메뉴 건너뛰기




Volumn 170, Issue 11, 2003, Pages 5491-5501

IL-12 administration accelerates autoimmune diabetes in both wild-type and IFN-γ-deficient nonobese diabetic mice, revealing pathogenic and protective effects of IL-12-induced IFN-γ

Author keywords

[No Author keywords available]

Indexed keywords

FAS LIGAND; GAMMA INTERFERON; GLYCOPROTEIN P 15095; INTERLEUKIN 12; PADGEM PROTEIN;

EID: 0037514387     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.170.11.5491     Document Type: Article
Times cited : (78)

References (73)
  • 1
    • 0025234628 scopus 로고
    • Type-I diabetes: A chronic autoimmune disease of human, mouse and rat
    • Castano, L., and G. S. Eisenbarth. 1990. Type-I diabetes: a chronic autoimmune disease of human, mouse and rat. Annu. Rev. Immunol. 8:647.
    • (1990) Annu. Rev. Immunol. , vol.8 , pp. 647
    • Castano, L.1    Eisenbarth, G.S.2
  • 2
    • 0026646694 scopus 로고
    • The murine autoimmune diabetes model: NOD and related strains
    • Kikutani, H., and S. Makino. 1992. The murine autoimmune diabetes model: NOD and related strains. Adv. Immunol. 51:285.
    • (1992) Adv. Immunol. , vol.51 , pp. 285
    • Kikutani, H.1    Makino, S.2
  • 3
    • 0033001488 scopus 로고    scopus 로고
    • The NOD mouse model of type 1 diabetes: As good as it gets?
    • Atkinson, M. A., and E. H. Leiter. 1999. The NOD mouse model of type 1 diabetes: as good as it gets? Nat. Med. 5:601.
    • (1999) Nat. Med. , vol.5 , pp. 601
    • Atkinson, M.A.1    Leiter, E.H.2
  • 5
    • 0033939014 scopus 로고    scopus 로고
    • Aberrant macrophage cytokine production is a conserved feature among autoimmune-prone mouse strains
    • Alleva, D. G., R. P. Pavlovich, C. Grant, S. B. Kaser, and D. I. Beller. 2000. Aberrant macrophage cytokine production is a conserved feature among autoimmune-prone mouse strains. Diabetes 49:1106.
    • (2000) Diabetes , vol.49 , pp. 1106
    • Alleva, D.G.1    Pavlovich, R.P.2    Grant, C.3    Kaser, S.B.4    Beller, D.I.5
  • 6
    • 0035424898 scopus 로고    scopus 로고
    • Dendritic cells from nonobese diabetic mice exhibit a defect in NF-κB regulation due to hyperactive IκB kinase
    • Weaver, D. J., Jr., B. Poligone, T. Bui, U. M. Abdel-Motal, A. S. Baldwin, and R. Tisch. 2001. Dendritic cells from nonobese diabetic mice exhibit a defect in NF-κB regulation due to hyperactive IκB kinase. J. Immunol. 167:1461.
    • (2001) J. Immunol. , vol.167 , pp. 1461
    • Weaver D.J., Jr.1    Poligone, B.2    Bui, T.3    Abdel-Motal, U.M.4    Baldwin, A.S.5    Tisch, R.6
  • 7
    • 0030271678 scopus 로고    scopus 로고
    • Interleukin 12 mRNA expression in islets correlates with β-cell destruction in NOD mice
    • Rabinovitch, A., W. L. Suarez-Pinzon, and O. Sorensen. 1996. Interleukin 12 mRNA expression in islets correlates with β-cell destruction in NOD mice. J. Autoimmun. 9:645.
