.
-
(2002)
J. Biol. Chem
, vol.277
, pp. 5330-5338
-
-
Nohe, A.1
-
49
-
-
34250663063
-
Proinvasive activity of BMP-7 through SMAD4/src-independent and ERK/Rac/JNK-dependent signaling pathways in colon cancer cells
-
Grijelmo, C, et al. 2007. Proinvasive activity of BMP-7 through SMAD4/src-independent and ERK/Rac/JNK-dependent signaling pathways in colon cancer cells. Cell Signal. 19:1722-1732.
-
(2007)
Cell Signal
, vol.19
, pp. 1722-1732
-
-
Grijelmo, C.1
-
50
-
-
22044454171
-
Bridging the BMP and Wnt pathways by PI3 kinase/Akt and 14-3-3zeta
-
Tian, Q., He, X.C., Hood, L., and Li, L. 2005. Bridging the BMP and Wnt pathways by PI3 kinase/Akt and 14-3-3zeta. Cell Cycle. 4:215-216.
-
(2005)
Cell Cycle
, vol.4
, pp. 215-216
-
-
Tian, Q.1
He, X.C.2
Hood, L.3
Li, L.4
-
51
-
-
4544386270
-
BMPR2 mutations in pulmonary arterial hypertension with congenital heart disease
-
Roberts, K.E., et al. 2004. BMPR2 mutations in pulmonary arterial hypertension with congenital heart disease. Eur Respir. J. 24:371-374.
-
(2004)
Eur Respir. J
, vol.24
, pp. 371-374
-
-
Roberts, K.E.1
-
52
-
-
18544376034
-
BMPR2 germline mutations in pulmonary hypertension associated with fenfluramine derivatives
-
Humbert, M., et al. 2002. BMPR2 germline mutations in pulmonary hypertension associated with fenfluramine derivatives. Eur Respir. J. 20:518-523.
-
(2002)
Eur Respir. J
, vol.20
, pp. 518-523
-
-
Humbert, M.1
-
53
-
-
0037046175
-
Primary pulmonary hypertension is associated with reduced pulmonary vascular expression of type II bone morphogenetic protein receptor
-
Atkinson, C, et al. 2002. Primary pulmonary hypertension is associated with reduced pulmonary vascular expression of type II bone morphogenetic protein receptor. Circulation. 105:1627-16787.
-
(2002)
Circulation
, vol.105
, pp. 1627-16787
-
-
Atkinson, C.1
-
54
-
-
0037421604
-
Signaling molecules in nonfamilial pulmonary hypertension
-
Du, L., et al. 2003. Signaling molecules in nonfamilial pulmonary hypertension. N. Engl J. Med. 348:500-509.
-
(2003)
N. Engl J. Med
, vol.348
, pp. 500-509
-
-
Du, L.1
-
55
-
-
33644865928
-
Bone morphogenetic protein receptor-2 signaling promotes pulmonary arterial endothelial cell survival: Implications for loss-of-function mutations in the pathogenesis of pulmonary hypertension
-
Teichert-Kuliszewska, K., et al. 2006. Bone morphogenetic protein receptor-2 signaling promotes pulmonary arterial endothelial cell survival: implications for loss-of-function mutations in the pathogenesis of pulmonary hypertension. Circ. Res. 98:209-217.
-
(2006)
Circ. Res
, vol.98
, pp. 209-217
-
-
Teichert-Kuliszewska, K.1
-
56
-
-
0035859940
-
Altered growth responses of pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension to transforming growth factor-beta(1) and bone morphogenetic proteins
-
Morrell, N.W., et al. 2001. Altered growth responses of pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension to transforming growth factor-beta(1) and bone morphogenetic proteins. Circulation. 104:790-795.
-
(2001)
Circulation
, vol.104
, pp. 790-795
-
-
Morrell, N.W.1
-
57
-
-
17944386754
-
Bone morphogenetic proteins induce apoptosis in human pulmonary vascular smooth muscle cells
-
Zhang, S., et al. 2003. Bone morphogenetic proteins induce apoptosis in human pulmonary vascular smooth muscle cells. Am. J. Physiol. Lung Cell Mol. Physiol. 285:L740-L754.
-
(2003)
Am. J. Physiol. Lung Cell Mol. Physiol
, vol.285
-
-
Zhang, S.1
-
58
-
-
43049092988
-
An antiproliferative BMP-2/PPARgamma/apoE axis in human and murine SMCs and its role in pulmonary hypertension
-
Hansmann, G., et al. 2008. An antiproliferative BMP-2/PPARgamma/apoE axis in human and murine SMCs and its role in pulmonary hypertension. J. Clin. Invest. 118:1846-1857.
