메뉴 건너뛰기




Volumn 9, Issue 1, 2006, Pages 51-58

Thrombin and inflammatory proteins are elevated in Alzheimer's disease microvessels: Implications for disease pathogenesis

Author keywords

Inflammation; Microvessels; Neurotoxin; Vascular

Indexed keywords

ALPHA5 INTEGRIN; ALPHAVBETA5 INTEGRIN; BETA5 INTEGRIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INTERLEUKIN 8; PROTEIN; THROMBIN; UNCLASSIFIED DRUG; VITRONECTIN RECEPTOR;

EID: 33646014454     PISSN: 13872877     EISSN: None     Source Type: Journal    
DOI: 10.3233/JAD-2006-9105     Document Type: Article
Times cited : (147)

References (69)
  • 1
    • 0026454599 scopus 로고
    • Thrombin accumulation in brains of patients with Alzheimer's disease
    • H. Akiyama, K. Ikeda, H. Kondo and P.L. McGeer, Thrombin accumulation in brains of patients with Alzheimer's disease, Neurosci Lett 146 (1992), 152-154.
    • (1992) Neurosci Lett , vol.146 , pp. 152-154
    • Akiyama, H.1    Ikeda, K.2    Kondo, H.3    McGeer, P.L.4
  • 2
    • 1442274909 scopus 로고    scopus 로고
    • alpha 1 Integrin activation: A link between beta-amyloid deposition and neuronal death in aging hippocampal neurons
    • K.L. Anderson and A. Ferreira, alpha 1 Integrin activation: a link between beta-amyloid deposition and neuronal death in aging hippocampal neurons, J Neurosci Res 75 (2004), 688-697.
    • (2004) J Neurosci Res , vol.75 , pp. 688-697
    • Anderson, K.L.1    Ferreira, A.2
  • 3
    • 22144467718 scopus 로고    scopus 로고
    • Reactive oxygen and nitrogen species in Alzheimer's disease
    • M. Aslan and T. Ozben, Reactive oxygen and nitrogen species in Alzheimer's disease, Curr Alzheimer Res 1 (2004), 111-119.
    • (2004) Curr Alzheimer Res , vol.1 , pp. 111-119
    • Aslan, M.1    Ozben, T.2
  • 4
    • 0036773010 scopus 로고    scopus 로고
    • Hypoxia signaling to genes: Significance in Alzheimer's disease
    • N.G. Bazan, R. Palacios-Pelaez and W.J. Lukiw, Hypoxia signaling to genes: significance in Alzheimer's disease, Mol Neurobiol 26 (2002), 283-298.
    • (2002) Mol Neurobiol , vol.26 , pp. 283-298
    • Bazan, N.G.1    Palacios-Pelaez, R.2    Lukiw, W.J.3
  • 6
    • 2542506333 scopus 로고    scopus 로고
    • Redox-sensitive regulation of the HIF pathway under non-hypoxic conditions in pulmonary artery smooth muscle cells
    • R.S. BelAiba, T. Djordjevic, S. Bonello, D. Flugel, J. Hess, T. Kietzman and A. Gorlach, Redox-sensitive regulation of the HIF pathway under non-hypoxic conditions in pulmonary artery smooth muscle cells, Biol Chem 385 (2004), 249-257.
    • (2004) Biol Chem , vol.385 , pp. 249-257
    • Belaiba, R.S.1    Djordjevic, T.2    Bonello, S.3    Flugel, D.4    Hess, J.5    Kietzman, T.6    Gorlach, A.7
  • 8
    • 1242316268 scopus 로고    scopus 로고
    • Involvement of beta (1) integrin in betaAP-induced apoptosis in human neuroblastoma cells
    • C. Bozzo, G. Lombardi, C. Santoro and P.L. Canonico, Involvement of beta (1) integrin in betaAP-induced apoptosis in human neuroblastoma cells, Mol Cell Neurosci 25 (2004), 1-8.
