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Volumn 73, Issue 6, 2007, Pages 752-759

Functional studies on the activity of efflux transporters in an ex vivo model with chicken splenocytes and evaluation of selected fluoroquinolones in this model

Author keywords

ABC efflux transporters; Chicken lymphocytes; Fluoroquinolones; Rhodamine 123

Indexed keywords

BREAST CANCER RESISTANCE PROTEIN; CIPROFLOXACIN; DANOFLOXACIN; DRUG CARRIER; ELACRIDAR; ENROFLOXACIN; FLUORESCENT DYE; GLYCOPROTEIN P; KO 143; MARBOFLOXACIN; MULTIDRUG RESISTANCE PROTEIN; PROTEIN INHIBITOR; QUINOLINE DERIVED ANTIINFECTIVE AGENT; QUINOLONE DERIVATIVE; RHODAMINE 123; UNCLASSIFIED DRUG; VALSPODAR; VERLUKAST;

EID: 33846877217     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2006.11.015     Document Type: Article
Times cited : (12)

References (55)
  • 1
    • 23744464363 scopus 로고    scopus 로고
    • Expression of the drug transporters MDR1/ABCB1, MRP1/ABCC1, MRP2/ABCC2, BCRP/ABCG2, and PXR in peripheral blood mononuclear cells and their relationship with the expression in intestine and liver
    • Albermann N., Schmitz-Winnenthal H., Zgraggen K., Volk C., Hoffmann M.M., Haefeli W.E., et al. Expression of the drug transporters MDR1/ABCB1, MRP1/ABCC1, MRP2/ABCC2, BCRP/ABCG2, and PXR in peripheral blood mononuclear cells and their relationship with the expression in intestine and liver. Biochem Pharmacol 70 (2005) 949-958
    • (2005) Biochem Pharmacol , vol.70 , pp. 949-958
    • Albermann, N.1    Schmitz-Winnenthal, H.2    Zgraggen, K.3    Volk, C.4    Hoffmann, M.M.5    Haefeli, W.E.6
  • 2
    • 0034821939 scopus 로고    scopus 로고
    • Role of transport proteins in drug absorption, distribution and excretion
    • Ayrton A., and Morgan P. Role of transport proteins in drug absorption, distribution and excretion. Xenobiotica 31 (2001) 469-497
    • (2001) Xenobiotica , vol.31 , pp. 469-497
    • Ayrton, A.1    Morgan, P.2
  • 3
    • 14844295815 scopus 로고    scopus 로고
    • Does inhibition of P-glycoprotein lead to drug-drug interactions?
    • Balayssaca D., Authiera N., Cayreb A., and Coudorea F. Does inhibition of P-glycoprotein lead to drug-drug interactions?. Toxicol Lett 156 (2005) 319-329
    • (2005) Toxicol Lett , vol.156 , pp. 319-329
    • Balayssaca, D.1    Authiera, N.2    Cayreb, A.3    Coudorea, F.4
  • 4
    • 0034844641 scopus 로고    scopus 로고
    • Expression of P-glycoprotein in the chicken
    • Barnes D.M. Expression of P-glycoprotein in the chicken. Comp Biochem Physiol A 130 (2001) 301-310
    • (2001) Comp Biochem Physiol A , vol.130 , pp. 301-310
    • Barnes, D.M.1
  • 5
    • 0343150951 scopus 로고    scopus 로고
    • Rhodamine 123-efflux from hematopoietic subpopulations and leukaemic blast populations marked by PerCP-conjugated monoclonal antibodies
    • Beck J., Gekelert V., Ringgei M., Handgretinger R., and Niethammer D. Rhodamine 123-efflux from hematopoietic subpopulations and leukaemic blast populations marked by PerCP-conjugated monoclonal antibodies. Cancer Lett 99 (1996) 97-207
    • (1996) Cancer Lett , vol.99 , pp. 97-207
    • Beck, J.1    Gekelert, V.2    Ringgei, M.3    Handgretinger, R.4    Niethammer, D.5
  • 7
    • 33646790191 scopus 로고    scopus 로고
    • Differential in vivo sensitivity to inhibition of P-glycoprotein located in lymphocytes, testes, and the blood-brain barrier
    • 10.1124/jpet.105.099648
    • Choo E.F., Kurnik D., Muszkat M., Ohkubo T., Shay S.D., Higginbotham J.N., et al. Differential in vivo sensitivity to inhibition of P-glycoprotein located in lymphocytes, testes, and the blood-brain barrier. J Pharmacol Exp Ther 317 (2006) 1012-1018 10.1124/jpet.105.099648
    • (2006) J Pharmacol Exp Ther , vol.317 , pp. 1012-1018
    • Choo, E.F.1    Kurnik, D.2    Muszkat, M.3    Ohkubo, T.4    Shay, S.D.5    Higginbotham, J.N.6
  • 8
    • 3242686014 scopus 로고    scopus 로고
    • Rapid induction of P-glycoprotein expression by high permeability compounds in colonic cells in vitro: a possible source of transporter mediated drug interactions?