-
(2008)
J. Clin. Invest
, vol.118
, pp. 1846-1857
-
-
Hansmann, G.1
-
59
-
-
0030860609
-
Regulation of tenascin-C, a vascular smooth muscle cell survival factor that interacts with the αvβ3 integrin to promote epidermal growth factor receptor phosphorylation and growth
-
Jones, P., Crack, J., and Rabinovitch, M. 1997. Regulation of tenascin-C, a vascular smooth muscle cell survival factor that interacts with the αvβ3 integrin to promote epidermal growth factor receptor phosphorylation and growth. J. Cell Biol. 139:279-293.
-
(1997)
J. Cell Biol
, vol.139
, pp. 279-293
-
-
Jones, P.1
Crack, J.2
Rabinovitch, M.3
-
60
-
-
22544484537
-
Epidermal growth factor receptor blockade mediates smooth muscle cell apoptosis and improves survival in rats with pulmonary hypertension
-
Merklinger, S.L., Jones, P.L., Martinez, E.C., and Rabinovitch, M. 2005. Epidermal growth factor receptor blockade mediates smooth muscle cell apoptosis and improves survival in rats with pulmonary hypertension. Circulation. 112:423-431.
-
(2005)
Circulation
, vol.112
, pp. 423-431
-
-
Merklinger, S.L.1
Jones, P.L.2
Martinez, E.C.3
Rabinovitch, M.4
-
61
-
-
8644256840
-
BMPR-II heterozygous mice have mild pulmonary hypertension and an impaired pulmonary vascular remodeling response to prolonged hypoxia
-
Beppu, H., et al. 2004. BMPR-II heterozygous mice have mild pulmonary hypertension and an impaired pulmonary vascular remodeling response to prolonged hypoxia. Am. J. Physiol. Lung Cell Mol Physiol. 287:L1241-L1247.
-
(2004)
Am. J. Physiol. Lung Cell Mol Physiol
, vol.287
-
-
Beppu, H.1
-
62
-
-
2342486700
-
Pulmonary hypertension in transgenic mice expressing a dominant-negative BMPRII gene in smooth muscle
-
West, J., et al. 2004. Pulmonary hypertension in transgenic mice expressing a dominant-negative BMPRII gene in smooth muscle. Circ. Res. 94:1109-1114.
-
(2004)
Circ. Res
, vol.94
, pp. 1109-1114
-
-
West, J.1
-
63
-
-
0141730236
-
Simvastatin rescues rats from fatal pulmonary hypertension by inducing apoptosis of neointimal smooth muscle cells
-
Nishimura, T., et al. 2003. Simvastatin rescues rats from fatal pulmonary hypertension by inducing apoptosis of neointimal smooth muscle cells. Circulation. 108:1640-1645.
-
(2003)
Circulation
, vol.108
, pp. 1640-1645
-
-
Nishimura, T.1
-
64
-
-
34247198299
-
Overexpression of human bone morphogenetic protein receptor 2 does not ameliorate monocrotaline pulmonary arterial hypertension
-
McMurtry, M.S., et al. 2007. Overexpression of human bone morphogenetic protein receptor 2 does not ameliorate monocrotaline pulmonary arterial hypertension. Am. J. Physiol. Lung Cell Mol Physiol. 292:L872- L878.
-
(2007)
Am. J. Physiol. Lung Cell Mol Physiol
, vol.292
-
-
McMurtry, M.S.1
-
65
-
-
12144274863
-
BMP4 inhibits proliferation and promotes myocyte differentiation of lung fibroblasts via Smad1 and JNK pathways
-
Jeffery, T.K., Upton, P.D., Trembath, R.C., and Morrell, N.W. 2005. BMP4 inhibits proliferation and promotes myocyte differentiation of lung fibroblasts via Smad1 and JNK pathways. Am. J. Physiol Lung Cell Mol Physiol. 288:L370-L378.
-
(2005)
Am. J. Physiol Lung Cell Mol Physiol
, vol.288
-
-
Jeffery, T.K.1
Upton, P.D.2
Trembath, R.C.3
Morrell, N.W.4
-
66
-
-
20344362689
-
Dysfunctional Smad signaling contributes to abnormal smooth muscle cell proliferation in familial pulmonary arterial hypertension
-
Yang, X.,et al. 2005. Dysfunctional Smad signaling contributes to abnormal smooth muscle cell proliferation in familial pulmonary arterial hypertension. Circ. Res. 96:1053-1063.
-
(2005)
Circ. Res
, vol.96
, pp. 1053-1063
-
-
Yang, X.1
-
67
-
-
24744471858
-
Bone morphogenetic protein 4 promotes pulmonary vascular remodeling in hypoxic pulmonary hypertension
-
Frank, D.B., et al. 2005. Bone morphogenetic protein 4 promotes pulmonary vascular remodeling in hypoxic pulmonary hypertension. Circ. Res. 97:496-504.
