Damage control, rather than unresponsiveness, effected by protective DX5+T cells in autoimmune diabetes

Nature Immunology

Volumn 2, Issue 12, 2001, Pages 1117-1125

  Gonzalez, Antonio ^a,b   Andre Schmutz, Isabelle ^a,c   Carnaud, Claude ^a,b   Mathis, Diane ^a,d   Benoist, Christophe ^a,d  

^a INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^b HÔPITAL NECKER ENFANTS MALADES   (France)

^c Instituto de Salud Carlos III   (Spain)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CD4 ANTIGEN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY BDC2.5; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNE DISEASE; B LYMPHOCYTE; CELL DESTRUCTION; CELL SURFACE; CLONE; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE COURSE; HELPER CELL; LYMPHOCYTE ACTIVATION; MOUSE; NONHUMAN; PANCREAS ISLET CELL; PRIORITY JOURNAL; PROTECTION; REGULATORY MECHANISM; SPLEEN CELL; STANDARD; T LYMPHOCYTE SUBPOPULATION; TRANSGENIC MOUSE;

ADOPTIVE TRANSFER; ANIMALS; ANTIGENS, SURFACE; AUTOIMMUNITY; CD4-POSITIVE T-LYMPHOCYTES; CYTOKINES; DIABETES MELLITUS, TYPE 1; DISEASE PROGRESSION; GENES, T-CELL RECEPTOR; IMMUNOPHENOTYPING; KINETICS; LYMPHOCYTE DEPLETION; MICE; MICE, INBRED NOD; MICE, KNOCKOUT; MICE, TRANSGENIC; PANCREAS; SELF TOLERANCE; T-LYMPHOCYTE SUBSETS;

EID: 0035198718     PISSN: 15292908     EISSN: None     Source Type: Journal    
DOI: 10.1038/ni738     Document Type: Article

References (52)

1. Following a diabetogenic T cell from genesis through pathogenesis
2. Pancreatic islet-specific T-cell clones from nonobese diabetic mice
3. Genetic control of diabetes progression
4. Cytotoxic T lymphocyte-associated antigen 4 regulates the unfolding of autoimmune diabetes
5. Cellular and molecular changes accompanying the progression from insulitis to diabetes
6. Spontaneous autoimmune diabetes in monoclonal T cell nonobese diabetic mice
7. Pinpointing when T cell costimulatory receptor CTLA-4 must be engaged to dampen diabetogenic T cells
8. The microbial product lipoploysaccharide confers diabetogenic potential on repertoire of BDC2.5/NOD mice: Implications for the etiology of autoimmunity
9. Diabetes induced by Coxsackie virus: Initiation by bystander damage and not molecular mimicry
10. Regulatory T cells and inflammatory bowel disease
11. Regulatory T cells: Key controllers of immunologic self-tolerance
12. NKT cells: Facts, functions and fallacies
13. The role of different subsets of T regulatory cells in controlling autoimmunity
14. + regulatory cells?
15. RAG-1-deficient mice have no mature B and T lymphocytes
16. Initiation of autoimmune diabetes by developmentally regulated presentation of islet cell antigens in the pancreatic lymph nodes
17. + T cells in initiation of insulin-dependent diabetes mellitus
18. Selecting and maintaining a diverse T-cell repertoire
19. Homeostatic T cell proliferation. How far can T cells be activated to self-ligands?
20. Protection against diabetes and improved NK/NKT cell performance in NOD. NKI. I mice congenic at the NK complex
21. The mouse NK cell-associated antigen recognized by DX5 monoclonal antibody is CD49b (α2 integrin, very late antigen-2)
22. +T cells
23. +T cells
24. Interleukin-4 deficiency does not worsen disease in NOD mice
25. Interleukin-10-deficient mice develop chronic enterocolitis
26. B cell apoptosis in T cell-mediated autoimmune diabetes
27. Regulatory CD4(+) T cells expressing endogenous T cell receptor chains protect myelin basic protein-specific transgenic mice from spontaneous autoimmune encephalomyelitis
28. +T cells that prevent spontaneous autoimmune encephalomyelitis
29. MHC class II molecules can protect from diabetes by positively selecting T cells with additional specificities
30. + Immunoregulatory T Cells that Control Autoimmune Diabetes
31. + T cells that prevent diabetes in nonobese diabetic mice
32. - T-cell deficiency and IDDM in NOD/Lt mice
33. Overexpression of natural killer T cells protects Vα14-Jα281 transgenic nonobese diabetic mice against diabetes
34. Germ line deletion of the CDI locus exacerbates diabetes in the NOD mouse
35. NKT cells are phenotypically and functionally diverse
36. + cells
37. + T cells exist in naive NKI. I allelic positive and negative mice, with the capacity to rapidly secrete large amounts of IL-4 and IFN-γ upon primary TCR stimulation
38. Diverse CD Id-restricted T cells: Diverse phenotypes, and diverse functions
39. +-like thymocytes in the NOD mouse
40. Cytometric and functional analyses of NK and NKT cell deficiency in NOD mice
41. Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation
42. Immunologic self-tolerance maintained by CD25(+)CD4(+) regulator cells constitutively expressing cytotoxic T lymphocyte-associated antigen
43. Immunotherapy with dendritic cells directed against tumor antigens shared with normal host cells results in severe autoimmune disease
44. + naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance
45. + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production
46. Editorial overview
47. Cell regulation: A special job or everyone's responsibility?
48. Lymphoid development in mice congenitally lacking T cell receptor αβ-expressing cells
49. Organ-specific disease provoked by systemic autoreactivity
50. Major histocompatibility complex class I molecules are required for the development of insulitis in non-obese diabetic mice
51. Another view of the selective model of thymocyte selection
52. Heterogeneity of intracellular cytokine synthesis at the single-cell level in polarized T helper I and T helper 2 populations