-
1
-
-
0037623284
-
Primary pulmonary hypertension
-
Runo JR, Loyd JE. Primary pulmonary hypertension. Lancet 2003;361:1533-1544.
-
(2003)
Lancet
, vol.361
, pp. 1533-1544
-
-
Runo, J.R.1
Loyd, J.E.2
-
2
-
-
0025837793
-
Survival in patients with primary pulmonary hypertension: Results from a national prospective registry
-
D'Alonzo GE, Barst RJ, Ayres SM, Bergofsky EH, Brundage BH, Detre KM, Fishman AP, Goldring RM, Groves BM, Kernis JT. Survival in patients with primary pulmonary hypertension: results from a national prospective registry. Ann Intern Med 1991;115:343-349.
-
(1991)
Ann Intern Med
, vol.115
, pp. 343-349
-
-
D'Alonzo, G.E.1
Barst, R.J.2
Ayres, S.M.3
Bergofsky, E.H.4
Brundage, B.H.5
Detre, K.M.6
Fishman, A.P.7
Goldring, R.M.8
Groves, B.M.9
Kernis, J.T.10
-
3
-
-
17144452827
-
Continuous intravenous epoprostenol for pulmonary hypertension due to the scleroderma spectrum of disease: A randomized, controlled trial
-
Badesch DB, Tapson VF, McGoon MD, Brundage BH, Rubin LJ, Wigley FM, Rich S, Barst RJ, Barrett PS, Kral KM, et al. Continuous intravenous epoprostenol for pulmonary hypertension due to the scleroderma spectrum of disease: a randomized, controlled trial. Ann Intern Med 2000;132:425-434.
-
(2000)
Ann Intern Med
, vol.132
, pp. 425-434
-
-
Badesch, D.B.1
Tapson, V.F.2
McGoon, M.D.3
Brundage, B.H.4
Rubin, L.J.5
Wigley, F.M.6
Rich, S.7
Barst, R.J.8
Barrett, P.S.9
Kral, K.M.10
-
4
-
-
0026632785
-
The effect of high doses of calcium-channel blockers on survival in primary pulmonary hypertension
-
Rich S, Kaufmann E, Levy PS. The effect of high doses of calcium-channel blockers on survival in primary pulmonary hypertension. N Engl J Med 1992;327:76-81.
-
(1992)
N Engl J Med
, vol.327
, pp. 76-81
-
-
Rich, S.1
Kaufmann, E.2
Levy, P.S.3
-
5
-
-
0030031888
-
A comparison of continuous intravenous epoprostenol (prostacyclin) with conventional therapy for primary pulmonary hypertension
-
The Primary Pulmonary Hypertension Study Group
-
Barst RJ, Rubin LJ, Long WA, McGoon MD, Rich S, Badesch DB, Groves BM, Tapson VF, Bourge RC, Brundage BH. A comparison of continuous intravenous epoprostenol (prostacyclin) with conventional therapy for primary pulmonary hypertension. The Primary Pulmonary Hypertension Study Group. N Engl J Med 1996;334:296-302.
-
(1996)
N Engl J Med
, vol.334
, pp. 296-302
-
-
Barst, R.J.1
Rubin, L.J.2
Long, W.A.3
McGoon, M.D.4
Rich, S.5
Badesch, D.B.6
Groves, B.M.7
Tapson, V.F.8
Bourge, R.C.9
Brundage, B.H.10
-
6
-
-
0037126044
-
Survival in primary pulmonary hypertension: The impact of epoprostenol therapy
-
McLaughlin VV, Shillington A, Rich S. Survival in primary pulmonary hypertension: the impact of epoprostenol therapy, Circulation 2002; 106:1477-1482.
-
(2002)
Circulation
, vol.106
, pp. 1477-1482
-
-
McLaughlin, V.V.1
Shillington, A.2
Rich, S.3
-
7
-
-
0035818316
-
Effects of the dual endothelin-receptor antagonist bosentan in patients with pulmonary hypertension: A randomised placebo-controlled study
-
Channick RN, Simonneau G, Sitbon O, Robbins IM, Frost A, Tapson VF, Badesch DB, Roux S, Rainisio M, Bodin F, et al. Effects of the dual endothelin-receptor antagonist bosentan in patients with pulmonary hypertension: a randomised placebo-controlled study. Lancet 2001; 358:1119-1123.