    • (2004) Mol Cell Neurosci , vol.25 , pp. 1-8
    • Bozzo, C.1    Lombardi, G.2    Santoro, C.3    Canonico, P.L.4
  • 9
    • 0032923562 scopus 로고    scopus 로고
    • Thrombin induces surface and intracellular secretion of amyloid precursor protein from human endothelial cells
    • J.R. Ciallella, H. Figueiredo, V. Smith-Swintosky and J.P. McGillis, Thrombin induces surface and intracellular secretion of amyloid precursor protein from human endothelial cells, Thromb Haemost 81 (1999), 630-637.
    • (1999) Thromb Haemost , vol.81 , pp. 630-637
    • Ciallella, J.R.1    Figueiredo, H.2    Smith-Swintosky, V.3    McGillis, J.P.4
  • 10
    • 0034016962 scopus 로고    scopus 로고
    • Endothelial dysfunction as a possible link between C-reactive protein levels and cardiovascular disease
    • S.J. Cleland, N. Sattar, J.R. Petrie, N.G. Forouhi, H.L. Elliot and J.M. Connell, Endothelial dysfunction as a possible link between C-reactive protein levels and cardiovascular disease, Clin Sci 98 (2000), 531-535.
    • (2000) Clin Sci , vol.98 , pp. 531-535
    • Cleland, S.J.1    Sattar, N.2    Petrie, J.R.3    Forouhi, N.G.4    Elliot, H.L.5    Connell, J.M.6
  • 11
    • 0036630634 scopus 로고    scopus 로고
    • Statins in the prevention and treatment of Alzheimer disease
    • M. Crisby, L.A. Carlson and B. Winblad, Statins in the prevention and treatment of Alzheimer disease, Alzheimer Dis Assoc Disord 16 (2002), 131-136.
    • (2002) Alzheimer Dis Assoc Disord , vol.16 , pp. 131-136
    • Crisby, M.1    Carlson, L.A.2    Winblad, B.3
  • 12
    • 0036218738 scopus 로고    scopus 로고
    • Alzheimer disease as a vascular disorder: Nosological evidence
    • J.C. de la Torre, Alzheimer disease as a vascular disorder: nosological evidence, Stroke 33 (2002), 1152-1162.
    • (2002) Stroke , vol.33 , pp. 1152-1162
    • De La Torre, J.C.1
  • 13
    • 0033668944 scopus 로고    scopus 로고
    • Evidence that Alzheimer's disease is microvascular disorder: The role of constitutive nitric oxide
    • J.C. de la Torre and G.B. Stefano, Evidence that Alzheimer's disease is microvascular disorder: the role of constitutive nitric oxide, Brain Res Rev 34 (2000), 119-136.
    • (2000) Brain Res Rev , vol.34 , pp. 119-136
    • De La Torre, J.C.1    Stefano, G.B.2
  • 14
    • 0019992577 scopus 로고
    • Primary culture of rat cerebral microvascular endothelial cells
    • C.A. Diglio, P. Grammas, F. Giacomelli and J. Wiener, Primary culture of rat cerebral microvascular endothelial cells, Lab Invest 46 (1982), 554-563.
    • (1982) Lab Invest , vol.46 , pp. 554-563
    • Diglio, C.A.1    Grammas, P.2    Giacomelli, F.3    Wiener, J.4
  • 15
    • 0027772023 scopus 로고
    • Isolation and characterization of cerebral resistance vessel endothelium in culture
    • C.A. Diglio, W. Liu, P. Grammas, F. Giacomelli and J. Wiener, Isolation and characterization of cerebral resistance vessel endothelium in culture, Tissue and Cell 25 (1993), 833-846.
    • (1993) Tissue and Cell , vol.25 , pp. 833-846
    • Diglio, C.A.1    Liu, W.2    Grammas, P.3    Giacomelli, F.4    Wiener, J.5
  • 17
    • 0031017154 scopus 로고    scopus 로고
    • C-reactive protein-like immunoreactivity in the neurofibrillary tangles of Alzheimer's disease
    • T. Duong, M. Nikolaeva and P.J. Acton, C-reactive protein-like immunoreactivity in the neurofibrillary tangles of Alzheimer's disease, Brain Res 749 (1997), 152-156.