    • Collett A., Tanianis-Hughes J., and Warhurst G. Rapid induction of P-glycoprotein expression by high permeability compounds in colonic cells in vitro: a possible source of transporter mediated drug interactions?. Biochem Pharmacol 68 (2004) 783-790
    • (2004) Biochem Pharmacol , vol.68 , pp. 783-790
    • Collett, A.1    Tanianis-Hughes, J.2    Warhurst, G.3
  • 10
    • 0034687719 scopus 로고    scopus 로고
    • Rhodamine 123 binds to multiple sites in the multidrug resistance protein (MRP1)
    • Daoud R., Kast C., Gros P., and Georges E. Rhodamine 123 binds to multiple sites in the multidrug resistance protein (MRP1). Biochemistry 39 (2000) 15344-15352
    • (2000) Biochemistry , vol.39 , pp. 15344-15352
    • Daoud, R.1    Kast, C.2    Gros, P.3    Georges, E.4
  • 11
    • 0032695270 scopus 로고    scopus 로고
    • Reversal of resistance by GF120918 in cell lines expressing the ABC halftransporter, MXR
    • de Bruin M., Miyake K., Litman T., Robey R., and Bates S.E. Reversal of resistance by GF120918 in cell lines expressing the ABC halftransporter, MXR. Cancer Lett 46 (1999) 117-126
    • (1999) Cancer Lett , vol.46 , pp. 117-126
    • de Bruin, M.1    Miyake, K.2    Litman, T.3    Robey, R.4    Bates, S.E.5
  • 12
    • 33745835398 scopus 로고    scopus 로고
    • Transmembrane transport of endo- and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins
    • Deeley R.G., Westlake C., and Cole S.P.C. Transmembrane transport of endo- and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins. Physiol Rev 86 (2006) 849-899
    • (2006) Physiol Rev , vol.86 , pp. 849-899
    • Deeley, R.G.1    Westlake, C.2    Cole, S.P.C.3
  • 14
    • 0026489452 scopus 로고
    • Subpopulations of normal peripheral blood and bone marrow cells express a functional multidrug resistant phenotype
    • Drach D., Zhao S., Drach J., Mahadevia R., Gattringer C., Huber H., et al. Subpopulations of normal peripheral blood and bone marrow cells express a functional multidrug resistant phenotype. Blood 80 (1992) 2729-2734
    • (1992) Blood , vol.80 , pp. 2729-2734
    • Drach, D.1    Zhao, S.2    Drach, J.3    Mahadevia, R.4    Gattringer, C.5    Huber, H.6
  • 15
    • 0032982612 scopus 로고    scopus 로고
    • Cmdr1, a chicken P-glycoprotein, confers multidrug resistance and interacts with estradiols
    • Edelmann H.M., Duchek P., Rosenthal F.E., Foger N., Glackin C., Kane S.E., et al. Cmdr1, a chicken P-glycoprotein, confers multidrug resistance and interacts with estradiols. Biol Chem 380 (1999) 231-241
    • (1999) Biol Chem , vol.380 , pp. 231-241
    • Edelmann, H.M.1    Duchek, P.2    Rosenthal, F.E.3    Foger, N.4    Glackin, C.5    Kane, S.E.6
  • 16
    • 0033555758 scopus 로고    scopus 로고
    • P-glycoprotein expression on normal and abnormally expanded natural killer cells and inhibition of P-glycoprotein function by cyclosporin A and its analogue, PSC833
    • Egashira M., Kawamata N., Sugimoto K., Kaneko T., and Oshimi K. P-glycoprotein expression on normal and abnormally expanded natural killer cells and inhibition of P-glycoprotein function by cyclosporin A and its analogue, PSC833. Blood 93 (1999) 599-606
    • (1999) Blood , vol.93 , pp. 599-606
    • Egashira, M.1    Kawamata, N.2    Sugimoto, K.3    Kaneko, T.4    Oshimi, K.5
  • 17
    • 0033920539 scopus 로고    scopus 로고
