메뉴 건너뛰기




Volumn 121, Issue 8, 1997, Pages 1567-1578

Fluoroquinolone (ciprofloxacin) secretion by human intestinal epithelial (Caco-2) cells

Author keywords

Caco 2 cells; Ciprofloxacin; Epithelia; Intestinal secretion; P glycoprotein

Indexed keywords

4 AMINOHIPPURIC ACID; 4,4' DIISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; ANTIBODY; BROMSULFOPHTHALEIN; CHLORIDE ION; CIPROFLOXACIN; GLYCOPROTEIN P; N METHYLNICOTINAMIDE; OXALIC ACID; POTASSIUM ION; PROBENECID; QUINOLINE DERIVED ANTIINFECTIVE AGENT; SODIUM ION; SUCCINIC ACID; SULFATE; TAUROCHOLIC ACID; TETRYLAMMONIUM; THIOSULFATE; VERAPAMIL; VINBLASTINE;

EID: 0030807188     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701302     Document Type: Article
Times cited : (60)

References (71)
  • 1
    • 0029013337 scopus 로고
    • Two highly similar multidrug transporters of Bacillus subtilis whose expression is differentially regulated
    • AHMED, M., LYASS, L., MARKHAM, P.N., TAYLOR, S.S., VAZQUEZ-LASLOP & NEYFAKH, A.A. (1995). Two highly similar multidrug transporters of Bacillus subtilis whose expression is differentially regulated. J. Bacteriol., 177, 3904-3910.
    • (1995) J. Bacteriol. , vol.177 , pp. 3904-3910
    • Ahmed, M.1    Lyass, L.2    Markham, P.N.3    Taylor, S.S.4    Vazquez-Laslop5    Neyfakh, A.A.6
  • 2
    • 0026482012 scopus 로고
    • Bacterial periplasmic permeases as model systems for the superfamily of traffic ATPases, including the multidrug resistance protein and the cystic fibrosis transmembrane conductance regulator
    • AMES, G.F.L. (1992). Bacterial periplasmic permeases as model systems for the superfamily of traffic ATPases, including the multidrug resistance protein and the cystic fibrosis transmembrane conductance regulator. Int. Rev. Cytol., 137, 1-35.
    • (1992) Int. Rev. Cytol. , vol.137 , pp. 1-35
    • Ames, G.F.L.1
  • 4
    • 0019861554 scopus 로고
    • Identification of two strains of cultures canine renal epithelial cells (MDCK cells) which display entirely different physiological properties
    • BARKER, G. & SIMMONS, N.L. (1981). Identification of two strains of cultures canine renal epithelial cells (MDCK cells) which display entirely different physiological properties. Q. J. Exp. Physiol., 66, 61-72.
    • (1981) Q. J. Exp. Physiol. , vol.66 , pp. 61-72
    • Barker, G.1    Simmons, N.L.2
  • 5
    • 0018620043 scopus 로고
    • Anion transport in red blood cells. Sites and sidedness of inhibition by high-affinity reversible binding probes
    • BARZILAY, M. & CABANTCHIK, Z.I. (1979). Anion transport in red blood cells. Sites and sidedness of inhibition by high-affinity reversible binding probes. Membr. Biochem., 2, 297-322.
    • (1979) Membr. Biochem. , vol.2 , pp. 297-322
    • Barzilay, M.1    Cabantchik, Z.I.2
  • 7
    • 0015962082 scopus 로고
    • Membrane proteins related to anion permeability of human red blood cells. I. Localisation of disulfonic stilbene binding sites in proteins involved in permeation
    • CABANTCHIK, Z. & ROTHSTEIN, A. (1974). Membrane proteins related to anion permeability of human red blood cells. I. Localisation of disulfonic stilbene binding sites in proteins involved in permeation. J. Membr. Biol., 15, 207-226.
    • (1974) J. Membr. Biol. , vol.15 , pp. 207-226
    • Cabantchik, Z.1    Rothstein, A.2
  • 8
    • 0026599145 scopus 로고
    • J774 macrophages secrete antibiotics via organic anion transporters
    • CAO, C.X., SILVERSTEIN, S.C., NEU, H.C. & STEINBERG, T.H. (1992). J774 macrophages secrete antibiotics via organic anion transporters. J. Infect Dis., 165, 322-328.
