Secretion of sparfloxacin from the human intestinal Caco-2 cell line is altered by P-glycoprotein inhibitors

Antimicrobial Agents and Chemotherapy

Volumn 42, Issue 10, 1998, Pages 2607-2611

  Cormet Boyaka, Estelle ^a,d   Huneau, Jean François ^a   Mordrelle, Agnès ^a   Boyaka, Prosper N ^a,d   Carbon, Claude ^b   Rubinstein, Ethan ^c   Tomé, Daniel ^a  

^a AGROPARISTECH   (France)

^b BICHAT HOSPITAL   (France)

^c TEL AVIV UNIVERSITY   (Israel)

^d UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEIN P; PROGESTERONE; PROTEIN INHIBITOR; SPARFLOXACIN; VERAPAMIL; VINBLASTINE;

ANIMAL CELL; ARTICLE; CELL STRAIN CACO 2; CONTROLLED STUDY; DIFFUSION; DRUG ELIMINATION; DRUG UPTAKE; HUMAN; HUMAN CELL; INTESTINE SECRETION; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0031692747     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.42.10.2607     Document Type: Article

References (28)

1. Cavet, M. W., and N. L. Simmoms. 1997. Fluoroquinolone (ciprofloxacin) secretion by human intestinal epithelial (Caco-2) cells. Br. J. Pharmacol. 121:1567-1578.
2. Cordon-Cardo, C., J. P. O'Brien, J. Boccia, D. Casals, J. R. Bertino, and M. R. Melamed. 1990. Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues. J. Histochem. Cytochem. 38:1277-1287.
3. Cormet, E., J. F. Huneau, M. Bouras, C. Carbon, E. Rubinstein, and D. Tome. 1947. Evidence for a passive diffusion mechanism for sparfloxacin uptake at the brush-border membrane of the human intestinal cell-line Caco-2. J. Pharm. Sci. 86:33-36.
4. Cormet, E., J. F. Huneau, and D. Tome. 1997. Sparfloxacin binds to rabbit intestinal brush-border membrane vesicles by ionic interactions. Int. J. Pharm. 159:127-130.
5. Ford, J. M., and W. Hait. 1990. Pharmacology of drugs that alter multidrug resistance in cancer. Pharmacol. Rev. 42:155-199.
6. Gan, L. S. L., and D. R. Thakker. 1997. Application of the Caco-2 model in the design and development of orally active drugs: elucidation of biochemical and physical barriers posed by the intestinal epithelium. Adv. Drug Deliv. Rev. 23:77-98.
7. Griffiths, N. M., B. H. Hirst, and N. L. Simmons. 1993. Active secretion of the fluoroquinolone ciprofloxacin by human intestinal epithelial Caco-2 cell layers. Br. J. Pharmacol. 108:575-576.
8. Griffiths, N. M., B. H. Hirst, and N. L. Simmons. 1994. Active intestinal secretion of the fluoroquinolones antibacterials ciprofloxacin, norfloxacin and petloxacin: a common secretory pathway? J. Pharmacol. Exp. Ther. 269:496-502.
9. Hidalgo, I. J., T. J. Raub, and R. T. Brochardt. 1989. Characterization of the human colon carcinoma cell-line (Caco-2) as a model system for intestinal epithelial permeability. Gastroenterology 96:736-749.
10. Huneau, J. F., D. Tome, J. Ramon, C. Carbon, and E. Rubinstein. 1993. Absorption and secretion of sparfloxacin in the isolated rabbit intestinal tract. Drugs 45:251.
11. Hunter, J., B. H. Hirst, and N. L. Simmons. 1993. Drug absorption limited by P-glycoprotein-mediated secretory drug transport in human intestinal epithelial Caco-2 cell layers. Pharm. Res. 10:743-749.
12. Hunter, J., M. A. Jepson, T. Tsuruo, N. L. Simmons, and B. H. Hirst. 1993. Functional expression of P-glycoprotein in apical membranes of human intestinal Caco-2 cells. J. Biol. Chem. 268:14991-14997.
