Aging and remodeling during healing of the wounded heart: Current therapies and novel drug targets

Current Drug Targets

Volumn 9, Issue 4, 2008, Pages 325-344

  Jugdutt, Bodh I ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Aging; Extracellular matrix; Healing specific proteins; Osteopontin; Secreted protein acidic and rich in cysteine; Secretory leucocyte protease inhibitor; ST segment elevation myocardial infarction; Ventricular remodeling

Indexed keywords

ALISKIREN; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DOXYCYCLINE; ENDOTHELIN A RECEPTOR ANTAGONIST; FIBRINOLYTIC AGENT; GELATINASE A; GELATINASE B; GLITAZONE DERIVATIVE; GRANULOCYTE COLONY STIMULATING FACTOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERSTITIAL COLLAGENASE; MARIMASTAT; MATRIX METALLOPROTEINASE INHIBITOR; MONOCLONAL ANTIBODY; OSTEONECTIN; OSTEOPONTIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; PEXELIXUMAB; PROSTAGLANDIN E2; SECRETORY LEUKOCYTE PROTEINASE INHIBITOR; STEM CELL FACTOR; STROMELYSIN; TELOMERASE; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA INHIBITOR; UNINDEXED DRUG; VALSARTAN;

AGING; ANTIINFLAMMATORY ACTIVITY; CLINICAL TRIAL; COLLAGEN SYNTHESIS; COMBINATION CHEMOTHERAPY; DRUG MEGADOSE; DRUG TARGETING; HEART INFARCTION; HEART INFARCTION SIZE; HEART LEFT VENTRICLE FAILURE; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART PROTECTION; HEART VENTRICLE HYPERTROPHY; HEART VENTRICLE REMODELING; HUMAN; HYPERTENSION; MONOTHERAPY; MORBIDITY; MORTALITY; NONHUMAN; REPERFUSION INJURY; REVIEW; SIDE EFFECT; ST SEGMENT ELEVATION; ST SEGMENT ELEVATION HEART INFARCTION; SURVIVAL RATE; WOUND HEALING; WOUND HEALING IMPAIRMENT; AGED; DRUG DELIVERY SYSTEM; DRUG EFFECT; MIDDLE AGED; PATHOPHYSIOLOGY; PHYSIOLOGY; POLYPHARMACY;

AGED; AGING; DRUG DELIVERY SYSTEMS; HUMANS; MIDDLE AGED; MYOCARDIAL INFARCTION; POLYPHARMACY; SURVIVAL RATE; VENTRICULAR REMODELING;

EID: 42949129182     PISSN: 13894501     EISSN: None     Source Type: Journal    
DOI: 10.2174/138945008783954934     Document Type: Review

References (357)