    • (1992) J. Infect Dis. , vol.165 , pp. 322-328
    • Cao, C.X.1    Silverstein, S.C.2    Neu, H.C.3    Steinberg, T.H.4
  • 9
    • 84963038462 scopus 로고
    • Accumulation, subcellular distribution and activity of azithromycin (Az) compared to roxithromycin (Rx) and ciprofloxacin (Cp) in J774 macrophages (MO)
    • New York: American Society of Microbiology
    • CARLIER, M.B., SCORNEAUX, B. & TULKENS, P.M. (1991). Accumulation, subcellular distribution and activity of azithromycin (Az) compared to roxithromycin (Rx) and ciprofloxacin (Cp) in J774 macrophages (MO). In Abstracts, 31st Interscience Conference on Antimicrobial Agents and Chemotherapy. New York: American Society of Microbiology.
    • (1991) Abstracts, 31st Interscience Conference on Antimicrobial Agents and Chemotherapy
    • Carlier, M.B.1    Scorneaux, B.2    Tulkens, P.M.3
  • 10
    • 0025133299 scopus 로고
    • Cellular uptake, localisation and activity of fluoroquinolones in uninfected and infected macrophages
    • CARLIER, M.B., SCORNEAUX, B., ZENEBERGH, A., DESNOTTES, J. & TULKENS, P.M. (1990). Cellular uptake, localisation and activity of fluoroquinolones in uninfected and infected macrophages. J. Antimicrobial. Chemother., 26 (B), 27-39.
    • (1990) J. Antimicrobial. Chemother. , vol.26 , Issue.B , pp. 27-39
    • Carlier, M.B.1    Scorneaux, B.2    Zenebergh, A.3    Desnottes, J.4    Tulkens, P.M.5
  • 11
  • 12
    • 0029997940 scopus 로고    scopus 로고
    • Transport and epithelial secretion of the cardiac glycoside by human intestinal epithelial Caco-2 cells
    • CAVET, M.E., WEST, M. & SIMMONS, N.L. (1996). Transport and epithelial secretion of the cardiac glycoside by human intestinal epithelial Caco-2 cells. Br. J. Pharmacol., 118, 1389-1396.
    • (1996) Br. J. Pharmacol. , vol.118 , pp. 1389-1396
    • Cavet, M.E.1    West, M.2    Simmons, N.L.3
  • 14
    • 0027480292 scopus 로고
    • Glutathione-conjugate transport by human colon adenocarcinoma cells (Caco-2 cells)
    • ELFERINK, P.J.O., BAKKER, C.T.M. & JANSEN, P.L.M. (1993). Glutathione-conjugate transport by human colon adenocarcinoma cells (Caco-2 cells). Biochem. J., 290, 759-764.
    • (1993) Biochem. J. , vol.290 , pp. 759-764
    • Elferink, P.J.O.1    Bakker, C.T.M.2    Jansen, P.L.M.3
  • 17
    • 0028054888 scopus 로고
    • Overexpression of multidrug resistance associated protein (MRP) increases resistance to natural products
    • GRANT, C., VALDIMARSSO, G., HIPFNER, D.R., ALMQUIST, K.C., COLE, S.P.C. & DEELEY, R.G. (1994). Overexpression of multidrug resistance associated protein (MRP) increases resistance to natural products. Cancer Res., 54, 357-361.
    • (1994) Cancer Res. , vol.54 , pp. 357-361
    • Grant, C.1    Valdimarsso, G.2    Hipfner, D.R.3    Almquist, K.C.4    Cole, S.P.C.5    Deeley, R.G.6
  • 18
    • 0027411562 scopus 로고
    • Active secretion of the fluoroquinolone ciprofloxacin by human intestinal epithelial Caco-2 cell layers
    • GRIFFITHS, N.M., HIRST, B.H. & SIMMONS, N.L. (1993). Active secretion of the fluoroquinolone ciprofloxacin by human intestinal epithelial Caco-2 cell layers. Br. J. Pharmacol., 108, 575-576.