    • (1996) J. Autoimmun. , vol.9 , pp. 645
    • Rabinovitch, A.1    Suarez-Pinzon, W.L.2    Sorensen, O.3
  • 8
    • 0036560003 scopus 로고    scopus 로고
    • Polymorphisms in the I112b gene affect structure and expression of IL-12 in NOD and other autoimmune-prone mouse strains
    • Ymer, S. I., D. Huang, G. Penna, S. Gregori, K. Branson, L. Adorini, and G. Morahan. 2002. Polymorphisms in the I112b gene affect structure and expression of IL-12 in NOD and other autoimmune-prone mouse strains. Genes Immun. 3:151.
    • (2002) Genes Immun. , vol.3 , pp. 151
    • Ymer, S.I.1    Huang, D.2    Penna, G.3    Gregori, S.4    Branson, K.5    Adorini, L.6    Morahan, G.7
  • 9
    • 0031824446 scopus 로고    scopus 로고
    • Autoimmune diabetes as a test for the Th1/Th2 paradigm
    • Adorini, L., and S. Trembleau. 1998. Autoimmune diabetes as a test for the Th1/Th2 paradigm. Immunologist 6:146.
    • (1998) Immunologist , vol.6 , pp. 146
    • Adorini, L.1    Trembleau, S.2
  • 10
    • 0035423434 scopus 로고    scopus 로고
    • g7 on a nonobese diabetic versus C57BL/6 genetic background
    • g7 on a nonobese diabetic versus C57BL/6 genetic background. J. Immunol. 167:1693.
    • (2001) J. Immunol. , vol.167 , pp. 1693
    • Koarada, S.1    Wu, Y.2    Ridgway, W.M.3
  • 11
    • 0030858075 scopus 로고    scopus 로고
    • Deviation of pancreas-infiltrating cells to Th2 by interleukin-12 antagonist administration inhibits autoimmune diabetes
    • Trembleau, S., G. Penna, S. Gregori, M. K. Gately, and L. Adorini. 1997. Deviation of pancreas-infiltrating cells to Th2 by interleukin-12 antagonist administration inhibits autoimmune diabetes. Eur. J. Immunol. 27:2330.
    • (1997) Eur. J. Immunol. , vol.27 , pp. 2330
    • Trembleau, S.1    Penna, G.2    Gregori, S.3    Gately, M.K.4    Adorini, L.5
  • 12
    • 0028926524 scopus 로고
    • IL-12 administration induces Th1 cells and accelerates autoimmune diabetes in NOD mice
    • Trembleau, S., G. Penna, E. Bosi, A. Mortara, M. K. Gately, and L. Adorini. 1995. IL-12 administration induces Th1 cells and accelerates autoimmune diabetes in NOD mice. J. Exp. Med. 181:817.
    • (1995) J. Exp. Med. , vol.181 , pp. 817
    • Trembleau, S.1    Penna, G.2    Bosi, E.3    Mortara, A.4    Gately, M.K.5    Adorini, L.6
  • 13
    • 0036006693 scopus 로고    scopus 로고
    • Elevated NF-κB activation in nonobese diabetic mouse dendritic cells results in enhanced APC function
    • Poligone, B., D. J. Weaver, Jr., P. Sen, A. S. Baldwin, Jr., and R. Tisch. 2002. Elevated NF-κB activation in nonobese diabetic mouse dendritic cells results in enhanced APC function. J. Immunol. 168:188.
    • (2002) J. Immunol. , vol.168 , pp. 188
    • Poligone, B.1    Weaver D.J., Jr.2    Sen, P.3    Baldwin A.S., Jr.4    Tisch, R.5
  • 15
    • 0025981388 scopus 로고
    • Essential role for interferon-γ and interleukin-6 in autoimmune insulin-dependent diabetes in NOD/Wehi mice
    • Campbell, I. L., T. W. H. Kay, L. Oxbrow, and L. C. Harrison. 1991. Essential role for interferon-γ and interleukin-6 in autoimmune insulin-dependent diabetes in NOD/Wehi mice. J. Clin. Invest 87:739.