1. American Heart Association. (2006) Circulation, 113(6), e85-e151.
2. Cheitlin, M.D. and Zipes, D.P. (2001) in Heart Disease (Braunwald, E.; Zipes, D.P.; Libby, P., Eds.), WB Saunders, Philadelphia, pp. 2019-2037.
3. St John Sutton, M.; Pfeffer, M.A.; Moye, L.; Plappert, T.; Rouleau, J.L.; Lamas, G.; Rouleau. J.; Parker, J.O.; Arnold, M.O.; Sussex, B. and Braunwald, E. (1997) Circulation, 96(10), 3294-3299.
4. Maggioni, A.P.; Maseri, A.; Fresco, C.; Franzosi, M.G.; Mauri, F.; Santoro, E. and Tognoni, G. (1993) New Engl. J. Med., 329(20), 1442-1448.
5. National Center for Health Statistics. Health, United States 2005, Hyattsville, MD. www.cdc.gov/nchs/data/hus/hus05.pdf (accessed December 2007).
6. Jugdutt, B.I. (2003) Circulation, 108(11), 1395-1403.
7. Ballard, V.L.T. and Edelberg, J.M. (2007) Circ. Res., 100(8), 1116-1127.
8. Jugdutt, B.I. (1993) Can. J. Cardiol., 9(1), 103-114.
9. Jugdutt, B.I. (1996) Heart Failure Reviews, 1, 115-129.
10. Jugdutt, B.I. (2003) Current Drug Targets, Cardiovasc. Haemat Disorders, 3(1), 1-30.
11. Weber, K.T. (1997) Circulation, 96(11), 4065-4082.
12. Deten, A.; Volz, H.C.; Briest, W. and Zimmer, H.G. (2002) Cardiovasc. Res., 55(2), 329-340.
13. Li, Y.Y.; McTiernan, C.F. and Feldman, A.M. (2000). Cardiovasc. Res., 46(2), 214-224.
14. Lakatta, E.; Gerstenblith, G. and Weisfeldt, M. (1997) in Heart Disease (Braunwald, E., Ed.), WB Saunders, Philadelphia, pp. 1687-1703.
15. Amrani, M.; Goodwin, A.T.; Gray, C.C. and Yacoub, M.H. (1996) Acta. Physiol. Scand., 157(1), 79-84.
16. Taddei, S., Virdis, A.; Ghiadoni, L.; Salvetti, G., Bernini, G.; Magagna, A. and Salvetti, A. (2001) Hypertension, 38(2), 274-9.
17. Komatsumoto, S. and Nara, M. (1995) Nippon Ronen. Igakkai. Zasshi., 32(10), 664-669.
18. Tschudi, M.R. and Luscher, T.F. (1995) Circulation, 91(9), 2415-2422.
19. Basso, N.; Cini, R.; Pietrelli, A.; Ferder, L. Terragno, N.A. and Inserra, F. (2007) Am. J. Physiol, Heart Circ. Physiol., 293(3), H1351-H1358.
20. Ferder, L.F.; Inserra, F. and Basso, N. (2002) Curr. Opin. Pharmacol., 2(2), 189-194.
21. Ishihata, A. and Katano, Y. (2006) Ann. N. Y. Acad. Sci., 1067, 173-181.
22. Van Guilder, G.P.; Westby, C.M.; Greiner, J.J.; Stauffer, B.L. and DeSouza, C.A. (2007) Hypertension, 50(2), 403-409.
23. Csiszar, A.; Ungvari, Z.; Edwards, J.G.; Kaminski, P.; Wolin, M.S. Koller, A. and Kaley, G. (2002) Circ. Res., 90(11), 1159-1166.
24. Donato, A.J.; Eskurza, I.; Silver, A.E., Levy, A.S.; Pierce, G.L.; Gates, P.E. and Seals, D.R. (2007) Circ Res., 100(11), 1659-1666.
25. Csiszar, A.; Ungvari, Z., Koller, A.; Edwards, J.G. and Kaley, G. (2003) FASEB J., 17(9), 1183-5.
26. Yildiz, O. (2007) Ann. N. Y. Acad Sci., 1100, 353-360.
27. Bauer, K.A., Weiss, L.M.; Sparrow, D.; Vokonas, P.S. and Rosenberg, R.D. (1987) Normative Aging Study. J. Clin. Invest., 80(6), 1527-1534.
