-
1
-
-
33645884127
-
Protease-activated receptor-2 peptides activate neurokinin-1 receptors in the mouse isolated trachea
-
Abey HT, Fairlie DP, Moffatt JD, Balzary RW, Cocks TM (2006) Protease-activated receptor-2 peptides activate neurokinin-1 receptors in the mouse isolated trachea. J Pharmacol Exp Ther 317:598-605
-
(2006)
J Pharmacol Exp Ther
, vol.317
, pp. 598-605
-
-
Abey, H.T.1
Fairlie, D.P.2
Moffatt, J.D.3
Balzary, R.W.4
Cocks, T.M.5
-
2
-
-
84951653316
-
A study of the adrenotropic receptors
-
Ahlquist RP (1948) A study of the adrenotropic receptors. Am J Physiol 153:586-600
-
(1948)
Am J Physiol
, vol.153
, pp. 586-600
-
-
Ahlquist, R.P.1
-
3
-
-
0034670162
-
Inhibition of cellular action of thrombin by N3-cyclopropyl-7-[[4-(1- methylethyl)phenyl]methyl]-7H-pyrrolo[3, 2-f]quinazoline-1,3-diamine (SCH 79797), a nonpeptide thrombin receptor antagonist
-
Ahn HS, Foster C, Boykow G, Stamford A, Manna M, Graziano M (2000) Inhibition of cellular action of thrombin by N3-cyclopropyl-7-[[4-(1- methylethyl)phenyl]methyl]-7H-pyrrolo[3, 2-f]quinazoline-1,3-diamine (SCH 79797), a nonpeptide thrombin receptor antagonist. Biochem Pharmacol 60:1425-1434
-
(2000)
Biochem Pharmacol
, vol.60
, pp. 1425-1434
-
-
Ahn, H.S.1
Foster, C.2
Boykow, G.3
Stamford, A.4
Manna, M.5
Graziano, M.6
-
5
-
-
0036151657
-
Modified proteinase-activated receptor-1 and -2 derived peptides inhibit proteinase-activated receptor-2 activation by trypsin
-
Al-Ani B, Saifeddine M, Wijesuriya SJ, Hollenberg MD (2002) Modified proteinase-activated receptor-1 and -2 derived peptides inhibit proteinase-activated receptor-2 activation by trypsin. J Pharmacol Exp Ther 300:702-708
-
(2002)
J Pharmacol Exp Ther
, vol.300
, pp. 702-708
-
-
Al-Ani, B.1
Saifeddine, M.2
Wijesuriya, S.J.3
Hollenberg, M.D.4
-
6
-
-
33747227271
-
Protease-activated receptor 2 sensitizes TRPV1 by protein kinase Cepsilon- and A-dependent mechanisms in rats and mice
-
Amadesi S, Cottrell GS, Divino L, Chapman K, Grady EF, Bautista F, Karanjia R, Barajas-Lopez C, Vanner S, Vergnolle N, Bunnett NW (2006) Protease-activated receptor 2 sensitizes TRPV1 by protein kinase Cepsilon- and A-dependent mechanisms in rats and mice. J Physiol 575:555-571
-
(2006)
J Physiol
, vol.575
, pp. 555-571
-
-
Amadesi, S.1
Cottrell, G.S.2
Divino, L.3
Chapman, K.4
Grady, E.F.5
Bautista, F.6
Karanjia, R.7
Barajas-Lopez, C.8
Vanner, S.9
Vergnolle, N.10
Bunnett, N.W.11
-
7
-
-
13044257730
-
Design, synthesis, and biological characterization of a peptide-mimetic antagonist for a tethered-ligand receptor
-
Andrade-Gordon P, Maryanoff BE, Derian CK, Zhang HC, Addo MF, Darrow AL, Eckardt AJ, Hoekstra WJ, McComsey DF, Oksenberg D, Reynolds EE, Santulli RJ, Scarborough RM, Smith CE, White KB (1999) Design, synthesis, and biological characterization of a peptide-mimetic antagonist for a tethered-ligand receptor. Proc Natl Acad Sci USA 96:12257-12262
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 12257-12262
-
-
Andrade-Gordon, P.1
Maryanoff, B.E.2
Derian, C.K.3
Zhang, H.C.4
Addo, M.F.5
Darrow, A.L.6
Eckardt, A.J.7
Hoekstra, W.J.8
McComsey, D.F.9
Oksenberg, D.10
Reynolds, E.E.11
Santulli, R.J.12
Scarborough, R.M.13
Smith, C.E.14
White, K.B.15
-
8
-
-
0036193921
-
Proteinase-activated receptor-1 agonists attenuate nociception in response to noxious stimuli
-
Asfaha S, Brussee V, Chapman K, Zochodne DW, Vergnolle N (2002) Proteinase-activated receptor-1 agonists attenuate nociception in response to noxious stimuli. Br J Pharmacol 135:1101-1106
-
(2002)
Br J Pharmacol
, vol.135
, pp. 1101-1106
-
-
Asfaha, S.1
Brussee, V.2
Chapman, K.3
Zochodne, D.W.4
Vergnolle, N.5
-
9
-
-
33846554731
-
Protease-activated receptor-4: A novel mechanism of inflammatory pain modulation
-
Asfaha S, Cenac N, Houle S, Altier C, Papez MD, Nguyen C, Steinhoff M, Chapman K, Zamponi GW, Vergnolle N (2007) Protease-activated receptor-4: a novel mechanism of inflammatory pain modulation. Br J Pharmacol 150:176-185
-
(2007)
Br J Pharmacol
, vol.150
, pp. 176-185
-
-
Asfaha, S.1
Cenac, N.2
Houle, S.3
Altier, C.4
Papez, M.D.5
Nguyen, C.6
Steinhoff, M.7
Chapman, K.8
Zamponi, G.W.9
Vergnolle, N.10
-
10
-
-
33845208358
-
Triggering endogenous immunosuppressive mechanisms by combined targeting of Dipeptidyl peptidase IV (DPIV/CD26) and Aminopeptidase N (APN/ CD13)-a novel approach for the treatment of inflammatory bowel disease
-
Bank U, Heimburg A, Helmuth M, Stefin S, Lendeckel U, Reinhold D, Faust J, Fuchs P, Sens B, Neubert K, Tager M, Ansorge S (2006) Triggering endogenous immunosuppressive mechanisms by combined targeting of Dipeptidyl peptidase IV (DPIV/CD26) and Aminopeptidase N (APN/ CD13)-a novel approach for the treatment of inflammatory bowel disease. Int Immunopharmacol 6:1925-1934
-
(2006)
Int Immunopharmacol
, vol.6
, pp. 1925-1934
-
-
Bank, U.1
Heimburg, A.2
Helmuth, M.3
Stefin, S.4
Lendeckel, U.5
Reinhold, D.6
Faust, J.7
Fuchs, P.8
Sens, B.9
Neubert, K.10
Tager, M.11
Ansorge, S.12
-
11
-
-
0021774158
-
Localization of a chemotactic domain in human thrombin
-
Bar-Shavit R, Kahn A, Mudd MS, Wilner GD, Mann KG, Fenton JW 2nd (1984) Localization of a chemotactic domain in human thrombin. Biochemistry 23:397-400
-
(1984)
Biochemistry
, vol.23
, pp. 397-400
-
-
Bar-Shavit, R.1
Kahn, A.2
Mudd, M.S.3
Wilner, G.D.4
Mann, K.G.5
Fenton II, J.W.6
-
12
-
-
0344908213
-
Identification of a thrombin sequence with growth factor activity on macrophages
-
Bar-Shavit R, Kahn AJ, Mann KG, Wilner GD (1986) Identification of a thrombin sequence with growth factor activity on macrophages. Proc Natl Acad Sci USA 83:976-980
-
(1986)
Proc Natl Acad Sci USA
, vol.83
, pp. 976-980
-
-
Bar-Shavit, R.1
Kahn, A.J.2
Mann, K.G.3
Wilner, G.D.4
-
13
-
-
0034765854
-
The role of molecular forms of prostate-specific antigen (PSA or hK3) and of human glandular kallikrein 2 (hK2) in the diagnosis and monitoring of prostate cancer and in extra-prostatic disease
-
Becker C, Noldus J, Diamandis E, Lilja H (2001) The role of molecular forms of prostate-specific antigen (PSA or hK3) and of human glandular kallikrein 2 (hK2) in the diagnosis and monitoring of prostate cancer and in extra-prostatic disease. Crit Rev Clin Lab Sci 38:357-399
-
(2001)
Crit Rev Clin Lab Sci
, vol.38
, pp. 357-399
-
-
Becker, C.1
Noldus, J.2
Diamandis, E.3
Lilja, H.4
-
15
-
-
8144222388
-
The emerging roles of human tissue kallikreins in cancer
-
Borgono CA, Diamandis EP (2004) The emerging roles of human tissue kallikreins in cancer. Nat Rev Cancer 4:876-879
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 876-879
-
-
Borgono, C.A.1
Diamandis, E.P.2
-
16
-
-
3543150203
-
Human tissue kallikreins: Physiologic roles and applications in cancer
-
Borgono CA, Michael IP, Diamandis EP (2004) Human tissue kallikreins: physiologic roles and applications in cancer. Mol Cancer Res 2:257-280