-
(2005)
Circ. Res
, vol.97
, pp. 496-504
-
-
Frank, D.B.1
-
68
-
-
21644447416
-
Bone morphogenetic protein (BMP) type II receptor deletion reveals BMP ligand-specific gain of signaling in pulmonary artery smooth muscle cells
-
Yu, P.B., Beppu, H., Kawai, N., Li, E., and Bloch, K.D. 2005. Bone morphogenetic protein (BMP) type II receptor deletion reveals BMP ligand-specific gain of signaling in pulmonary artery smooth muscle cells. J. Biol. Chem. 280:24443-24450.
-
(2005)
J. Biol. Chem
, vol.280
, pp. 24443-24450
-
-
Yu, P.B.1
Beppu, H.2
Kawai, N.3
Li, E.4
Bloch, K.D.5
-
69
-
-
39449096751
-
Smooth muscle protein 22alpha-mediated patchy deletion of Bmprla impairs cardiac contractility but protects against pulmonary vascular remodeling
-
El-Bizri, N., et al. 2008. Smooth muscle protein 22alpha-mediated patchy deletion of Bmprla impairs cardiac contractility but protects against pulmonary vascular remodeling. Circ. Res. 102:380-388.
-
(2008)
Circ. Res
, vol.102
, pp. 380-388
-
-
El-Bizri, N.1
-
70
-
-
9144219585
-
Molecular and functional analysis identifies ALK-1 as the predominant cause of pulmonary hypertension related to hereditary haemorrhagic telangiectasia
-
Harrison, R.E., et al. 2003. Molecular and functional analysis identifies ALK-1 as the predominant cause of pulmonary hypertension related to hereditary haemorrhagic telangiectasia. J. Med. Genet. 40:865-871.
-
(2003)
J. Med. Genet
, vol.40
, pp. 865-871
-
-
Harrison, R.E.1
-
71
-
-
2442519516
-
Endoglin germline mutation in a patient with hereditary haemorrhagic telangiectasia and dexfenfluramine associated pulmonary arterial hypertension
-
Chaouat, A., et al. 2004. Endoglin germline mutation in a patient with hereditary haemorrhagic telangiectasia and dexfenfluramine associated pulmonary arterial hypertension. Thorax. 59:446-448.
-
(2004)
Thorax
, vol.59
, pp. 446-448
-
-
Chaouat, A.1
-
72
-
-
0035910729
-
Microsatellite instability of endothelial cell growth and apoptosis genes within plexiform lesions in primary pulmonary hypertension
-
Yeager, M.E., Halley, G.R., Golpon, H.A., Voelkel, N.F., andTuder, R.M. 2001. Microsatellite instability of endothelial cell growth and apoptosis genes within plexiform lesions in primary pulmonary hypertension. Circ. Res. 88:E2-E11.
-
(2001)
Circ. Res
, vol.88
-
-
Yeager, M.E.1
Halley, G.R.2
Golpon, H.A.3
Voelkel, N.F.4
andTuder, R.M.5
-
73
-
-
33751227533
-
Pulmonary hypertension due to BMPR2 mutation: A new paradigm for tissue remodeling?
-
Morrell, N.W. 2006. Pulmonary hypertension due to BMPR2 mutation: a new paradigm for tissue remodeling? Proc. Am. Thorac. Soc. 3:680-686.
-
(2006)
Proc. Am. Thorac. Soc
, vol.3
, pp. 680-686
-
-
Morrell, N.W.1
-
74
-
-
33746801074
-
Hypoxia regulates bone morphogenetic protein signaling through C-terminal-binding protein 1
-
Wu, X., Chang, M.S., Mitsialis, S.A., and Kourem-banas, S. 2006. Hypoxia regulates bone morphogenetic protein signaling through C-terminal-binding protein 1. Circ. Res. 99:240-247.
-
(2006)
Circ. Res
, vol.99
, pp. 240-247
-
-
Wu, X.1
Chang, M.S.2
Mitsialis, S.A.3
Kourem-banas, S.4
-
75
-
-
34247282656
-
Rosiglitazone attenuates hypoxia-induced pulmonary arterial remodeling
-
Crossno, J.T., Jr., et al. 2007. Rosiglitazone attenuates hypoxia-induced pulmonary arterial remodeling. Am. J. Physiol. Lung Cell Mol. Physiol. 292:L885-L897.
-
(2007)
Am. J. Physiol. Lung Cell Mol. Physiol
, vol.292
-
-
Crossno Jr., J.T.1
-
76
-
-
33947731898
-
Pulmonary arterial hypertension is linked to insulin resistance and reversed by peroxisome proliferator-activated receptor-gamma activation
-
Hansmann, G., et al. 2007. Pulmonary arterial hypertension is linked to insulin resistance and reversed by peroxisome proliferator-activated receptor-gamma activation. Circulation. 115:1275-1284.