-
(2001)
Lancet
, vol.358
, pp. 1119-1123
-
-
Channick, R.N.1
Simonneau, G.2
Sitbon, O.3
Robbins, I.M.4
Frost, A.5
Tapson, V.F.6
Badesch, D.B.7
Roux, S.8
Rainisio, M.9
Bodin, F.10
-
8
-
-
0037149718
-
Bosentan therapy for pulmonary arterial hypertension
-
Rubin LJ, Badesch DB, Barst RJ, Galie N, Black CM, Keogh A, Pulido T, Frost A. Roux S, Leconte I, et al. Bosentan therapy for pulmonary arterial hypertension. N Engl J Med 2002;346:896-903.
-
(2002)
N Engl J Med
, vol.346
, pp. 896-903
-
-
Rubin, L.J.1
Badesch, D.B.2
Barst, R.J.3
Galie, N.4
Black, C.M.5
Keogh, A.6
Pulido, T.7
Frost, A.8
Roux, S.9
Leconte, I.10
-
9
-
-
13844280943
-
Survival with first-line bosentan in patients with primary pulmonary hypertension
-
McLaughlin VV, Sitbon O, Badesch DB, Barst RJ, Black C, Galie N, Rainisio M, Simonneau G, Rubin LJ. Survival with first-line bosentan in patients with primary pulmonary hypertension. Eur Respir J 2005; 25:244-249.
-
(2005)
Eur Respir J
, vol.25
, pp. 244-249
-
-
McLaughlin, V.V.1
Sitbon, O.2
Badesch, D.B.3
Barst, R.J.4
Black, C.5
Galie, N.6
Rainisio, M.7
Simonneau, G.8
Rubin, L.J.9
-
10
-
-
0025985055
-
Distribution of endothelin-like immunoreactivity and mRNA in the developing and adult human lung
-
Giaid A, Polak JM, Gaitonde V, Hamid QA, Moscoso G, Legon S, Uwanogho D, Roncalli M, Shinmi O, Sawamura T, et al Distribution of endothelin-like immunoreactivity and mRNA in the developing and adult human lung. Am J Respir Cell Mol Biol 1991;4:50-58.
-
(1991)
Am J Respir Cell Mol Biol
, vol.4
, pp. 50-58
-
-
Giaid, A.1
Polak, J.M.2
Gaitonde, V.3
Hamid, Q.A.4
Moscoso, G.5
Legon, S.6
Uwanogho, D.7
Roncalli, M.8
Shinmi, O.9
Sawamura, T.10
-
11
-
-
0033553509
-
Cyclic GMP phosphodiesterase-5: Target of sildenafil
-
Corbin JD, Francis SH. Cyclic GMP phosphodiesterase-5: target of sildenafil. J Biol Chem 1999;274:13729-13732.
-
(1999)
J Biol Chem
, vol.274
, pp. 13729-13732
-
-
Corbin, J.D.1
Francis, S.H.2
-
12
-
-
0042859823
-
Cyclic GMP phosphodiesterases and regulation of smooth muscle function
-
Rybalkin SD, Yan C, Bornfeldt KE. Beavo JA. Cyclic GMP phosphodiesterases and regulation of smooth muscle function, Circ Res 2003;93:280-291.
-
(2003)
Circ Res
, vol.93
, pp. 280-291
-
-
Rybalkin, S.D.1
Yan, C.2
Bornfeldt, K.E.3
Beavo, J.A.4
-
13
-
-
0033832073
-
Guanylyl cyclases and signaling by cyclic GMP
-
Lucas KA, Pitari GM, Kazerounian S, Ruiz-Stewart I, Park J, Schulz S, Chepenik KP, Waldman SA. Guanylyl cyclases and signaling by cyclic GMP. Pharmacol Rev 2000;52:375-414.