    • (1997) Brain Res , vol.749 , pp. 152-156
    • Duong, T.1    Nikolaeva, M.2    Acton, P.J.3
  • 18
    • 3042677724 scopus 로고    scopus 로고
    • Thrombin induces angiogenesis and vascular endothelial growth factor expression in human endothelial cells: Possible relevance to HIF-1alpha
    • E. Dupuy, A. Habib, M. Lebret, R. Yang, S. Levy-Toledano and G. Tobelem, Thrombin induces angiogenesis and vascular endothelial growth factor expression in human endothelial cells: possible relevance to HIF-1alpha, J Thromb Haemost 1 (2003), 1096-1102.
    • (2003) J Thromb Haemost , vol.1 , pp. 1096-1102
    • Dupuy, E.1    Habib, A.2    Lebret, M.3    Yang, R.4    Levy-Toledano, S.5    Tobelem, G.6
  • 20
    • 0034186091 scopus 로고    scopus 로고
    • Motor neuron cell death in wobbler mutant mice follows overexpression of the G-protein coupled, protease-activated receptor for thrombin
    • B.W. Festoff, M.R. D'Andrea, B.A. Citron, R.M. Salcedo, I.V. Smirnova and P. Andrade-Gordon, Motor neuron cell death in wobbler mutant mice follows overexpression of the G-protein coupled, protease-activated receptor for thrombin, Mol Med 6 (2000), 410-429.
    • (2000) Mol Med , vol.6 , pp. 410-429
    • Festoff, B.W.1    D'Andrea, M.R.2    Citron, B.A.3    Salcedo, R.M.4    Smirnova, I.V.5    Andrade-Gordon, P.6
  • 22
    • 0034603509 scopus 로고    scopus 로고
    • A damaged microcirculation contributes to neuronal cell death in Alzheimer's disease
    • P. Grammas, A damaged microcirculation contributes to neuronal cell death in Alzheimer's disease, Neurobiol Aging 21 (2000), 199-205.
    • (2000) Neurobiol Aging , vol.21 , pp. 199-205
    • Grammas, P.1
  • 23
    • 0032915154 scopus 로고    scopus 로고
    • Alzheimer's disease brain microvessels kill neurons in vitro
    • P. Grammas, P. Moore and P.H. Weigel, Alzheimer's disease brain microvessels kill neurons in vitro, Am J Pathol 154 (1999), 337-342.
    • (1999) Am J Pathol , vol.154 , pp. 337-342
    • Grammas, P.1    Moore, P.2    Weigel, P.H.3
  • 25
    • 0035690770 scopus 로고    scopus 로고
    • Inflammatory factors are elevated in brain microvessels in Alzheimer's disease
    • P. Grammas and R. Ovase, Inflammatory factors are elevated in brain microvessels in Alzheimer's disease, Neurobiol Aging 22 (2001), 837-842.
    • (2001) Neurobiol Aging , vol.22 , pp. 837-842
    • Grammas, P.1    Ovase, R.2
  • 26
    • 0002734459 scopus 로고
    • Decreased α-adrenergic receptors at the blood-brain barrier in Alzheimer's disease
    • K. Iqbal, D.R.C. McLachlan, B. Winblad and H.M. Wisniewski, eds, John Wiley & Sons., Ltd.
    • P. Grammas, A.E. Roher and M.J. Ball, Decreased α-adrenergic receptors at the blood-brain barrier in Alzheimer's disease, in: In Alzheimer's Disease: Basic Mechanisms, Diagnosis and Therapeutic Strategies, K. Iqbal, D.R.C. McLachlan, B. Winblad and H.M. Wisniewski, eds, John Wiley & Sons., Ltd., 1991, pp. 129-136.