    • (1993) Br. J. Pharmacol. , vol.108 , pp. 575-576
    • Griffiths, N.M.1    Hirst, B.H.2    Simmons, N.L.3
  • 19
    • 0028321687 scopus 로고
    • Active intestinal secretion of the fluoroquinolone antibacterials ciprofloxacin, norfloxacin and perfloxacin; a common secretory pathway?
    • GRIFFITHS, N.M., HIRST, B.H. & SIMMONS, N.L. (1994). Active intestinal secretion of the fluoroquinolone antibacterials ciprofloxacin, norfloxacin and perfloxacin; a common secretory pathway? J. Pharmacol. Exp. Ther., 269, 496-502.
    • (1994) J. Pharmacol. Exp. Ther. , vol.269 , pp. 496-502
    • Griffiths, N.M.1    Hirst, B.H.2    Simmons, N.L.3
  • 20
    • 0029078530 scopus 로고
    • Difloxacin reverses multidrug resistance in P388/ADR cells via a mechanism independent of P-glycoprotein and without correcting drug transport or subcellular drug distribution
    • GUPTA, S., THADEPALLI, F. & GOLLAPUDI, S. (1995). Difloxacin reverses multidrug resistance in P388/ADR cells via a mechanism independent of P-glycoprotein and without correcting drug transport or subcellular drug distribution. Int. J. Oncol., 7, 475-480.
    • (1995) Int. J. Oncol. , vol.7 , pp. 475-480
    • Gupta, S.1    Thadepalli, F.2    Gollapudi, S.3
  • 21
    • 0028805557 scopus 로고
    • The intestinal transport mechanism of fluoroquinolones: Inhibitory effect of ciprofloxacin, an enoxacin derivative, on the membrane potential-dependent uptake of enoxacin
    • HIRANO, T., ISEKI, K., SATO, I., MIYAZAKI, S., TAKADA, M., KOBAYASHI, M., SUGAWARA, M. & MIYAZAKI, S. (1995a). The intestinal transport mechanism of fluoroquinolones: Inhibitory effect of ciprofloxacin, an enoxacin derivative, on the membrane potential-dependent uptake of enoxacin. Pharmacol. Res., 12, 1299-1303.
    • (1995) Pharmacol. Res. , vol.12 , pp. 1299-1303
    • Hirano, T.1    Iseki, K.2    Sato, I.3    Miyazaki, S.4    Takada, M.5    Kobayashi, M.6    Sugawara, M.7    Miyazaki, S.8
  • 22
    • 0028930041 scopus 로고
    • Transport mechanism of enoxacin in rat brush-border membrane of renal cortex: Interaction with organic cation transport system and ionic diffusion potential dependent uptake
    • HIRANO, T., ISEKI, K., SUGAWARA, M., MIYAZAKI, S., TAKADA, M. & MIYAZAKI, K. (1995b) Transport mechanism of enoxacin in rat brush-border membrane of renal cortex: Interaction with organic cation transport system and ionic diffusion potential dependent uptake. Biol. Pharmac. Bull., 18, 342-346.
    • (1995) Biol. Pharmac. Bull. , vol.18 , pp. 342-346
    • Hirano, T.1    Iseki, K.2    Sugawara, M.3    Miyazaki, S.4    Takada, M.5    Miyazaki, K.6
  • 23
    • 0024449848 scopus 로고
    • Transepithelial transport of drugs by the multidrug transporter in cultured Madin-Darby canine kidney cell epithelia
    • HORIO, M., CHIN, K.V., CURRIER, S.J., GOLDENBERG, S., WILLIAMS, C., PASTAN, I., GOTTESMAN, M.M. & HANDLER, J. (1989). Transepithelial transport of drugs by the multidrug transporter in cultured Madin-Darby canine kidney cell epithelia. J. Biol. Chem., 264, 14880-14884.