-
(2004)
Mol Cancer Res
, vol.2
, pp. 257-280
-
-
Borgono, C.A.1
Michael, I.P.2
Diamandis, E.P.3
-
17
-
-
0344923324
-
Up-regulation of proteinase-activated receptor 1 expression in astrocytes during HIV encephalitis
-
Boven LA, Vergnolle N, Henry SD, Silva C, Imai Y, Holden J, Warren K, Hollenberg MD, Power C (2003) Up-regulation of proteinase-activated receptor 1 expression in astrocytes during HIV encephalitis. J Immunol 170:2638-2646
-
(2003)
J Immunol
, vol.170
, pp. 2638-2646
-
-
Boven, L.A.1
Vergnolle, N.2
Henry, S.D.3
Silva, C.4
Imai, Y.5
Holden, J.6
Warren, K.7
Hollenberg, M.D.8
Power, C.9
-
18
-
-
34248141719
-
The emergence of proteinase-activated receptor-2 as a novel target for the treatment of inflammation-related CNS disorders
-
Bushell T (2007) The emergence of proteinase-activated receptor-2 as a novel target for the treatment of inflammation-related CNS disorders. J Physiol 581:7-16
-
(2007)
J Physiol
, vol.581
, pp. 7-16
-
-
Bushell, T.1
-
19
-
-
33745714789
-
Protective effect of proteinase-activated receptor 2 activation on motility impairment and tissue damage induced by intestinal ischemia/reperfusion in rodents
-
Cattaruzza F, Cenac N, Barocelli E, Impicciatore M, Hyun E, Vergnolle N, Sternini C (2006) Protective effect of proteinase-activated receptor 2 activation on motility impairment and tissue damage induced by intestinal ischemia/reperfusion in rodents. Am J Pathol 169:177-188
-
(2006)
Am J Pathol
, vol.169
, pp. 177-188
-
-
Cattaruzza, F.1
Cenac, N.2
Barocelli, E.3
Impicciatore, M.4
Hyun, E.5
Vergnolle, N.6
Sternini, C.7
-
20
-
-
0036840275
-
Induction of intestinal inflammation in mouse by activation of proteinase-activated receptor-2
-
Cenac N, Coelho AM, Nguyen C, Compton S, Andrade-Gordon P, MacNaughton WK, Wallace JL, Hollenberg MD, Bunnett NW, Garcia-Villar R, Bueno L, Vergnolle N (2002) Induction of intestinal inflammation in mouse by activation of proteinase-activated receptor-2. Am J Pathol 161:1903-1915
-
(2002)
Am J Pathol
, vol.161
, pp. 1903-1915
-
-
Cenac, N.1
Coelho, A.M.2
Nguyen, C.3
Compton, S.4
Andrade-Gordon, P.5
MacNaughton, W.K.6
Wallace, J.L.7
Hollenberg, M.D.8
Bunnett, N.W.9
Garcia-Villar, R.10
Bueno, L.11
Vergnolle, N.12
-
21
-
-
25444440807
-
Proteinase-activated receptor-1 is an anti-inflammatory signal for colitis mediated by a type 2 immune response
-
Cenac N, Cellars L, Steinhoff M, Andrade-Gordon P, Hollenberg MD, Wallace JL, Fiorucci S, Vergnolle N (2005) Proteinase-activated receptor-1 is an anti-inflammatory signal for colitis mediated by a type 2 immune response. Inflamm Bowel Dis 11:792-798
-
(2005)
Inflamm Bowel Dis
, vol.11
, pp. 792-798
-
-
Cenac, N.1
Cellars, L.2
Steinhoff, M.3
Andrade-Gordon, P.4
Hollenberg, M.D.5
Wallace, J.L.6
Fiorucci, S.7
Vergnolle, N.8
-
22
-
-
33847342529
-
Role for protease activity in visceral pain in irritable bowel syndrome
-
Cenac N, Andrews CN, Holzhausen M, Chapman K, Cottrell G, Andrade-Gordon P, Steinhoff M, Barbara G, Beck P, Bunnett NW, Sharkey KA, Ferraz JG, Shaffer E, Vergnolle N (2007) Role for protease activity in visceral pain in irritable bowel syndrome. J Clin Invest 117:636-647
-
(2007)
J Clin Invest
, vol.117
, pp. 636-647
-
-
Cenac, N.1
Andrews, C.N.2
Holzhausen, M.3
Chapman, K.4
Cottrell, G.5
Andrade-Gordon, P.6
Steinhoff, M.7
Barbara, G.8
Beck, P.9
Bunnett, N.W.10
Sharkey, K.A.11
Ferraz, J.G.12
Shaffer, E.13
Vergnolle, N.14
-
23
-
-
0036268435
-
Substrate specificity of human kallikrein 2 (hK2) as determined by phage display technology
-
Cloutier SM, Chagas JR, Mach JP, Gygi CM, Leisinger HJ, Deperthes D (2002) Substrate specificity of human kallikrein 2 (hK2) as determined by phage display technology. Eur J Biochem 269:2747-2754
-
(2002)
Eur J Biochem
, vol.269
, pp. 2747-2754
-
-
Cloutier, S.M.1
Chagas, J.R.2
MacH, J.P.3
Gygi, C.M.4
Leisinger, H.J.5
Deperthes, D.6
-
24
-
-
1842414265
-
Mast cell tryptase regulates rat colonic myocytes through proteinase-activated receptor 2
-
Corvera CU, Déry O, McConalogue K, Böhm SK, Khitin LM, Caughey GH, Payan DG, Bunnett NW (1997) Mast cell tryptase regulates rat colonic myocytes through proteinase-activated receptor 2. J Clin Invest 100:1383-1393
-
(1997)
J Clin Invest
, vol.100
, pp. 1383-1393
-
-
Corvera, C.U.1
Déry, O.2
McConalogue, K.3
Böhm, S.K.4
Khitin, L.M.5
Caughey, G.H.6
Payan, D.G.7
Bunnett, N.W.8
-
25
-
-
0345004978
-
Thrombin and mast cell tryptase regulate guinea-pig myenteric neurons through proteinase-activated receptors-1 and -2
-
Corvera CU, Déry O, McConalogue K, Gamp P, Thoma M, Al-Ani B, Caughey GH, Hollenberg MD, Bunnett NW (1999) Thrombin and mast cell tryptase regulate guinea-pig myenteric neurons through proteinase-activated receptors-1 and -2. J Physiol 517:741-756
-
(1999)
J Physiol
, vol.517
, pp. 741-756
-
-
Corvera, C.U.1
Déry, O.2
McConalogue, K.3
Gamp, P.4
Thoma, M.5
Al-Ani, B.6
Caughey, G.H.7
Hollenberg, M.D.8
Bunnett, N.W.9
-
26
-
-
1842791710
-
Trypsin IV, a novel agonist of protease-activated receptors 2 and 4
-
Cottrell GS, Amadesi S, Grady EF, Bunnett NW (2004) Trypsin IV, a novel agonist of protease-activated receptors 2 and 4. J Biol Chem 279:13532-13539
-
(2004)
J Biol Chem
, vol.279
, pp. 13532-13539
-
-
Cottrell, G.S.1
Amadesi, S.2
Grady, E.F.3
Bunnett, N.W.4
-
27
-
-
0034648757
-
Thrombin signalling and protease-activated receptors
-
Coughlin SR (2000) Thrombin signalling and protease-activated receptors. Nature 407:258-264
-
(2000)
Nature
, vol.407
, pp. 258-264
-
-
Coughlin, S.R.1
-
28
-
-
28344436780
-
Protease-activated receptors in hemostasis, thrombosis and vascular biology
-
Coughlin SR (2005) Protease-activated receptors in hemostasis, thrombosis and vascular biology. J Thromb Haemost 3:1800-1814
-
(2005)
J Thromb Haemost
, vol.3
, pp. 1800-1814
-
-
Coughlin, S.R.1
-
29
-
-
0036797590
-
Pepducin-based intervention of thrombin-receptor signaling and systemic platelet activation
-
Covic L, Misra M, Badar J, Singh C, Kuliopulos A (2002) Pepducin-based intervention of thrombin-receptor signaling and systemic platelet activation. Nat Med 8:1161-1165
-
(2002)
Nat Med
, vol.8
, pp. 1161-1165
-
-
Covic, L.1
Misra, M.2
Badar, J.3
Singh, C.4
Kuliopulos, A.5
-
30
-
-
0015150783
-
Perturbation of the insulin receptor of isolated fat cells with proteolytic enzymes
-
Cuatrecasas P (1971) Perturbation of the insulin receptor of isolated fat cells with proteolytic enzymes. J Biol Chem 246:6522-6531
-
(1971)
J Biol Chem
, vol.246
, pp. 6522-6531
-
-
Cuatrecasas, P.1
-
31
-
-
0032988474
-
Cardiovascular responses mediated by protease-activated receptor-2 (PAR-2) and thrombin receptor (PAR-1) are distinguished in mice deficient in PAR-2 or PAR-1
-