-
(2007)
Circulation
, vol.115
, pp. 1275-1284
-
-
Hansmann, G.1
-
77
-
-
23044455604
-
Low density lipoprotein receptor-related protein 1 (LRP1) controls endocytosis and c-CBL-mediated ubiquitination of the platelet-derived growth factor receptor beta (PDGFRbeta)
-
Takayama, Y., May, P., Anderson, R.G., and Herz, J. 2005. Low density lipoprotein receptor-related protein 1 (LRP1) controls endocytosis and c-CBL-mediated ubiquitination of the platelet-derived growth factor receptor beta (PDGFRbeta). J. Biol Chem. 280:18504-18510.
-
(2005)
J. Biol Chem
, vol.280
, pp. 18504-18510
-
-
Takayama, Y.1
May, P.2
Anderson, R.G.3
Herz, J.4
-
78
-
-
26444540768
-
Reversal of experimental pulmonary hypertension by PDGF inhibition
-
Schermuly, R.T., et al. 2005. Reversal of experimental pulmonary hypertension by PDGF inhibition. J. Clin. Invest. 115:2811-2821.
-
(2005)
J. Clin. Invest
, vol.115
, pp. 2811-2821
-
-
Schermuly, R.T.1
-
79
-
-
25444484658
-
Imatinib for the treatment of pulmonary arterial hypertension
-
Ghofrani, H.A., Seeger, W., and Grimminger, F. 2005. Imatinib for the treatment of pulmonary arterial hypertension. N. Engl J. Med. 353:1412-1413.
-
(2005)
N. Engl J. Med
, vol.353
, pp. 1412-1413
-
-
Ghofrani, H.A.1
Seeger, W.2
Grimminger, F.3
-
80
-
-
0037129861
-
Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell
-
Arita, Y., et al. 2002. Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell. Circulation. 105:2893-2898.
-
(2002)
Circulation
, vol.105
, pp. 2893-2898
-
-
Arita, Y.1
-
81
-
-
0032504763
-
AML1-like transcription factor induces serine elastase activity in ovine pulmonary artery smooth muscle cells
-
Wigle, D.A., et al. 1998. AML1-like transcription factor induces serine elastase activity in ovine pulmonary artery smooth muscle cells. Circ. Res. 83:252-263.
-
(1998)
Circ. Res
, vol.83
, pp. 252-263
-
-
Wigle, D.A.1
-
82
-
-
38749138478
-
Evidence of a role for osteo-protegerin in the pathogenesis of pulmonary arterial hypertension
-
Lawrie, A., et al. 2008. Evidence of a role for osteo-protegerin in the pathogenesis of pulmonary arterial hypertension. Am. J. Pathol. 172:256-264.
-
(2008)
Am. J. Pathol
, vol.172
, pp. 256-264
-
-
Lawrie, A.1
-
83
-
-
33749360245
-
Tenascin-C is induced by mutated BMP type II receptors in familial forms of pulmonary arterial hypertension
-
Ihida-Stansbury, K., et al. 2006. Tenascin-C is induced by mutated BMP type II receptors in familial forms of pulmonary arterial hypertension. Am. J. Physiol. Lung Cell Mol. Physiol. 291:L694-L702.
-
(2006)
Am. J. Physiol. Lung Cell Mol. Physiol
, vol.291
-
-
Ihida-Stansbury, K.1
-
84
-
-
0026779181
-
Increased pulmonary artery elastolytic activity in adult rats with monocrotaline-induced progressive hypertensive pulmonary vascular disease compared with infant rats with nonprogressive disease
-
Todorovich-Hunter, L., et al. 1992. Increased pulmonary artery elastolytic activity in adult rats with monocrotaline-induced progressive hypertensive pulmonary vascular disease compared with infant rats with nonprogressive disease. Am. Rev. Respir. Dis. 146:213-223.
-
(1992)
Am. Rev. Respir. Dis
, vol.146
, pp. 213-223
-
-
Todorovich-Hunter, L.1
-
85
-
-
0025946760
-
Inhibition of elastolysis by SC-37698 reduces development and progression of monocrotaline pulmonary hypertension
-
Ye, C., and Rabinovitch, M. 1991. Inhibition of elastolysis by SC-37698 reduces development and progression of monocrotaline pulmonary hypertension. Am. J. Physiol. 261:H1255-H1267.
-
(1991)
Am. J. Physiol
, vol.261
-
-
Ye, C.1
Rabinovitch, M.2
-
86
-
-
0026320578
-
Chronic hypoxic pulmonary hypertension in rats and increased elastolytic activity
-
Maruyama, K., et al. 1991. Chronic hypoxic pulmonary hypertension in rats and increased elastolytic activity. Am. J. Physiol. 261:H1716- H1726.
-
(1991)
Am. J. Physiol
, vol.261
-
-
Maruyama, K.1
-
87
-
-
0034126770
-
Complete reversal of fatal pulmonary hypertension in rats by a serine elastase inhibitor
-
Cowan, K.N., et al. 2000. Complete reversal of fatal pulmonary hypertension in rats by a serine elastase inhibitor. Nat. Med. 6:698-702.