    • (1991) In Alzheimer's Disease: Basic Mechanisms, Diagnosis and Therapeutic Strategies , pp. 129-136
    • Grammas, P.1    Roher, A.E.2    Ball, M.J.3
  • 27
  • 28
    • 0030817878 scopus 로고    scopus 로고
    • Thrombin promotes endothelial cell alignment in Matrigel in vitro and angiogenesis in vivo
    • G.C. Haralabopoulos, D.S. Grant, H.K. Kleinman and M.E. Maragoudakis, Thrombin promotes endothelial cell alignment in Matrigel in vitro and angiogenesis in vivo, Am J Physiol 272 (1997), 239-245.
    • (1997) Am J Physiol , vol.272 , pp. 239-245
    • Haralabopoulos, G.C.1    Grant, D.S.2    Kleinman, H.K.3    Maragoudakis, M.E.4
  • 29
    • 7044237034 scopus 로고    scopus 로고
    • Divide and die: Cell cycle events as triggers of nerve cell death
    • K. Herrup, R. Neve, S.L. Ackerman and A. Copani, Divide and die: cell cycle events as triggers of nerve cell death, J Neurosci 24 (2004), 9232-9239.
    • (2004) J Neurosci , vol.24 , pp. 9232-9239
    • Herrup, K.1    Neve, R.2    Ackerman, S.L.3    Copani, A.4
  • 31
    • 0036493752 scopus 로고    scopus 로고
    • Thrombin induces increased expression and secretion of angiopoietin-2 from human umbilical vein endothelial cells
    • Y.-Q. Huang, J.-J. Li, L. Lu, M. Lee and S. Karpatkin, Thrombin induces increased expression and secretion of angiopoietin-2 from human umbilical vein endothelial cells, Blood 99 (2002), 1646-1650.
    • (2002) Blood , vol.99 , pp. 1646-1650
    • Huang, Y.-Q.1    Li, J.-J.2    Lu, L.3    Lee, M.4    Karpatkin, S.5
  • 32
    • 0033976342 scopus 로고    scopus 로고
    • Hypoxic regulation of inducible nitric oxide synthase via hypoxia inducible factor-1 in cardiac myocytes
    • F. Jung, L.A. Palmer, N. Zhou and R.A. Johns, Hypoxic regulation of inducible nitric oxide synthase via hypoxia inducible factor-1 in cardiac myocytes, Circ Res 86 (2000), 319-325.
    • (2000) Circ Res , vol.86 , pp. 319-325
    • Jung, F.1    Palmer, L.A.2    Zhou, N.3    Johns, R.A.4
  • 34
    • 0042889191 scopus 로고    scopus 로고
    • Reciprocal regulation between nitric oxide and vascular endothelial growth factor in angiogenesis
    • H. Kimura and H. Esumi, Reciprocal regulation between nitric oxide and vascular endothelial growth factor in angiogenesis, Acta Biochim Pol 50 (2003), 49-59.
    • (2003) Acta Biochim Pol , vol.50 , pp. 49-59
    • Kimura, H.1    Esumi, H.2
  • 35
    • 3142752573 scopus 로고    scopus 로고
    • Leukocyte adhesion during hypoxia is mediated by HIF-1-dependent induction of beta2 integrin gene expression
    • T. Kong, H.K. Eltzschig, J. Karhausen, S.P. Colgan and C.S. Shelley, Leukocyte adhesion during hypoxia is mediated by HIF-1-dependent induction of beta2 integrin gene expression, Proc Natl Acad Sci USA 101 (2004), 10440-10445.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 10440-10445
    • Kong, T.1    Eltzschig, H.K.2    Karhausen, J.3    Colgan, S.P.4    Shelley, C.S.5
  • 36
    • 0029858997 scopus 로고    scopus 로고
    • Characterization of an inducible endothelial cell prothrombin activator
    • L. Liu and G.M. Rodgers, Characterization of an inducible endothelial cell prothrombin activator, Blood 88 (1996), 2989-2994.