Damiano BP, Cheung WM, Santulli RJ, Fung-Leung WP, Ngo K, Ye RD, Darrow AL, Derian CK, de Garavilla L, Andrade-Gordon P (1999) Cardiovascular responses mediated by protease-activated receptor-2 (PAR-2) and thrombin receptor (PAR-1) are distinguished in mice deficient in PAR-2 or PAR-1. J Pharmacol Exp Ther 288:671-678
-
(1999)
J Pharmacol Exp Ther
, vol.288
, pp. 671-678
-
-
Damiano, B.P.1
Cheung, W.M.2
Santulli, R.J.3
Fung-Leung, W.P.4
Ngo, K.5
Ye, R.D.6
Darrow, A.L.7
Derian, C.K.8
De Garavilla, L.9
Andrade-Gordon, P.10
-
32
-
-
2442692682
-
Protease-activated receptor 2 in colon cancer: Trypsin-induced MAPK phosphorylation and cell proliferation are mediated by epidermal growth factor receptor transactivation
-
Darmoul D, Gratio V, Devaud H, Laburthe M (2004) Protease-activated receptor 2 in colon cancer: trypsin-induced MAPK phosphorylation and cell proliferation are mediated by epidermal growth factor receptor transactivation. J Biol Chem 279:20927-20934
-
(2004)
J Biol Chem
, vol.279
, pp. 20927-20934
-
-
Darmoul, D.1
Gratio, V.2
Devaud, H.3
Laburthe, M.4
-
33
-
-
0034888212
-
Agonists of proteinase-activated receptor 1 induce plasma extravasation by a neurogenic mechanism
-
de Garavilla L, Vergnolle N, Young SH, Ennes H, Steinhoff M, Ossovskaya VS, D'Andrea MR, Mayer EA, Wallace JL, Hollenberg MD, Andrade-Gordon P, Bunnett NW (2001) Agonists of proteinase-activated receptor 1 induce plasma extravasation by a neurogenic mechanism. Br J Pharmacol 133:975-987
-
(2001)
Br J Pharmacol
, vol.133
, pp. 975-987
-
-
De Garavilla, L.1
Vergnolle, N.2
Young, S.H.3
Ennes, H.4
Steinhoff, M.5
Ossovskaya, V.S.6
D'Andrea, M.R.7
Mayer, E.A.8
Wallace, J.L.9
Hollenberg, M.D.10
Andrade-Gordon, P.11
Bunnett, N.W.12
-
34
-
-
0034940423
-
Beneficial effects of Batimastat (BB-94), a matrix metalloproteinase inhibitor, in rat experimental colitis
-
Di Sebastiano P, di Mola FF, Artese L, Rossi C, Mascetta G, Pernthaler H, Innocenti P (2001) Beneficial effects of Batimastat (BB-94), a matrix metalloproteinase inhibitor, in rat experimental colitis. Digestion 63:234-239
-
(2001)
Digestion
, vol.63
, pp. 234-239
-
-
Di Sebastiano, P.1
Di Mola, F.F.2
Artese, L.3
Rossi, C.4
Mascetta, G.5
Pernthaler, H.6
Innocenti, P.7
-
35
-
-
18244404006
-
Pseudomonas aeruginosa elastase disables proteinase-activated receptor 2 in respiratory epithelial cells
-
Dulon S, Leduc D, Cottrell GS, D'Alayer J, Hansen KK, Bunnett NW, Hollenberg MD, Pidard D, Chignard M (2005) Pseudomonas aeruginosa elastase disables proteinase-activated receptor 2 in respiratory epithelial cells. Am J Respir Cell Mol Biol 32:411-419
-
(2005)
Am J Respir Cell Mol Biol
, vol.32
, pp. 411-419
-
-
Dulon, S.1
Leduc, D.2
Cottrell, G.S.3
D'Alayer, J.4
Hansen, K.K.5
Bunnett, N.W.6
Hollenberg, M.D.7
Pidard, D.8
Chignard, M.9
-
36
-
-
33749452415
-
In silico identification and Bayesian phylogenetic analysis of multiple new mammalian kallikrein gene families
-
Elliott MB, Irwin DM, Diamandis EP (2006) In silico identification and Bayesian phylogenetic analysis of multiple new mammalian kallikrein gene families. Genomics 88:591-599
-
(2006)
Genomics
, vol.88
, pp. 591-599
-
-
Elliott, M.B.1
Irwin, D.M.2
Diamandis, E.P.3
-
37
-
-
34248192457
-
Human tissue kallikreins: A road under construction
-
Emami N, Diamandis EP (2007) Human tissue kallikreins: a road under construction. Clin Chim Acta 381:78-84
-
(2007)
Clin Chim Acta
, vol.381
, pp. 78-84
-
-
Emami, N.1
Diamandis, E.P.2
-
38
-
-
0031927754
-
Thrombin receptor overexpression in malignant and physiological invasion processes
-
Even-Ram S, Uziely B, Cohen P, Grisaru-Granovsky S, Maoz M, Ginzburg Y, Reich R, Vlodavsky I, Bar-Shavit R (1998) Thrombin receptor overexpression in malignant and physiological invasion processes. Nat Med 4:909-914
-
(1998)
Nat Med
, vol.4
, pp. 909-914
-
-
Even-Ram, S.1
Uziely, B.2
Cohen, P.3
Grisaru-Granovsky, S.4
Maoz, M.5
Ginzburg, Y.6
Reich, R.7
Vlodavsky, I.8
Bar-Shavit, R.9
-
39
-
-
20144389752
-
Enzymatic profiling of human kallikrein 14 using phage-display substrate technology
-
Felber LM, Borgono CA, Cloutier SM, Kundig C, Kishi T, Ribeiro Chagas J, Jichlinski P, Gygi CM, Leisinger HJ, Diamandis EP, Deperthes D (2005) Enzymatic profiling of human kallikrein 14 using phage-display substrate technology. Biol Chem 386:291-298
-
(2005)
Biol Chem
, vol.386
, pp. 291-298
-
-
Felber, L.M.1
Borgono, C.A.2
Cloutier, S.M.3
Kundig, C.4
Kishi, T.5
Ribeiro Chagas, J.6
Jichlinski, P.7
Gygi, C.M.8
Leisinger, H.J.9
Diamandis, E.P.10
Deperthes, D.11
-
40
-
-
0037247658
-
Essential role for proteinase-activated receptor-2 in arthritis
-
Ferrell WR, Lockhart JC, Kelso EB, Dunning L, Plevin R, Meek SE, Smith AJ, Hunter GD, McLean JS, McGarry F, Ramage R, Jiang L, Kanke T, Kawagoe J (2003) Essential role for proteinase-activated receptor-2 in arthritis. J Clin Invest 111:35-41
-
(2003)
J Clin Invest
, vol.111
, pp. 35-41
-
-
Ferrell, W.R.1
Lockhart, J.C.2
Kelso, E.B.3
Dunning, L.4
Plevin, R.5
Meek, S.E.6
Smith, A.J.7
Hunter, G.D.8
McLean, J.S.9
McGarry, F.10
Ramage, R.11
Jiang, L.12
Kanke, T.13
Kawagoe, J.14
-
41
-
-
0035923526
-
Proteinase-activated receptor 2 is an anti-inflammatory signal for colonic lamina propria lymphocytes in a mouse model of colitis
-
Fiorucci S, Mencarelli A, Palazzetti B, Distrutti E, Vergnolle N, Hollenberg MD, Wallace JL, Morelli A, Cirino G (2001) Proteinase-activated receptor 2 is an anti-inflammatory signal for colonic lamina propria lymphocytes in a mouse model of colitis. Proc Natl Acad Sci USA 98:13936-13941
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 13936-13941
-
-
Fiorucci, S.1
Mencarelli, A.2
Palazzetti, B.3
Distrutti, E.4
Vergnolle, N.5
Hollenberg, M.D.6
Wallace, J.L.7
Morelli, A.8
Cirino, G.9
-
42
-
-
0024104359
-
Synthetic peptides bind to high-affinity thrombin receptors and modulate thrombin mitogenesis
-
Glenn KC, Frost GH, Bergmann JS, Carney DH (1988) Synthetic peptides bind to high-affinity thrombin receptors and modulate thrombin mitogenesis. Pept Res 1:65-73
-
(1988)
Pept Res
, vol.1
, pp. 65-73
-
-
Glenn, K.C.1
Frost, G.H.2
Bergmann, J.S.3
Carney, D.H.4
-
43
-
-
33645687693
-
Tissue plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1) in children with ulcerative colitis
-
Grabarczyk E, Szaflarska-Poplawska A, Goralczyk K, Rosc D (2006) Tissue plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1) in children with ulcerative colitis. Pol Merkuriusz Lek 20:326-328
-
(2006)
Pol Merkuriusz Lek
, vol.20
, pp. 326-328
-
-
Grabarczyk, E.1
Szaflarska-Poplawska, A.2
Goralczyk, K.3
Rosc, D.4
-
44
-
-
33846502156
-
Protease-activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice
-
Grant AD, Cottrell GS, Amadesi S, Trevisani M, Nicoletti P, Materazzi S, Altier C, Cenac N, Zamponi GW, Bautista-Cruz F, Lopez CB, Joseph EK, Levine JD, Liedtke W, Vanner S, Vergnolle N, Geppetti P, Bunnett NW (2007) Protease-activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice. J Physiol 578:715-733