-
(2000)
Pharmacol Rev
, vol.52
, pp. 375-414
-
-
Lucas, K.A.1
Pitari, G.M.2
Kazerounian, S.3
Ruiz-Stewart, I.4
Park, J.5
Schulz, S.6
Chepenik, K.P.7
Waldman, S.A.8
-
14
-
-
0035942990
-
Sildenafil inhibits hypoxia-induced pulmonary hypertension
-
Zhao L, Mason NA, Morrell NW. Kojonazarov B, Sadykov A, Maripov A, Mirrakhimov MM, Aldashev A, Wilkins MR. Sildenafil inhibits hypoxia-induced pulmonary hypertension. Circulation 2001;104:424-428.
-
(2001)
Circulation
, vol.104
, pp. 424-428
-
-
Zhao, L.1
Mason, N.A.2
Morrell, N.W.3
Kojonazarov, B.4
Sadykov, A.5
Maripov, A.6
Mirrakhimov, M.M.7
Aldashev, A.8
Wilkins, M.R.9
-
15
-
-
0037741441
-
Phosphodiesterase type 5 as a target for the treatment of hypoxia-induced pulmonary hypertension
-
Sebkhi A, Strange JW, Phillips SC, Wharton J, Wilkins MR. Phosphodiesterase type 5 as a target for the treatment of hypoxia-induced pulmonary hypertension. Circulation 2003;107:3230-3235.
-
(2003)
Circulation
, vol.107
, pp. 3230-3235
-
-
Sebkhi, A.1
Strange, J.W.2
Phillips, S.C.3
Wharton, J.4
Wilkins, M.R.5
-
16
-
-
0035845634
-
Effect of inhaled iloprost plus oral sildenafll in patients with primary pulmonary hypertension
-
Wilkens H, Guth A, Konig J, Forestier N, Cremers B, Hennen B, Bohm M, Sybrecht GW. Effect of inhaled iloprost plus oral sildenafll in patients with primary pulmonary hypertension. Circulation 2001;104:1218-1222.
-
(2001)
Circulation
, vol.104
, pp. 1218-1222
-
-
Wilkens, H.1
Guth, A.2
Konig, J.3
Forestier, N.4
Cremers, B.5
Hennen, B.6
Bohm, M.7
Sybrecht, G.W.8
-
17
-
-
10444246635
-
Combination therapy with bosentan and sildenafil in idiopathic pulmonary arterial hypertension
-
Hoeper MM, Faulenbach C, Golpon H, Winkler J, Welte T, Niedermeyer J. Combination therapy with bosentan and sildenafil in idiopathic pulmonary arterial hypertension. Eur Respir J 2004;24:1007-1010.
-
(2004)
Eur Respir J
, vol.24
, pp. 1007-1010
-
-
Hoeper, M.M.1
Faulenbach, C.2
Golpon, H.3
Winkler, J.4
Welte, T.5
Niedermeyer, J.6
-
18
-
-
0034868447
-
Recommendations on the management of pulmonary hypertension in clinical practice
-
British Cardiac Society Medical Practice Committee. Recommendations on the management of pulmonary hypertension in clinical practice. Heart 2001;86:i1-i13.
-
(2001)
Heart
, vol.86
-
-
-
19
-
-
0034039691
-
Development and evaluation of the Kansas City Cardiomyopathy Questionnaire: A new health status measure for heart failure
-
Green CP, Porter CB, Bresnahan DR, Spertus JA. Development and evaluation of the Kansas City Cardiomyopathy Questionnaire: a new health status measure for heart failure. J Am Coll Cardiol 2000;35:1245-1255.
-
(2000)
J Am Coll Cardiol
, vol.35
, pp. 1245-1255
-
-
Green, C.P.1
Porter, C.B.2
Bresnahan, D.R.3
Spertus, J.A.4
-
20
-
-
0842304408
-
Interstudy reproducibility of right ventricular volumes, function, and mass with cardiovascular magnetic resonance
-
Grothues F, Moon JC, Bellenger NG, Smith GS, Klein HU, Pennell DJ. Interstudy reproducibility of right ventricular volumes, function, and mass with cardiovascular magnetic resonance. Am Heart J 2004;147:218-223.
-
(2004)
Am Heart J
, vol.147
, pp. 218-223
-
-
Grothues, F.1
Moon, J.C.2
Bellenger, N.G.3
Smith, G.S.4
Klein, H.U.5
Pennell, D.J.6
-
21
-
-
0036104746
-
Breath-hold FLASH and FISP cardiovascular MR imaging: Left ventricular volume differences and reproducibility
-
Moon JC, Lorenz CH, Francis JM, Smith GC, Penneil DJ. Breath-hold FLASH and FISP cardiovascular MR imaging: left ventricular volume differences and reproducibility. Radiology 2002;223:789-797.
