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Volumn 284, Issue 4 47-4, 2003, Pages

Interleukin-6 inhibits hepatic growth hormone signaling via upregulation of Cis and Socs-3

Author keywords

Cytokines; Endotoxin; STAT3; STAT5; Suppressors of cytokine signaling

Indexed keywords

CYTOKINE INDUCIBLE SH2 CONTAINING PROTEIN 1; GROWTH FACTOR; GROWTH HORMONE RECEPTOR; HEPATIC GROWTH HORMONE; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; PROTEIN INHIBITOR; STAT3 PROTEIN; STAT5 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 1; SUPPRESSOR OF CYTOKINE SIGNALING 2; SUPPRESSOR OF CYTOKINE SIGNALING 3; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR 1; UNCLASSIFIED DRUG;

EID: 0037378320     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.00178.2002     Document Type: Article
Times cited : (86)

References (38)
  • 1
    • 0033535958 scopus 로고    scopus 로고
    • Autoregulation of pituitary corticotroph SOCS-3 expression: Characterization of the murine SOCS- 3 promoter
    • Auernhammer CJ, Bousquet C, and Melmed S. Autoregulation of pituitary corticotroph SOCS-3 expression: characterization of the murine SOCS-3 promoter. Proc Natl Acad Sci USA 96: 6964-6969, 1999.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 6964-6969
    • Auernhammer, C.J.1    Bousquet, C.2    Melmed, S.3
  • 2
    • 0034021675 scopus 로고    scopus 로고
    • Growth failure occurs through a decrease in insulin-like growth factor 1 which is independent of undernutrition in a rat model of colitis
    • Ballinger AB, Azooz O, El-Haj T, Poole S, and Farthing MJ. Growth failure occurs through a decrease in insulin-like growth factor 1 which is independent of undernutrition in a rat model of colitis. Gut 46: 694-700, 2000.
    • (2000) Gut , vol.46 , pp. 694-700
    • Ballinger, A.B.1    Azooz, O.2    El-Haj, T.3    Poole, S.4    Farthing, M.J.5
  • 3
    • 0035077955 scopus 로고    scopus 로고
    • Growth failure and intestinal inflammation
    • Ballinger AB, Camacho-Hubner C, and Croft NM. Growth failure and intestinal inflammation. QJM 94: 121-125, 2001.
    • (2001) QJM , vol.94 , pp. 121-125
    • Ballinger, A.B.1    Camacho-Hubner, C.2    Croft, N.M.3
  • 5
    • 0034635550 scopus 로고    scopus 로고
    • Role of the suppressor of cytokine signaling-3 in mediating the inhibitory effects of interleukin-lbeta on the growth hormone-dependent transcription of the acid-labile subunit gene in liver cells
    • Boisclair YR, Wang J, Shi J, Hurst KR, and Ooi GT. Role of the suppressor of cytokine signaling-3 in mediating the inhibitory effects of interleukin-lbeta on the growth hormone-dependent transcription of the acid-labile subunit gene in liver cells. J Biol Chem 275: 3841-3847, 2000.
    • (2000) J Biol Chem , vol.275 , pp. 3841-3847
    • Boisclair, Y.R.1    Wang, J.2    Shi, J.3    Hurst, K.R.4    Ooi, G.T.5
  • 7
    • 0033037268 scopus 로고    scopus 로고
    • SOCS-3 is tyrosine phosphorylated in response to interleukin-2 and suppresses STAT5 phosphorylation and lymphocyte proliferation
    • Cohney SJ, Sanden D, Cacalano NA, Yoshimura A, Mui A, Migone TS, and Johnston JA. SOCS-3 is tyrosine phosphorylated in response to interleukin-2 and suppresses STAT5 phosphorylation and lymphocyte proliferation. Mol Cell Biol 19: 4980-4988, 1999.