-
(2007)
J Physiol
, vol.578
, pp. 715-733
-
-
Grant, A.D.1
Cottrell, G.S.2
Amadesi, S.3
Trevisani, M.4
Nicoletti, P.5
Materazzi, S.6
Altier, C.7
Cenac, N.8
Zamponi, G.W.9
Bautista-Cruz, F.10
Lopez, C.B.11
Joseph, E.K.12
Levine, J.D.13
Liedtke, W.14
Vanner, S.15
Vergnolle, N.16
Geppetti, P.17
Bunnett, N.W.18
-
46
-
-
20444385865
-
A major role for proteolytic activity and proteinase-activated receptor-2 in the pathogenesis of infectious colitis
-
Hansen KK, Sherman PM, Cellars L, Andrade-Gordon P, Pan Z, Baruch A, Wallace JL, Hollenberg MD, Vergnolle N (2005) A major role for proteolytic activity and proteinase-activated receptor-2 in the pathogenesis of infectious colitis. Proc Natl Acad Sci USA 102:8363-8368
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 8363-8368
-
-
Hansen, K.K.1
Sherman, P.M.2
Cellars, L.3
Andrade-Gordon, P.4
Pan, Z.5
Baruch, A.6
Wallace, J.L.7
Hollenberg, M.D.8
Vergnolle, N.9
-
47
-
-
9844267307
-
Protease activity in a hapten-induced model of ulcerative colitis in rats
-
Hawkins JV, Emmel EL, Feuer JJ, Nedelman MA, Harvey CJ, Klein HJ, Rozmiarek H, Kennedy AR, Lichtenstein GR, Billings PC (1997) Protease activity in a hapten-induced model of ulcerative colitis in rats. Dig Dis Sci 42:1969-1980
-
(1997)
Dig Dis Sci
, vol.42
, pp. 1969-1980
-
-
Hawkins, J.V.1
Emmel, E.L.2
Feuer, J.J.3
Nedelman, M.A.4
Harvey, C.J.5
Klein, H.J.6
Rozmiarek, H.7
Kennedy, A.R.8
Lichtenstein, G.R.9
Billings, P.C.10
-
49
-
-
0036262319
-
International Union of Pharmacology. XXVIII. Proteinase-activated receptors
-
Hollenberg MD, Compton SJ (2002) International Union of Pharmacology. XXVIII. Proteinase-activated receptors. Pharmacol Rev 54:203-217
-
(2002)
Pharmacol Rev
, vol.54
, pp. 203-217
-
-
Hollenberg, M.D.1
Compton, S.J.2
-
51
-
-
0027174547
-
Role of the amino- and carboxyl-terminal domains of thrombin receptor-derived polypeptides in biological activity in vascular endothelium and gastric smooth muscle: Evidence for receptor subtypes
-
Hollenberg MD, Laniyonu AA, Saifeddine M, Moore GJ (1993) Role of the amino- and carboxyl-terminal domains of thrombin receptor-derived polypeptides in biological activity in vascular endothelium and gastric smooth muscle: evidence for receptor subtypes. Mol Pharmacol 43:921-930
-
(1993)
Mol Pharmacol
, vol.43
, pp. 921-930
-
-
Hollenberg, M.D.1
Laniyonu, A.A.2
Saifeddine, M.3
Moore, G.J.4
-
52
-
-
7544230083
-
Proteinase-activated receptor-4: Evaluation of tethered ligand-derived peptides as probes for receptor function and as inflammatory agonists in vivo
-
Hollenberg MD, Saifeddine M, Sandhu S, Houle S, Vergnolle N (2004) Proteinase-activated receptor-4: evaluation of tethered ligand-derived peptides as probes for receptor function and as inflammatory agonists in vivo. Br J Pharmacol 143:443-454
-
(2004)
Br J Pharmacol
, vol.143
, pp. 443-454
-
-
Hollenberg, M.D.1
Saifeddine, M.2
Sandhu, S.3
Houle, S.4
Vergnolle, N.5
-
53
-
-
27644557524
-
Neutrophils and the kallikrein-kinin system in proteinase-activated receptor 4-mediated inflammation in rodents
-
Houle S, Papez MD, Ferazzini M, Hollenberg MD, Vergnolle N (2005) Neutrophils and the kallikrein-kinin system in proteinase-activated receptor 4-mediated inflammation in rodents. Br J Pharmacol 146:670-678
-
(2005)
Br J Pharmacol
, vol.146
, pp. 670-678
-
-
Houle, S.1
Papez, M.D.2
Ferazzini, M.3
Hollenberg, M.D.4
Vergnolle, N.5
-
54
-
-
33745726787
-
Anti-tryptase treatment using nafamostat mesilate has a therapeutic effect on experimental colitis
-
Isozaki Y, Yoshida N, Kuroda M, Handa O, Takagi T, Kokura S, Ichikawa H, Naito Y, Okanoue T, Yoshikawa T (2006) Anti-tryptase treatment using nafamostat mesilate has a therapeutic effect on experimental colitis. Scand J Gastroenterol 41:944-953
-
(2006)
Scand J Gastroenterol
, vol.41
, pp. 944-953
-
-
Isozaki, Y.1
Yoshida, N.2
Kuroda, M.3
Handa, O.4
Takagi, T.5
Kokura, S.6
Ichikawa, H.7
Naito, Y.8
Okanoue, T.9
Yoshikawa, T.10
-
56
-
-
1342345222
-
Distinct roles for protease-activated receptors 1 and 2 in vasomotor modulation in rat superior mesenteric artery
-
Kawabata A, Kubo S, Nakaya Y, Ishiki T, Kuroda R, Sekiguchi F, Kawao N, Nishikawa H (2004) Distinct roles for protease-activated receptors 1 and 2 in vasomotor modulation in rat superior mesenteric artery. Cardiovasc Res 61:683-692
-
(2004)
Cardiovasc Res
, vol.61
, pp. 683-692
-
-
Kawabata, A.1
Kubo, S.2
Nakaya, Y.3
Ishiki, T.4
Kuroda, R.5
Sekiguchi, F.6
Kawao, N.7
Nishikawa, H.8
-
57
-
-
33644783885
-
Therapeutic promise of proteinase-activated receptor-2 antagonism in joint inflammation
-
Kelso EB, Lockhart JC, Hembrough T, Dunning L, Plevin R, Hollenberg MD, Sommerhoff CP, McLean JS, Ferrell WR (2006) Therapeutic promise of proteinase-activated receptor-2 antagonism in joint inflammation. J Pharmacol Exp Ther 316:1017-1024
-
(2006)
J Pharmacol Exp Ther
, vol.316
, pp. 1017-1024
-
-
Kelso, E.B.1
Lockhart, J.C.2
Hembrough, T.3
Dunning, L.4
Plevin, R.5
Hollenberg, M.D.6
Sommerhoff, C.P.7
McLean, J.S.8
Ferrell, W.R.9
-
58
-
-
0029779961
-
Plasmin-platelet interaction involves cleavage of functional thrombin receptor
-
Kimura M, Andersen TT, Fenton JW 2nd, Bahou WF, Aviv A (1996) Plasmin-platelet interaction involves cleavage of functional thrombin receptor. Am J Physiol 271:C54-C60
-
(1996)
Am J Physiol
, vol.271
-
-
Kimura, M.1
Andersen, T.T.2
Fenton II, J.W.3
Bahou, W.F.4
Aviv, A.5
-
59
-
-
0027231364
-
Rabbit and rat platelets do not respond to thrombin receptor peptides that activate human platelets
-
Kinlough-Rathbone RL, Rand ML, Packham MA (1993) Rabbit and rat platelets do not respond to thrombin receptor peptides that activate human platelets. Blood 82:103-106
-
(1993)
Blood
, vol.82
, pp. 103-106
-
-
Kinlough-Rathbone, R.L.1
Rand, M.L.2
Packham, M.A.3
-
60
-
-
0030741026
-
Luminal trypsin may regulate enterocytes through proteinase-activated receptor 2
-
Kong W, McConalogue K, Khitin LM, Hollenberg MD, Payan DG, Böhm SK, Bunnett NW (1997) Luminal trypsin may regulate enterocytes through proteinase-activated receptor 2. Proc Natl Acad Sci USA 94:8884-8889
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 8884-8889
-
-
Kong, W.1
McConalogue, K.2
Khitin, L.M.3
Hollenberg, M.D.4
Payan, D.G.5
Böhm, S.K.6
Bunnett, N.W.7
-
61
-
-
0015240289
-
Insulin-like effects of trypsin on fat cells. Localization of the metabolic steps and the cellular site affected by the enzyme
-
Kono T, Barham FW (1971) Insulin-like effects of trypsin on fat cells. Localization of the metabolic steps and the cellular site affected by the enzyme. J Biol Chem 246:6204-6209
-
(1971)
J Biol Chem
, vol.246
, pp. 6204-6209
-
-
Kono, T.1
Barham, F.W.2
-
62
-
-
0033528761
-
1 thrombin receptor: Kinetics, sites of truncation, and implications for thrombolytic therapy
-