    • Altered development of intestinal intraepithelial lymphocytes in P-glycoprotein-deficient mice
    • Eisenbraun M.D., Mosley R.L., Teitelbaum D.H., and Millera R.A. Altered development of intestinal intraepithelial lymphocytes in P-glycoprotein-deficient mice. Dev Comp Immunol 24 (2000) 783-795
    • (2000) Dev Comp Immunol , vol.24 , pp. 783-795
    • Eisenbraun, M.D.1    Mosley, R.L.2    Teitelbaum, D.H.3    Millera, R.A.4
  • 18
    • 33846857452 scopus 로고    scopus 로고
    • Haritova A, Schrickx J, Fink-Gremmels J. MDR1 and MRP2 mRNA expression in poultry tissues, submitted for publication.
  • 19
    • 17644377916 scopus 로고    scopus 로고
    • Cyclosporine interacts with mycophenolic acid by inhibiting the multidrug resistance-associated protein 2
    • Hesselink D.A., van Hest R.M., Mathot R.A.A., Bonthuis F., Weimar W., de Bruin R.W.F., et al. Cyclosporine interacts with mycophenolic acid by inhibiting the multidrug resistance-associated protein 2. Am J Transplant 5 (2005) 987-994
    • (2005) Am J Transplant , vol.5 , pp. 987-994
    • Hesselink, D.A.1    van Hest, R.M.2    Mathot, R.A.A.3    Bonthuis, F.4    Weimar, W.5    de Bruin, R.W.F.6
  • 20
    • 0032534883 scopus 로고    scopus 로고
    • Reference method for detection of Pgp mediated multidrug resistance in human hematological malignancies: a method validated by the laboratories of the French drug resistance network
    • Huet S., Marie J.-P., Gualde N., and Robert J. Reference method for detection of Pgp mediated multidrug resistance in human hematological malignancies: a method validated by the laboratories of the French drug resistance network. Cytometry 34 (1998) 248-256
    • (1998) Cytometry , vol.34 , pp. 248-256
    • Huet, S.1    Marie, J.-P.2    Gualde, N.3    Robert, J.4
  • 21
    • 21444438059 scopus 로고    scopus 로고
    • Regional difference in P-glycoprotein function in rat intestine
    • Iida A., Tomita M., and Hayashi M. Regional difference in P-glycoprotein function in rat intestine. Drug Metab Pharmacokinet 20 (2005) 100-106
    • (2005) Drug Metab Pharmacokinet , vol.20 , pp. 100-106
    • Iida, A.1    Tomita, M.2    Hayashi, M.3
  • 22
    • 8544227674 scopus 로고    scopus 로고
    • Transport of quinolone antibacterial drugs by human P-glycoprotein expressed in a kidney epithelial cell line, LLC-PK1
    • Ito T., Yano I., Tanaka K., and Inui K.-I. Transport of quinolone antibacterial drugs by human P-glycoprotein expressed in a kidney epithelial cell line, LLC-PK1. J Pharmacol Exp Ther 282 (1997) 955-960
    • (1997) J Pharmacol Exp Ther , vol.282 , pp. 955-960
    • Ito, T.1    Yano, I.2    Tanaka, K.3    Inui, K.-I.4
  • 23
    • 1542707162 scopus 로고    scopus 로고
    • Effects of cyclosporin A treatment on the pathogenesis of avian leukosis virus subgroup J infection in broiler chickens with Marek's disease virus exposure
    • Kim Y., Brown T.P., and Pantin-Jackwood M.J. Effects of cyclosporin A treatment on the pathogenesis of avian leukosis virus subgroup J infection in broiler chickens with Marek's disease virus exposure. J Vet Sci 4 (2003) 245-255
    • (2003) J Vet Sci , vol.4 , pp. 245-255
    • Kim, Y.1    Brown, T.P.2    Pantin-Jackwood, M.J.3
  • 24
    • 0028263913 scopus 로고
    • Biochemical and functional characterization of an avian homolog of the integrin GPIIb-IIIa present on chicken thrombocytes
