Insulin induces SOCS-6 expression and its binding to the p85 monomer of phosphoinositide 3-kinase, resulting in improvement in glucose metabolism

Journal of Biological Chemistry

Volumn 279, Issue 33, 2004, Pages 34107-34114

  Li, Li ^a,d   Grønning, Line M ^b   Anderson, Per O ^a,d   Li, Suling ^d   Edvardsen, Klaus ^d   Johnston, Jim ^e   Kioussis, Dimitris ^c   Shepherd, Peter R ^b   Wang, Ping ^a,d  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^d LUND UNIVERSITY   (Sweden)

^e QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ASSOCIATION REACTIONS; BINDING ENERGY; CELLS; DEGRADATION; GROWTH KINETICS; MONOMERS;

PHENOTYPES; SIGNALING PATHWAYS; SUPPRESSORS OF CYTOKINE SIGNALING (SOCS); UNSTIMULATED CELLS;

INSULIN;

CYTOKINE; DIMER; GLUCOSE; GROWTH FACTOR; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; MESSENGER RNA; MONOMER; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEASOME INHIBITOR; PROTEIN KINASE B; PROTEIN P110; PROTEIN P85; SUPPRESSOR OF CYTOKINE SIGNALING; SUPPRESSOR OF CYTOKINE SIGNALING 6; UNCLASSIFIED DRUG; CYSTEINE PROTEINASE; MULTIENZYME COMPLEX; NUCLEAR PROTEIN; ONCOPROTEIN; PROTEASOME; PROTEIN; PROTEIN SERINE THREONINE KINASE; SOCS6 PROTEIN, HUMAN; SOCS7 PROTEIN, HUMAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ATTENUATION; CHEMICAL ANALYSIS; CONTROLLED STUDY; EMBRYO; FIBROBLAST; GENE EXPRESSION REGULATION; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; GLUCOSE TOLERANCE; HEMATOPOIETIC SYSTEM; IN VIVO STUDY; INSULIN RESPONSE; INSULIN TOLERANCE TEST; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN INTERACTION; PROTEIN SYNTHESIS; TRANSGENIC MOUSE; ANIMAL; C57BL MOUSE; CELL CULTURE; CELL DIVISION; CHO CELL; GENETIC TRANSFECTION; HAMSTER; HEART MUSCLE CELL; METABOLISM; NORTHERN BLOTTING; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN TERTIARY STRUCTURE; SIGNAL TRANSDUCTION; TIME; TRANSGENE;

ANIMALIA; MUS MUSCULUS;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; BLOOD GLUCOSE; BLOTTING, NORTHERN; CELL DIVISION; CELLS, CULTURED; CHO CELLS; CRICETINAE; CYSTEINE ENDOPEPTIDASES; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FIBROBLASTS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUCOSE; INSULIN; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MULTIENZYME COMPLEXES; MYOCYTES, CARDIAC; NUCLEAR PROTEINS; PHENOTYPE; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BIOSYNTHESIS; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; TIME FACTORS; TRANSFECTION; TRANSGENES;

EID: 4544287063     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M312672200     Document Type: Article

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