28. Hager, K.; Setzer, J.; Vogl, T.; Voit, J. and Platt, D. (1989) Arch. Gerontol. Geriatr., 9(3), 277-282.
29. Reed, M.J. and Edelberg, J.M. (2004) Sci. Aging. Knowledge. Environ., 2004(7), pe7.
30. Vasa, M.; Fichtlscherer, S.; Adler, K.; Aicher, A.; Martin, H., Zeiher, A.M. and Dimmeler, S. (2001) Circulation, 103(24), 2885-2890.
31. Scheubel, R.J.; Zorn, H.; Silber, R.E.; Kuss, O.; Morawietz, H., Holtz, J. and Simm, A. (2003) J. Am. Coll. Cardiol., 42(12):2073-2080.
32. Heiss, C.; Keymel, S.; Niesler, U.; Ziemann, J.; Kelm, M. and Kalka, C. (2005) J. Am. Coll. Cardiol., 45(9), 1441-1448.
33. Erusalimsky, J.D. and Kurz, D.J. (2006) Handb. Exp. Pharmacol., 176(Pt 2), 213-48.
34. Ashcroft, G.S.; Horan, M.A. and Ferguson, M.W. (1997) J. Invest. Dermatol., 108(4), 403-407.
35. Murphy, G. and Reynolds, J. (1993) in Connective Tissue and its Heritable Disorders, (Royce, P. and Steinmann, B., Eds.), Wiley-Liss and Sons, New York, pp. 287-316.
36. Bruce, S.A. and Deamond, S.F. (1991) Exp. Gerontol., 26(1), 17-27.
37. Ashcroft, G.S.; Mills, S.J. and Ashworth, J.J. (2002) Biogerontology, 3(6), 337-345.
38. Ashcroft, G.S.; Dodsworth, J.; van Boxtel, E.; Tamuzzer, R.W.; Horan, M.A.; Schultz, G.S. and Ferguson, M.W. (1997) Nat. Med., 3(11), 1209-1215.
39. Chung, H.Y.; Kim, H.J.; Kim, J.W. and Yu, B.P. (2001) Ann. N. Y. Acad. Sci., 928, 327-335.
40. Gould, K.E.; Taffet, G.E.; Michael, L.H.; Christie, R.M.; Konkol, D.L.; Pocius, J.S.; Zachariah, J.P.; Chaupin, D.F., Daniel, S.L.; Sandusky, G.E. Jr; Hartley, C.J. and Entman, M.L. (2002) Am. J. Physiol. Heart Circ. Physiol., 282(2), H615-H621.
41. Yang, X.S., Willems, J.L.; Pardaens, J.and De Geest, H. (1987) Acta Cardiol., 42(1), 59-68.
42. Lesnefsky, E.J.; Lundergan, C.F.; Hodgson, J.M.; Nair, R.; Reiner, J.S.; Greenhouse, S.W.; Califf, R.M.and Ross, A.M. (1996) J. Am. Coll. Cardiol., 28(2), 331-7.
43. White, H.D.; Barbash, G.I.; Califf, R.M.; Simes, R.J. Granger, C.B.; Weaver, W.D.; Kleiman, N.S.; Aylward, P.E.; Gore, J.M.; Vahanian, A.; Lee, K.L.; Ross, A.M. and Topol, E.J. (1996) Circulation. 94(8), 1826-1833.
44. Jugdutt, B.I. and Warnica, J.W. (1988) Circulation, 78(4), 906-919.
45. Jugdutt, B.I. (1990) Clin. Cardiol., 13(1), 28-40.
46. Jugdutt, B.I.; Tang, S.B.; Khan, M.I. and Basualdo, C.A. (1992) J. Am. Coll. Cardiol., 20(3), 722-731.
47. Jugdutt, B.I. and Michorowski, B. (1987) Clin. Cardiol., 10(11), 641-652.
48. Jugdutt, B.I. and Basualdo, C.A. (1989) Can. J. Cardiol., 5(4);211-221.
49. Heymans, S.; Luttun, A.; Nuyens, D.; Theilmeier, G.; Creemers, E.; Moons, L.; Dyspersin, G.D.; Cleutjens, J.P.; Shipley, M., Angellilo, A.; Levi, M.; Nube, O.; Baker, A.; Keshet, E.; Lupu, F.; Herbert, J.M.; Smits, J.F. Shapiro, S.D.; Baes, M.; Borgers, M.; Collen, D.; Daemen. M.J. and Carmeliet, P. (1999) Nat. Med., 5(10), 1135-1142.