-
(2002)
Radiology
, vol.223
, pp. 789-797
-
-
Moon, J.C.1
Lorenz, C.H.2
Francis, J.M.3
Smith, G.C.4
Penneil, D.J.5
-
22
-
-
0021231847
-
Atrial volume in a normal adult population by two-dimensional echocardiography
-
Wang Y, Gutman JM, Heilbron D, Wahr D, Schiller NB. Atrial volume in a normal adult population by two-dimensional echocardiography. Chest 1984;86:595-601.
-
(1984)
Chest
, vol.86
, pp. 595-601
-
-
Wang, Y.1
Gutman, J.M.2
Heilbron, D.3
Wahr, D.4
Schiller, N.B.5
-
23
-
-
0021987449
-
An echocardiographic index for separation of right ventricular volume and pressure overload
-
Ryan T, Petrovic O, Dillon JC. Feigenbaum H, Conley MJ, Armstrong WF. An echocardiographic index for separation of right ventricular volume and pressure overload. J Am Coll Cardiol 1985;5:918-927.
-
(1985)
J Am Coll Cardiol
, vol.5
, pp. 918-927
-
-
Ryan, T.1
Petrovic, O.2
Dillon, J.C.3
Feigenbaum, H.4
Conley, M.J.5
Armstrong, W.F.6
-
24
-
-
0030281648
-
Doppler echocardiographic index for assessment of global right ventricular function
-
Tei C, Dujardin KS, Hodge DO, Bailey KR, McGoon MD, Tajik AJ, Seward SB. Doppler echocardiographic index for assessment of global right ventricular function. J Am Soc Echocardiogr 1996;9:838-847.
-
(1996)
J Am Soc Echocardiogr
, vol.9
, pp. 838-847
-
-
Tei, C.1
Dujardin, K.S.2
Hodge, D.O.3
Bailey, K.R.4
McGoon, M.D.5
Tajik, A.J.6
Seward, S.B.7
-
25
-
-
1042267416
-
Identification of previously undiagnosed left ventricular systolic dysfunction: Community screening using natriuretic peptides and electrocardiography
-
Ng LL, Loke I, Davies JE, Khunti K, Stone M, Abrams KR, Chin DT, Squire IB. Identification of previously undiagnosed left ventricular systolic dysfunction: community screening using natriuretic peptides and electrocardiography. Eur J Heart Fail 2003;5:775-782.
-
(2003)
Eur J Heart Fail
, vol.5
, pp. 775-782
-
-
Ng, L.L.1
Loke, I.2
Davies, J.E.3
Khunti, K.4
Stone, M.5
Abrams, K.R.6
Chin, D.T.7
Squire, I.B.8
-
26
-
-
2942604605
-
End points and clinical trial designs in pulmonary arterial hypertension: Clinical and regulatory perspectives
-
Hoeper MM, Oudiz RJ, Peacock A. Tapson VF, Haworth SG, Frost AE, Torbicki A. End points and clinical trial designs in pulmonary arterial hypertension: clinical and regulatory perspectives. J Am Coll Cardiol 2004;43:485-558.
-
(2004)
J Am Coll Cardiol
, vol.43
, pp. 485-558
-
-
Hoeper, M.M.1
Oudiz, R.J.2
Peacock, A.3
Tapson, V.F.4
Haworth, S.G.5
Frost, A.E.6
Torbicki, A.7
-
27
-
-
0032543366
-
Molecular cloning and expression of human cGMP-binding cGMP-specific phosphodiesterase (PDE5)
-
Stacey P, Rulten S, Dapling A, Phillips SC. Molecular cloning and expression of human cGMP-binding cGMP-specific phosphodiesterase (PDE5). Biochem Biophys Res Commun 1999;247:249-254.
