메뉴 건너뛰기




Volumn 97, Issue 9, 2008, Pages 3483-3493

Fluoroquinolone efflux mediated by ABC transporters

Author keywords

ABC transporters; BCRP ABCG2; Drug resistance; Efflux pumps; Fluoroquinolones; Mammary transport; P glycoprotein; Pharmacokinetics

Indexed keywords

ABC TRANSPORTER; BREAST CANCER RESISTANCE PROTEIN; CIMETIDINE; CIPROFLOXACIN; CYCLOSPORIN A; DANOFLOXACIN; ENROFLOXACIN; ERYTHROMYCIN; GLYCOPROTEIN P; GREPAFLOXACIN; LEVOFLOXACIN; MESYLIC ACID; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 2; NORFLOXACIN; OFLOXACIN; PROBENECID; QUINOLINE DERIVED ANTIINFECTIVE AGENT; SPARFLOXACIN; VINCRISTINE;

EID: 42949154087     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.21233     Document Type: Article
Times cited : (73)

References (78)
  • 1
    • 0033926264 scopus 로고    scopus 로고
    • Quinolone generations: Natural history or natural selection
    • Ball P. 2000. Quinolone generations: Natural history or natural selection. J Antimicrob Chemother 46:17-24.
    • (2000) J Antimicrob Chemother , vol.46 , pp. 17-24
    • Ball, P.1
  • 3
    • 0035038683 scopus 로고    scopus 로고
    • Emerging mechanisms of fluoroquinolone resistance
    • Hooper DC. 2001. Emerging mechanisms of fluoroquinolone resistance. Emerg Infect Dis 7:337-341.
    • (2001) Emerg Infect Dis , vol.7 , pp. 337-341
    • Hooper, D.C.1
  • 4
    • 0037648419 scopus 로고    scopus 로고
    • Antibiotic efflux pumps in prokaryotic cells: Occurrence, impact on resistance and strategies for the future of antimicrobial therapy
    • Van Bambeke F, Glupczynski Y, Plésiat P, Pechère JC, Tulkens PM. 2003. Antibiotic efflux pumps in prokaryotic cells: Occurrence, impact on resistance and strategies for the future of antimicrobial therapy. J Antimicrob Chemother 51:1055-1065.
    • (2003) J Antimicrob Chemother , vol.51 , pp. 1055-1065
    • Van Bambeke, F.1    Glupczynski, Y.2    Plésiat, P.3    Pechère, J.C.4    Tulkens, P.M.5
  • 5
    • 0038323939 scopus 로고    scopus 로고
    • Antibiotic efflux pumps in eukaryotic cells: Occurrence and impact on antibiotic cellular pharmacokinetics, pharmacodynamics and toxicodynamics
    • Van Bambeke F, Michot JM, Tulkens PM. 2003. Antibiotic efflux pumps in eukaryotic cells: Occurrence and impact on antibiotic cellular pharmacokinetics, pharmacodynamics and toxicodynamics. J Antimicrob Chemother 51:1067-1077.
    • (2003) J Antimicrob Chemother , vol.51 , pp. 1067-1077
    • Van Bambeke, F.1    Michot, J.M.2    Tulkens, P.M.3
  • 6
    • 0033839497 scopus 로고    scopus 로고
    • The fluoroquinolone antibacterials: Past, present and future perspectives
    • Appelbaum PC, Hunter PA. 2000. The fluoroquinolone antibacterials: Past, present and future perspectives. Int J Antimicrob Agents 16:5-15.
    • (2000) Int J Antimicrob Agents , vol.16 , pp. 5-15
    • Appelbaum, P.C.1    Hunter, P.A.2
  • 7
    • 33745016515 scopus 로고    scopus 로고
    • Pharmacology of the fluoroquinolones: A perspective for the use in domestic animals
    • Martinez M, McDermott P, Walker R. 2006. Pharmacology of the fluoroquinolones: A perspective for the use in domestic animals. Vet J 172: 10-28.
    • (2006) Vet J , vol.172 , pp. 10-28
    • Martinez, M.1    McDermott, P.2    Walker, R.3
  • 8
    • 0001369472 scopus 로고
    • Mechanism of action of nalidixic acid on Escherichia coli
    • Goss WA, Deitz WH, Cook TM. 1965. Mechanism of action of nalidixic acid on Escherichia coli. J Bacteriol 89:1068-1074.