-
(2000)
Nat. Med
, vol.6
, pp. 698-702
-
-
Cowan, K.N.1
-
88
-
-
20444483234
-
Gene therapy targeting survivin selectively induces pulmonary vascular apoptosis and reverses pulmonary arterial hypertension
-
McMurtry, M.S., et al. 2005. Gene therapy targeting survivin selectively induces pulmonary vascular apoptosis and reverses pulmonary arterial hypertension. J. Clin. Invest. 115:1479-1491.
-
(2005)
J. Clin. Invest
, vol.115
, pp. 1479-1491
-
-
McMurtry, M.S.1
-
89
-
-
33751087216
-
Bone morphogenetic protein-2 upregulates expression and function of voltage-gated K+ channels in human pulmonary artery smooth muscle cells
-
Fantozzi, I., et al. 2006. Bone morphogenetic protein-2 upregulates expression and function of voltage-gated K+ channels in human pulmonary artery smooth muscle cells. Am. J. Physiol. Lung Cell Mol. Physiol. 291:L993-L1004.
-
(2006)
Am. J. Physiol. Lung Cell Mol. Physiol
, vol.291
-
-
Fantozzi, I.1
-
90
-
-
0037080541
-
Dichloroacetate, a metabolic modulator, prevents and reverses chronic hypoxic pulmonary hypertension in rats: Role of increased expression and activity of voltage-gated potassium channels
-
Michelakis, E.D., et al. 2002. Dichloroacetate, a metabolic modulator, prevents and reverses chronic hypoxic pulmonary hypertension in rats: role of increased expression and activity of voltage-gated potassium channels. Circulation. 105:244-250.
-
(2002)
Circulation
, vol.105
, pp. 244-250
-
-
Michelakis, E.D.1
-
91
-
-
6344257102
-
Dichloroacetate prevents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis
-
McMurtry, M.S., et al. 2004. Dichloroacetate prevents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis. Circ. Res. 95:830-840.
-
(2004)
Circ. Res
, vol.95
, pp. 830-840
-
-
McMurtry, M.S.1
-
92
-
-
33745155785
-
An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: Similarities to human pulmonary arterial hypertension
-
Bonnet, S., et al. 2006. An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: similarities to human pulmonary arterial hypertension. Circulation. 113:2630-2641.
-
(2006)
Circulation
, vol.113
, pp. 2630-2641
-
-
Bonnet, S.1
-
93
-
-
33646145730
-
Serotonin inhibits voltage-gated K+ currents in pulmonary artery smooth muscle cells: Role of 5-HT2A receptors, caveolin-1, and KV1.5 channel internalization
-
Cogolludo, A., et al. 2006. Serotonin inhibits voltage-gated K+ currents in pulmonary artery smooth muscle cells: role of 5-HT2A receptors, caveolin-1, and KV1.5 channel internalization. Circ. Res. 98:931-938.
-
(2006)
Circ. Res
, vol.98
, pp. 931-938
-
-
Cogolludo, A.1
-
94
-
-
4644290321
-
Enhanced expression of transient receptor potential channels in idiopathic pulmonary arterial hypertension
-
Yu, Y., et al. 2004. Enhanced expression of transient receptor potential channels in idiopathic pulmonary arterial hypertension. Proc. Natl. Acad. Sci. U. S. A. 101:13861-13866.
-
(2004)
Proc. Natl. Acad. Sci. U. S. A
, vol.101
, pp. 13861-13866
-
-
Yu, Y.1
-
95
-
-
34447286761
-
Pulmonary artery smooth muscle cells from normal subjects and IPAH patients show divergent cAMP-mediated effects on TRPC expression and capacitative Ca2+ entry
-
Zhang, S., et al. 2007. Pulmonary artery smooth muscle cells from normal subjects and IPAH patients show divergent cAMP-mediated effects on TRPC expression and capacitative Ca2+ entry. Am. J. Physiol. Lung Cell Mol. Physiol. 292:L1202-L1210.
-
(2007)
Am. J. Physiol. Lung Cell Mol. Physiol
, vol.292
-
-
Zhang, S.1
-
96
-
-
0033839977
-
Early abnormalities of pulmonary vascular development in the Fawn-Hooded rat raised at Denver's altitude
-
Le Cras, T.D., Kim, D.H., Markham, N.E., and Abman, A.S. 2000. Early abnormalities of pulmonary vascular development in the Fawn-Hooded rat raised at Denver's altitude. Am. J. Physiol. Lung Cell Mol. Physiol. 279:L283-L291.