-
(1999)
Biochem Biophys Res Commun
, vol.247
, pp. 249-254
-
-
Stacey, P.1
Rulten, S.2
Dapling, A.3
Phillips, S.C.4
-
28
-
-
0025041146
-
Characterisation of a purified bovine lung cGMP-binding cGMP phosphodiesterase
-
Thomas MK, Francis SH, Corbin JD. Characterisation of a purified bovine lung cGMP-binding cGMP phosphodiesterase. J Biol Chem 1990; 265:14964-14970.
-
(1990)
J Biol Chem
, vol.265
, pp. 14964-14970
-
-
Thomas, M.K.1
Francis, S.H.2
Corbin, J.D.3
-
29
-
-
0242349756
-
Long-term treatment with oral sildenafil is safe and improves functional capacity and hemodynamics in patients with pulmonary arterial hypertension
-
Michelakis ED, Tymchak W, Noga M, Webster L, Wu XC, Lien D, Wang SH, Modry D, Archer SL. Long-term treatment with oral sildenafil is safe and improves functional capacity and hemodynamics in patients with pulmonary arterial hypertension. Circulation 2003;108:2066-2069.
-
(2003)
Circulation
, vol.108
, pp. 2066-2069
-
-
Michelakis, E.D.1
Tymchak, W.2
Noga, M.3
Webster, L.4
Wu, X.C.5
Lien, D.6
Wang, S.H.7
Modry, D.8
Archer, S.L.9
-
30
-
-
17844381569
-
Cardiac phosphodiesterase 5 (cGMP-specific) modulates beta-adrenergic signaling in vivo and is down-regulated in heart failure
-
Senzaki H, Smith CJ, Juang GJ, Isoda T, Mayer SP, Ohler A, Paolocci N, Tomaselli GF, Hare JM, Kass DA, Cardiac phosphodiesterase 5 (cGMP-specific) modulates beta-adrenergic signaling in vivo and is down-regulated in heart failure, FASEB J 2001;15:1718-1726.
-
(2001)
FASEB J
, vol.15
, pp. 1718-1726
-
-
Senzaki, H.1
Smith, C.J.2
Juang, G.J.3
Isoda, T.4
Mayer, S.P.5
Ohler, A.6
Paolocci, N.7
Tomaselli, G.F.8
Hare, J.M.9
Kass, D.A.10
-
31
-
-
20044363270
-
Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy
-
Takimoto E, Champion HC, Li M, Belardi D, Ren S, Rodriguez ER, Bedja D, Gabrielson KL, Wang Y, Kass DA. Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy. Nat Med 2005;11:214-222.
-
(2005)
Nat Med
, vol.11
, pp. 214-222
-
-
Takimoto, E.1
Champion, H.C.2
Li, M.3
Belardi, D.4
Ren, S.5
Rodriguez, E.R.6
Bedja, D.7
Gabrielson, K.L.8
Wang, Y.9
Kass, D.A.10
-
32
-
-
0034702908
-
Plasma brain natriuretic peptide as a prognostic indicator in patients with primary pulmonary hypertension
-
Nagaya N, Nishikimi T, Uematsu M, Satoh T, Kyotani S, Sakamaki F, Kakishita M, Fukushima K, Okano Y, Nakanishi N, et al. Plasma brain natriuretic peptide as a prognostic indicator in patients with primary pulmonary hypertension. Circulation 2000;102:865-870.
-
(2000)
Circulation
, vol.102
, pp. 865-870
-
-
Nagaya, N.1
Nishikimi, T.2
Uematsu, M.3
Satoh, T.4
Kyotani, S.5
Sakamaki, F.6
Kakishita, M.7
Fukushima, K.8
Okano, Y.9
Nakanishi, N.10
-
33
-
-
0034107636
-
Clinical correlates and prognostic significance of six-minute walk test in patients with primary pulmonary hypertension: Comparison with cardiopulmonary exercise testing
-
Miyamoto S, Nagaya N, Satoh T, Kyotani S, Sakamaki F, Fujita M, Nakanishi N, Miyatake K. Clinical correlates and prognostic significance of six-minute walk test in patients with primary pulmonary hypertension: comparison with cardiopulmonary exercise testing. Am J Respir Crit Care Med 2000;161:487-492.