    • (1996) Blood , vol.88 , pp. 2989-2994
    • Liu, L.1    Rodgers, G.M.2
  • 41
    • 0029824524 scopus 로고    scopus 로고
    • Modulation of fibrin assembly and polymerization by the beta-amyloid of Alzheimer's disease
    • D.L. Merkle, C.H. Cheng, F.J. Castellino and B.A. Chibber, Modulation of fibrin assembly and polymerization by the beta-amyloid of Alzheimer's disease, Blood Coagul Fibrinolysis 7 (1996), 650-658.
    • (1996) Blood Coagul Fibrinolysis , vol.7 , pp. 650-658
    • Merkle, D.L.1    Cheng, C.H.2    Castellino, F.J.3    Chibber, B.A.4
  • 42
  • 43
    • 0042388002 scopus 로고    scopus 로고
    • Cerebral hypoperfusion induces cortical watershed microinfarcts which may further aggravate cognitive decline in Alzheimer's disease
    • J. Miklossy, Cerebral hypoperfusion induces cortical watershed microinfarcts which may further aggravate cognitive decline in Alzheimer's disease, Neurol Res 25 (2003), 605-610.
    • (2003) Neurol Res , vol.25 , pp. 605-610
    • Miklossy, J.1
  • 44
    • 0036682158 scopus 로고    scopus 로고
    • The integrin family of cell adhesion molecules has multiple functions within the CNS
    • R. Milner and I.L. Campbell, The integrin family of cell adhesion molecules has multiple functions within the CNS, J Neurosci Res 69 (2002), 286-291.
    • (2002) J Neurosci Res , vol.69 , pp. 286-291
    • Milner, R.1    Campbell, I.L.2
  • 45
    • 0034612175 scopus 로고    scopus 로고
    • Inflammation and Alzheimer's disease
    • Neuroinflammation Working Group, Inflammation and Alzheimer's disease, Neurobiol Aging 21 (2000), 383-421.
    • (2000) Neurobiol Aging , vol.21 , pp. 383-421
  • 46
    • 0025042545 scopus 로고
    • The effect of hypoxia on capillary endothelial cell function: Modulation of barrier and coagulant function
    • S. Ogawa, R. Shreeniwas, J. Brett, M. Clauss, M. Furie and D.M. Stern, The effect of hypoxia on capillary endothelial cell function: modulation of barrier and coagulant function, Br J Haematol 75 (1990), 517-524.
    • (1990) Br J Haematol , vol.75 , pp. 517-524
    • Ogawa, S.1    Shreeniwas, R.2    Brett, J.3    Clauss, M.4    Furie, M.5    Stern, D.M.6
  • 47
    • 3142548720 scopus 로고    scopus 로고
    • Rapid chemokines secretion from endothelial cells orginates from 2 distinct compartments
    • I. Oynebraten, O. Bakke, P. Brandtzaeg, F.E. Johansen and G. Haraldsen, Rapid chemokines secretion from endothelial cells orginates from 2 distinct compartments, Blood 15 (2004), 314-320.
    • (2004) Blood , vol.15 , pp. 314-320
    • Oynebraten, I.1    Bakke, O.2    Brandtzaeg, P.3    Johansen, F.E.4    Haraldsen, G.5
  • 48
    • 0036252562 scopus 로고    scopus 로고
    • Alzheimer's disease and vascular factors: Facts and theories
    • K. Pansari, A. Gupta and P. Thomas, Alzheimer's disease and vascular factors: facts and theories, Int J Clin Pract 56 (2002), 197-203.
    • (2002) Int J Clin Pract , vol.56 , pp. 197-203
    • Pansari, K.1    Gupta, A.2    Thomas, P.3
  • 49
    • 0030250384 scopus 로고    scopus 로고
    • Expression of CAP37, a novel inflammatory mediator in Alzheimer's disease
    • H.A. Pereira, P. Kumar and P. Grammas, Expression of CAP37, a novel inflammatory mediator in Alzheimer's disease, Neurobiol Aging 17 (1996), 753-759.
    • (1996) Neurobiol Aging , vol.17 , pp. 753-759
    • Pereira, H.A.1    Kumar, P.2    Grammas, P.3
  • 50
    • 0038037735 scopus 로고    scopus 로고
    • Regulation of angiogenesis by hypoxia: Role of the HIF system
    • C.W. Pugh and P.J. Ratcliffe, Regulation of angiogenesis by hypoxia: role of the HIF system, Nat Med 9 (2003), 677-684.