    • (1989) J. Biol. Chem. , vol.264 , pp. 14880-14884
    • Horio, M.1    Chin, K.V.2    Currier, S.J.3    Goldenberg, S.4    Williams, C.5    Pastan, I.6    Gottesman, M.M.7    Handler, J.8
  • 24
    • 0027180795 scopus 로고
    • Drug absorption limited by P-glycoprotein-mediated secretory drug transport in human intestinal epithelial Caco-2 cell layers
    • HUNTER, J., HIRST, B.H. & SIMMONS, N.L. (1993a). Drug absorption limited by P-glycoprotein-mediated secretory drug transport in human intestinal epithelial Caco-2 cell layers. Pharmacol. Res., 10, 743-749.
    • (1993) Pharmacol. Res. , vol.10 , pp. 743-749
    • Hunter, J.1    Hirst, B.H.2    Simmons, N.L.3
  • 25
    • 0027368043 scopus 로고
    • Transepithelial secretion, cellular accumulation and cytotoxicity of vinblastine in defined MDCK cell strains
    • HUNTER, J., HIRST, B.H. & SIMMONS, N.L. (1993b). Transepithelial secretion, cellular accumulation and cytotoxicity of vinblastine in defined MDCK cell strains. Biochim. Biophys. Acta, 1179, 1-10.
    • (1993) Biochim. Biophys. Acta , vol.1179 , pp. 1-10
    • Hunter, J.1    Hirst, B.H.2    Simmons, N.L.3
  • 26
    • 0027181852 scopus 로고
    • Functional expression of P-glycoprotein in apical membranes of human intestinal Caco-2 cells. Kinetics of vinblastine secretion and interaction with modulators
    • HUNTER, J., JEPSON, M.A., TSURUO, T., SIMMONS, N.L. & HIRST, B.H. (1993c). Functional expression of P-glycoprotein in apical membranes of human intestinal Caco-2 cells. Kinetics of vinblastine secretion and interaction with modulators. J. Biol. Chem., 268, 14991-14997.
    • (1993) J. Biol. Chem. , vol.268 , pp. 14991-14997
    • Hunter, J.1    Jepson, M.A.2    Tsuruo, T.3    Simmons, N.L.4    Hirst, B.H.5
  • 28
    • 0026331027 scopus 로고
    • Expression of the hepatocellular chloride-dependent sulfobromophthalein uptake system in xenopus laevis oocytes
    • JACQUEMIN, E., HAGENBUCH, B., STEIGER, B., WOLKOFF, A.W. & MEIER, P.J. (1991). Expression of the hepatocellular chloride-dependent sulfobromophthalein uptake system in xenopus laevis oocytes. J. Clin. Invest., 88, 2146-2149.
    • (1991) J. Clin. Invest. , vol.88 , pp. 2146-2149
    • Jacquemin, E.1    Hagenbuch, B.2    Steiger, B.3    Wolkoff, A.W.4    Meier, P.J.5
  • 31
    • 0030063480 scopus 로고
    • ATP-dependent transport of glutathione-S-conjugates by the multidrug resistance-associated protein
    • JEDLITSCHKY, G., LEIER, I., BUCHHOLZ, U., CENTRE, M. & KEPPLER, D. (1994). ATP-dependent transport of glutathione-S-conjugates by the multidrug resistance-associated protein. Cancer Res., 56, 988-994.
    • (1994) Cancer Res. , vol.56 , pp. 988-994
    • Jedlitschky, G.1    Leier, I.2    Buchholz, U.3    Centre, M.4    Keppler, D.5
  • 32
    • 0027270540 scopus 로고
    • Efflux-mediated fluoroquinolone resistance in Staphylococcus aureus
    • KAATZ, G., SEO, S.M. & RUBLE, C.A. (1993). Efflux-mediated fluoroquinolone resistance in Staphylococcus aureus. Antimicrobial Agents Chemother., 37, 1086-1094.
    • (1993) Antimicrobial Agents Chemother. , vol.37 , pp. 1086-1094
    • Kaatz, G.1    Seo, S.M.2    Ruble, C.A.3
  • 33
    • 0027146389 scopus 로고
    • Transport of celiprolol across human intestinal epithelial (Caco-2) cells: Mediation of secretion by multiple transporters including P-glycoprotein
    • KARLSSON, J., KUO, S.M., ZIEMNIAK, J. & ARTURSSON, P. (1993). Transport of celiprolol across human intestinal epithelial (Caco-2) cells: mediation of secretion by multiple transporters including P-glycoprotein. Br. J. Pharmacol., 110, 1009-1016.
