An orally active matrix metalloproteinase inhibitor, ONO-4817, reduces dextran sulfate sodium-induced colitis in mice

Inflammation Research

Volumn 53, Issue 9, 2004, Pages 462-468

  Naito, Y ^a   Takagi, T ^a   Kuroda, M ^a   Katada, K ^a   Ichikawa, H ^a   Kokura, S ^a   Yoshida, N ^a   Okanoue, T ^a   Yoshikawa, T ^a  

^a KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

Author keywords

Colitis; Inflammatory cytokine; Inhibitor; Matrix metalloproteinase; Neutrophil

Indexed keywords

5 ETHOXYMETHOXY N HYDROXY 2 METHYL 4 (4 PHENOXYBENZAMIDO)PENTANAMIDE; DEXTRAN SULFATE; DRINKING WATER; GAMMA INTERFERON; GELATINASE B; MACROPHAGE ELASTASE; MATRILYSIN; MATRIX METALLOPROTEINASE INHIBITOR; MESSENGER RNA; MYELOPEROXIDASE; N HYDROXY 5 ETHOXYMETHYLOXY 2 METHYL 4 (4 PHENOXYBENZOYL)AMINOPENTANAMIDE; STROMELYSIN; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOCHEMISTRY; CELL DISRUPTION; CELL INFILTRATION; COLITIS; COLON MUCOSA; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE ACTIVITY; DRUG EFFECT; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; FECES ANALYSIS; FEMALE; HISTOLOGY; IMMUNOASSAY; INFLAMMATORY CELL; INTESTINE; MOUSE; MUCOSA CELL; MUCOSA INFLAMMATION; NEUTROPHIL; NONHUMAN; OCCULT BLOOD; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STATISTICAL SIGNIFICANCE; TISSUE SECTION; UPREGULATION; WEIGHT REDUCTION;

ADMINISTRATION, ORAL; ANIMALS; COLITIS; COLON; DEXTRAN SULFATE; ENZYME INHIBITORS; FEMALE; MATRIX METALLOPROTEINASES; MICE; MICE, INBRED BALB C; PHENYL ETHERS; SEVERITY OF ILLNESS INDEX; TISSUE INHIBITOR OF METALLOPROTEINASE-1;

EID: 6044263423     PISSN: 10233830     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00011-004-1281-1     Document Type: Article

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