    • Lacoste-Eleaume A.-S., Bleux C., Quere P., Coudert F., Corbel C., and Kanellopoulos-Langevin C. Biochemical and functional characterization of an avian homolog of the integrin GPIIb-IIIa present on chicken thrombocytes. Exp Cell Res 213 (1994) 198-209
    • (1994) Exp Cell Res , vol.213 , pp. 198-209
    • Lacoste-Eleaume, A.-S.1    Bleux, C.2    Quere, P.3    Coudert, F.4    Corbel, C.5    Kanellopoulos-Langevin, C.6
  • 25
    • 33846868767 scopus 로고    scopus 로고
    • Laffont C. Factors affecting the disposition of ivermectin in the target species. Ph.D. thesis, Utrecht University, Utrecht, The Netherlands; 2002.
  • 26
    • 17544368685 scopus 로고    scopus 로고
    • Multidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense
    • Leslie E.M., Deeley R.G., and Cole S.P.C. Multidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense. Toxicol Appl Pharmacol Membr Transporters Toxicol 204 (2005) 216-237
    • (2005) Toxicol Appl Pharmacol Membr Transporters Toxicol , vol.204 , pp. 216-237
    • Leslie, E.M.1    Deeley, R.G.2    Cole, S.P.C.3
  • 27
    • 0037457793 scopus 로고    scopus 로고
    • Drug-drug interaction mediated by inhibition and induction of P-glycoprotein
    • Lin J.H. Drug-drug interaction mediated by inhibition and induction of P-glycoprotein. Adv Drug Deliv Rev 55 (2003) 53-81
    • (2003) Adv Drug Deliv Rev , vol.55 , pp. 53-81
    • Lin, J.H.1
  • 28
    • 0037057583 scopus 로고    scopus 로고
    • Cyclosporins: structure-activity relationships for the inhibition of the human MDR1 P-glycoprotein ABC transporter
    • Loor F., Tiberghien F., Wenandy T., Didier A., and Traber R. Cyclosporins: structure-activity relationships for the inhibition of the human MDR1 P-glycoprotein ABC transporter. J Med Chem 45 (2002) 4598-4612
    • (2002) J Med Chem , vol.45 , pp. 4598-4612
    • Loor, F.1    Tiberghien, F.2    Wenandy, T.3    Didier, A.4    Traber, R.5
  • 29
    • 0036199337 scopus 로고    scopus 로고
    • Multiple pathways for fluoroquinolone secretion by human intestinal epithelial (Caco-2) cells
    • Lowes S., and Simmons N.L. Multiple pathways for fluoroquinolone secretion by human intestinal epithelial (Caco-2) cells. Br J Pharmacol 135 (2002) 1263-1275
    • (2002) Br J Pharmacol , vol.135 , pp. 1263-1275
    • Lowes, S.1    Simmons, N.L.2
  • 30
    • 0032254285 scopus 로고    scopus 로고
    • Chicken CD4, CD8ab, and CD8aa T Cell co-Receptor molecules
    • Luhtala M. Chicken CD4, CD8ab, and CD8aa T Cell co-Receptor molecules. Poult Sci 77 (1998) 1858-1873
    • (1998) Poult Sci , vol.77 , pp. 1858-1873
    • Luhtala, M.1
  • 32
    • 0030781139 scopus 로고    scopus 로고
    • Full blockade of intestinal P-glycoprotein and extensive inhibition of blood-brain barrier P-glycoprotein by oral treatment of mice with PSC833
    • Mayer U., Wagenaar E., Dorobek B., Beijnen J.H., Borst P., and Schinkel A.H. Full blockade of intestinal P-glycoprotein and extensive inhibition of blood-brain barrier P-glycoprotein by oral treatment of mice with PSC833. J Clin Invest 100 (1997) 2430-2436
    • (1997) J Clin Invest , vol.100 , pp. 2430-2436
    • Mayer, U.1    Wagenaar, E.2    Dorobek, B.3    Beijnen, J.H.4    Borst, P.5    Schinkel, A.H.6
  • 33
    • 0037745009 scopus 로고    scopus 로고