1 thrombin receptor: kinetics, sites of truncation, and implications for thrombolytic therapy. Biochemistry 38:4572-4585
-
(1999)
Biochemistry
, vol.38
, pp. 4572-4585
-
-
Kuliopulos, A.1
Covic, L.2
Seeley, S.K.3
Sheridan, P.J.4
Helin, J.5
Costello, C.E.6
-
63
-
-
0035396863
-
Activation of pro-(matrix metalloproteinase-2) (pro-MMP-2) by thrombin is membrane-type-MMP-dependent in human umbilical vein endothelial cells and generates a distinct 63 kDa active species
-
Lafleur MA, Hollenberg MD, Atkinson SJ, Knauper V, Murphy G, Edwards DR (2001) Activation of pro-(matrix metalloproteinase-2) (pro-MMP-2) by thrombin is membrane-type-MMP-dependent in human umbilical vein endothelial cells and generates a distinct 63 kDa active species. Biochem J 357:107-115
-
(2001)
Biochem J
, vol.357
, pp. 107-115
-
-
Lafleur, M.A.1
Hollenberg, M.D.2
Atkinson, S.J.3
Knauper, V.4
Murphy, G.5
Edwards, D.R.6
-
64
-
-
33645733466
-
Identification of the annexin A2 heterotetramer as a receptor for the plasmin-induced signaling in human peripheral monocytes
-
Laumonnier Y, Syrovets T, Burysek L, Simmet T (2006) Identification of the annexin A2 heterotetramer as a receptor for the plasmin-induced signaling in human peripheral monocytes. Blood 107:3342-3349
-
(2006)
Blood
, vol.107
, pp. 3342-3349
-
-
Laumonnier, Y.1
Syrovets, T.2
Burysek, L.3
Simmet, T.4
-
66
-
-
0035019636
-
Proteinase-activated receptors
-
Macfarlane SR, Seatter MJ, Kanke T, Hunter GD, Plevin R (2001) Proteinase-activated receptors. Pharmacol Rev 53:245-282
-
(2001)
Pharmacol Rev
, vol.53
, pp. 245-282
-
-
MacFarlane, S.R.1
Seatter, M.J.2
Kanke, T.3
Hunter, G.D.4
Plevin, R.5
-
67
-
-
2442702842
-
2-furoyl-LIGRLO-amide: A potent and selective proteinase-activated receptor 2 agonist
-
McGuire JJ, Saifeddine M, Triggle CR, Sun K, Hollenberg MD (2004a) 2-furoyl-LIGRLO-amide: a potent and selective proteinase-activated receptor 2 agonist. J Pharmacol Exp Ther 309:1124-1131
-
(2004)
J Pharmacol Exp Ther
, vol.309
, pp. 1124-1131
-
-
McGuire, J.J.1
Saifeddine, M.2
Triggle, C.R.3
Sun, K.4
Hollenberg, M.D.5
-
68
-
-
14844320457
-
Hyperpolarization of murine small caliber mesenteric arteries by activation of endothelial proteinase-activated receptor 2
-
McGuire JJ, Hollenberg MD, Bennett BM, Triggle CR (2004b) Hyperpolarization of murine small caliber mesenteric arteries by activation of endothelial proteinase-activated receptor 2. Can J Physiol Pharmacol 82:1103-1112
-
(2004)
Can J Physiol Pharmacol
, vol.82
, pp. 1103-1112
-
-
McGuire, J.J.1
Hollenberg, M.D.2
Bennett, B.M.3
Triggle, C.R.4
-
69
-
-
33747626518
-
Role of matrix metalloproteinases in intestinal inflammation
-
Medina C, Radomski MW (2006) Role of matrix metalloproteinases in intestinal inflammation. J Pharmacol Exp Ther 318:933-938
-
(2006)
J Pharmacol Exp Ther
, vol.318
, pp. 933-938
-
-
Medina, C.1
Radomski, M.W.2
-
70
-
-
0034762688
-
Therapeutic effect of phenantroline in two rat models of inflammatory bowel disease
-
Medina C, Videla S, Radomski A, Radomski M, Antolin M, Guarner F, Vilaseca J, Salas A, Malagelada JR (2001) Therapeutic effect of phenantroline in two rat models of inflammatory bowel disease. Scand J Gastroenterol 36:1314-1319
-
(2001)
Scand J Gastroenterol
, vol.36
, pp. 1314-1319
-
-
Medina, C.1
Videla, S.2
Radomski, A.3
Radomski, M.4
Antolin, M.5
Guarner, F.6
Vilaseca, J.7
Salas, A.8
Malagelada, J.R.9
-
71
-
-
33745296164
-
Matrix metalloproteinase-9 modulates intestinal injury in rats with transmural colitis
-
Medina C, Santana A, Paz MC, Diaz-Gonzalez F, Farre E, Salas A, Radomski MW, Quintero E (2006) Matrix metalloproteinase-9 modulates intestinal injury in rats with transmural colitis. J Leukoc Biol 79:954-962
-
(2006)
J Leukoc Biol
, vol.79
, pp. 954-962
-
-
Medina, C.1
Santana, A.2
Paz, M.C.3
Diaz-Gonzalez, F.4
Farre, E.5
Salas, A.6
Radomski, M.W.7
Quintero, E.8
-
72
-
-
33748710916
-
Cathepsins B, L and D in inflammatory bowel disease macrophages and potential therapeutic effects of cathepsin inhibition in vivo
-
Menzel K, Hausmann M, Obermeier F, Schreiter K, Dunger N, Bataille F, Falk W, Scholmerich J, Herfarth H, Rogler G (2006) Cathepsins B, L and D in inflammatory bowel disease macrophages and potential therapeutic effects of cathepsin inhibition in vivo. Clin Exp Immunol 146:169-180
-
(2006)
Clin Exp Immunol
, vol.146
, pp. 169-180
-
-
Menzel, K.1
Hausmann, M.2
Obermeier, F.3
Schreiter, K.4
Dunger, N.5
Bataille, F.6
Falk, W.7
Scholmerich, J.8
Herfarth, H.9
Rogler, G.10
-
73
-
-
0030783689
-
Mitogenic responses mediated through the proteinase-activated receptor-2 are induced by expressed forms of mast cell alpha- or beta-tryptases
-
Mirza H, Schmidt VA, Derian CK, Jesty J, Bahou WF (1997) Mitogenic responses mediated through the proteinase-activated receptor-2 are induced by expressed forms of mast cell alpha- or beta-tryptases. Blood 90:3914-3922
-
(1997)
Blood
, vol.90
, pp. 3914-3922
-
-
Mirza, H.1
Schmidt, V.A.2
Derian, C.K.3
Jesty, J.4
Bahou, W.F.5
-
74
-
-
33847645880
-
Proteinase-activated receptors in the lower urinary tract
-
Moffatt JD (2007) Proteinase-activated receptors in the lower urinary tract. Naunyn-Schmiedeberg's Arch Pharmacol 375:1-9
-
(2007)
Naunyn-Schmiedeberg's Arch Pharmacol
, vol.375
, pp. 1-9
-
-
Moffatt, J.D.1
-
75
-
-
15444346942
-
Interactions of mast cell tryptase with thrombin receptors and PAR-2
-
Molino M, Barnathan ES, Numerof R, Clark J, Dreyer M, Cumashi A, Hoxie JA, Schechter N, Woolkalis M, Brass LF (1997) Interactions of mast cell tryptase with thrombin receptors and PAR-2. J Biol Chem 272:4043-4049
-
(1997)
J Biol Chem
, vol.272
, pp. 4043-4049
-
-
Molino, M.1
Barnathan, E.S.2
Numerof, R.3
Clark, J.4
Dreyer, M.5
Cumashi, A.6
Hoxie, J.A.7
Schechter, N.8
Woolkalis, M.9
Brass, L.F.10
-
76
-
-
33744806687
-
Inhibition of neutrophil elastase prevents the development of murine dextran sulfate sodium-induced colitis
-
Morohoshi Y, Matsuoka K, Chinen H, Kamada N, Sato T, Hisamatsu T, Okamoto S, Inoue N, Takaishi H, Ogata H, Iwao Y, Hibi T (2006) Inhibition of neutrophil elastase prevents the development of murine dextran sulfate sodium-induced colitis. J Gastroenterol 41:318-324
-
(2006)
J Gastroenterol
, vol.41
, pp. 318-324
-
-
Morohoshi, Y.1
Matsuoka, K.2
Chinen, H.3
Kamada, N.4
Sato, T.5
Hisamatsu, T.6
Okamoto, S.7
Inoue, N.8
Takaishi, H.9
Ogata, H.10
Iwao, Y.11
Hibi, T.12
-
78
-
-
6044263423
-
An orally active matrix metalloproteinase inhibitor, ONO-4817, reduces dextran sulfate sodium-induced colitis in mice
-
Naito Y, Takagi T, Kuroda M, Katada K, Ichikawa H, Kokura S, Yoshida N, Okanoue T, Yoshikawa T (2004) An orally active matrix metalloproteinase inhibitor, ONO-4817, reduces dextran sulfate sodium-induced colitis in mice. Inflamm Res 53:462-468
-
(2004)
Inflamm Res
, vol.53
, pp. 462-468
-
-
Naito, Y.1