-
(2000)
Am. J. Physiol. Lung Cell Mol. Physiol
, vol.279
-
-
Le Cras, T.D.1
Kim, D.H.2
Markham, N.E.3
Abman, A.S.4
-
97
-
-
0034096980
-
Attenuated hypoxic pulmonary hypertension in mice lacking the 5-hydroxytryptamine transporter gene
-
Eddahibi, S., et al. 2000. Attenuated hypoxic pulmonary hypertension in mice lacking the 5-hydroxytryptamine transporter gene. J. Clin. Invest. 105:1555-1562.
-
(2000)
J. Clin. Invest
, vol.105
, pp. 1555-1562
-
-
Eddahibi, S.1
-
98
-
-
2442519344
-
Overexpression of the 5-hydroxytryptamine transporter gene: Effect on pulmonary hemodynamics and hypoxia-induced pulmonary hypertension
-
MacLean, M.R., et al. 2004. Overexpression of the 5-hydroxytryptamine transporter gene: effect on pulmonary hemodynamics and hypoxia-induced pulmonary hypertension. Circulation. 109:2150-2155.
-
(2004)
Circulation
, vol.109
, pp. 2150-2155
-
-
MacLean, M.R.1
-
99
-
-
33744970745
-
Transgenic mice over-expressing the 5-hydroxytryptamine transporter gene in smooth muscle develop pulmonary hypertension
-
Guignabert, C, et al. 2006. Transgenic mice over-expressing the 5-hydroxytryptamine transporter gene in smooth muscle develop pulmonary hypertension. Circ. Res. 98:1323-1330.
-
(2006)
Circ. Res
, vol.98
, pp. 1323-1330
-
-
Guignabert, C.1
-
100
-
-
33645751955
-
Serotonin increases susceptibility to pulmonary hypertension in BMPR2-deficientmice
-
Long, L., et al. 2006. Serotonin increases susceptibility to pulmonary hypertension in BMPR2-deficientmice. Circ. Res. 98:818-827.
-
(2006)
Circ. Res
, vol.98
, pp. 818-827
-
-
Long, L.1
-
101
-
-
34548482510
-
The 5-HT transporter transactivates the PDGF{beta} receptor in pulmonary artery smooth muscle cells
-
Liu, Y, Li, M., Warburton, R.R., Hill, N.S., and Fanburg, B.L. 2007. The 5-HT transporter transactivates the PDGF{beta} receptor in pulmonary artery smooth muscle cells. FASEB J. 21:2725-2734.
-
(2007)
FASEB J
, vol.21
, pp. 2725-2734
-
-
Liu, Y.1
Li, M.2
Warburton, R.R.3
Hill, N.S.4
Fanburg, B.L.5
-
102
-
-
0037931726
-
Activation of GATA-4 by serotonin in pulmonary artery smooth muscle cells
-
Suzuki, Y.J., et al. 2003. Activation of GATA-4 by serotonin in pulmonary artery smooth muscle cells. J. Biol. Chem. 278:17525-17531.
-
(2003)
J. Biol. Chem
, vol.278
, pp. 17525-17531
-
-
Suzuki, Y.J.1
-
103
-
-
25844461916
-
-
Simon, A.R., et al. 2005. 5-HT induction of c-fos gene expression requires reactive oxygen species and Rac1 and Ras GTPases. Cell Bio chem. Biophys. 42:263-276.
-
Simon, A.R., et al. 2005. 5-HT induction of c-fos gene expression requires reactive oxygen species and Rac1 and Ras GTPases. Cell Bio chem. Biophys. 42:263-276.
-
-
-
-
104
-
-
23344441118
-
Interdependent serotonin transporter and receptor pathways regulate S100A4/Mts1, a gene associated with pulmonary vascular disease
-
Lawrie, A., et al. 2005. Interdependent serotonin transporter and receptor pathways regulate S100A4/Mts1, a gene associated with pulmonary vascular disease. Circ. Res. 97:227-235.
-
(2005)
Circ. Res
, vol.97
, pp. 227-235
-
-
Lawrie, A.1
-
105
-
-
0142085751
-
Polymorphism of the serotonin transporter gene and pulmonary hypertension in chronic obstructive pulmonary disease
-
Eddahibi, S., et al. 2003. Polymorphism of the serotonin transporter gene and pulmonary hypertension in chronic obstructive pulmonary disease. Circulation. 108:1839-1844.
-
(2003)
Circulation
, vol.108
, pp. 1839-1844
-
-
Eddahibi, S.1
-
106
-
-
0029878250
-
Primary pulmonary hypertension in HIV infection: An outcome determined by particular HLA class II alleles
-
Morse, J.H., et al. 1996. Primary pulmonary hypertension in HIV infection: an outcome determined by particular HLA class II alleles. Am. J. Respir. Crit. Care Med. 153:1299-1301.