    • Experimental demonstration of the unstirred water layer effect on drug transport in Caco-2 cells
    • Naruhashi K., Tamai I., Li Q., Sai Y., and Tsuji A. Experimental demonstration of the unstirred water layer effect on drug transport in Caco-2 cells. J Pharm Sci 92 (2003) 1502-1508
    • (2003) J Pharm Sci , vol.92 , pp. 1502-1508
    • Naruhashi, K.1    Tamai, I.2    Li, Q.3    Sai, Y.4    Tsuji, A.5
  • 34
    • 0035046689 scopus 로고    scopus 로고
    • A human lymphocyte based ex vivo assay to study the effect of drugs on P-glycoprotein (P-gp) function
    • Parasrampuria D.A., Lantz M.V., and Benet L.Z. A human lymphocyte based ex vivo assay to study the effect of drugs on P-glycoprotein (P-gp) function. Pharm Res 18 (2001) 39-44
    • (2001) Pharm Res , vol.18 , pp. 39-44
    • Parasrampuria, D.A.1    Lantz, M.V.2    Benet, L.Z.3
  • 36
    • 12844255054 scopus 로고    scopus 로고
    • Single amino acid (482) variants of the ABCG2 multidrug transporter: major differences in transport capacity and substrate recognition
    • Özvegy-Laczka C., Kfblfs G., Sarkadi B., and Váradi A. Single amino acid (482) variants of the ABCG2 multidrug transporter: major differences in transport capacity and substrate recognition. Biochim Biophys Acta 1668 (2005) 53-63
    • (2005) Biochim Biophys Acta , vol.1668 , pp. 53-63
    • Özvegy-Laczka, C.1    Kfblfs, G.2    Sarkadi, B.3    Váradi, A.4
  • 37
    • 0021322257 scopus 로고
    • Immunomorphologic characterization of chicken thrombocytes
    • Ries S., Kfiufer U., Reinacher M., and Weiss E. Immunomorphologic characterization of chicken thrombocytes. Cell Tissue Res 236 (1984) 1-3
    • (1984) Cell Tissue Res , vol.236 , pp. 1-3
    • Ries, S.1    Kfiufer, U.2    Reinacher, M.3    Weiss, E.4
  • 38
    • 0030824648 scopus 로고    scopus 로고
    • Carrier-mediated hepatic uptake of quinolone antibiotics in the rat
    • Sasabe H., Terasaki T., Tsuji A., and Sugiyama Y. Carrier-mediated hepatic uptake of quinolone antibiotics in the rat. J Pharmacol Exp Ther 282 (1997) 162-171
    • (1997) J Pharmacol Exp Ther , vol.282 , pp. 162-171
    • Sasabe, H.1    Terasaki, T.2    Tsuji, A.3    Sugiyama, Y.4
  • 39
    • 3342900005 scopus 로고    scopus 로고
    • Differential involvement of multidrug resistance-associated protein 1 and P-glycoprotein in tissue distribution and excretion of grepafloxacin in mice
    • Sasabe H., Kato Y., Suzuki T., Itose M., Miyamoto G., and Sugiyama Y. Differential involvement of multidrug resistance-associated protein 1 and P-glycoprotein in tissue distribution and excretion of grepafloxacin in mice. J Pharmacol Exp Ther 310 (2004) 648-655
    • (2004) J Pharmacol Exp Ther , vol.310 , pp. 648-655
    • Sasabe, H.1    Kato, Y.2    Suzuki, T.3    Itose, M.4    Miyamoto, G.5    Sugiyama, Y.6
  • 40
    • 0037457802 scopus 로고    scopus 로고
    • Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview
    • Schinkel A.H., and Jonker J.W. Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview. Adv Drug Deliv Rev 55 (2003) 3-29
    • (2003) Adv Drug Deliv Rev , vol.55 , pp. 3-29
    • Schinkel, A.H.1    Jonker, J.W.2
  • 41
    • 33846865243 scopus 로고    scopus 로고
    • Schrickx JA, Fink-Gremmels J. Danofloxacin-mesylate is a substrate for ATP-dependent efflux transporters. Br J Pharmacol, in press.