    • (1965) J Bacteriol , vol.89 , pp. 1068-1074
    • Goss, W.A.1    Deitz, W.H.2    Cook, T.M.3
  • 10
    • 0028223448 scopus 로고
    • Quinolone antibacterials. An update of their pharmacology and therapeutic use
    • Von Rosenstiel N, Adam D. 1994. Quinolone antibacterials. An update of their pharmacology and therapeutic use. Drugs 47:872-890.
    • (1994) Drugs , vol.47 , pp. 872-890
    • Von Rosenstiel, N.1    Adam, D.2
  • 11
    • 0035884910 scopus 로고    scopus 로고
    • Quinolone molecular structure-activity relationships: What we have learned about improving antimicrobial activity
    • Peterson LR. 2001. Quinolone molecular structure-activity relationships: What we have learned about improving antimicrobial activity. Clin Infect Dis 33: S180-S186.
    • (2001) Clin Infect Dis , vol.33
    • Peterson, L.R.1
  • 13
    • 0026468457 scopus 로고
    • The molecular basis of quinolone action
    • Maxwell A. 1992. The molecular basis of quinolone action. J Antimicrob Chemother 30:409-414.
    • (1992) J Antimicrob Chemother , vol.30 , pp. 409-414
    • Maxwell, A.1
  • 14
    • 0028034698 scopus 로고
    • The complex of DNA gyrase and quinolone drugs with DNA forms a barrier to transcription by RNA polymerase
    • Willmott CJ, Critchlow SE, Eperon IC, Maxwell A. 1994. The complex of DNA gyrase and quinolone drugs with DNA forms a barrier to transcription by RNA polymerase. J Mol Biol 242:351-363.
    • (1994) J Mol Biol , vol.242 , pp. 351-363
    • Willmott, C.J.1    Critchlow, S.E.2    Eperon, I.C.3    Maxwell, A.4
  • 15
    • 0031407768 scopus 로고    scopus 로고
    • DNA gyrase, topoisomerase IV, and the 4-quinolones
    • Drlica K, Zhao X. 1997. DNA gyrase, topoisomerase IV, and the 4-quinolones. Microbiol Mol Biol 61:377-392.
    • (1997) Microbiol Mol Biol , vol.61 , pp. 377-392
    • Drlica, K.1    Zhao, X.2
  • 16
    • 0028174984 scopus 로고
    • DNA topoisomerases: Essential enzymes and lethal targets
    • Chen AY, Liu LF. 1994. DNA topoisomerases: Essential enzymes and lethal targets. Annu Rev Pharmacol Toxicol 34:191-218.
    • (1994) Annu Rev Pharmacol Toxicol , vol.34 , pp. 191-218
    • Chen, A.Y.1    Liu, L.F.2
  • 17
    • 1542603083 scopus 로고    scopus 로고
    • Fluoroquinolones: Mechanism of action, classification, and development of resistance
    • Blondeau JM. 2004. Fluoroquinolones: Mechanism of action, classification, and development of resistance. Surv Ophthalmol 49:S73-S78.
    • (2004) Surv Ophthalmol , vol.49
    • Blondeau, J.M.1
  • 19
    • 0024516261 scopus 로고
    • Pharmacokinetic disposition of quinolones in human body fluids and tissues
    • Sörgel F, Jaehde U, Naber KG, Stephan U. 1989. Pharmacokinetic disposition of quinolones in human body fluids and tissues. Clin Pharmacokinet 16:51S-68S.
    • (1989) Clin Pharmacokinet , vol.16
    • Sörgel, F.1    Jaehde, U.2    Naber, K.G.3    Stephan, U.4
  • 21
    • 0041716722 scopus 로고    scopus 로고
    • Intestinal elimination of ofloxacin enantiomers in the rat: Evidence of a carrier-mediated process
    • Rabbaa L, Dautrey S, Colas-Linhart N, Carbon C, Farinotti R. 1996. Intestinal elimination of ofloxacin enantiomers in the rat: Evidence of a carrier-mediated process. Antimicrob Agents Chemother 36:2506-2511.
    • (1996) Antimicrob Agents Chemother , vol.36 , pp. 2506-2511
    • Rabbaa, L.1    Dautrey, S.2    Colas-Linhart, N.3    Carbon, C.4    Farinotti, R.5
  • 22
    • 0026599145 scopus 로고
    • J774 macrophages secrete antibiotics via organic anion transporters
    • Cao CX, Silverstein SC, Neu C, Steinberg TH. 1992. J774 macrophages secrete antibiotics via organic anion transporters. J Infect Dis 165:322-328.