    • (1991) J. Clin. Invest. , vol.87 , pp. 739
    • Campbell, I.L.1    Kay, T.W.H.2    Oxbrow, L.3    Harrison, L.C.4
  • 16
    • 0030444632 scopus 로고    scopus 로고
    • The effects of a nonimmunogenic form of murine soluble interferon-γ receptor on the development of autoimmune diabetes in the NOD mouse
    • Nicoletti, F., P. Zaccone, R. Di Marco, M. Di Mauro, G. Magro, S. Grasso, L. Mughini, P. Meroni, and G. Garotta. 1996. The effects of a nonimmunogenic form of murine soluble interferon-γ receptor on the development of autoimmune diabetes in the NOD mouse. Endocrinology 137:5567.
    • (1996) Endocrinology , vol.137 , pp. 5567
    • Nicoletti, F.1    Zaccone, P.2    Di Marco, R.3    Di Mauro, M.4    Magro, G.5    Grasso, S.6    Mughini, L.7    Meroni, P.8    Garotta, G.9
  • 17
    • 0035576007 scopus 로고    scopus 로고
    • IFN-γ affects homing of diabetogenic T cells
    • Savinov, A. Y., F. S. Wong, and A. V. Chervonsky. 2001. IFN-γ affects homing of diabetogenic T cells. J. Immunol. 167:6637.
    • (2001) J. Immunol. , vol.167 , pp. 6637
    • Savinov, A.Y.1    Wong, F.S.2    Chervonsky, A.V.3
  • 18
    • 0035313059 scopus 로고    scopus 로고
    • IFN-γ/TNF-α synergism as the final effector in autoimmune diabetes: A key role for STATI/IFN regulatory factor-1 pathway in pancreatic β cell death
    • Suk, K., S. Kim, Y.-H. Kim, K.-A. Kim, I. Chang, H. Yagita, M. Shong, and M.-S. Lee. 2001. IFN-γ/TNF-α synergism as the final effector in autoimmune diabetes: a key role for STATI/IFN regulatory factor-1 pathway in pancreatic β cell death. J. Immunol. 166:4481.
    • (2001) J. Immunol. , vol.166 , pp. 4481
    • Suk, K.1    Kim, S.2    Kim, Y.-H.3    Kim, K.-A.4    Chang, I.5    Yagita, H.6    Shong, M.7    Lee, M.-S.8
  • 19
    • 0029948898 scopus 로고    scopus 로고
    • Genetic absence of γ-interferon delays but does not prevent diabetes in NOD mice
    • Hultgren, B., X. Huang, N. Dybdal, and T. A. Stewart. 1996. Genetic absence of γ-interferon delays but does not prevent diabetes in NOD mice. Diabetes 45:812.
    • (1996) Diabetes , vol.45 , pp. 812
    • Hultgren, B.1    Huang, X.2    Dybdal, N.3    Stewart, T.A.4
  • 20
    • 0033669375 scopus 로고    scopus 로고
    • Interferon-γ receptor signaling is dispensable in the development of autoimmune type 1 diabetes in NOD mice
    • Serreze, D. V., C. M. Post, H. D. Chapman, E. A. Johnson, B. Lu, and P. B. Rothman. 2000. Interferon-γ receptor signaling is dispensable in the development of autoimmune type 1 diabetes in NOD mice. Diabetes 49:2007.
    • (2000) Diabetes , vol.49 , pp. 2007
    • Serreze, D.V.1    Post, C.M.2    Chapman, H.D.3    Johnson, E.A.4    Lu, B.5    Rothman, P.B.6
  • 22
    • 0034175965 scopus 로고    scopus 로고
    • Protection of nonobese diabetic mice from diabetes by gene(s) closely linked to IFN-γ/receptor loci
    • Kanagawa, O., G. Xu, A. Tevaarwerk, and B. A. Vaupel. 2000. Protection of nonobese diabetic mice from diabetes by gene(s) closely linked to IFN-γ/receptor loci. J. Immunol. 164:3919.