50. Sawicki, G.; Menon, V. and Jugdutt, B.I. (2004) J. Cardiac Failure., 10(5), 442-449.
51. Jugdutt, B.I.; Menon, V.; Kumar, D. and Idikio, H. (2002) J. Am. Coll. Cardiol., 39(9), 1538-1545.
52. Frangogiannis, N.G.; Smith, C.W. and Entrnan, M.L. (2002) Cardiovasc. Res., 3(1), 31-47.
53. Jugduff, B.I.; Idikio, H. and Menon, V. (2003) in Proceedings, 5th International Congress Coronary Artery Disease - From Prevention to Intervention, Monduzzi Editore, Bologna, pp. 277-281.
54. Goldberg, R.J.; Gore, J.M.; Gurwitz, J.H.; Alpert, J.S.; Brady, P.; Strohsnitter, W.; Chen, Z.Y. and Dalen, J.E. (1989) Am. Heart J., 117(3), 543-549.
55. Mehta, R.H.; Rathore, S.S.; Radford, M.J.; Wang, Y.; Wang, Y. and Krumholz, H.M. (2001) J. Am. Coll. Cardiol., 38(3), 736-741.
56. Bueno, H.; Martinez-Selles, M., Perez-David, E. and Lopez-Palop, R. (2005) Eur. Heart J., 26(17), 1705-1711.
57. Menon, V.; Webb, J.G.; Hillis, L.D.; Sleeper, L.A.; Abboud, R.; Dzavik, V.; Slater, J.N.; Forman, R.; Monrad, E.S., Talley, J.D. and Hochman, J.S. (2000) J. Am. Coll. Cardiol., 36(3 Suppl A), 1110-1116.
58. Waller, B.F.; Rothbaum, D.A.; Pinkerton, C.A.; Cowley, M.J.; Linnemeier, T.J., Orr, C.; Irons, M.; Helmuth, R.A.; Wills, E.R., and Aust, C. (1987) J. Am. Coll. Cardiol., 9(4), 785-801.
59. Aguirre, F.V.; McMahon, R.P.; Mueller, H.; Kleiman, N.S.; Kern, M.J.; Desvigne-Nickens, P.; Hamilton, W.P.; Chaitman, B.R. (1994) Circulation, 90(1), 78-86.
60. Roberts, W.C. and Shirani, J. (1998) Am. J. Cardiol., 82(5), 627-631.
61. Gurwitz, J.H.; Goldberg, R.J.; Chen, Z.; Gore, J.M.; Alpert, J.S. (1994) Arch. Intern. Med., 154(19), 2202-2208.
62. Rask-Madsen, C.; Jensen, G.; Kober, L.; Melchior, T.; Torp-Pedersen, C.; Hildebrand, P. (1997) Eur Heart J., 18(9), 1426-1431.
63. Tofler, G.H.; Muller, J.E.; Stone, P.H.; Willich, S.N.; Davis, V.G.; Poole, W.K. and Braunwald, E. (1988) Am. J. Cardiol., 62(13), 860-867.
64. Antman, E.M.; Armstrong, P.W.; Green, L.A.; Hand, M.; Hochman, J.S.; Krumholz, H.M.; Kushner, F.G.; Lamas, G.A.; Mullany, C.J.; Ornato, J.P.; Pearle, D.L.; Sloan, M.A.; Smith, S.C., Jr; Alpert, J.S.; Anderson, J.L.; Faxon, D.P.; Fuster, V.; Gibbons, R.J.; Gregoratos, G., Halperin, J.L.; Hiratzka,. L.F.; Hunt, S.A. and Jacobs, A.K. (2004) Circulation, 110(5), 588-636.
65. Anderson, J.L.; Adams, C.D.; Antman, E.M.; Bridges, C.R.; Califf, R.M.; Casey, D.E. Jr.; Chavey, W.E. 2nd.; Fesmire, F.M.; Hochman, J.S.; Levin, T.N.; Lincoff, A.M.; Peterson, E.D.; Theroux, P.; Wenger, N.K.; Wright, R.S.; Smith, S.C. Jr.; Jacobs, A.K.; Adams, C.D.; Anderson, J.L.; Antman, E.M., Halperin, J.L.; Hunt, S.A.; Krumholz, H.M.; Kushner, F.G.; Lytle, B.W.; Nishimura, R.; Ornato, J.P.; Page, R.L. and Riegel, B. (2007) J. Am. Coll. Cardiol., 50(7), 652-726.