    • (1992) J Infect Dis , vol.165 , pp. 322-328
    • Cao, C.X.1    Silverstein, S.C.2    Neu, C.3    Steinberg, T.H.4
  • 23
    • 0027411562 scopus 로고
    • Active secretion of the fluoroquinolone ciprofloxacin by human intestinal epithelial Caco-2 cell layers
    • Griffiths NM, Hirst BH, Simmons NL. 1993. Active secretion of the fluoroquinolone ciprofloxacin by human intestinal epithelial Caco-2 cell layers. Br J Pharmacol 108:575-576.
    • (1993) Br J Pharmacol , vol.108 , pp. 575-576
    • Griffiths, N.M.1    Hirst, B.H.2    Simmons, N.L.3
  • 24
    • 0028321687 scopus 로고
    • Active intestinal secretion of the fluoroquinolone antibacterials ciprofloxacin, norfloxacin and Pefloxacin; a common secretory pathway
    • Griffiths NM, Hirst BH, Simmons NL. 1994. Active intestinal secretion of the fluoroquinolone antibacterials ciprofloxacin, norfloxacin and Pefloxacin; a common secretory pathway. J Pharmacol Exp Ther 269:496-502.
    • (1994) J Pharmacol Exp Ther , vol.269 , pp. 496-502
    • Griffiths, N.M.1    Hirst, B.H.2    Simmons, N.L.3
  • 25
    • 0035685449 scopus 로고    scopus 로고
    • Complete characterization of the human ABC gene family
    • Dean M, Allikmets R. 2001. Complete characterization of the human ABC gene family. J Bioenerg Biomembr 33:475-479.
    • (2001) J Bioenerg Biomembr , vol.33 , pp. 475-479
    • Dean, M.1    Allikmets, R.2
  • 26
    • 0037457802 scopus 로고    scopus 로고
    • Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: An overview
    • Schinkel AH, Jonker JW. 2003. Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: An overview. Adv Drug Deliver Rev 55:3-29.
    • (2003) Adv Drug Deliver Rev , vol.55 , pp. 3-29
    • Schinkel, A.H.1    Jonker, J.W.2
  • 27
    • 0036792874 scopus 로고    scopus 로고
    • Multidrug resistance and cancer: The role of the human ABC transporter AB CG2
    • Ejendal KFK, Hrycyna CA. 2002. Multidrug resistance and cancer: The role of the human ABC transporter AB CG2. Curr Protein Pept Sci 3: 503-511.
    • (2002) Curr Protein Pept Sci , vol.3 , pp. 503-511
    • Ejendal, K.F.K.1    Hrycyna, C.A.2
  • 28
    • 0042167430 scopus 로고    scopus 로고
    • P-Glycoprotein inhibitors and their screening: A perspective from bioavailability enhancement
    • Varma MVS, Ashokraj Y, Dey CS, Pachagnula R. 2003. P-Glycoprotein inhibitors and their screening: A perspective from bioavailability enhancement. Pharmacol Res 48:347-359.
    • (2003) Pharmacol Res , vol.48 , pp. 347-359
    • Varma, M.V.S.1    Ashokraj, Y.2    Dey, C.S.3    Pachagnula, R.4
  • 29
    • 2542491777 scopus 로고    scopus 로고
    • The role of ABC transporters in drug resistance, metabolism and toxicity
    • Glavinas H, Krajcsi P, Cserepes J, Sarkadi B. 2004. The role of ABC transporters in drug resistance, metabolism and toxicity. Curr Drug Deliv 1: 27-42.
    • (2004) Curr Drug Deliv , vol.1 , pp. 27-42
    • Glavinas, H.1    Krajcsi, P.2    Cserepes, J.3    Sarkadi, B.4
  • 30
    • 17544368685 scopus 로고    scopus 로고
    • Multidrug resistance proteins: Role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense
    • Leslie EM, Deeley RG, Cole SP. 2005. Multidrug resistance proteins: Role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense. Toxicol Appl Pharmacol 204:216-237.
    • (2005) Toxicol Appl Pharmacol , vol.204 , pp. 216-237
    • Leslie, E.M.1    Deeley, R.G.2    Cole, S.P.3
  • 31
    • 33644847684 scopus 로고    scopus 로고
    • Transporters as a determinant of drug clearance and tissue distribution
    • Shitara Y, Horie T, Sugiyama Y. 2006. Transporters as a determinant of drug clearance and tissue distribution. Eur J Pharm Sci 27:425-446.
    • (2006) Eur J Pharm Sci , vol.27 , pp. 425-446
    • Shitara, Y.1    Horie, T.2    Sugiyama, Y.3
  • 33
    • 0032464623 scopus 로고    scopus 로고
    • Transport of quinolone antibacterial drugs in a kidney epithelial cell line, LLC- PK1
    • Matsuo Y, Yano I, Ito T, Hashimoto Y, Inui K. 1998. Transport of quinolone antibacterial drugs in a kidney epithelial cell line, LLC- PK1. J Pharmacol Exp Ther 287:672-678.