    • (1999) Mol Cell Biol , vol.19 , pp. 4980-4988
    • Cohney, S.J.1    Sanden, D.2    Cacalano, N.A.3    Yoshimura, A.4    Mui, A.5    Migone, T.S.6    Johnston, J.A.7
  • 8
    • 0033752093 scopus 로고    scopus 로고
    • Potentiation of growth hormone-induced liver suppressors of cytokine signaling messenger ribonucleic acid by cytokines
    • Colson A, Le Cam A, Maiter D, Edery M, and Thissen JP. Potentiation of growth hormone-induced liver suppressors of cytokine signaling messenger ribonucleic acid by cytokines. Endocrinology 141: 3687-3695, 2000.
    • (2000) Endocrinology , vol.141 , pp. 3687-3695
    • Colson, A.1    Le Cam, A.2    Maiter, D.3    Edery, M.4    Thissen, J.P.5
  • 9
    • 0033544884 scopus 로고    scopus 로고
    • STAT5b-deficient mice are growth hormone pulseresistant. Role of STAT5b in sex-specific liver p450 expression
    • Davey HW, Park SH, Grattan DR, McLachlan MJ, and Waxman DJ. STAT5b-deficient mice are growth hormone pulseresistant. Role of STAT5b in sex-specific liver p450 expression. J Biol Chem 274: 35331-35336, 1999.
    • (1999) J Biol Chem , vol.274 , pp. 35331-35336
    • Davey, H.W.1    Park, S.H.2    Grattan, D.R.3    McLachlan, M.J.4    Waxman, D.J.5
  • 11
    • 0031025204 scopus 로고    scopus 로고
    • Interleukin 6 causes growth impairment in transgenic mice through a decrease in insulin-like growth factor-I. A model for stunted growth in children with chronic inflammation
    • De Benedetti F, Alonzi T, Moretta A, Lazzaro D, Costa P, Poli V, Martini A, Ciliberto G, and Fattori E. Interleukin 6 causes growth impairment in transgenic mice through a decrease in insulin-like growth factor-I. A model for stunted growth in children with chronic inflammation. J Clin Invest 99: 643-650, 1997.
    • (1997) J Clin Invest , vol.99 , pp. 643-650
    • De Benedetti, F.1    Alonzi, T.2    Moretta, A.3    Lazzaro, D.4    Costa, P.5    Poli, V.6    Martini, A.7    Ciliberto, G.8    Fattori, E.9
  • 12
    • 0032945579 scopus 로고    scopus 로고
    • GH insensitivity induced by endotoxin injection is associated with decreased liver GH receptors
    • Defalque D, Brandt N, Ketelslegers JM, and Thissen JP. GH insensitivity induced by endotoxin injection is associated with decreased liver GH receptors. Am J Physiol Endocrinol Metab 276: E565-E572, 1999.
    • (1999) Am J Physiol Endocrinol Metab , vol.276
    • Defalque, D.1    Brandt, N.2    Ketelslegers, J.M.3    Thissen, J.P.4
  • 13
    • 0034994026 scopus 로고    scopus 로고
    • TNF-α downregulates murine hepatic growth hormone receptor expression by inhibiting Sp1 and Sp3 binding
    • Denson LA, Menon RK, Shaufl A, Bajwa HS, Williams CR, and Karpen SJ. TNF-α downregulates murine hepatic growth hormone receptor expression by inhibiting Sp1 and Sp3 binding. J Clin Invest 107: 1451-1458, 2001.
    • (2001) J Clin Invest , vol.107 , pp. 1451-1458
    • Denson, L.A.1    Menon, R.K.2    Shaufl, A.3    Bajwa, H.S.4    Williams, C.R.5    Karpen, S.J.6
  • 15
    • 0030013088 scopus 로고    scopus 로고
    • The inflammatory response in interleukin-1 beta-deficient mice: Comparison with other cytokine-related knock-out mice
    • Fantuzzi G and Dinarello CA. The inflammatory response in interleukin-1 beta-deficient mice: comparison with other cytokine-related knock-out mice. J Leukoc Biol 59: 489-493, 1996.