13. Karlsson, J., S. M. Kuo, J. Ziemniak, and P. Artursson. 1993. Transport of celiprolol across human intestinal epithelial (Caco-2) cells: mediation by multiple transporters including P-glycoprotein. Br. J. Pharmacol. 110:1009-1016.
14. 14C]-sparfloxacin in the rat. Arzneim.-Forsch./Drug Res. 41:747-759.
15. Montay, G., J. C. Vergniol, M. Ebmeier, Y. Le Roux, C. Guimart, A. Frydman, D. Chassard, and J. J. Thebault. 1994. Pharmacokinetics of sparfloxacin in humans after single oral administration at doses of 200, 400, 600, and 800 mg. J. Clin. Pharmacol. 34:1071-1076.
16. Nakamura, S., N. Kurobe, M. Hashimoto, and M. Shimizu. 1990. Pharmacokinetics of a novel quinolone, AT-4140, in animals. Antimicrob. Agents Chemother. 34:89-93.
17. Pinto, M., S. Robine-Leon, M. D. Appay, M. Kedinger, N. Triadou, E. Dussaulx, B. Lacroix, P. Simon-Assmann, K. Haffen, J. Fogh, and A. Zweibaum. 1983. Enterocyte-like differentiation and polarization of the human colon carcinoma cell-line Caco-2 in culture. Biol. Cell 47:323-330.
18. Quaroni, A., and K. J. Isselbacher. 1981. Cytotoxic effects and metabolism of benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene in duodenal and ileal epithelial cell cultures. J. Natl. Cancer Inst. 67:1353-1362.
19. Rabbaa, L., S. Dautrey, N. Colaslinhart, C. Carbon, and R. Farinotti. 1996. Intestinal elimination of ofloxacin enantiomers in the rat: evidence of a carrier-mediated process. Antimicrob. Agents Chemother. 40:2126-2130.
20. Rohwedder, R., T. Bergan, S. B. Thorsteinson, and H. Scholl. 1990. Transintestinal elimination of ciprofloxacin. Chemotherapy (Basel) 36:77-84.
21. Rubinstein, E., L. St. Julien, J. Ramon, S. Dautrey, R. Farinotti, J. F. Huneau, and C. Carbon. 1994. The intestinal elimination of ciprofloxacin in the rat. J. Infect. Dis. 169:218-221.
22. Rubinstein, E., S. Dautrey, R. Farinotti, L. St. Julien, J. Ramon, and C. Carbon. 1995. Intestinal elimination of sparfloxacin, fleroxacin, and ciprofloxacin in rats. Antimicrob. Agents Chemother. 39:99-102.
23. Smith, P. K., R. I. Krohn, G. T. Hermanson, A. K. Mallia, F. H. Gartner, M. D. Provenzano, E. K. Fujimoto, N. M. Geoke, B. J. Olson, and D. C. Klenk. 1985. Measurement of protein using hicinchoninic acid. Anal. Biochem. 150:76-85.
24. Sorgel, F., K. G. Nager, U. Jaehde, A. Reiter, R. Seelmann, and G. Sigl. 1989. Brief report: gastrointestinal secretion of ciprofloxacin, evaluation of the charcoal model for investigation in healthy volunteers. Am. J. Med. 87:62S-65S.
25. Sorgel, F., and M. Kinzig. 1993. Pharmacokinetics of gyrase inhibitor. Part 1. Basic chemistry and gastrointestinal disposition. Am. J. Med. 94(Suppl. 3A): 44S-51S.
26. Trezise, A. E. O., P. R. Romano, D. R. Gill, S. C. Hyde, F. V. Sepulveda, M. Buchwald, and C. F. Higgins. 1992. The multidrug resistance and cystic fibrosis gene have complementary patterns of epithelial expression. EMBO J. 11:4291-4303.
27. Tsuji, A., and I. Tamai. 1996. Carrier-mediated intestinal transport of drugs. Pharm. Res. 13:963-977.
28. Zabinski, R. A., K. J. Walker, A. J. Larsson, J. A. Moody, G. W. Kaatz, and J. C. Rotschafer. 1995. Effect of aerobic and anaerobic environments on antistaphylococcal activities of five fluoroquinolones. Antimicrob. Agents Chemother. 39:507-512.