    • (1998) J Pharmacol Exp Ther , vol.287 , pp. 672-678
    • Matsuo, Y.1    Yano, I.2    Ito, T.3    Hashimoto, Y.4    Inui, K.5
  • 34
    • 33645108568 scopus 로고    scopus 로고
    • Breast cancer resistance protein (BCRP/ABCG2) transports fluoroquinolone antibiotics and affects their oral availability, pharmacokinetics, and milk secretion
    • Merino G, Alvarez AI, Pulido MM, Molina AJ, Schinkel AH, Prieto JG. 2006. Breast cancer resistance protein (BCRP/ABCG2) transports fluoroquinolone antibiotics and affects their oral availability, pharmacokinetics, and milk secretion. Drug Metab Dispos 34:690-695.
    • (2006) Drug Metab Dispos , vol.34 , pp. 690-695
    • Merino, G.1    Alvarez, A.I.2    Pulido, M.M.3    Molina, A.J.4    Schinkel, A.H.5    Prieto, J.G.6
  • 35
    • 0036175308 scopus 로고    scopus 로고
    • Pharmacokinetic role of P-glycoprotein in oral bioavailability and intestinal secretion of grepafloxacin in vivo
    • Yamaguchi H, Yano I, Saito H, Inui KI. 2002. Pharmacokinetic role of P-glycoprotein in oral bioavailability and intestinal secretion of grepafloxacin in vivo. J Pharmacol Exp Ther 300:1063-1069.
    • (2002) J Pharmacol Exp Ther , vol.300 , pp. 1063-1069
    • Yamaguchi, H.1    Yano, I.2    Saito, H.3    Inui, K.I.4
  • 36
    • 16644374851 scopus 로고    scopus 로고
    • Cotransport of macrolide and fluoroquinolones, a beneficial interaction reversing P-glycoprotein efflux
    • Sikri V, Pal D, Jain R, Kalyani D, Mitra AK. 2004. Cotransport of macrolide and fluoroquinolones, a beneficial interaction reversing P-glycoprotein efflux. Am J Ther 11:433-442.
    • (2004) Am J Ther , vol.11 , pp. 433-442
    • Sikri, V.1    Pal, D.2    Jain, R.3    Kalyani, D.4    Mitra, A.K.5
  • 37
    • 0032793835 scopus 로고    scopus 로고
    • Stereoselective permeation of new fluorinated quinolone derivatives across LLC-PK1 cell monolayers
    • Sasaya M, Hatakeyama Y, Saitoh H, Takada M. 1999. Stereoselective permeation of new fluorinated quinolone derivatives across LLC-PK1 cell monolayers. Biol Pharm Bull 22:707-712.
    • (1999) Biol Pharm Bull , vol.22 , pp. 707-712
    • Sasaya, M.1    Hatakeyama, Y.2    Saitoh, H.3    Takada, M.4
  • 38
    • 0037421590 scopus 로고    scopus 로고
    • Pharmacogenomics and drug disposition, drug targets, and side effects
    • Evans WE, McLeod HL. 2003. Pharmacogenomics and drug disposition, drug targets, and side effects. N Engl J Med 348:538-549.
    • (2003) N Engl J Med , vol.348 , pp. 538-549
    • Evans, W.E.1    McLeod, H.L.2
  • 39
    • 10044257623 scopus 로고    scopus 로고
    • Recent advances in pharmacogenetic approaches to anticancer drug development
    • Smith N, Figg WD, Sparreboom A. 2004. Recent advances in pharmacogenetic approaches to anticancer drug development. Drug Dev Res 62:233-253.
    • (2004) Drug Dev Res , vol.62 , pp. 233-253
    • Smith, N.1    Figg, W.D.2    Sparreboom, A.3
  • 40
    • 30144435485 scopus 로고    scopus 로고
    • The genetics of ATP-binding cassette transporters
    • Dean M. 2005. The genetics of ATP-binding cassette transporters. Methods Enzymol 400:409-429.
    • (2005) Methods Enzymol , vol.400 , pp. 409-429
    • Dean, M.1
  • 41
    • 0036724716 scopus 로고    scopus 로고
    • Fluoroquinolone resistance among Grampositive cocci
    • Hooper DC. 2002. Fluoroquinolone resistance among Grampositive cocci. Lancet Infect Dis 2: 530-538.
