IFN-γ affects homing of diabetogenic T cells

Journal of Immunology

Volumn 167, Issue 11, 2001, Pages 6637-6643

  Savinov, A Y ^a   Wong, F S ^a   Chervonsky, A V ^a  

^a JACKSON LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON;

ADOPTIVE TRANSFER; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY SPECIFICITY; ANTIGEN PRESENTATION; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; DIABETES MELLITUS; DIABETOGENESIS; IMMUNE RESPONSE; LANGERHANS CELL; MICROVASCULATURE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

EID: 0035576007     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.167.11.6637     Document Type: Article

References (55)

1. Apoptotic and effector pathways in autoimmunity
2. The role of Fas in autoimmune diabetes
3. In autoimmune diabetes the transition from benign to pernicious insulitis requires an islet cell response to tumor necrosis factor α
4. + T lymphocytes
5. + T cells
6. IFN-γ gene expression in pancreatic islet-infiltrating mononuclear cells correlates with autoimmune diabetes in nonobese diabetic mice
7. Insulin-dependent diabetes mellitus induced in transgenic mice by ectopic expression of class II MHC and interferon-γ
8. Loss of pancreatic islet tolerance induced by β-cell expression of interferon-γ
9. Essential role for interferon-γ and interleukin-6 in autoimmune insulin-dependent diabetes in NOD/Wehi mice
10. Prevention of diabetes in NOD mice treated with antibody to murine IFN γ
11. Prevention of autoimmune diabetes by intramuscular gene therapy with a nonviral vector encoding an interferon-α receptor/IgGl fusion protein
12. The effects of a nonimmunogenic form of murine soluble interferon-γ receptor on the development of autoimmune diabetes in the NOD mouse
13. Multiple defects of immune cell function in mice with disrupted interferon-γ genes
14. Genetic absence of γ-interferon delays but does not prevent diabetes in NOD mice
15. Interferon γ impacts at multiple points during the progression of autoimmune diabetes
16. Interferon-γ receptor signaling is dispensable in the development of autoimmune type I diabetes in NOD mice
17. Protection of nonobese diabetic mice from diabetes by gene(s) closely linked to IFN-γ receptor loci
18. Cellular responses to interferon-γ
19. Immune response in mice that lack the interferon-γ receptor
20. Extreme Th l bias of invariant Vα24JαQ T cells in type I diabetes
21. Regulation of development and function of memory CD4 subsets
22. Effect of interferon-γ and glucose on major histocompatibility complex class I and class 11 expression by pancreatic β- and non-β-cells
23. IFN-γ action on pancreatic β cells causes class I MHC up-regulation but not diabetes
24. Class II transactivator regulates the expression of multiple genes involved in antigen presentation
25. Expression of transporter associated with antigen processing-l in the endocrine cells of human pancreatic islets: Effect of cytokines and evidence of hyperexpression in IDDM
26. Determination of lymphocyte division by flow cytometry
27. Identification of an MHC class I-restricted autoantigen in type I diabetes by screening an organ-specific cDNA library
28. CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells
29. Prevention of diabetes in NOD mice by injection of autoreactive T-lymphocytes
30. The pathogenicity of isletinfiltrating lymphocytes in the non-obese diabetic (NOD) mouse
31. Immunohistochemical demonstration of c-erbB-2 oncoprotein in gastric adenocarcinoma: Comparison of cryostat and paraffin wax sections and effect of fixation
32. Multiple defects in innate and adaptive immunologic function in NOD/LtSz-SCID mice
33. Lack of interferon γ receptor β chain and the prevention of interferon γ signaling in THI cells
34. Identification of MECL-I (LMP-10) as the third IFN-γ-inducible proteasome subunit
35. -/- mice
36. MHC antigen induction by interferon γ on cultured mouse pancreatic β cells and macrophages: Genetic analysis of strain differences and discovery of an "occult" class I-like antigen in NOD/Lt mice
37. Cell adhesion: The molecular basis of tissue architecture and morphogenesis
38. T-cell function and migration: Two sides of the same coin
39. Cell migration: A physically integrated molecular process
40. SOCSI deficiency causes a lymphocyte-dependent perinatal lethality
41. Modulation of PECAM-I (CD3I) expression in human endothelial cells: Effect of IFN-γ and IL- 10
42. Kinetics and polarization of the membrane expression of cytokine-induced ICAM-I on rat brain endothelial cells
43. Induction of vascular addressins and adhesion molecules in the pancreas of IFN-γ transgenic mice
44. Migration of leukocytes across endothelium and beyond: Molecules involved in the transmigration and fate of monocytes
45. Lymphocyte traffic control by chemokines
46. The chemokine receptor CXCR3 mediates rapid and shear-resistant adhesion-induction of effector T lymphocytes by the chemokines IPI0 and Mig
47. Up-regulation of macrophage inflammatory protein-3α/CCL20 and CC chemokine receptor 6 in psoriasis
48. Selective diapedesis of Thl cells induced by endothelial cell RANTES
49. Patterns for RANTES secretion and intercellular adhesion molecule I expression mediate transepithelial T cell traffic based on analyses in vitro and in vivo
50. The harmony of the spheres: Inducible nitric oxide synthase and related genes in pancreatic β cells
51. Interferon-γ is essential for destruction of β cells and development of insulin-dependent diabetes mellitus
52. Identification and mapping to chromosome I of a susceptibility locus for periinsulitis in non-obese diabetic mice
53. NOD Idd5 locus controls insulitis and diabetes and overlaps the orthologous CTLA4/IDDMI2 and NRAMPI loci in humans
54. The NOD Idd9 genetic interval influences the pathogenicity of insulitis and contains molecular variants of Cd30, Tnfr2, and Cd137