-
(2000)
Am J Respir Crit Care Med
, vol.161
, pp. 487-492
-
-
Miyamoto, S.1
Nagaya, N.2
Satoh, T.3
Kyotani, S.4
Sakamaki, F.5
Fujita, M.6
Nakanishi, N.7
Miyatake, K.8
-
34
-
-
0037086133
-
Continuous subcutaneous infusion of treprostinil. A prostacyclin analogue, in patients with pulmonary arterial hypertension: A double-blind, randomized, placebo-controlled trial
-
Simonneau G, Barst RJ, Galie N, Naeije R, Rich S, Bourge RC, Keogh A, Oudiz R, Frost A, Blackburn SD, et al. Continuous subcutaneous infusion of treprostinil. a prostacyclin analogue, in patients with pulmonary arterial hypertension: a double-blind, randomized, placebo-controlled trial. Am J Respir Crit Care Med 2002;165:800-804.
-
(2002)
Am J Respir Crit Care Med
, vol.165
, pp. 800-804
-
-
Simonneau, G.1
Barst, R.J.2
Galie, N.3
Naeije, R.4
Rich, S.5
Bourge, R.C.6
Keogh, A.7
Oudiz, R.8
Frost, A.9
Blackburn, S.D.10
-
35
-
-
0038037766
-
Beraprost therapy for pulmonary arterial hypertension
-
Barst RJ, McGoon M, McLaughlin V, Tapson V, Rich S, Rubin L, Wasserman K, Oudiz R, Shapiro S, Robbins IM, et al. Beraprost therapy for pulmonary arterial hypertension. J Am Coll Cardiol 2003;41:2119-2125.
-
(2003)
J Am Coll Cardiol
, vol.41
, pp. 2119-2125
-
-
Barst, R.J.1
McGoon, M.2
McLaughlin, V.3
Tapson, V.4
Rich, S.5
Rubin, L.6
Wasserman, K.7
Oudiz, R.8
Shapiro, S.9
Robbins, I.M.10
-
36
-
-
12144286644
-
Clinical and haemodynamic effects of sildenafil in pulmonary hypertension: Acute and mid-term effects
-
Mikhail GW, Prasad SK, Li W, Rogers P, Chester AH, Bayne S, Stephens D, Khan M, Gibbs JS, Evans TW, et al. Clinical and haemodynamic effects of sildenafil in pulmonary hypertension: acute and mid-term effects. Eur Heart J 2004;25:431-436.
-
(2004)
Eur Heart J
, vol.25
, pp. 431-436
-
-
Mikhail, G.W.1
Prasad, S.K.2
Li, W.3
Rogers, P.4
Chester, A.H.5
Bayne, S.6
Stephens, D.7
Khan, M.8
Gibbs, J.S.9
Evans, T.W.10
-
37
-
-
0037484589
-
Effects of the dual endothelin receptor antagonist bosentan in patients with pulmonary arterial hypertension: A 1-year follow-up study
-
Sitbon O, Badesch DB. Channick RN, Frost A, Robbins IM, Simonneau G, Tapson VF, Rubin LJ. Effects of the dual endothelin receptor antagonist bosentan in patients with pulmonary arterial hypertension: a 1-year follow-up study. Chest 2003;124:247-254.
-
(2003)
Chest
, vol.124
, pp. 247-254
-
-
Sitbon, O.1
Badesch, D.B.2
Channick, R.N.3
Frost, A.4
Robbins, I.M.5
Simonneau, G.6
Tapson, V.F.7
Rubin, L.J.8
-
38
-
-
0344837813
-
Effects of the oral endothelin-receptor antagonist bosentan on echocardiographic and Doppler measures in patients with pulmonary arterial hypertension
-
Galie N, Hinderliter AL, Torbicki A, Fourme T, Simonneau G, Pulido T, Espinola-Zavaleta N, Rocchi G, Manes A, Frantz R, et al. Effects of the oral endothelin-receptor antagonist bosentan on echocardiographic and Doppler measures in patients with pulmonary arterial hypertension. J Am Coll Cardiol 2003;41:1380-1386.
-
(2003)
J Am Coll Cardiol
, vol.41
, pp. 1380-1386
-
-
Galie, N.1
Hinderliter, A.L.2
Torbicki, A.3
Fourme, T.4
Simonneau, G.5
Pulido, T.6
Espinola-Zavaleta, N.7
Rocchi, G.8
Manes, A.9
Frantz, R.10
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