    • (2002) Lancet Infect Dis , vol.2 , pp. 530-538
    • Hooper, D.C.1
  • 43
    • 1242314678 scopus 로고    scopus 로고
    • Effect of cisplatin-induced acute renal failure on bioavailability and intestinal secretion of quinolone antibacterial drugs in rat
    • Yamaguchi H, Yano I, Saito H, Inui KI. 2004. Effect of cisplatin-induced acute renal failure on bioavailability and intestinal secretion of quinolone antibacterial drugs in rat. Pharm Res 21:330-338.
    • (2004) Pharm Res , vol.21 , pp. 330-338
    • Yamaguchi, H.1    Yano, I.2    Saito, H.3    Inui, K.I.4
  • 45
    • 33847165756 scopus 로고    scopus 로고
    • Danoflox-acin-mesylate is a substrate for ATP-dependent efflux transporters
    • Schrickx JA, Fink-Gremmels J. 2007. Danoflox-acin-mesylate is a substrate for ATP-dependent efflux transporters. Br J Pharmacol 150:463-469.
    • (2007) Br J Pharmacol , vol.150 , pp. 463-469
    • Schrickx, J.A.1    Fink-Gremmels, J.2
  • 46
    • 33745726825 scopus 로고    scopus 로고
    • Interaction of enrofloxacin with breast cancer resistance protein (BCRP/ABCG2): Influence of flavonoids and role in milk secretion in sheep
    • Pulido MM, Molina AJ, Merino G, Mendoza G, Prieto JG, Alvarez AI. 2006. Interaction of enrofloxacin with breast cancer resistance protein (BCRP/ABCG2): Influence of flavonoids and role in milk secretion in sheep. J Vet Pharmacol Ther 29:279-287.
    • (2006) J Vet Pharmacol Ther , vol.29 , pp. 279-287
    • Pulido, M.M.1    Molina, A.J.2    Merino, G.3    Mendoza, G.4    Prieto, J.G.5    Alvarez, A.I.6
  • 47
    • 0030807188 scopus 로고    scopus 로고
    • Fluoroquinolone (ciprofloxacin) secretion by human intestinal epithelial (Caco-2) cells
    • Cavet ME, West M, Simmons NL. 1997. Fluoroquinolone (ciprofloxacin) secretion by human intestinal epithelial (Caco-2) cells. Br J Pharmacol 121:1567-1578.
    • (1997) Br J Pharmacol , vol.121 , pp. 1567-1578
    • Cavet, M.E.1    West, M.2    Simmons, N.L.3
  • 48
    • 0032775326 scopus 로고    scopus 로고
    • Active intestinal elimination of ciprofloxacin in rats: Modulation by different substrates
    • Dautrey S, Felice K, Petiet A, Lacour B, Carbon C, Farinotti R. 1999. Active intestinal elimination of ciprofloxacin in rats: Modulation by different substrates. Br J Pharmacol 127:1728-1734.
    • (1999) Br J Pharmacol , vol.127 , pp. 1728-1734
    • Dautrey, S.1    Felice, K.2    Petiet, A.3    Lacour, B.4    Carbon, C.5    Farinotti, R.6
  • 49
    • 0036199337 scopus 로고    scopus 로고
    • Multiple pathways for fluoroquinolone secretion by human intestinal epithelial (Caco-2) cells
    • Lowes S, Simmons NL. 2002. Multiple pathways for fluoroquinolone secretion by human intestinal epithelial (Caco-2) cells. Br J Pharmacol 135:1263-1275.
    • (2002) Br J Pharmacol , vol.135 , pp. 1263-1275
    • Lowes, S.1    Simmons, N.L.2
  • 50
    • 0033798408 scopus 로고    scopus 로고
    • Secretory mechanisms of grepafloxacin and levofloxacin in the human intestinal cell line Caco-2
    • Yamaguchi H, Yano I, Hashimoto Y, Inui KI. 2000. Secretory mechanisms of grepafloxacin and levofloxacin in the human intestinal cell line Caco-2. J Pharmacol Exp Ther 295:360-366.
    • (2000) J Pharmacol Exp Ther , vol.295 , pp. 360-366
    • Yamaguchi, H.1    Yano, I.2    Hashimoto, Y.3    Inui, K.I.4
  • 51
    • 0035941155 scopus 로고    scopus 로고
    • Transport characteristics of grepafloxacin and levofloxacin in the human intestinal cell line Caco-2
    • Yamaguchi H, Yano I, Saito H, Inui KI. 2001. Transport characteristics of grepafloxacin and levofloxacin in the human intestinal cell line Caco-2. Eur J Pharmacol 431:297-303.