-
(1996)
Am. J. Respir. Crit. Care Med
, vol.153
, pp. 1299-1301
-
-
Morse, J.H.1
-
107
-
-
0141679188
-
Expression of human herpesvirus 8 in primary pulmonary hypertension
-
Cool, CD., et al. 2003. Expression of human herpesvirus 8 in primary pulmonary hypertension. N. Engl. J. Med. 349:1113-1122.
-
(2003)
N. Engl. J. Med
, vol.349
, pp. 1113-1122
-
-
Cool, C.D.1
-
108
-
-
39149131039
-
Reactivation of gammaHV68 induces neointimal lesions in pulmonary arteries of S100A4/Mts1-overexpressing mice in association with degradation of elastin
-
Spiekerkoetter, E., et al. 2008. Reactivation of gammaHV68 induces neointimal lesions in pulmonary arteries of S100A4/Mts1-overexpressing mice in association with degradation of elastin. Am. J. Physiol. Lung Cell Mol. Physiol. 294:L276-L289.
-
(2008)
Am. J. Physiol. Lung Cell Mol. Physiol
, vol.294
-
-
Spiekerkoetter, E.1
-
109
-
-
33747135052
-
HIV-1 Nefis associated with complex pulmonary vascular lesions in SHIV-nef-infected macaques
-
Marecki,J.C., et al. 2006. HIV-1 Nefis associated with complex pulmonary vascular lesions in SHIV-nef-infected macaques. Am. J. Respir. Crit. Care Med. 174:437-445.
-
(2006)
Am. J. Respir. Crit. Care Med
, vol.174
, pp. 437-445
-
-
Marecki, J.C.1
-
110
-
-
39549087002
-
Pulmonary arterial remodeling induced by a Th2 immune response
-
Daley, E., et al. 2008. Pulmonary arterial remodeling induced by a Th2 immune response. J. Exp. Med. 205:361-372.
-
(2008)
J. Exp. Med
, vol.205
, pp. 361-372
-
-
Daley, E.1
-
111
-
-
0346458560
-
Selective cleavage of nucleolar autoantigen B23 by granzyme B in differentiated vascular smooth muscle cells: Insights into the association of specific autoantibodies with distinct disease phenotypes
-
Ulanet, D.B., Flavahan, N.A., Casciola-Rosen, L., and Rosen, A. 2004. Selective cleavage of nucleolar autoantigen B23 by granzyme B in differentiated vascular smooth muscle cells: insights into the association of specific autoantibodies with distinct disease phenotypes. Arthritis Rheum. 50:233-241.
-
(2004)
Arthritis Rheum
, vol.50
, pp. 233-241
-
-
Ulanet, D.B.1
Flavahan, N.A.2
Casciola-Rosen, L.3
Rosen, A.4
-
112
-
-
23044504042
-
Increased susceptibility to pulmonary hypertension in heterozygous BMPR2-mutantmice
-
Song, Y., et al. 2005. Increased susceptibility to pulmonary hypertension in heterozygous BMPR2-mutantmice. Circulation. 112:553-562.
-
(2005)
Circulation
, vol.112
, pp. 553-562
-
-
Song, Y.1
-
113
-
-
0022512741
-
Repeated eschrerichia coli endotocin-induced pulmonary inflammation causes chronic pulmonary hypertension in sheep
-
Meyrick, B.,and Brigham, K. 1986. Repeated eschrerichia coli endotocin-induced pulmonary inflammation causes chronic pulmonary hypertension in sheep. Lab. Invest. 55:164-176.
-
(1986)
Lab. Invest
, vol.55
, pp. 164-176
-
-
Meyrick, B.1
Brigham, K.2
-
114
-
-
0026644119
-
Acute and long-term TNF-alpha administration increases pulmonary vascular reactivity in isolated rat lungs
-
Stevens, T., Janssen, P.L., and Tucker, A.D. 1992. Acute and long-term TNF-alpha administration increases pulmonary vascular reactivity in isolated rat lungs. J. Appl. Physiol. 73:708-712.
-
(1992)
J. Appl. Physiol
, vol.73
, pp. 708-712
-
-
Stevens, T.1
Janssen, P.L.2
Tucker, A.D.3
-
115
-
-
34250205557
-
Absence of T cells confers increased pulmonary arterial hypertension and vascular remodeling
-
Taraseviciene-Stewart, L., et al. 2007. Absence of T cells confers increased pulmonary arterial hypertension and vascular remodeling. Am. J. Respir. Crit. Care Med. 175:1280-1289.
-
(2007)
Am. J. Respir. Crit. Care Med
, vol.175
, pp. 1280-1289
-
-
Taraseviciene-Stewart, L.1
-
116
-
-
34248209543
-
Fractalkine-induced smooth muscle cell proliferation in pulmonary hypertension
-
Perros, F., et al. 2007. Fractalkine-induced smooth muscle cell proliferation in pulmonary hypertension. Eur Respir. J. 29:937-943.