    • (1993) Br. J. Pharmacol. , vol.110 , pp. 1009-1016
    • Karlsson, J.1    Kuo, S.M.2    Ziemniak, J.3    Artursson, P.4
  • 34
    • 0017600919 scopus 로고
    • Fluxes of ions and drugs in isolated guinea-pig intestinal mucosa
    • LAUTERBACH, F. (1977a). Fluxes of ions and drugs in isolated guinea-pig intestinal mucosa. J. Physiol., 266, 27P-28P.
    • (1977) J. Physiol. , vol.266
    • Lauterbach, F.1
  • 35
    • 0009992726 scopus 로고
    • Intestinal secretion of organic ions and drugs
    • ed. Kramer, M. & Lauterbach, F. Amsterdam, Oxford: Excerpta Medica
    • LAUTERBACH, F. (1977b). Intestinal secretion of organic ions and drugs. In Intestinal Permeation. ed. Kramer, M. & Lauterbach, F. pp. 173-194. Amsterdam, Oxford: Excerpta Medica.
    • (1977) Intestinal Permeation , pp. 173-194
    • Lauterbach, F.1
  • 36
    • 14444282739 scopus 로고
    • Intestinal secretion of drugs
    • ed. Gilles-Baillien M. & Gilles, R. Berlin, Heidelburg: Springer-Verlag
    • LAUTERBACH, F. (1983). Intestinal secretion of drugs. In Intestinale Transport. ed. Gilles-Baillien M. & Gilles, R. pp. 76-86. Berlin, Heidelburg: Springer-Verlag.
    • (1983) Intestinale Transport , pp. 76-86
    • Lauterbach, F.1
  • 37
    • 0030013072 scopus 로고    scopus 로고
    • Active efflux of fluoroquinolones in Mycobacterium smegmatis mediated by LfrA, a multidrug efflux pump
    • LIU, J., TAKIFF, H.E. & NIKAIDO, H. (1996). Active efflux of fluoroquinolones in Mycobacterium smegmatis mediated by LfrA, a multidrug efflux pump. J. Bacteriol., 178, 3791-3795.
    • (1996) J. Bacteriol. , vol.178 , pp. 3791-3795
    • Liu, J.1    Takiff, H.E.2    Nikaido, H.3
  • 38
    • 0029860174 scopus 로고    scopus 로고
    • Substantial excretion of digoxin via the intestinal mucosa and prevention of long-term digoxin accumulation in the brain by the mdr1a P-glycoprotein
    • MAYER, U., WAGENAAR, E., BEIJNEN, J.H., SMIT, J.W., MEIJER, D.K.F., VAN ASPEREN, J., BORST, P. & SCHINKEL, A.H. (1996). Substantial excretion of digoxin via the intestinal mucosa and prevention of long-term digoxin accumulation in the brain by the mdr1a P-glycoprotein. Br. J. Pharmacol., 119, 1038-1044.
    • (1996) Br. J. Pharmacol. , vol.119 , pp. 1038-1044
    • Mayer, U.1    Wagenaar, E.2    Beijnen, J.H.3    Smit, J.W.4    Meijer, D.K.F.5    Van Asperen, J.6    Borst, P.7    Schinkel, A.H.8
  • 39
    • 0026697225 scopus 로고
    • Volume-activated Cl secretion and transepithelial vinblastine secretion mediated by P-glycoprotein are not correlated in cultured human T84 intestinal epithelial layers
    • MCEWAN, G.T.A., HUNTER, J., HIRST, B.H. & SIMMONS, N.L. (1992). Volume-activated Cl secretion and transepithelial vinblastine secretion mediated by P-glycoprotein are not correlated in cultured human T84 intestinal epithelial layers. FEBS Lett., 304, 233-236.