  • 42
    • 16644374851 scopus 로고    scopus 로고
    • Cotransport of macrolide and fluoroquinolones, a beneficial interaction reversing P-glycoprotein efflux
    • Sikri V., Pal D., Jain R., Kalyani D., and Mitra A.K. Cotransport of macrolide and fluoroquinolones, a beneficial interaction reversing P-glycoprotein efflux. Am J Ther 11 (2004) 433-442
    • (2004) Am J Ther , vol.11 , pp. 433-442
    • Sikri, V.1    Pal, D.2    Jain, R.3    Kalyani, D.4    Mitra, A.K.5
  • 43
    • 0036052296 scopus 로고    scopus 로고
    • BCRP gene expression is associated with a poor response to remission induction in therapy in childhood acute myeloid leukemia
    • Steinbach D., Sell W., Voigt A., Hermann J., Zint F., and Sauerbrey A. BCRP gene expression is associated with a poor response to remission induction in therapy in childhood acute myeloid leukemia. Leukemia 16 (2002) 1443-1447
    • (2002) Leukemia , vol.16 , pp. 1443-1447
    • Steinbach, D.1    Sell, W.2    Voigt, A.3    Hermann, J.4    Zint, F.5    Sauerbrey, A.6
  • 44
    • 0031812725 scopus 로고    scopus 로고
    • Differences in rhodamine-123 efflux in B-type chronic lymphocytic leukemia suggest possible gender and stage variations in drug-resistance gene activity
    • Steiner H., Polliack A., Kimchi-Sarfaty C., Libster D., Fibach E., and Rund D. Differences in rhodamine-123 efflux in B-type chronic lymphocytic leukemia suggest possible gender and stage variations in drug-resistance gene activity. Ann Hematol 76 (1998) 189-194
    • (1998) Ann Hematol , vol.76 , pp. 189-194
    • Steiner, H.1    Polliack, A.2    Kimchi-Sarfaty, C.3    Libster, D.4    Fibach, E.5    Rund, D.6
  • 45
    • 9544233652 scopus 로고    scopus 로고
    • A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin resistant human cancer cell lines with decreased drug accumulation
    • Taniguchi K., Wada M., Kohno K., Nakamura T., Kawabe T., Kawakami M., et al. A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin resistant human cancer cell lines with decreased drug accumulation. Cancer Res 56 (1996) 4124-4129
    • (1996) Cancer Res , vol.56 , pp. 4124-4129
    • Taniguchi, K.1    Wada, M.2    Kohno, K.3    Nakamura, T.4    Kawabe, T.5    Kawakami, M.6
  • 47
    • 20744453684 scopus 로고    scopus 로고
    • Clinical relevance of the expression of P-glycoprotein on peripheral blood lymphocytes to steroid resistance in patients with systemic lupus erythematosus
    • Tsujimura S., Saito K., Nakayamada S., Nakano K., and Tanaka Y. Clinical relevance of the expression of P-glycoprotein on peripheral blood lymphocytes to steroid resistance in patients with systemic lupus erythematosus. Arthritis Rheum 52 (2005) 1676-1683
    • (2005) Arthritis Rheum , vol.52 , pp. 1676-1683
    • Tsujimura, S.1    Saito, K.2    Nakayamada, S.3    Nakano, K.4    Tanaka, Y.5
  • 48
    • 0038323939 scopus 로고    scopus 로고
    • Antibiotic efflux pumps in eukaryotic cells: occurrence and impact on antibiotic cellular pharmacokinetics, pharmacodynamics and toxicodynamics