    • (2000) J. Immunol. , vol.164 , pp. 3919
    • Kanagawa, O.1    Xu, G.2    Tevaarwerk, A.3    Vaupel, B.A.4
  • 24
    • 0028922437 scopus 로고
    • Genetic control of autoimmune diabetes in the NOD mouse
    • Wicker, L. S., J. A. Todd, and L. B. Peterson. 1995. Genetic control of autoimmune diabetes in the NOD mouse. Annu. Rev. Immunol. 13:179.
    • (1995) Annu. Rev. Immunol. , vol.13 , pp. 179
    • Wicker, L.S.1    Todd, J.A.2    Peterson, L.B.3
  • 25
  • 28
    • 0034671983 scopus 로고    scopus 로고
    • Early Th1 response in unprimed nonobese diabetic mice to the tyrosine phosphatase-like insulinoma-associated protein 2, an autoantigen in type 1 diabetes
    • Trembleau, S., G. Penna. S. Gregori, G. Magistrelli, A. Isacchi, and L. Adorini. 2000. Early Th1 response in unprimed nonobese diabetic mice to the tyrosine phosphatase-like insulinoma-associated protein 2, an autoantigen in type 1 diabetes. J. Immunol. 165:6748.
    • (2000) J. Immunol. , vol.165 , pp. 6748
    • Trembleau, S.1    Penna, G.2    Gregori, S.3    Magistrelli, G.4    Isacchi, A.5    Adorini, L.6
  • 30
    • 0031225999 scopus 로고    scopus 로고
    • Developmental pathways of dendritic cells in vivo: Distinct function, phenotype, and localization of dendritic cell subsets in FLT3 ligand-treated mice
    • Pulendran, B., J. Lingappa, M. K. Kennedy, J. Smith, M. Teepe, A. Rudensky, C. R. Maliszewski, and E. Maraskovsky. 1997. Developmental pathways of dendritic cells in vivo: distinct function, phenotype, and localization of dendritic cell subsets in FLT3 ligand-treated mice. J. Immunol. 159:2222.
    • (1997) J. Immunol. , vol.159 , pp. 2222
    • Pulendran, B.1    Lingappa, J.2    Kennedy, M.K.3    Smith, J.4    Teepe, M.5    Rudensky, A.6    Maliszewski, C.R.7    Maraskovsky, E.8
  • 31
    • 0033579875 scopus 로고    scopus 로고
    • Initiation of autoimmune diabetes by developmentally regulated presentation of islet cell antigens in the pancreatic lymph nodes
    • Höglund, P., J. Mintern, C. Waltzinger, W. Heath, C. Benoist, and D. Mathis. 1999. Initiation of autoimmune diabetes by developmentally regulated presentation of islet cell antigens in the pancreatic lymph nodes. J. Exp. Med. 189:331.
    • (1999) J. Exp. Med. , vol.189 , pp. 331
    • Höglund, P.1    Mintern, J.2    Waltzinger, C.3    Heath, W.4    Benoist, C.5    Mathis, D.6
  • 32
    • 0027531609 scopus 로고
    • Monoclonal antibody J11d.2 recognizes cell cycle-dormant, primitive hematopoietic progenitors of mice
    • Shih, J. P., and M. Ogawa. 1993. Monoclonal antibody J11d.2 recognizes cell cycle-dormant, primitive hematopoietic progenitors of mice. Blood 81:1155.
    • (1993) Blood , vol.81 , pp. 1155
    • Shih, J.P.1    Ogawa, M.2
  • 35
    • 0031854250 scopus 로고    scopus 로고
    • Splenic macrophages from the NOD mouse are defective in the ability to present antigen
    • Piganelli, J. D., T. Martin, and K. Haskins. 1998. Splenic macrophages from the NOD mouse are defective in the ability to present antigen. Diabetes 47:1212.