    • (1992) FEBS Lett. , vol.304 , pp. 233-236
    • Mcewan, G.T.A.1    Hunter, J.2    Hirst, B.H.3    Simmons, N.L.4
  • 40
    • 0026711242 scopus 로고
    • Efficient inhibition of P-glycoprotein-mediated multidrug resistance with a monoclonal antibody
    • MECHETNER, E. & RONINSON, I.B. (1992). Efficient inhibition of P-glycoprotein-mediated multidrug resistance with a monoclonal antibody. Proc. Natl. Acad. Sci., 89, 5824-5828.
    • (1992) Proc. Natl. Acad. Sci. , vol.89 , pp. 5824-5828
    • Mechetner, E.1    Roninson, I.B.2
  • 41
    • 0023786923 scopus 로고
    • Transport of guanidine in rabbit intestinal brush-border membrane vesicles
    • MIYAMOTO, Y., GANAPATHY, V. & LEIBACH, F.H. (1988). Transport of guanidine in rabbit intestinal brush-border membrane vesicles. Am. J. Physiol., 255, G85-G92.
    • (1988) Am. J. Physiol. , vol.255
    • Miyamoto, Y.1    Ganapathy, V.2    Leibach, F.H.3
  • 42
    • 0016236752 scopus 로고
    • Galactose transport in rabbit ileum
    • NAFTALIN, R. & CURRAN, P.F. (1974). Galactose transport in rabbit ileum. J. Membr. Biol., 16, 257-278.
    • (1974) J. Membr. Biol. , vol.16 , pp. 257-278
    • Naftalin, R.1    Curran, P.F.2
  • 43
    • 0027514765 scopus 로고
    • Fluoroquinolone resistance protein norA of Staphylococcus aureus is a multidrug efflux transporter
    • NEYFAKH, A., BORSCH, C.M. & KAATZ, G.W. (1993). Fluoroquinolone resistance protein norA of Staphylococcus aureus is a multidrug efflux transporter. Antimicrobial Agents Chemother., 37, 128-129.
    • (1993) Antimicrobial Agents Chemother. , vol.37 , pp. 128-129
    • Neyfakh, A.1    Borsch, C.M.2    Kaatz, G.W.3
  • 44
    • 0025672578 scopus 로고
    • Interaction of ofloxacin with organic cation transport system in rat renal brush-border membranes
    • OKANO, T., MAEGAWA, H., INUI, K.I. & HORI, R. (1990). Interaction of ofloxacin with organic cation transport system in rat renal brush-border membranes. J. Pharmacol. Exp. Ther., 255, 1033-1037.
    • (1990) J. Pharmacol. Exp. Ther. , vol.255 , pp. 1033-1037
    • Okano, T.1    Maegawa, H.2    Inui, K.I.3    Hori, R.4
  • 45
    • 0029922224 scopus 로고    scopus 로고
    • Characterisation of the transport properties of a quinolone antibiotic, fleroxacin, in rat choroid plexus
    • OOIE, T., SUZUKI, H., TERASAKI, T. & SUGIYAMA, Y. (1996). Characterisation of the transport properties of a quinolone antibiotic, fleroxacin, in rat choroid plexus. Pharmacol. Res., 13, 523-527.
    • (1996) Pharmacol. Res. , vol.13 , pp. 523-527
    • Ooie, T.1    Suzuki, H.2    Terasaki, T.3    Sugiyama, Y.4
  • 47
    • 0026664073 scopus 로고
    • Biochemical characterization of resistance to mitoxanthrone and adriamycin in Caco-2 human adenocarcinoma cells; a possible role for glutathione-S-transferases
    • PETERS, W.H.M. & ROELOFS, H.M.J. (1992). Biochemical characterization of resistance to mitoxanthrone and adriamycin in Caco-2 human adenocarcinoma cells; a possible role for glutathione-S-transferases. Cancer Res., 52, 1886-1890.
    • (1992) Cancer Res. , vol.52 , pp. 1886-1890
    • Peters, W.H.M.1    Roelofs, H.M.J.2
  • 48
  • 49
    • 0027133590 scopus 로고
    • Mechanism mediating renal secretion of organic anions and organic cations
    • PRITCHARD, J.B. & MILLER, D. (1993). Mechanism mediating renal secretion of organic anions and organic cations. Physiol. Rev., 73, 765-797.