Takagi, T.2
Kuroda, M.3
Katada, K.4
Ichikawa, H.5
Kokura, S.6
Yoshida, N.7
Okanoue, T.8
Yoshikawa, T.9
-
79
-
-
0034724445
-
Protease-activated receptor-2 modulates myocardial ischemia-reperfusion injury in the rat heart
-
Napoli C, Cicala C, Wallace JL, de Nigris F, Santagada V, Caliendo G, Franconi F, Ignarro LJ, Cirino G (2000) Protease-activated receptor-2 modulates myocardial ischemia-reperfusion injury in the rat heart. Proc Natl Acad Sci USA 97:3678-3683
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 3678-3683
-
-
Napoli, C.1
Cicala, C.2
Wallace, J.L.3
De Nigris, F.4
Santagada, V.5
Caliendo, G.6
Franconi, F.7
Ignarro, L.J.8
Cirino, G.9
-
80
-
-
2442507928
-
Evidence that protease activated receptor 2 expression is enhanced in human coronary atherosclerotic lesions
-
Napoli C, de Nigris F, Wallace JL, Hollenberg MD, Tajana G, De Rosa G, Sica V, Cirino G (2004) Evidence that protease activated receptor 2 expression is enhanced in human coronary atherosclerotic lesions. J Clin Pathol 57:513-516
-
(2004)
J Clin Pathol
, vol.57
, pp. 513-516
-
-
Napoli, C.1
De Nigris, F.2
Wallace, J.L.3
Hollenberg, M.D.4
Tajana, G.5
De Rosa, G.6
Sica, V.7
Cirino, G.8
-
81
-
-
0141727806
-
Colitis induced by proteinase-activated receptor-2 agonists is mediated by a neurogenic mechanism
-
Nguyen C, Coelho AM, Grady E, Compton SJ, Wallace JL, Hollenberg MD, Cenac N, Garcia-Villar R, Bueno L, Steinhoff M, Bunnett NW, Vergnolle N (2003) Colitis induced by proteinase-activated receptor-2 agonists is mediated by a neurogenic mechanism. Can J Physiol Pharm 81:920-927
-
(2003)
Can J Physiol Pharm
, vol.81
, pp. 920-927
-
-
Nguyen, C.1
Coelho, A.M.2
Grady, E.3
Compton, S.J.4
Wallace, J.L.5
Hollenberg, M.D.6
Cenac, N.7
Garcia-Villar, R.8
Bueno, L.9
Steinhoff, M.10
Bunnett, N.W.11
Vergnolle, N.12
-
82
-
-
0032533268
-
Protease-activated receptor 1 (PAR-1) is required and rate-limiting for thrombin-enhanced experimental pulmonary metastasis
-
Nierodzik ML, Chen K, Takeshita K, Li JJ, Huang YQ, Feng XS, D'Andrea MR, Andrade-Gordon P, Karpatkin S (1998) Protease-activated receptor 1 (PAR-1) is required and rate-limiting for thrombin-enhanced experimental pulmonary metastasis. Blood 92:3694-3700
-
(1998)
Blood
, vol.92
, pp. 3694-3700
-
-
Nierodzik, M.L.1
Chen, K.2
Takeshita, K.3
Li, J.J.4
Huang, Y.Q.5
Feng, X.S.6
D'Andrea, M.R.7
Andrade-Gordon, P.8
Karpatkin, S.9
-
83
-
-
18944373354
-
Proteinase-activated receptor-2 induction by neuroinflammation prevents neuronal death during HIV infection
-
Noorbakhsh F, Vergnolle N, McArthur JC, Silva C, Vodjgani M, Andrade-Gordon P, Hollenberg MD, Power C (2005) Proteinase-activated receptor-2 induction by neuroinflammation prevents neuronal death during HIV infection. J Immunol 174:7320-7329
-
(2005)
J Immunol
, vol.174
, pp. 7320-7329
-
-
Noorbakhsh, F.1
Vergnolle, N.2
McArthur, J.C.3
Silva, C.4
Vodjgani, M.5
Andrade-Gordon, P.6
Hollenberg, M.D.7
Power, C.8
-
84
-
-
33344473933
-
Proteinase-activated receptor 2 modulates neuroinflammation in experimental autoimmune encephalomyelitis and multiple sclerosis
-
Noorbakhsh F, Tsutsui S, Vergnolle N, Boven LA, Shariat N, Vodjgani M, Warren KG, Andrade-Gordon P, Hollenberg MD, Power C (2006) Proteinase-activated receptor 2 modulates neuroinflammation in experimental autoimmune encephalomyelitis and multiple sclerosis. J Exp Med 203:425-435
-
(2006)
J Exp Med
, vol.203
, pp. 425-435
-
-
Noorbakhsh, F.1
Tsutsui, S.2
Vergnolle, N.3
Boven, L.A.4
Shariat, N.5
Vodjgani, M.6
Warren, K.G.7
Andrade-Gordon, P.8
Hollenberg, M.D.9
Power, C.10
-
86
-
-
33745664539
-
Kallikrein-mediated cell signalling: Targeting proteinase-activated receptors (PARs)
-
Oikonomopoulou K, Hansen KK, Saifeddine M, Vergnolle N, Tea I, Blaber M, Blaber SI, Scarisbrick I, Diamandis EP, Hollenberg MD (2006a) Kallikrein-mediated cell signalling: targeting proteinase-activated receptors (PARs). Biol Chem 387:817-824
-
(2006)
Biol Chem
, vol.387
, pp. 817-824
-
-
Oikonomopoulou, K.1
Hansen, K.K.2
Saifeddine, M.3
Vergnolle, N.4
Tea, I.5
Blaber, M.6
Blaber, S.I.7
Scarisbrick, I.8
Diamandis, E.P.9
Hollenberg, M.D.10
-
87
-
-
33845955449
-
Proteinase-activated receptors, targets for kallikrein signaling
-
Oikonomopoulou K, Hansen KK, Saifeddine M, Tea I, Blaber M, Blaber SI, Scarisbrick I, Andrade-Gordon P, Cottrell GS, Bunnett NW, Diamandis EP, Hollenberg MD (2006b) Proteinase-activated receptors, targets for kallikrein signaling. J Biol Chem 281:32095-32112
-
(2006)
J Biol Chem
, vol.281
, pp. 32095-32112
-
-
Oikonomopoulou, K.1
Hansen, K.K.2
Saifeddine, M.3
Tea, I.4
Blaber, M.5
Blaber, S.I.6
Scarisbrick, I.7
Andrade-Gordon, P.8
Cottrell, G.S.9
Bunnett, N.W.10
Diamandis, E.P.11
Hollenberg, M.D.12
-
88
-
-
1642279517
-
Protease-activated receptors: Contribution to physiology and disease
-
Ossovskaya VS, Bunnett NW (2004) Protease-activated receptors: contribution to physiology and disease. Physiol Rev 84:579-621
-
(2004)
Physiol Rev
, vol.84
, pp. 579-621
-
-
Ossovskaya, V.S.1
Bunnett, N.W.2
-
89
-
-
34548242780
-
Tissue kallikrein proteolytic cascade pathways in normal physiology and cancer
-
Pampalakis G, Sotiropoulou G (2007) Tissue kallikrein proteolytic cascade pathways in normal physiology and cancer. Biochim Biophys Acta 1776:22-31
-
(2007)
Biochim Biophys Acta
, vol.1776
, pp. 22-31
-
-
Pampalakis, G.1
Sotiropoulou, G.2
-
90
-
-
33646059852
-
Development of activity-based probes for trypsin-family serine proteases
-
Pan Z, Jeffery DA, Chehade K, Beltman J, Clark JM, Grothaus P, Bogyo M, Baruch A (2006) Development of activity-based probes for trypsin-family serine proteases. Bioorg Med Chem Lett 16:2882-2885
-
(2006)
Bioorg Med Chem Lett
, vol.16
, pp. 2882-2885
-
-
Pan, Z.1
Jeffery, D.A.2
Chehade, K.3
Beltman, J.4
Clark, J.M.5
Grothaus, P.6
Bogyo, M.7
Baruch, A.8
-
91
-
-
0033599039
-
EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF
-
Prenzel N, Zwick E, Daub H, Leserer M, Abraham R, Wallasch C, Ullrich A (1999) EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF. Nature 402:884-888
-
(1999)
Nature
, vol.402
, pp. 884-888
-
-
Prenzel, N.1
Zwick, E.2
Daub, H.3
Leserer, M.4
Abraham, R.5
Wallasch, C.6
Ullrich, A.7
-
92
-
-
2442452711
-
Plasmin-mediated activation of platelets occurs by cleavage of protease-activated receptor 4
-
Quinton TM, Kim S, Derian CK, Jin J, Kunapuli SP (2004) Plasmin-mediated activation of platelets occurs by cleavage of protease-activated receptor 4. J Biol Chem 279:18434-18439
-
(2004)
J Biol Chem
, vol.279
, pp. 18434-18439
-
-
Quinton, T.M.1
Kim, S.2
Derian, C.K.3
Jin, J.4
Kunapuli, S.P.5
-
93
-
-
0035120812
-
Release of mast cell tryptase from human colorectal mucosa in inflammatory bowel disease
-
Raithel M, Winterkamp S, Pacurar A, Ulrich P, Hochberger J, Hahn EG (2001) Release of mast cell tryptase from human colorectal mucosa in inflammatory bowel disease. Scand J Gastroenterol 36:174-179