    • (2001) Eur J Pharmacol , vol.431 , pp. 297-303
    • Yamaguchi, H.1    Yano, I.2    Saito, H.3    Inui, K.I.4
  • 53
    • 17844383698 scopus 로고    scopus 로고
    • Expression, localization, and functional characteristics of breast cancer resistance protein in Caco-2 cells
    • Xia CQ, Liu N, Yang D, Miwa G, Gan LS. 2005. Expression, localization, and functional characteristics of breast cancer resistance protein in Caco-2 cells. Drug Metab Dispos 33:637-643.
    • (2005) Drug Metab Dispos , vol.33 , pp. 637-643
    • Xia, C.Q.1    Liu, N.2    Yang, D.3    Miwa, G.4    Gan, L.S.5
  • 54
    • 18744366654 scopus 로고    scopus 로고
    • Kinetic modelling of the intestinal transport of sarafloxacin. Studies in situ in rat and in vitro in Caco-2 cells
    • Fernandez-Teruel C, Gonzalez-Alvarez I, Casabo VG, Ruiz-Garcia A, Bermejo M. 2005. Kinetic modelling of the intestinal transport of sarafloxacin. Studies in situ in rat and in vitro in Caco-2 cells. J Drug Target 13:199-212.
    • (2005) J Drug Target , vol.13 , pp. 199-212
    • Fernandez-Teruel, C.1    Gonzalez-Alvarez, I.2    Casabo, V.G.3    Ruiz-Garcia, A.4    Bermejo, M.5
  • 55
    • 0030824648 scopus 로고    scopus 로고
    • Carrier-mediated hepatic uptake of quinolone antibiotics in the rat
    • Sasabe H, Terasaki T, Tsuji A, Sugiyama Y. 1997. Carrier-mediated hepatic uptake of quinolone antibiotics in the rat. J Pharmacol Exp Ther 282:162-171.
    • (1997) J Pharmacol Exp Ther , vol.282 , pp. 162-171
    • Sasabe, H.1    Terasaki, T.2    Tsuji, A.3    Sugiyama, Y.4
  • 56
    • 0031911625 scopus 로고    scopus 로고
    • Carrier-mediated mechanism for the biliary excretion of the quinolone antibiotic grepafloxacin and its glucuronide in rats
    • Sasabe H, Tsuji A, Sugiyama Y. 1998. Carrier-mediated mechanism for the biliary excretion of the quinolone antibiotic grepafloxacin and its glucuronide in rats. J Pharmacol Exp Ther 284:1033-1039.
    • (1998) J Pharmacol Exp Ther , vol.284 , pp. 1033-1039
    • Sasabe, H.1    Tsuji, A.2    Sugiyama, Y.3
  • 57
    • 0031884441 scopus 로고    scopus 로고
    • Stereoselective hepatobiliary transport of the quinolone antibiotic grepafloxacin and its glucuronide in the rat
    • Sasabe H, Kato Y, Tsuji A, Sugiyama Y. 1998. Stereoselective hepatobiliary transport of the quinolone antibiotic grepafloxacin and its glucuronide in the rat. J Pharmacol Exp Ther 284:661-668.
    • (1998) J Pharmacol Exp Ther , vol.284 , pp. 661-668
    • Sasabe, H.1    Kato, Y.2    Tsuji, A.3    Sugiyama, Y.4
  • 59
    • 3342900005 scopus 로고    scopus 로고
    • Differential involvement of multidrug resistance-associated protein 1 and P-glycoprotein in tissue distribution and excretion of grepafloxaein in mice
    • Sasabe H, Kato Y, Suzuki T, Itose M, Miyamoto G, Sugiyama Y. 2004. Differential involvement of multidrug resistance-associated protein 1 and P-glycoprotein in tissue distribution and excretion of grepafloxaein in mice. J Pharmacol Exp Ther 310:648-655.
    • (2004) J Pharmacol Exp Ther , vol.310 , pp. 648-655
    • Sasabe, H.1    Kato, Y.2    Suzuki, T.3    Itose, M.4    Miyamoto, G.5    Sugiyama, Y.6
  • 61
    • 34748877360 scopus 로고    scopus 로고
    • Involvement of breast cancer resistance protein (ABCG2) in the biliary excretion mechanism of fluoroquinolones
    • Ando T, Kusuhara H, Merino G, Alvarez AI, Schinkel AH, Sugiyama Y. 2007. Involvement of breast cancer resistance protein (ABCG2) in the biliary excretion mechanism of fluoroquinolones. Drug Metab Dispos 35:1873-1879.