    • Van Bambeke F., Michot J.-M., and Tulkens P.M. Antibiotic efflux pumps in eukaryotic cells: occurrence and impact on antibiotic cellular pharmacokinetics, pharmacodynamics and toxicodynamics. J Antimicrob Chemother 51 (2003) 1067-1077
    • (2003) J Antimicrob Chemother , vol.51 , pp. 1067-1077
    • Van Bambeke, F.1    Michot, J.-M.2    Tulkens, P.M.3
  • 50
    • 0038480045 scopus 로고    scopus 로고
    • Structure-activity relationship: analyses of p-glycoprotein substrates and inhibitors
    • Wang R.B., Kuo C.L., Lien L.L., and Lien E.J. Structure-activity relationship: analyses of p-glycoprotein substrates and inhibitors. J Clin Pharm Ther 28 (2003) 203-228
    • (2003) J Clin Pharm Ther , vol.28 , pp. 203-228
    • Wang, R.B.1    Kuo, C.L.2    Lien, L.L.3    Lien, E.J.4
  • 51
    • 2142640820 scopus 로고    scopus 로고
    • The effect of age on P-glycoprotein expression and function in the Fischer-344 rat
    • Warrington J.S., Greenblatt D.J., and von Moltke L.L. The effect of age on P-glycoprotein expression and function in the Fischer-344 rat. J Pharmacol Exp Ther 309 (2004) 730-736
    • (2004) J Pharmacol Exp Ther , vol.309 , pp. 730-736
    • Warrington, J.S.1    Greenblatt, D.J.2    von Moltke, L.L.3
  • 52
    • 0030000216 scopus 로고    scopus 로고
    • The detection of rhodamine 123 drug efflux at low levels of drug resistance
    • Webb M., Raphael C., Asbahr H., Erber W., and Meyer B. The detection of rhodamine 123 drug efflux at low levels of drug resistance. Br J Haematol 93 (1996) 650-655
    • (1996) Br J Haematol , vol.93 , pp. 650-655
    • Webb, M.1    Raphael, C.2    Asbahr, H.3    Erber, W.4    Meyer, B.5
  • 53
    • 0027175441 scopus 로고
    • Increased function of P-glycoprotein in T lymphocyte subsets of aging mice
    • Witkowski J.M., and Miller R.A. Increased function of P-glycoprotein in T lymphocyte subsets of aging mice. J Immunol 150 (1993) 1296-1306
    • (1993) J Immunol , vol.150 , pp. 1296-1306
    • Witkowski, J.M.1    Miller, R.A.2
  • 54
    • 0035941155 scopus 로고    scopus 로고
    • Transport characteristics of grepafloxacin and levofloxacin in the human intestinal cell line Caco-2
    • Yamaguchi H., Yano I., Saito H., and Inui K. Transport characteristics of grepafloxacin and levofloxacin in the human intestinal cell line Caco-2. Eur J Pharmacol 431 (2001) 297-303
    • (2001) Eur J Pharmacol , vol.431 , pp. 297-303
    • Yamaguchi, H.1    Yano, I.2    Saito, H.3    Inui, K.4
  • 55
    • 0033798408 scopus 로고    scopus 로고
    • Secretory mechanisms of grepafloxacin and levofloxacin in the human intestinal cell line Caco-2
    • Yamaguchi H., Yano I., Hashimoto Y., and Inui K. Secretory mechanisms of grepafloxacin and levofloxacin in the human intestinal cell line Caco-2. J Pharmacol Exp Ther 295 (2000) 360-366
    • (2000) J Pharmacol Exp Ther , vol.295 , pp. 360-366
    • Yamaguchi, H.1    Yano, I.2    Hashimoto, Y.3    Inui, K.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.