    • (1998) Diabetes , vol.47 , pp. 1212
    • Piganelli, J.D.1    Martin, T.2    Haskins, K.3
  • 36
    • 0027173029 scopus 로고
    • Defects in the differentiation and function of antigen presenting cells in NOD/Lt mice
    • Serreze, D. V., H. R. Gaskins, and E. H. Leiter. 1993. Defects in the differentiation and function of antigen presenting cells in NOD/Lt mice. J. Immunol. 150:2534.
    • (1993) J. Immunol. , vol.150 , pp. 2534
    • Serreze, D.V.1    Gaskins, H.R.2    Leiter, E.H.3
  • 37
    • 0031871335 scopus 로고    scopus 로고
    • An update on cytokines in the pathogenesis of insulindependent diabetes mellitus
    • Rabinovitch, A. 1998. An update on cytokines in the pathogenesis of insulindependent diabetes mellitus. Diabetes Metab. Rev. 14:129.
    • (1998) Diabetes Metab. Rev. , vol.14 , pp. 129
    • Rabinovitch, A.1
  • 39
    • 0031054445 scopus 로고    scopus 로고
    • P-selectin glycoprotein ligand-1 (PSGL-1) on T helper 1 but not on T helper 2 cells binds to P-selectin and supports migration into inflamed skin
    • Borges, E., W. Tietz, M. Steegmaier, T. Moll, R. Hallmann, A. Hamann, and D. Vestweber. 1997. P-selectin glycoprotein ligand-1 (PSGL-1) on T helper 1 but not on T helper 2 cells binds to P-selectin and supports migration into inflamed skin. J. Exp. Med. 185:573.
    • (1997) J. Exp. Med. , vol.185 , pp. 573
    • Borges, E.1    Tietz, W.2    Steegmaier, M.3    Moll, T.4    Hallmann, R.5    Hamann, A.6    Vestweber, D.7
  • 41
    • 0033559862 scopus 로고    scopus 로고
    • Expression of functional selectin ligands on Th cells is differentially regulated by IL-12 and IL-4
    • Lim, Y.-C., L. Henault, A. J. Wagers, G. S. Kansas, F. W. Luscinskas, and A. H. Lichtman. 1999. Expression of functional selectin ligands on Th cells is differentially regulated by IL-12 and IL-4. J. Immunol. 162:3193.
    • (1999) J. Immunol. , vol.162 , pp. 3193
    • Lim, Y.-C.1    Henault, L.2    Wagers, A.J.3    Kansas, G.S.4    Luscinskas, F.W.5    Lichtman, A.H.6
  • 44
    • 0023726937 scopus 로고
    • Anti-proliferative effect of IFN-γ in immune regulation. 1. IFN-γ inhibits the proliferation of Th2 but not Th1 murine helper T lymphocyte clones
    • Gajewski, T. F., and F. W. Fitch. 1988. Anti-proliferative effect of IFN-γ in immune regulation. 1. IFN-γ inhibits the proliferation of Th2 but not Th1 murine helper T lymphocyte clones. J. Immunol. 140:4245.
    • (1988) J. Immunol. , vol.140 , pp. 4245
    • Gajewski, T.F.1    Fitch, F.W.2
  • 45
    • 0023685864 scopus 로고
    • Anti-proliferative effect of IFN-γ in immune regulation. II. IFN-γ inhibits the proliferation of murine bone marrow cells stimulated with IL-3, IL-4, or granulocyte-macrophage colony-stimulating factor
    • Gajewski, T. F., E. Goldwasser, and F. W. Fitch. 1988. Anti-proliferative effect of IFN-γ in immune regulation. II. IFN-γ inhibits the proliferation of murine bone marrow cells stimulated with IL-3, IL-4, or granulocyte-macrophage colony-stimulating factor. J. Immunol. 141:2635.
