Distribution characteristics of levofloxacin and grepafloxacin in rat kidney

Pharmaceutical Research

Volumn 16, Issue 4, 1999, Pages 534-539

  Ito, Tatsuya ^a   Yano, Ikuko ^a   Masuda, Satohiro ^a   Hashimoto, Yukiya ^a   Inui, Ken ichi ^a  

^a KYOTO UNIVERSITY HOSPITAL   (Japan)

Author keywords

Cortical slices; Grepafloxacin; Levofloxacin; Quinolone antibacterial drugs; Renal transport; Tissue distribution

Indexed keywords

4 AMINOHIPPURIC ACID; GREPAFLOXACIN; LEVOFLOXACIN; QUINIDINE; TETRYLAMMONIUM;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG TISSUE LEVEL; DRUG UPTAKE; INTRAVENOUS DRUG ADMINISTRATION; KIDNEY CORTEX; KIDNEY TUBULE ABSORPTION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0032901503     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1018871029244     Document Type: Article

References (11)

1. 1. M. Nakashima, T. Uematsu, M. Kanamaru, O. Okazaki, and H. Hakusui. Phase I study of levofloxacin, (S)-(-)-ofloxacin. Jpn. J. Clin. Pharmacol. Ther. 23:515-520 (1992).
2. 2. I. Yano, T. Ito, M. Takano, and K. Inui. Evaluation of renal tubular secretion and reabsorption of levofloxacin in rats. Pharm. Res. 14:508-511 (1997).
3. 1: Interaction with organic cation transporters in apical and basolateral membranes. J. Pharmacol. Exp. Ther. 276:1143-1148 (1996).
4. 1. J. Pharmacol. Exp. Ther. 287:672-678 (1998).
5. 5. M. Nakashima, T. Uematsu, S. Nagashima, K. Kosuge, and M. Kanamaru. Phase I study of grepafloxacin. Jpn. J. Chemother. 43(S-1):155-175 (1995).
6. 6. H. Sasabe, T. Terasaki, A. Tsuji, and Y. Sugiyama. Carrier-mediated hepatic uptake of quinolone antibiotics in the rat. J. Pharmacol. Exp. Ther. 282:162-171 (1997).
7. 7. H. Saito, S. Masuda, and K. Inui. Cloning and functional characterization of a novel rat organic anion transporter mediating basolateral uptake of methotrexate in the kidney. J. Biol. Chem. 271:20719-20725 (1996).
8. 8. R. Hori, Y. Ishikawa, M. Takano, T. Okano, S. Kitazawa, and K. Inui. The interaction of cephalosporin antibiotics with renal cortex of rats: Accumulation to cortical slices and binding to purified plasma membranes. Biochem. Pharmacol. 31:2267-2272 (1982).
9. 9. W. O. Berndt. Use of the tissue slice technique for evaluation of renal transport processes. Environ. Health Perspect. 15:73-88 (1976).
10. 10. K. J. Ullrich, G. Rumrich, C. David, and G. Fritzsch. Bisubstrates: substances that interact with both, renal contraluminal organic anion and organic cation transport systems II. zwitterionic substrates: dipeptides, cephalosporins, quinolone-carboxylate gyrase inhibitors and phosphamide thiazine carboxylates; nonionizable substrates: steroid hormones and cyclophosphamides. Pflügers Arch 425:300-312 (1993).
11. 11. N. M. Griffiths, B. H. Hirst, and N. L. Simmons. Active intestinal secretion of the fluoroquinolone antibacterials ciprofloxacin, norfloxacin and pefloxacin; a common secretory pathway? J. Pharmacol. Exp. Ther. 269:496-502 (1994).