    • (1996) J Leukoc Biol , vol.59 , pp. 489-493
    • Fantuzzi, G.1    Dinarello, C.A.2
  • 18
    • 0034647541 scopus 로고    scopus 로고
    • Regulation of SOCS-1 expression by translational repression
    • Gregorieff A, Pyronnet S, Sonenberg N, and Veillette A. Regulation of SOCS-1 expression by translational repression. J Biol Chem 275: 21596-21604, 2000.
    • (2000) J Biol Chem , vol.275 , pp. 21596-21604
    • Gregorieff, A.1    Pyronnet, S.2    Sonenberg, N.3    Veillette, A.4
  • 19
    • 0031952892 scopus 로고    scopus 로고
    • Systemic action of human growth hormone following adenovirus-mediated gene transfer to rat submandibular glands
    • He X, Goldsmith CM, Marmary Y, Wellner RB, Parlow AF, Nieman LK, and Baum BJ. Systemic action of human growth hormone following adenovirus-mediated gene transfer to rat submandibular glands. Gene Ther 5: 537-541, 1998.
    • (1998) Gene Ther , vol.5 , pp. 537-541
    • He, X.1    Goldsmith, C.M.2    Marmary, Y.3    Wellner, R.B.4    Parlow, A.F.5    Nieman, L.K.6    Baum, B.J.7
  • 20
    • 0033103805 scopus 로고    scopus 로고
    • Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: Implications for joint and gut-associated immunopathologies
    • Kontoyiannis D, Pasparakis M, Pizarro TT, Cominelli F, and Kollias G. Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies. Immunity 10: 387-398, 1999.
    • (1999) Immunity , vol.10 , pp. 387-398
    • Kontoyiannis, D.1    Pasparakis, M.2    Pizarro, T.T.3    Cominelli, F.4    Kollias, G.5
  • 21
    • 0033828672 scopus 로고    scopus 로고
    • SOCS physiological suppressors of cytokine signaling
    • Krebs DL and Hilton DJ. SOCS: physiological suppressors of cytokine signaling. J Cell Sci 113: 2813-2819, 2000.
    • (2000) J Cell Sci , vol.113 , pp. 2813-2819
    • Krebs, D.L.1    Hilton, D.J.2
  • 23
  • 26
    • 0033808087 scopus 로고    scopus 로고
    • Regulation of expression of the rat SOCS-3 gene in hepatocytes by growth hormone, interleukin-6 and glucocorticoids mRNA analysis and promoter characterization
    • Paul C, Seiliez I, Thissen JP, and Le Cam A. Regulation of expression of the rat SOCS-3 gene in hepatocytes by growth hormone, interleukin-6 and glucocorticoids mRNA analysis and promoter characterization. Eur J Biochem 267: 5849-5857, 2000.
    • (2000) Eur J Biochem , vol.267 , pp. 5849-5857
    • Paul, C.1    Seiliez, I.2    Thissen, J.P.3    Le Cam, A.4
  • 27
    • 0033544899 scopus 로고    scopus 로고
    • SOCS/CIS protein inhibition of growth hormone-stimulated STAT 5 signaling by multiple mechanisms
    • Ram PA and Waxman DJ. SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms. J Biol Chem 274: 35553-35561, 1999.
    • (1999) J Biol Chem , vol.274 , pp. 35553-35561
    • Ram, P.A.1    Waxman, D.J.2
  • 28
    • 0034671535 scopus 로고    scopus 로고
    • Role of the cytokine-inducible SH 2 protein CIS in desensitization of STAT5b signaling by continuous growth hormone
    • Ram PA and Waxman DJ. Role of the cytokine-inducible SH2 protein CIS in desensitization of STAT5b signaling by continuous growth hormone. J Biol Chem 275: 39487-39496, 2000.
    • (2000) J Biol Chem , vol.275 , pp. 39487-39496
    • Ram, P.A.1    Waxman, D.J.2
  • 29
    • 0027327619 scopus 로고