    • (1988) J. Immunol. , vol.141 , pp. 2635
    • Gajewski, T.F.1    Goldwasser, E.2    Fitch, F.W.3
  • 46
    • 0035856952 scopus 로고    scopus 로고
    • β-cell death during progression to diabetes
    • Mathis, D., L. Vence, and C. Benoist. 2001. β-Cell death during progression to diabetes. Nature 414:792.
    • (2001) Nature , vol.414 , pp. 792
    • Mathis, D.1    Vence, L.2    Benoist, C.3
  • 47
    • 0032579373 scopus 로고    scopus 로고
    • Transgenic mice overexpressing type 2 nitric-oxide synthase in pancreatic β cells develop insulin-dependent diabetes without insulitis
    • Takamura, T., I. Kato, N. Kimura, T. Nakazawa, H. Yonekura, S. Takasawa, and H. Okamoto. 1997. Transgenic mice overexpressing type 2 nitric-oxide synthase in pancreatic β cells develop insulin-dependent diabetes without insulitis. J. Biol. Chem. 273:2493.
    • (1997) J. Biol. Chem. , vol.273 , pp. 2493
    • Takamura, T.1    Kato, I.2    Kimura, N.3    Nakazawa, T.4    Yonekura, H.5    Takasawa, S.6    Okamoto, H.7
  • 49
    • 0028931469 scopus 로고
    • IL-12 exacerbates rather than suppresses T helper 2-dependent pathology in the absence of endogenous IFN-γ J
    • Wynn, T. A., D. Jankovic, S. Hieny, K. Zioncheck, P. Jardieu, A. W. Cheever. and A. Sher. 1995. IL-12 exacerbates rather than suppresses T helper 2-dependent pathology in the absence of endogenous IFN-γ J. Immunol. 154:3999.
    • (1995) Immunol. , vol.154 , pp. 3999
    • Wynn, T.A.1    Jankovic, D.2    Hieny, S.3    Zioncheck, K.4    Jardieu, P.5    Cheever, A.W.6    Sher, A.7
  • 50
    • 0031569126 scopus 로고    scopus 로고
    • Roles of IL-4 and IFN-γ in stabilizing the T helper cell type 1 and 2 phenotype
    • Nakamura, T., R. K. Lee, S. Y. Nam, E. R. Poday, K. Bottomly, and R. A. Flavell. 1997. Roles of IL-4 and IFN-γ in stabilizing the T helper cell type 1 and 2 phenotype. J. Immunol. 158:2648.
    • (1997) J. Immunol. , vol.158 , pp. 2648
    • Nakamura, T.1    Lee, R.K.2    Nam, S.Y.3    Poday, E.R.4    Bottomly, K.5    Flavell, R.A.6
  • 53
    • 0028266819 scopus 로고
    • Effects of IL- 12 on the response and susceptibility to experimental viral infections
    • Orange, J. S., S. F. Wolf, and C. A. Biron. 1994. Effects of IL- 12 on the response and susceptibility to experimental viral infections. J. Immunol. 152:1253.
    • (1994) J. Immunol. , vol.152 , pp. 1253
    • Orange, J.S.1    Wolf, S.F.2    Biron, C.A.3
  • 54
    • 0032476615 scopus 로고    scopus 로고
    • Immune suppression by recombinant interleukin (rIL)-12 involves interferon γ induction of nitric oxide synthase 2 (iNOS) activity: Inhibitors of NO generation reveal the extent of rIL-12 vaccine adjuvant effect
    • Kurzawa Koblish, H., C. A. Hunter, M. Wysocka, G. Trinchieri, and W. M. F. Lee. 1998. Immune suppression by recombinant interleukin (rIL)-12 involves interferon γ induction of nitric oxide synthase 2 (iNOS) activity: inhibitors of NO generation reveal the extent of rIL-12 vaccine adjuvant effect. J. Exp. Med. 188:1608.