-
(2001)
Scand J Gastroenterol
, vol.36
, pp. 174-179
-
-
Raithel, M.1
Winterkamp, S.2
Pacurar, A.3
Ulrich, P.4
Hochberger, J.5
Hahn, E.G.6
-
94
-
-
45849100939
-
Proteinases and signaling: Pathophysiological and therapeutic implications via PARs and more
-
in press
-
Ramachandran R, Hollenberg MD (2007) Proteinases and signaling: pathophysiological and therapeutic implications via PARs and more. Brit J Pharmacol, in press
-
(2007)
Brit J Pharmacol
-
-
Ramachandran, R.1
Hollenberg, M.D.2
-
95
-
-
0025784847
-
CDNA cloning and expression of a hamster alpha-thrombin receptor coupled to Ca2+ mobilization
-
Rasmussen UB, Vouret-Craviari V, Jallat S, Schlesinger Y, Pages G, Pavirani A, Lecocq JP, Pouysségur J, Van Obberghen-Schilling E (1991) cDNA cloning and expression of a hamster alpha-thrombin receptor coupled to Ca2+ mobilization. FEBS Lett 288:123-128
-
(1991)
FEBS Lett
, vol.288
, pp. 123-128
-
-
Rasmussen, U.B.1
Vouret-Craviari, V.2
Jallat, S.3
Schlesinger, Y.4
Pages, G.5
Pavirani, A.6
Lecocq, J.P.7
Pouysségur, J.8
Van Obberghen-Schilling, E.9
-
96
-
-
34547868524
-
2): A tumor suppressor in skin carcinogenesis
-
2): a tumor suppressor in skin carcinogenesis. J Invest Dermatol 127:2245-2252
-
(2007)
J Invest Dermatol
, vol.127
, pp. 2245-2252
-
-
Rattenholl, A.1
Seeliger, S.2
Buddenkotte, J.3
Schön, M.4
Schön, M.P.5
Ständer, S.6
Vergnolle, N.7
Steinhoff, M.8
-
97
-
-
0014056205
-
The insulin-like action of pepsin and pepsinogen
-
Rieser P (1967) The insulin-like action of pepsin and pepsinogen. Acta Endocrinol (Copenhagen) 54:375-379
-
(1967)
Acta Endocrinol (Copenhagen)
, vol.54
, pp. 375-379
-
-
Rieser, P.1
-
98
-
-
0013587817
-
Anabolic responses of diaphragm muscle to insulin and to other pancreatic proteins
-
Rieser P, Rieser CH (1964) Anabolic responses of diaphragm muscle to insulin and to other pancreatic proteins. Proc Soc Exp Biol Med 116:669-671
-
(1964)
Proc Soc Exp Biol Med
, vol.116
, pp. 669-671
-
-
Rieser, P.1
Rieser, C.H.2
-
99
-
-
0037036069
-
Activation of endothelial cell protease activated receptor 1 by the protein C pathway
-
Riewald M, Petrovan RJ, Donner A, Mueller BM, Ruf W (2002) Activation of endothelial cell protease activated receptor 1 by the protein C pathway. Science 296:1880-1882
-
(2002)
Science
, vol.296
, pp. 1880-1882
-
-
Riewald, M.1
Petrovan, R.J.2
Donner, A.3
Mueller, B.M.4
Ruf, W.5
-
102
-
-
0030008482
-
Rat proteinase-activated receptor-2 (PAR-2): CDNA sequence and activity of receptor-derived peptides in gastric and vascular tissue
-
Saifeddine M, Al-Ani B, Cheng CH, Wang L, Hollenberg MD (1996) Rat proteinase-activated receptor-2 (PAR-2): cDNA sequence and activity of receptor-derived peptides in gastric and vascular tissue. Br J Pharmacol 118:521-530
-
(1996)
Br J Pharmacol
, vol.118
, pp. 521-530
-
-
Saifeddine, M.1
Al-Ani, B.2
Cheng, C.H.3
Wang, L.4
Hollenberg, M.D.5
-
103
-
-
36849080985
-
Proteinase-activated receptor-2 activating peptides: Distinct canine coronary artery receptor systems
-
(in press). doi: 10.1152/ajpheart.00519.2007
-
Saifeddine M, Seymour ML, Xiao YP, Compton SJ, Houle S, Ramachandran R, Macnaughton WK, Simonet S, Vayssettes-Courchay C, Verbeuren TJ, Hollenberg MD (2007) Proteinase-activated receptor-2 activating peptides: Distinct canine coronary artery receptor systems. Am J Physiol Heart Circ Physiol (in press). doi: 10.1152/ajpheart.00519.2007
-
(2007)
Am J Physiol Heart Circ Physiol
-
-
Saifeddine, M.1
Seymour, M.L.2
Xiao, Y.P.3
Compton, S.J.4
Houle, S.5
Ramachandran, R.6
Macnaughton, W.K.7
Simonet, S.8
Vayssettes-Courchay, C.9
Verbeuren, T.J.10
Hollenberg, M.D.11
-
104
-
-
33750967361
-
Attenuation of dextran sodium sulphate induced colitis in matrix metalloproteinase-9 deficient mice
-
Santana A, Medina C, Paz-Cabrera MC, Diaz-Gonzalez F, Farre E, Salas A, Radomski MW, Quintero E (2006) Attenuation of dextran sodium sulphate induced colitis in matrix metalloproteinase-9 deficient mice. World J Gastroenterol 12:6464-6472
-
(2006)
World J Gastroenterol
, vol.12
, pp. 6464-6472
-
-
Santana, A.1
Medina, C.2
Paz-Cabrera, M.C.3
Diaz-Gonzalez, F.4
Farre, E.5
Salas, A.6
Radomski, M.W.7
Quintero, E.8
-
105
-
-
34547634419
-
Distribution of 15 human kallikreins in tissues and biological fluids
-
Shaw JLV, Diamandis EP (2007) Distribution of 15 human kallikreins in tissues and biological fluids. Clin Chem 53:1423-1432
-
(2007)
Clin Chem
, vol.53
, pp. 1423-1432
-
-
Shaw, J.L.V.1
Diamandis, E.P.2
-
107
-
-
0023913099
-
Tryptic activation of the insulin receptor. Proteolytic truncation of the alpha-subunit releases the beta-subunit from inhibitory control
-
Shoelson SE, White MF, Kahn CR (1988) Tryptic activation of the insulin receptor. Proteolytic truncation of the alpha-subunit releases the beta-subunit from inhibitory control. J Biol Chem 263:4852-4860
-
(1988)
J Biol Chem
, vol.263
, pp. 4852-4860
-
-
Shoelson, S.E.1
White, M.F.2
Kahn, C.R.3
-
108
-
-
0032867472
-
Evidence for selective effects of chronic hypertension on cerebral artery vasodilatation to protease-activated receptor-2 activation
-
Sobey CG, Moffatt JD, Cocks TM (1999) Evidence for selective effects of chronic hypertension on cerebral artery vasodilatation to protease-activated receptor-2 activation. Stroke 30:1933-1940
-
(1999)
Stroke
, vol.30
, pp. 1933-1940
-
-
Sobey, C.G.1
Moffatt, J.D.2
Cocks, T.M.3
-
109
-
-
0033971235
-
Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism
-
Steinhoff M, Vergnolle N, Young SH, Tognetto M, Amadesi S, Ennes HS, Trevisani M, Hollenberg MD, Wallace JL, Caughey GH, Mitchell SE, Williams LM, Geppetti P, Mayer EA, Bunnett NW (2000) Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism. Nat Med 6:151-158
-
(2000)
Nat Med
, vol.6
, pp. 151-158
-
-
Steinhoff, M.1
Vergnolle, N.2
Young, S.H.3
Tognetto, M.4
Amadesi, S.5
Ennes, H.S.6
Trevisani, M.7
Hollenberg, M.D.8
Wallace, J.L.9
Caughey, G.H.10
Mitchell, S.E.11
Williams, L.M.12
Geppetti, P.13
Mayer, E.A.14
Bunnett, N.W.15
-
110
-
-
13444249470
-
Proteinase-activated receptors: Transducers of proteinase-mediated signaling in inflammation and immune response
-
Steinhoff M, Buddenkotte J, Shpacovitch V, Rattenholl A, Moormann C, Vergnolle N, Luger TA, Hollenberg MD (2005) Proteinase-activated receptors: transducers of proteinase-mediated signaling in inflammation and immune response. Endocr Rev 26:1-43
-
(2005)
Endocr Rev
, vol.26
, pp. 1-43
-
-
Steinhoff, M.1
Buddenkotte, J.2
Shpacovitch, V.3
Rattenholl, A.4
Moormann, C.5
Vergnolle, N.6
Luger, T.A.7
Hollenberg, M.D.8
-
111
-
-
0032722533
-
The effect of an inhibitor of matrix metalloproteinases on colonic inflammation in a trinitrobenzenesulphonic acid rat model of inflammatory bowel disease
-