    • Mice lacking the tumour necrosis factor receptor 1 are resistant to TNF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes
    • Rothe J, Lesslauer W, Lotscher H, Lang Y, Koebel P, Kontgen F, Althage A, Zinkernagel R, Steinmetz M, and Bluethmann H. Mice lacking the tumour necrosis factor receptor 1 are resistant to TNF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes. Nature 364: 798-802, 1993.
    • (1993) Nature , vol.364 , pp. 798-802
    • Rothe, J.1    Lesslauer, W.2    Lotscher, H.3    Lang, Y.4    Koebel, P.5    Kontgen, F.6    Althage, A.7    Zinkernagel, R.8    Steinmetz, M.9    Bluethmann, H.10
  • 30
    • 0034908363 scopus 로고    scopus 로고
    • Impaired JAK-STAT signal transduction contributes to growth hormone resistance in chronic uremia
    • Schaefer F, Chen Y, Tsao T, Nouri P, and Rabkin R. Impaired JAK-STAT signal transduction contributes to growth hormone resistance in chronic uremia. J Clin Invest 108: 467-475, 2001.
    • (2001) J Clin Invest , vol.108 , pp. 467-475
    • Schaefer, F.1    Chen, Y.2    Tsao, T.3    Nouri, P.4    Rabkin, R.5
  • 34
    • 0031046710 scopus 로고    scopus 로고
    • Inhibition by interleukin-1 beta and tumor necrosis factor-alpha of the insulin-like growth factor I messenger ribonucleic acid response to growth hormone in rat hepatocyte primary culture
    • Thissen JP and Verniers J. Inhibition by interleukin-1 beta and tumor necrosis factor-alpha of the insulin-like growth factor I messenger ribonucleic acid response to growth hormone in rat hepatocyte primary culture. Endocrinology 138: 1078-1084, 1997.
    • (1997) Endocrinology , vol.138 , pp. 1078-1084
    • Thissen, J.P.1    Verniers, J.2
  • 36
    • 0036145323 scopus 로고    scopus 로고
    • Mechanism of growth hormone insensitivity induced by endotoxin
    • Wang P, Li N, and Li JS. Mechanism of growth hormone insensitivity induced by endotoxin. Acta Pharmacol Sin 23: 16-22, 2002.
    • (2002) Acta Pharmacol Sin , vol.23 , pp. 16-22
    • Wang, P.1    Li, N.2    Li, J.S.3
  • 37
    • 0030512124 scopus 로고    scopus 로고
    • Proinflammatory cytokines interleukin 1 beta and tumor necrosis factor alpha inhibit growth hormone stimulation of insulin-like growth factor I synthesis and growth hormone receptor mRNA levels in cultured rat liver cells
    • Wolf M, Bohm S, Brand M, and Kreymann G. Proinflammatory cytokines interleukin 1 beta and tumor necrosis factor alpha inhibit growth hormone stimulation of insulin-like growth factor I synthesis and growth hormone receptor mRNA levels in cultured rat liver cells. Eur J Endocrinol 135: 729-737, 1996.
    • (1996) Eur J Endocrinol , vol.135 , pp. 729-737
    • Wolf, M.1    Bohm, S.2    Brand, M.3    Kreymann, G.4
  • 38
    • 0035816531 scopus 로고    scopus 로고
    • Growth hormone (GH)-induced dimerization inhibits phorbol ester-stimulated GH receptor proteolysis
    • Zhang Y, Guan R, Jiang J, Kopchick JJ, Black RA, Baumann G, and Frank SJ. Growth hormone (GH)-induced dimerization inhibits phorbol ester-stimulated GH receptor proteolysis. J Biol Chem 276: 24565-24573, 2001.
    • (2001) J Biol Chem , vol.276 , pp. 24565-24573
    • Zhang, Y.1    Guan, R.2    Jiang, J.3    Kopchick, J.J.4    Black, R.A.5    Baumann, G.6    Frank, S.J.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.