    • (1998) J. Exp. Med. , vol.188 , pp. 1608
    • Kurzawa Koblish, H.1    Hunter, C.A.2    Wysocka, M.3    Trinchieri, G.4    Lee, W.M.F.5
  • 55
    • 0035423415 scopus 로고    scopus 로고
    • Intrathecal delivery of IFN-γ protects C57BL/6 mice from chronic-progressive experimental autoimmune encephalomyelitis by increasing apoptosis of central nervous system-infiltrating lymphocytes
    • Furlan, R., E. Brambilla, F. Ruffini, P. L. Poliani, A. Bergami, P. C. Marconi. D. M, Franciotta, G. Penna, G. Comi, L. Adorini, and G. Martino. 2001. Intrathecal delivery of IFN-γ protects C57BL/6 mice from chronic-progressive experimental autoimmune encephalomyelitis by increasing apoptosis of central nervous system-infiltrating lymphocytes. J. Immunol. 167:1821.
    • (2001) J. Immunol. , vol.167 , pp. 1821
    • Furlan, R.1    Brambilla, E.2    Ruffini, F.3    Poliani, P.L.4    Bergami, A.5    Marconi, P.C.6    Franciotta, D.M.7    Penna, G.8    Comi, G.9    Adorini, L.10    Martino, G.11
  • 56
    • 0033579881 scopus 로고    scopus 로고
    • Interleukin 12 protects from a T helper type 1-mediated autoimmune disease, experimental autoimmune uveitis, through a mechanism involving interferon γ, nitric oxid, and apoptosis
    • Tarrant, T. K., P. B. Silver. J. L. Wahlsten, L. V. Rizzo. C.-C. Chan, B. Wiggert, and R. R. Caspi. 1999. Interleukin 12 protects from a T helper type 1-mediated autoimmune disease, experimental autoimmune uveitis, through a mechanism involving interferon γ, nitric oxid, and apoptosis. J. Exp. Med. 189:219.
    • (1999) J. Exp. Med. , vol.189 , pp. 219
    • Tarrant, T.K.1    Silver, P.B.2    Wahlsten, J.L.3    Rizzo, L.V.4    Chan, C.-C.5    Wiggert, B.6    Caspi, R.R.7
  • 57
    • 0030069075 scopus 로고    scopus 로고
    • High doses of interleukin-12 inhibit the development of joint disease in DBA/1 mice immunized with type 11 collagen in complete Freund's adjuvant
    • Hess, H., M. K. Gately, E. Rude, E. Schmitt, J. Szeliga, and T. Germann. 1996. High doses of interleukin-12 inhibit the development of joint disease in DBA/1 mice immunized with type 11 collagen in complete Freund's adjuvant. Eur. J. Immunol. 26:187.
    • (1996) Eur. J. Immunol. , vol.26 , pp. 187
    • Hess, H.1    Gately, M.K.2    Rude, E.3    Schmitt, E.4    Szeliga, J.5    Germann, T.6
  • 59
    • 0035861580 scopus 로고    scopus 로고
    • Low levels of IFN-γ down-regulate the integrin-dependent adhesion of B cells by activating a pathway that interferes with cytoskeleton rearrangement
    • Flaishon, L., F. Lantner, R. Hershkoviz, Y. Levo, and I. Shachar. 2001. Low levels of IFN-γ down-regulate the integrin-dependent adhesion of B cells by activating a pathway that interferes with cytoskeleton rearrangement. J. Biol. Chem. 276:46701.
    • (2001) J. Biol. Chem. , vol.276 , pp. 46701
    • Flaishon, L.1    Lantner, F.2    Hershkoviz, R.3    Levo, Y.4    Shachar, I.5
  • 61
    • 0030913257 scopus 로고    scopus 로고
    • - B cells: Possible involvement in age-associated cytokine dysregulation
    • - B cells: possible involvement in age-associated cytokine dysregulation. Int. Immunol. 9:745.