    • (2003) Nat Med , vol.9 , pp. 677-684
    • Pugh, C.W.1    Ratcliffe, P.J.2
  • 53
    • 0034666128 scopus 로고    scopus 로고
    • Integrin-mediated regulation of synaptic morphology, transmission, and plasticity
    • J. Rohrbough, M.S. Grotewiel, R.L. Davis and K. Broadie, Integrin-mediated regulation of synaptic morphology, transmission, and plasticity, J Neurosci 20 (2000), 6868-6878.
    • (2000) J Neurosci , vol.20 , pp. 6868-6878
    • Rohrbough, J.1    Grotewiel, M.S.2    Davis, R.L.3    Broadie, K.4
  • 54
    • 0034680309 scopus 로고    scopus 로고
    • VLDL, apolipoproteins B, CIII, and E, and risk of recurrent coronary events in the cholesterol and recurrent event (CARE) trial
    • F.M. Sacks, P. Alaupovic, L.A. Moye, T.G.Cole, B. Sussez, M.J. Stampfer, M.A. Pfeffer and E. Braunwald, VLDL, apolipoproteins B, CIII, and E, and risk of recurrent coronary events in the cholesterol and recurrent event (CARE) trial, Circulation 102 (2000), 1886-1892.
    • (2000) Circulation , vol.102 , pp. 1886-1892
    • Sacks, F.M.1    Alaupovic, P.2    Moye, L.A.3    Cole, T.G.4    Sussez, B.5    Stampfer, M.J.6    Pfeffer, M.A.7    Braunwald, E.8
  • 55
    • 0019869177 scopus 로고
    • Internatlization and degradation of thrombin and up regulation of thrombin-binding sites in corneal endothelial cells
    • N. Savion, J.D. Isaacs, D. Gospodarowicz and M.A. Shuman, Internatlization and degradation of thrombin and up regulation of thrombin-binding sites in corneal endothelial cells, J Biol Chem 256 (1981), 4514-4519.
    • (1981) J Biol Chem , vol.256 , pp. 4514-4519
    • Savion, N.1    Isaacs, J.D.2    Gospodarowicz, D.3    Shuman, M.A.4
  • 56
    • 0034104016 scopus 로고    scopus 로고
    • Vascular risk factors in dementia
    • R. Schmidt, H. Schmidt and F. Fazekas, Vascular risk factors in dementia, J Neurol 247 (2000), 81-87.
    • (2000) J Neurol , vol.247 , pp. 81-87
    • Schmidt, R.1    Schmidt, H.2    Fazekas, F.3
  • 57
    • 20444412299 scopus 로고    scopus 로고
    • Oxidative stress and atherosclerosis
    • P.C. Schulze and R.T. Lee, Oxidative stress and atherosclerosis, Curr Atheroscler Rep 7 (2005), 242-248.
    • (2005) Curr Atheroscler Rep , vol.7 , pp. 242-248
    • Schulze, P.C.1    Lee, R.T.2
  • 58
    • 0034603414 scopus 로고    scopus 로고
    • Vascular abnormalities: The insidious pathogenesis of Alzheimer's disease
    • J. Shi, G. Perry, M.A. Smith and R.P. Friedland, Vascular abnormalities: the insidious pathogenesis of Alzheimer's disease, Neurobiol Aging 21 (2000), 357-361.
    • (2000) Neurobiol Aging , vol.21 , pp. 357-361
    • Shi, J.1    Perry, G.2    Smith, M.A.3    Friedland, R.P.4
  • 59
    • 0035949755 scopus 로고    scopus 로고
    • Cholesterol and Alzheimer's disease: Is there a link?