    • (1993) Physiol. Rev. , vol.73 , pp. 765-797
    • Pritchard, J.B.1    Miller, D.2
  • 50
    • 0029145405 scopus 로고
    • Stereoselectivity of ofloxacin intestinal transport in the rat
    • RABBAA, L., DAUTREY, S., COLAS-LINHART, N., CARBON, C. & FARINOTTI, R. (1995). Stereoselectivity of ofloxacin intestinal transport in the rat. Drugs, 49 (Suppl.2), 333-334.
    • (1995) Drugs , vol.49 , Issue.2 SUPPL. , pp. 333-334
    • Rabbaa, L.1    Dautrey, S.2    Colas-Linhart, N.3    Carbon, C.4    Farinotti, R.5
  • 55
    • 0030433190 scopus 로고    scopus 로고
    • The secretory intestinal transport of some beta-lactam antibiotics and anionic compound: A mechanism contributing to poor oral absorption
    • SAITOH, H., GERARD, C. & AUNGST, B.J. (1996). The secretory intestinal transport of some beta-lactam antibiotics and anionic compound: A mechanism contributing to poor oral absorption. J. Pharmacol. Exp. Ther., 278, 205-211.
    • (1996) J. Pharmacol. Exp. Ther. , vol.278 , pp. 205-211
    • Saitoh, H.1    Gerard, C.2    Aungst, B.J.3
  • 56
    • 0027419562 scopus 로고
    • Pharmacokinetics of gyrase inhibitors, Part 1: Basic chemistry and gastrointestinal disposition
    • SORGEL, F. & KINZIG, M. (1993a). Pharmacokinetics of gyrase inhibitors, Part 1: Basic chemistry and gastrointestinal disposition. Am. J. Med.,94, 44S-55S.
    • (1993) Am. J. Med. , vol.94
    • Sorgel, F.1    Kinzig, M.2
  • 57
    • 0027414911 scopus 로고
    • Pharmacokinetics of gyrase inhibitors, Part 2: Reral and hepatic elimination pathways and drug interactions
    • SORGEL, F. & KINZIG, M. (1993b). Pharmacokinetics of gyrase inhibitors, Part 2: Reral and hepatic elimination pathways and drug interactions. Am. J. Med., 94, 56S-69S.
    • (1993) Am. J. Med. , vol.94
    • Sorgel, F.1    Kinzig, M.2
  • 58
    • 0024981660 scopus 로고
    • Brief report: Gastrointestinal secretion of ciprofloxacin. Evaluation of the charcoal model for investigations in healthy volunteers
    • SORGEL, F., NABER, K.G., JAEHDE, U., REITTER, A., SEELMAN, R. & SIGL, G. (1989). Brief report: gastrointestinal secretion of ciprofloxacin. Evaluation of the charcoal model for investigations in healthy volunteers. Am. J. Med., 87, 62S-65S.
    • (1989) Am. J. Med. , vol.87
    • Sorgel, F.1    Naber, K.G.2    Jaehde, U.3    Reitter, A.4    Seelman, R.5    Sigl, G.6
  • 59
    • 0026339097 scopus 로고
    • Comparative pharmacokinetics of ciprofloxacin and temafloxacin in humans: A review
    • SORGEL, F., NABER, K.G., KINZIG, M., MAHR, G. & MUTH, P. (1991). Comparative pharmacokinetics of ciprofloxacin and temafloxacin in humans: A review. Am. J. Med., 91, 51S-65S.
    • (1991) Am. J. Med. , vol.91
    • Sorgel, F.1    Naber, K.G.2    Kinzig, M.3    Mahr, G.4    Muth, P.5
  • 60
    • 0028007124 scopus 로고
    • Cellular transport of drugs
    • STEINBURG, T. (1994). Cellular transport of drugs. Clin. Infect. Dis., 19, 916-921.