    • (2007) Drug Metab Dispos , vol.35 , pp. 1873-1879
    • Ando, T.1    Kusuhara, H.2    Merino, G.3    Alvarez, A.I.4    Schinkel, A.H.5    Sugiyama, Y.6
  • 62
    • 0031941928 scopus 로고    scopus 로고
    • Effects of probenecid and Cimetidine on renal disposition of ofloxacin in rats
    • Foote EF, Halstenson CE. 1998. Effects of probenecid and Cimetidine on renal disposition of ofloxacin in rats. Antimicrob Agents Chemother 42:456-458.
    • (1998) Antimicrob Agents Chemother , vol.42 , pp. 456-458
    • Foote, E.F.1    Halstenson, C.E.2
  • 63
    • 0032901503 scopus 로고    scopus 로고
    • Distribution characteristics of levofloxacin and grepafloxaein in rat kidney
    • Ito T, Yano I, Masuda S, Hashimoto Y, Inui K. 1999. Distribution characteristics of levofloxacin and grepafloxaein in rat kidney. Pharm Res 16: 534-539.
    • (1999) Pharm Res , vol.16 , pp. 534-539
    • Ito, T.1    Yano, I.2    Masuda, S.3    Hashimoto, Y.4    Inui, K.5
  • 64
    • 0034017506 scopus 로고    scopus 로고
    • Transepithelial transport of levofloxacin in the isolated perfused rat kidney
    • Ito T, Yano I, Hashimoto Y, Inui K. 2000. Transepithelial transport of levofloxacin in the isolated perfused rat kidney. Pharm Res 17:236-241.
    • (2000) Pharm Res , vol.17 , pp. 236-241
    • Ito, T.1    Yano, I.2    Hashimoto, Y.3    Inui, K.4
  • 65
    • 8544227674 scopus 로고    scopus 로고
    • Ito T,Yano I.Tanaka K,Inui K. 1997. Transport of quinolone antibacterial drugs by human P-Glycoprotein expressed in a kidney epithelial cell line, LLC-PK1. J Pharmacol Exp Ther 282:955-960.
    • Ito T,Yano I.Tanaka K,Inui K. 1997. Transport of quinolone antibacterial drugs by human P-Glycoprotein expressed in a kidney epithelial cell line, LLC-PK1. J Pharmacol Exp Ther 282:955-960.
  • 66
    • 0030826493 scopus 로고    scopus 로고
    • The transport of ciprofloxacin in cultured kidney epithelial cells LLC-PK1
    • Sasaya M, Oda M, Endo T, Saitoh H, Takada M. 1997. The transport of ciprofloxacin in cultured kidney epithelial cells LLC-PK1. Biol Pharm Bull 20:887-891.
    • (1997) Biol Pharm Bull , vol.20 , pp. 887-891
    • Sasaya, M.1    Oda, M.2    Endo, T.3    Saitoh, H.4    Takada, M.5
  • 67
    • 0033815392 scopus 로고    scopus 로고
    • Limited distribution of new quinolone antibacterial agents into brain caused by multiple efflux transporters at the blood-brain barrier
    • Tamai I, Yamashita J, Kido Y, Ohnari A, Sai Y, Shima Y, Naruhashi K, Koizumi S, Tsuji A. 2000. Limited distribution of new quinolone antibacterial agents into brain caused by multiple efflux transporters at the blood-brain barrier. J Pharmacol Exp Ther 295:146-152.
    • (2000) J Pharmacol Exp Ther , vol.295 , pp. 146-152
    • Tamai, I.1    Yamashita, J.2    Kido, Y.3    Ohnari, A.4    Sai, Y.5    Shima, Y.6    Naruhashi, K.7    Koizumi, S.8    Tsuji, A.9
  • 68
    • 0030610838 scopus 로고    scopus 로고
    • Quantitative brain microdialysis study on the mechanism of quinolones distribution in the central nervous system
    • Ooie T, Suzuki H, Terasaki T, Sugiyama Y. 1997. Quantitative brain microdialysis study on the mechanism of quinolones distribution in the central nervous system. Drug Metab Disp 25:784-789.
    • (1997) Drug Metab Disp , vol.25 , pp. 784-789
    • Ooie, T.1    Suzuki, H.2    Terasaki, T.3    Sugiyama, Y.4
  • 69
    • 0030799004 scopus 로고    scopus 로고
    • Kinetic evidence for active efflux transport across the blood-brain barrier of quinolone antibiotics
    • Ooie T, Suzuki H, Terasaki T, Sugiyama Y. 1997. Kinetic evidence for active efflux transport across the blood-brain barrier of quinolone antibiotics. J Pharmacol Exp Ther 283:293-304.