    • (1996) Int. Immunol. , vol.9 , pp. 745
    • Spencer, N.F.L.1    Daynes, R.A.2
  • 64
    • 0029958126 scopus 로고    scopus 로고
    • Interleukin-12 and -10 and γ interferon regulate polyclonal and ligand-specific expansion of murine B-1 cells
    • Velupillai, P., J. Sypek, and D. A. Harn. 1996. Interleukin-12 and -10 and γ interferon regulate polyclonal and ligand-specific expansion of murine B-1 cells. Infect. Immun. 64:4557.
    • (1996) Infect. Immun. , vol.64 , pp. 4557
    • Velupillai, P.1    Sypek, J.2    Harn, D.A.3
  • 65
    • 0027998004 scopus 로고
    • T cell- independent and T cell-dependent B cell activation increases IFN-γR expression and renders B cells sensitive to IFN-γ-mediated inhibition
    • Abed, N. S., J. H. Chase, and J. S. Cowdery. 1994. T cell- independent and T cell-dependent B cell activation increases IFN-γR expression and renders B cells sensitive to IFN-γ-mediated inhibition. J. Immunol. 153:3369,
    • (1994) J. Immunol. , vol.153 , pp. 3369
    • Abed, N.S.1    Chase, J.H.2    Cowdery, J.S.3
  • 67
    • 0030969531 scopus 로고    scopus 로고
    • B-cells are required for the initiation of insulitis and sialitis in nonobese diabetic mice
    • Noorchashm, H., N. Noorchashm, J. Kern, S. Y. Rostami, C. F. Barker, and A. Naji. 1997. B-cells are required for the initiation of insulitis and sialitis in nonobese diabetic mice. Diabetes 46:941.
    • (1997) Diabetes , vol.46 , pp. 941
    • Noorchashm, H.1    Noorchashm, N.2    Kern, J.3    Rostami, S.Y.4    Barker, C.F.5    Naji, A.6
  • 68
    • 0032532294 scopus 로고    scopus 로고
    • B lymphocytes are critical antigen-presenting cells for the initiation of T cell-mediated autoimmune diabetes in nonobese diabetic mice
    • Serreze, D. V., S. A. Fleming, H. D. Chapman, S. D. Richard, E. H. Leiter, and R. M. Tisch. 1998. B lymphocytes are critical antigen-presenting cells for the initiation of T cell-mediated autoimmune diabetes in nonobese diabetic mice. J. Immunol. 161:3912.
    • (1998) J. Immunol. , vol.161 , pp. 3912
    • Serreze, D.V.1    Fleming, S.A.2    Chapman, H.D.3    Richard, S.D.4    Leiter, E.H.5    Tisch, R.M.6
  • 69
    • 0032145276 scopus 로고    scopus 로고
    • B lymphocytes are crucial antigen-presenting cells in the pathogenic autoimmune response to GAD65 antigen in nonobese diabetic mice
    • Falcone, M., J. Lee, G. Patstone, B. Yeung, and N. Sarvetnick. 1998. B lymphocytes are crucial antigen-presenting cells in the pathogenic autoimmune response to GAD65 antigen in nonobese diabetic mice. J. Immunol. 161:1163.
    • (1998) J. Immunol. , vol.161 , pp. 1163
    • Falcone, M.1    Lee, J.2    Patstone, G.3    Yeung, B.4    Sarvetnick, N.5
  • 72
    • 0028223127 scopus 로고
    • Immunohistological characterization of monocytes-macrophages and dendritic cells involved in the initiation of the insulitis and β cell destruction in NOD mice
    • Jansen, A., F. Homo-Delarche, H. Hooijkaas, P. J. Leenen, M. Dardenne, and H. A. Drexhage. 1994. Immunohistological characterization of monocytes-macrophages and dendritic cells involved in the initiation of the insulitis and β cell destruction in NOD mice. Diabetes 43:667.
    • (1994) Diabetes , vol.43 , pp. 667
    • Jansen, A.1    Homo-Delarche, F.2    Hooijkaas, H.3    Leenen, P.J.4    Dardenne, M.5    Drexhage, H.A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.