    • (1994) Clin. Infect. Dis. , vol.19 , pp. 916-921
    • Steinburg, T.1
  • 62
    • 0027487992 scopus 로고
    • +-coupled dipeptide (glycylsarcosine) transport across apical and basal borders of human intestinal Caco-2 cell monolayer display distinctive characteristics
    • +-coupled dipeptide (glycylsarcosine) transport across apical and basal borders of human intestinal Caco-2 cell monolayer display distinctive characteristics. Biochem. Biophys. Acta, 1151, 237-245.
    • (1993) Biochem. Biophys. Acta , vol.1151 , pp. 237-245
    • Thwaites, D.T.1    Brown, C.D.A.2    Hirst, B.H.3    Simmons, N.L.4
  • 66
    • 0017325874 scopus 로고
    • Absorption and secretion of monoquarternary ammonium compounds by the isolated intestinal mucosa
    • TURNHEIM, K. & LAUTERBACH, F. (1977). Absorption and secretion of monoquarternary ammonium compounds by the isolated intestinal mucosa. Biochem. Pharmacol., 26, 99-108.
    • (1977) Biochem. Pharmacol. , vol.26 , pp. 99-108
    • Turnheim, K.1    Lauterbach, F.2
  • 67
    • 0018976653 scopus 로고
    • Interaction between intestinal absorption and secretion of monoquarternary ammonium compounds in guinea pigs - A concept of the absorption kinetics of organic cations
    • TURNHEIM, K. & LAUTERBACH, F. (1980). Interaction between intestinal absorption and secretion of monoquarternary ammonium compounds in guinea pigs - A concept of the absorption kinetics of organic cations. J. Pharmacol. Exp. Ther., 212, 418-424.
    • (1980) J. Pharmacol. Exp. Ther. , vol.212 , pp. 418-424
    • Turnheim, K.1    Lauterbach, F.2
  • 68
    • 0027373329 scopus 로고
    • Bisubstrates: Substances that interact with renal contraluminal organic anion and organic cation transport systems. II. Zwitterionic substrates: dipeptides, cephalosporins, quinolone-carboxylate gyrase inhibitors and phosphamide thiazine carboxylates; Nonionizable substrates: Steroid hormones and cyclophosphamides
    • ULLRICH, K.J., RUMRICH, G., DAVID, C. & FRITZSCH, G. (1993a). Bisubstrates: Substances that interact with renal contraluminal organic anion and organic cation transport systems. II. Zwitterionic substrates: dipeptides, cephalosporins, quinolone-carboxylate gyrase inhibitors and phosphamide thiazine carboxylates; Nonionizable substrates: Steroid hormones and cyclophosphamides. Pflügers Archiv. Eur. J. Physiol., 425, 300-312.
    • (1993) Pflügers Archiv. Eur. J. Physiol. , vol.425 , pp. 300-312
    • Ullrich, K.J.1    Rumrich, G.2    David, C.3    Fritzsch, G.4
  • 69
    • 0027378438 scopus 로고
    • Bisubstrates: Substances that interact with renal contraluminal organic anion and organic cation transport systems. I. Amines, piperidines, piperazines, azepines, pyridine, quinolines, imidazoles, thiazoles, guanidines and hydrazines
    • ULLRICH, K.J., RUMRICH, G., DAVID, C. & FRITZSCH, G. (1993b). Bisubstrates: Substances that interact with renal contraluminal organic anion and organic cation transport systems. I. Amines, piperidines, piperazines, azepines, pyridine, quinolines, imidazoles, thiazoles, guanidines and hydrazines. Pflügers Archiv. Eur. J. Physiol., 425, 280-299.
    • (1993) Pflügers Archiv. Eur. J. Physiol. , vol.425 , pp. 280-299
    • Ullrich, K.J.1    Rumrich, G.2    David, C.3    Fritzsch, G.4
  • 70
    • 0023916963 scopus 로고
    • Contraluminal transport systems in the proximal tubule involved in secretion of organic anions
    • ULLRICH, K.J. & RUMRICH, G. (1988). Contraluminal transport systems in the proximal tubule involved in secretion of organic anions. Am. J. Physiol., 254, F453-F462.
    • (1988) Am. J. Physiol. , vol.254
    • Ullrich, K.J.1    Rumrich, G.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.