Sykes AP, Bhogal R, Brampton C, Chander C, Whelan C, Parsons ME, Bird J (1999) The effect of an inhibitor of matrix metalloproteinases on colonic inflammation in a trinitrobenzenesulphonic acid rat model of inflammatory bowel disease. Aliment Pharmacol Ther 13:1535-1542
-
(1999)
Aliment Pharmacol Ther
, vol.13
, pp. 1535-1542
-
-
Sykes, A.P.1
Bhogal, R.2
Brampton, C.3
Chander, C.4
Whelan, C.5
Parsons, M.E.6
Bird, J.7
-
112
-
-
2442526798
-
Modulation of visceral pain and inflammation by protease-activated receptors
-
Vergnolle N (2004) Modulation of visceral pain and inflammation by protease-activated receptors. Br J Pharmacol 141:1264-1274
-
(2004)
Br J Pharmacol
, vol.141
, pp. 1264-1274
-
-
Vergnolle, N.1
-
113
-
-
19544392708
-
Clinical relevance of proteinase activated receptors (PARs) in the gut
-
Vergnolle N (2005) Clinical relevance of proteinase activated receptors (PARs) in the gut. Gut 54:867-874
-
(2005)
Gut
, vol.54
, pp. 867-874
-
-
Vergnolle, N.1
-
117
-
-
0034927070
-
Proteinase-activated receptor-2 and hyperalgesia: A novel pain pathway
-
Vergnolle N, Bunnett NW, Sharkey KA, Brussee V, Compton SJ, Grady EF, Cirino G, Gerard N, Basbaum AI, Andrade-Gordon P, Hollenberg MD, Wallace JL (2001a) Proteinase-activated receptor-2 and hyperalgesia: a novel pain pathway. Nat Med 7:821-826
-
(2001)
Nat Med
, vol.7
, pp. 821-826
-
-
Vergnolle, N.1
Bunnett, N.W.2
Sharkey, K.A.3
Brussee, V.4
Compton, S.J.5
Grady, E.F.6
Cirino, G.7
Gerard, N.8
Basbaum, A.I.9
Andrade-Gordon, P.10
Hollenberg, M.D.11
Wallace, J.L.12
-
118
-
-
0035282747
-
Protease-activated receptors in inflammation, neuronal signaling and pain
-
Vergnolle N, Wallace JL, Bunnett NW, Hollenberg MD (2001b) Protease-activated receptors in inflammation, neuronal signaling and pain. Trends Pharmacol Sci 22:146-152
-
(2001)
Trends Pharmacol Sci
, vol.22
, pp. 146-152
-
-
Vergnolle, N.1
Wallace, J.L.2
Bunnett, N.W.3
Hollenberg, M.D.4
-
119
-
-
0036681940
-
Characterization of thrombin-induced leukocyte rolling and adherence: A potential proinflammatory role for proteinase-activated receptor-4
-
Vergnolle N, Derian CK, D'Andrea MR, Steinhoff M, Andrade-Gordon P (2002) Characterization of thrombin-induced leukocyte rolling and adherence: a potential proinflammatory role for proteinase-activated receptor-4. J Immunol 169:1467-1473
-
(2002)
J Immunol
, vol.169
, pp. 1467-1473
-
-
Vergnolle, N.1
Derian, C.K.2
D'Andrea, M.R.3
Steinhoff, M.4
Andrade-Gordon, P.5
-
120
-
-
85047689926
-
A role for proteinase-activated receptor-1 in inflammatory bowel diseases
-
Vergnolle N, Cellars L, Mencarelli A, Rizzo G, Swaminathan S, Beck P, Steinhoff M, Andrade-Gordon P, Bunnett NW, Hollenberg MD, Wallace JL, Cirino G, Fiorucci S (2004) A role for proteinase-activated receptor-1 in inflammatory bowel diseases. J Clin Invest 114:1444-1456
-
(2004)
J Clin Invest
, vol.114
, pp. 1444-1456
-
-
Vergnolle, N.1
Cellars, L.2
Mencarelli, A.3
Rizzo, G.4
Swaminathan, S.5
Beck, P.6
Steinhoff, M.7
Andrade-Gordon, P.8
Bunnett, N.W.9
Hollenberg, M.D.10
Wallace, J.L.11
Cirino, G.12
Fiorucci, S.13
-
121
-
-
0033933804
-
Differential expression of matrix metalloproteinases and their tissue inhibitors in colon mucosa of patients with inflammatory bowel disease
-
von Lampe B, Barthel B, Coupland SE, Riecken EO, Rosewicz S (2000) Differential expression of matrix metalloproteinases and their tissue inhibitors in colon mucosa of patients with inflammatory bowel disease. Gut 47:63-73
-
(2000)
Gut
, vol.47
, pp. 63-73
-
-
Von Lampe, B.1
Barthel, B.2
Coupland, S.E.3
Riecken, E.O.4
Rosewicz, S.5
-
122
-
-
0026035523
-
Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation
-
Vu TK, Hung DT, Wheaton VI, Coughlin SR (1991) Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell 64:1057-1068
-
(1991)
Cell
, vol.64
, pp. 1057-1068
-
-
Vu, T.K.1
Hung, D.T.2
Wheaton, V.I.3
Coughlin, S.R.4
-
123
-
-
11144293489
-
Redundant signaling mechanisms contribute to the vasodilatory response of the afferent arteriole to proteinase-activated receptor-2
-
Wang X, Hollenberg MD, Loutzenhiser R (2005) Redundant signaling mechanisms contribute to the vasodilatory response of the afferent arteriole to proteinase-activated receptor-2. Am J Physiol Renal Physiol 288:F65-F75
-
(2005)
Am J Physiol Renal Physiol
, vol.288
-
-
Wang, X.1
Hollenberg, M.D.2
Loutzenhiser, R.3
-
124
-
-
0842263887
-
Proteinase-activated receptor (PAR)-mediated vasorelaxation in pulmonary arteries from normotensive and hypoxic pulmonary hypertensive rats
-
Wanstall JC, Gambino A (2004) Proteinase-activated receptor (PAR)-mediated vasorelaxation in pulmonary arteries from normotensive and hypoxic pulmonary hypertensive rats. Pulm Pharmacol Ther 17:97-103
-
(2004)
Pulm Pharmacol Ther
, vol.17
, pp. 97-103
-
-
Wanstall, J.C.1
Gambino, A.2
-
125
-
-
34548513539
-
Identification of a specific exosite on activated protein C for interaction with protease activated receptor 1
-
Yang L, Bae JS, Manithody C, Rezaie AR (2007) Identification of a specific exosite on activated protein C for interaction with protease activated receptor 1. J Biol Chem 282:25493-25500
-
(2007)
J Biol Chem
, vol.282
, pp. 25493-25500
-
-
Yang, L.1
Bae, J.S.2
Manithody, C.3
Rezaie, A.R.4
-
126
-
-
0034045641
-
Detection of proteolytic activity by fluorescent zymogram in-gel assays
-
Yasothornsrikul S, Hook VYH (2000) Detection of proteolytic activity by fluorescent zymogram in-gel assays. Biotechniques 28:1166-1173
-
(2000)
Biotechniques
, vol.28
, pp. 1166-1173
-
-
Yasothornsrikul, S.1
Hook, V.Y.H.2
-
127
-
-
36148969695
-
Activation profiles and regulatory cascades of the human kallikrein-related peptidases
-
(in press). doi: 10.1074/jbc.M705190200
-
Yoon H, Laxmikanthan G, Lee J, Blaber SI, Rodriguez A, Kogot JM, Scarisbrick IA, Blaber M (2007) Activation profiles and regulatory cascades of the human kallikrein-related peptidases. J Biol Chem (in press). doi: 10.1074/jbc.M705190200
-
(2007)
J Biol Chem
-
-
Yoon, H.1
Laxmikanthan, G.2
Lee, J.3
Blaber, S.I.4
Rodriguez, A.5
Kogot, J.M.6
Scarisbrick, I.A.7
Blaber, M.8
-
128
-
-
0036661263
-
Human tissue kallikreins: A new enzymatic cascade pathway?
-
Yousef GM, Diamandis EP (2002) Human tissue kallikreins: a new enzymatic cascade pathway? Biol Chem 383:1045-1057
-
(2002)
Biol Chem
, vol.383
, pp. 1045-1057
-
-
Yousef, G.M.1
Diamandis, E.P.2
-
129
-
-
0347764627
-
Trypsin activity assay in substrate-specific one- and two-dimensional gels: A powerful method to separate and characterize novel proteases in active form in biological samples
-
Zhao Z, Russell PJ (2003) Trypsin activity assay in substrate-specific one- and two-dimensional gels: a powerful method to separate and characterize novel proteases in active form in biological samples. Electrophoresis 24:3284-3288
-
(2003)
Electrophoresis
, vol.24
, pp. 3284-3288
-
-
Zhao, Z.1
Russell, P.J.2
|