-
(2007)
Eur Respir. J
, vol.29
, pp. 937-943
-
-
Perros, F.1
-
117
-
-
34447534205
-
Interaction of interleukin-6 and the BMP pathway in pulmonary smooth muscle
-
Hagen, M., et al. 2007. Interaction of interleukin-6 and the BMP pathway in pulmonary smooth muscle. Am. J. Physiol. Lung Cell Mol. Physiol. 292:L1473-L1479.
-
(2007)
Am. J. Physiol. Lung Cell Mol. Physiol
, vol.292
-
-
Hagen, M.1
-
118
-
-
34547456414
-
The nuclear factor of activated T cells in pulmonary arterial hypertension can be therapeutically targeted
-
Bonnet, S., et al. 2007. The nuclear factor of activated T cells in pulmonary arterial hypertension can be therapeutically targeted. Proc. Natl. Acad. Sci. U. S. A. 104:11418-11423.
-
(2007)
Proc. Natl. Acad. Sci. U. S. A
, vol.104
, pp. 11418-11423
-
-
Bonnet, S.1
-
119
-
-
33846980821
-
Intratracheal mesenchymal stem cell administration attenuates monocrotaline-induced pulmonary hypertension and endothelial dysfunction
-
Baber, S.R., et al. 2006. Intratracheal mesenchymal stem cell administration attenuates monocrotaline-induced pulmonary hypertension and endothelial dysfunction. Am. J. Physiol. Heart Circ. Physiol. 292:H1120-H1128.
-
(2006)
Am. J. Physiol. Heart Circ. Physiol
, vol.292
-
-
Baber, S.R.1
-
120
-
-
33644523417
-
Inhibition of vascular smooth muscle cell proliferation in vitro by genetically engineered marrow stromal cells secreting calcitonin gene-related peptide
-
Deng, W., et al. 2006. Inhibition of vascular smooth muscle cell proliferation in vitro by genetically engineered marrow stromal cells secreting calcitonin gene-related peptide. Life Sci. 78:1830-1838.
-
(2006)
Life Sci
, vol.78
, pp. 1830-1838
-
-
Deng, W.1
-
121
-
-
33747186449
-
Implantation of mesenchymal stem cells overexpressing endothelial nitric oxide synthase improves right ventricular impairments caused by pulmonary hypertension
-
Kanki-Horimoto, S., et al. 2006. Implantation of mesenchymal stem cells overexpressing endothelial nitric oxide synthase improves right ventricular impairments caused by pulmonary hypertension. Circulation. 114:I181-I185.
-
(2006)
Circulation
, vol.114
-
-
Kanki-Horimoto, S.1
-
122
-
-
14844360656
-
Rescue of monocrotaline-induced pulmonary arterial hypertension using bone marrow-derived endothelial-like progenitor cells: Efficacy of combined cell and eNOS gene therapy in established disease
-
Zhao, Y.D., et al. 2005. Rescue of monocrotaline-induced pulmonary arterial hypertension using bone marrow-derived endothelial-like progenitor cells: efficacy of combined cell and eNOS gene therapy in established disease. Circ. Res. 96:442-450.
-
(2005)
Circ. Res
, vol.96
, pp. 442-450
-
-
Zhao, Y.D.1
-
123
-
-
34047108549
-
Transplantation of autologous endothelial progenitor cells may be beneficial in patients with idiopathic pulmonary arterial hypertension: A pilot randomized controlled trial
-
Wang, X.X., et al. 2007. Transplantation of autologous endothelial progenitor cells may be beneficial in patients with idiopathic pulmonary arterial hypertension: a pilot randomized controlled trial. J. Am. Coll. Cardiol. 49:1566-1571.
-
(2007)
J. Am. Coll. Cardiol
, vol.49
, pp. 1566-1571
-
-
Wang, X.X.1
-
124
-
-
7544234586
-
Extraction of pulmonary vascular compliance, pulmonary vascular resistance, and right ventricular work from single-pressure and Doppler flow measurements in children with pulmonary hypertension: A new method for evaluating reactivity: in vitro and clinical studies
-
Weinberg, C.E., et al. 2004. Extraction of pulmonary vascular compliance, pulmonary vascular resistance, and right ventricular work from single-pressure and Doppler flow measurements in children with pulmonary hypertension: a new method for evaluating reactivity: in vitro and clinical studies. Circulation. 110:2609-2617.
-
(2004)
Circulation
, vol.110
, pp. 2609-2617
-
-
Weinberg, C.E.1
-
125
-
-
34249043564
-
Right ventricular failure complicating heart failure: Pathophysiology, significance, and management strategies
-
Mahmud, M., and Champion, H.C. 2007. Right ventricular failure complicating heart failure: pathophysiology, significance, and management strategies. Curr. Cardiol. Rep. 9:200-208.
-
(2007)
Curr. Cardiol. Rep
, vol.9
, pp. 200-208
-
-
Mahmud, M.1
Champion, H.C.2
|