Graves' disease is associated with an altered CXCR3 and CCR5 expression in thyroid-derived compared to peripheral blood lymphocytes

Clinical and Experimental Immunology

Volumn 127, Issue 3, 2002, Pages 479-485

  Aust, G ^b   Sittig, D ^b   Steinert, M ^a   Lamesch, P ^a   Lohmann, T ^b  

^a Institute of Anatomy   (Germany)

^b UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

CCR3; Chemokine receptor; CXCR5; Grave's disease; Thyroid

Indexed keywords

AUTOANTIBODY; CD4 ANTIGEN; CD45 ANTIGEN; CHEMOKINE RECEPTOR CCR2; CHEMOKINE RECEPTOR CCR3; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR3; CHEMOKINE RECEPTOR CXCR4; MESSENGER RNA; THYROID PEROXIDASE;

ADULT; ARTICLE; CELL ISOLATION; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE ASSOCIATION; FEMALE; FLOW CYTOMETRY; GRAVES DISEASE; HUMAN; IMMUNOHISTOLOGY; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE SUBPOPULATION; TH2 CELL; THYROID GLAND;

ADULT; ANTIGENS, CD3; CD4-POSITIVE T-LYMPHOCYTES; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GRAVES DISEASE; HUMANS; IMMUNOHISTOCHEMISTRY; RECEPTORS, CCR5; RECEPTORS, CHEMOKINE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, HELPER-INDUCER; THYROID GLAND;

EID: 0036233501     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.2002.01778.x     Document Type: Article

References (36)

1. Analysis of cytokine gene expression in Graves' disease and multinodular goiter
2. Intrathyroidal cytokine gene expression profiles in autoimmune thyroiditis
3. Mast cell proteinases activate precursor forms of collagenase and stromelysin, but not of gelatinases A and B
4. Single-cell analysis of intrathyroidal lymphocytes shows differential cytokine expression in Hashimoto's and Graves' disease
5. Manipulation of the Th1/Th2 balance in autoimmune disease
6. Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes
7. Assessment of chemokine receptor expression by human Th1 and Th2 cells in vitro and in vivo
8. The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflamma-tory reactions
9. Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s
10. T cell phenotypes of the normal nasal mucosa: Induction of Th2 cytokines and CCR3 expression by IL-4
11. The HIV core-ceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes
12. CC chemokine receptor 2 is critical for induction of experimental autoimmune encephalomyelitis
13. Resistance to experimental autoimmune encephalomyelitis in mice lacking the CC chemokine receptor (CCR) 2
14. Mice with a selective deletion of the CC chemokine receptors 5 or 2 are protected from dextran sodium sulfate-mediated colitis: Lack of CC chemokine receptor 5 expression results in a NK1.1+ lymphocyte-associated Th2-type immune response in the intestine
15. Different immunophenotype and autoantibody production by peripheral blood and thyroid-derived lymphocytes in patients with Graves' disease
16. Expression of TNF-alpha mRNA and protein in pathological thyroid tissue and carcinoma cell lines
17. Different cytokine mRNA profiles in Graves' disease, Hashimoto's thyroiditis and non-autoimmune thyroid disorders determined by quantitative reverse transcriptase chain reaction (RT PCR)
18. Expression and regulation of regulated on activation, normal t cells expressed and secreted in thyroid tissue of patients with Graves' disease and thyroid autonomy and in thyroid-derived cell populations
19. Reduced expression of stromal-derived factor 1 in autonomous thyroid adenomas and its regulation in thyroid-derived cells
20. The role of chemokine receptors in directing traffic of naive, type 1 and type 2 T cells
21. Activated and IFN-gamma producing thyroid-derived T cells are detected in Graves' disease, thyroid autonomy as well as in non-toxic multinodular goiter
22. Immunohistochemical analysis of intrathyroidal lymphocytes in Graves' disease: Evidence of activated T cells and production of interferon-gamma
23. Is pathogenic humoral autoimmunity a Th1 response? Lessons from (for) myasthenia gravis
24. Interferon gamma (IFN-gamma) is necessary for the genesis of acetylcholine receptor-induced clinical experimental autoimmune myasthenia gravis in mice
25. Lack of correlation between chemokine receptor and T (h) 1/T (h) 2 cytokine expression by individual memory T cells
26. Intracellular and surface expression of the HIV-1 coreceptor CXCR4/fusin on various leukocyte subsets: Rapid internalization and recycling upon activation
27. Stromal cell-derived factor-1-CXC chemokine receptor 4 interactions play a central role in CD4 (+) T cell accumulation in rheumatoid arthritis synovium
28. Persistent induction of the chemokine receptor CXCR4 by TGF-beta 1 on synovial T cells contributes to their accumulation within the rheumatoid synovium
29. Human endothelial cells express CCR2 and respond to MCP-1: Direct role of MCP-1 in angio-genesis and tumor progression
30. CXC chemokine receptor expression on human endothelial cells
31. CXCR4 receptor expression on human retinal pigment epithelial cells from the blood-retina barrier leads to chemokine secretion and migration in response to stromal cell-derived factor 1alpha
32. Chemokine receptor expression by human intestinal epithelial cells
33. Functional expression of chemokine receptor CXCR4 on human epithelial cells
34. International union of pharmacology. XXII. Nomenclature for chemokine receptors
35. A one-tube polymerase chain reaction protocol demonstrates CC chemokine overexpression in Graves' disease glands
36. Expression of monocyte chemoattractant protein-1 mRNA and protein in cultured human thyrocytes