    • M. Simons, P. Keller, J. Dichgans and J.B. Schulz, Cholesterol and Alzheimer's disease: is there a link? Neurology 57 (2001), 1089-1093
    • (2001) Neurology , vol.57 , pp. 1089-1093
    • Simons, M.1    Keller, P.2    Dichgans, J.3    Schulz, J.B.4
  • 60
    • 0031813736 scopus 로고    scopus 로고
    • Thrombin is an extracellular signal that activates intracellular death protease pathways inducing apoptosis in model motor neurons
    • I.V. Smirnova, S.X. Zhang, B.A. Citron, P.M. Arnold and B.W. Festoff, Thrombin is an extracellular signal that activates intracellular death protease pathways inducing apoptosis in model motor neurons, J Neurobiol 36 (1998), 64-80.
    • (1998) J Neurobiol , vol.36 , pp. 64-80
    • Smirnova, I.V.1    Zhang, S.X.2    Citron, B.A.3    Arnold, P.M.4    Festoff, B.W.5
  • 61
    • 0033978764 scopus 로고    scopus 로고
    • Inflammatory mediators of cerebral endothelium: A role in ischemic brain inflammation
    • D. Stanimirovic and K. Satoh, Inflammatory mediators of cerebral endothelium: a role in ischemic brain inflammation, Brain Pathol 10 (2000), 113-126.
    • (2000) Brain Pathol , vol.10 , pp. 113-126
    • Stanimirovic, D.1    Satoh, K.2
  • 63
    • 0033372336 scopus 로고    scopus 로고
    • Vascular risk factors and Alzheimer's disease
    • R. Stewart, M. Prince and A. Mann, Vascular risk factors and Alzheimer's disease, Aust N ZJ Psychiatry 33 (1999), 809-813.
    • (1999) Aust N ZJ Psychiatry , vol.33 , pp. 809-813
    • Stewart, R.1    Prince, M.2    Mann, A.3
  • 64
  • 66
    • 0141733132 scopus 로고    scopus 로고
    • Rapid tau aggregation and delayed hippocampal neuronal death induced by persistent thrombin signaling
    • Z. Suo, M. Wu, B.A. Citron, R.E. Palazzo and B.W. Festoff, Rapid tau aggregation and delayed hippocampal neuronal death induced by persistent thrombin signaling, J Biol Chem 278 (2003), 37681-37689.
    • (2003) J Biol Chem , vol.278 , pp. 37681-37689
    • Suo, Z.1    Wu, M.2    Citron, B.A.3    Palazzo, R.E.4    Festoff, B.W.5
  • 67
    • 4944258716 scopus 로고    scopus 로고
    • The role of inflammation in Alzheimer's disease
    • E.E. Tuppo and H.R. Arias, The role of inflammation in Alzheimer's disease, Int J Biochem Cell Biol 37 (2005), 289-305.
    • (2005) Int J Biochem Cell Biol , vol.37 , pp. 289-305
    • Tuppo, E.E.1    Arias, H.R.2
  • 68
    • 0033588371 scopus 로고    scopus 로고
    • On the mechanism of thrombin-induced angiogenesis. Potentiation of vascular endothelial growth factor activity on endothelial cells by regulation of its receptors
    • N.E. Tsopanoglou and M.E. Maragoudakis, On the mechanism of thrombin-induced angiogenesis. Potentiation of vascular endothelial growth factor activity on endothelial cells by regulation of its receptors, J Biol Chem 274 (1999), 23969-23976.
    • (1999) J Biol Chem , vol.274 , pp. 23969-23976
    • Tsopanoglou, N.E.1    Maragoudakis, M.E.2
  • 69
    • 0032945017 scopus 로고    scopus 로고
    • Activation of the protease-activated thrombin receptor (PAR)-1 induces motoneuron degeneration in the developing avian embryo
    • V.L. Turgeon, C.E. Milligan and L.J. Houenou, Activation of the protease-activated thrombin receptor (PAR)-1 induces motoneuron degeneration in the developing avian embryo, J Neuropathol Exp Neurol 58 (1999), 499-504.
    • (1999) J Neuropathol Exp Neurol , vol.58 , pp. 499-504
    • Turgeon, V.L.1    Milligan, C.E.2    Houenou, L.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.