    • (1997) J Pharmacol Exp Ther , vol.283 , pp. 293-304
    • Ooie, T.1    Suzuki, H.2    Terasaki, T.3    Sugiyama, Y.4
  • 70
  • 71
    • 0033743228 scopus 로고    scopus 로고
    • In vitro and in vivo investigations on fluoroquinolones; effects of the P-glycoprotein efflux transporter on brain distribution of Sparfloxacin
    • Lange EC, Marchand S, van den Berg D, van der Sandt IC, de Boer AG, Delon A, Bouquet S, Couet W. 2000. In vitro and in vivo investigations on fluoroquinolones; effects of the P-glycoprotein efflux transporter on brain distribution of Sparfloxacin. Eur J Pharm Sci 12:85-93.
    • (2000) Eur J Pharm Sci , vol.12 , pp. 85-93
    • Lange, E.C.1    Marchand, S.2    van den Berg, D.3    van der Sandt, I.C.4    de Boer, A.G.5    Delon, A.6    Bouquet, S.7    Couet, W.8
  • 72
    • 2342644918 scopus 로고    scopus 로고
    • Expression, up-regulation, and transport activity of the multidrug-resistance protein Abcg2 at the mouse blood-brain barrier
    • Cisternino S, Mercier C, Bourasset F, Roux F, Scherrmann JM. 2004. Expression, up-regulation, and transport activity of the multidrug-resistance protein Abcg2 at the mouse blood-brain barrier. Cancer Res 64:3296-3301.
    • (2004) Cancer Res , vol.64 , pp. 3296-3301
    • Cisternino, S.1    Mercier, C.2    Bourasset, F.3    Roux, F.4    Scherrmann, J.M.5
  • 74
    • 33644855549 scopus 로고    scopus 로고
    • Carrier-mediated uptake of grepafloxaein, a fluoroquinolone antibiotic, by the isolated rat lung cells
    • Sasabe H, Kato Y, Suzuki T, Itose M, Miyamoto G, Sugiyama Y. 2005. Carrier-mediated uptake of grepafloxaein, a fluoroquinolone antibiotic, by the isolated rat lung cells. Drug Metab Pharmacokinet 20:491-495.
    • (2005) Drug Metab Pharmacokinet , vol.20 , pp. 491-495
    • Sasabe, H.1    Kato, Y.2    Suzuki, T.3    Itose, M.4    Miyamoto, G.5    Sugiyama, Y.6
  • 75
    • 33846877217 scopus 로고    scopus 로고
    • Functional studies on the activity of efflux transporters in an ex vivo model with chicken splenocytes and evaluation of selected fluoroquinolones in this model
    • Haritova AM, Schrickx JA, Fink-Gremmels J. 2007. Functional studies on the activity of efflux transporters in an ex vivo model with chicken splenocytes and evaluation of selected fluoroquinolones in this model. Biochem Pharmacol 73:752-759.
    • (2007) Biochem Pharmacol , vol.73 , pp. 752-759
    • Haritova, A.M.1    Schrickx, J.A.2    Fink-Gremmels, J.3
  • 76
    • 0038101671 scopus 로고    scopus 로고
    • Influence of P-glycoprotein and MRP efflux pump inhibitors on the intracellular activity of azithromycin and ciprofloxacin in macrophages infected by Listeria monocytogenes or Staphylococcus aureus
    • Seral C, Carryn S, Tulkens PM, Van Bambeke F. 2003. Influence of P-glycoprotein and MRP efflux pump inhibitors on the intracellular activity of azithromycin and ciprofloxacin in macrophages infected by Listeria monocytogenes or Staphylococcus aureus. J Antimicrob Chemother 51:1167-1173.
    • (2003) J Antimicrob Chemother , vol.51 , pp. 1167-1173
    • Seral, C.1    Carryn, S.2    Tulkens, P.M.3    Van Bambeke, F.4
  • 77
    • 19544390531 scopus 로고    scopus 로고
    • Related articles, influence of efflux transporters on the accumulation and efflux of four quinolones (ciprofloxacin, levofloxacin, garenoxacin, and moxifloxacin) in J774 macrophages
    • Michot JM, Seral C, Van Bambeke F, Mingeot-Leclercq MP, Tulkens PM. 2005. Related articles, influence of efflux transporters on the accumulation and efflux of four quinolones (ciprofloxacin, levofloxacin, garenoxacin, and moxifloxacin) in J774 macrophages. Antimicrob Agents Chemother 49: 2429-2437.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 2429-2437
    • Michot, J.M.1    Seral, C.2    Van Bambeke, F.3    Mingeot-Leclercq, M.P.4    Tulkens, P.M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.