66. Alexander, K.P.; Newby, L.K.; Cannon, C.P.; Armstrong, P.W.; Gibler, W.B.; Rich, M.W.; Van de Werf, F.; White, H.D.; Weaver, W.D.; Naylor, M.D.; Gore, J.M.; Krumholz, H.M. and Ohman, E.M.; American Heart Association Council on Clinical Cardiology; Society of Geriatric Cardiology. (2007) Circulation, 115(19), 2549-2569.
67. Alexander, K.P.; Newby, L.K.; Armstrong, P.W.; Cannon, C.P.; Gibler, W.B.; Rich, M.W.; Van de Werf, F.; White, H.D.; Weaver, W.D.; Naylor, M.D.; Gore, J.M., Krumholz, H.M. and Ohman E.M.; American Heart Association Council on Clinical Cardiology; Society of Geriatric Cardiology. (2007) Circulation, 115(19), 2570-2589.
68. Jugdutt, B.I. (1997) Am. J. Physiol., 272(3 Pt 2), H1205-1211.
69. Kloner, R.A.; Ellis, S.G.; Lange, R. and Braunwald, E. (1983) Circulation, 68(2 Pt 2), 18-115.
70. Fliss, H. and Gattinger, D. (1996) Circ. Res., 76(5), 949-956.
71. Cleutjens, J.P.; Kandala, J.C.; Guardal E.; Guntaka, R.V. and Weber, K.T. (1995) J. Mol. Cell Cardiol., 27(6), 1281-1292.
72. Fujiwara, H.; Ashraf, M.; Sato, S. and Millard, K.W. (1982) Circ. Res., 51(6), 683-693.
73. Sato, S.; Ashraf, M.; Millard, R.W.; Fujiwara, H. and Schwartz, A. (1983) J. Mol. Cell Cardiol., 15(4), 261-275.
74. Przyklenk, K. and Kloner, R.A. (1986) Circ. Res., 58(1), 148-156.
75. Zhao, M.J.; Zhang, H.; Robinson, T.F.; Factor, S.M.; Sonnenblick, E.H. and Eng, C. (1987) J. Am. Coll. Cardiol., 10(6), 1322-1334.
76. Takahashi, S.; Barry, A.C. and Factor, S.M. (1990) Collagen degradation in ischaemic rat hearts. Biochem. J., 265(1), 233-241.
77. Charney, R.H.; Takahashi, S.; Zhao, M.; Sonnenblick, E.H. and Eng, C. (1992) Circulation, 85(4), 1483-1490.
78. Danielsen, C.C.; Wiggers, H. and Anderson, H.R. (1998) J. Mol. Cell Cardiol., 30(7), 1431-1442.
79. Murakami, T.; Kusachi, S.; Murakami, M.; Sano, I.; Uesugi, T.; Hirami, R.; Kajiyama, A.; Kondo, J. and Tsuji, T. (1998) Clin. Chem., 44(12), 2453-2461.
80. Connelly, C.M.; Vogel, W.M.; Wiegner, A.W.; Osmers, E.L.; Bing, O.H.; Kloner, R.A.; Dunn-Lanchantin, D.M.; Franzblau, C. and Apstein, C.S. (1985) Circ. Res., 57(4), 562-577.
81. Vinten-Johansen, J. (2004) Cardiovasc. Res., 61(3), 481-497.
82. Boyle, M.P. and Weisman, H.F. (1993) Circulation, 88(6), 2872-2883.
83. Bolognese, L.; Neskovic, A.N.; Parodi, G.; Cerisano, G.; Buonamici, P.; Santoro, G.M. and Antoniucci, D. (2002) Circulation, 106(18), 2351-2357.
84. Lewis, E.F.; Moye, L.A.; Rouleau, J.L.; Sacks, F.M.; Arnold, J.M.; Warnica, J.W.; Flaker, G.C.; Braunwald, E. and Pfeffer, M.A.; CARE Study. (2003) J. Am. Coll. Cardiol., 42(8), 1446-1453.
85. Ndrepepa, G.; Mehilli, J.; Martinoff, S.; Schwaiger, M., Schomig, A. and Kastrati, A. (2007) J. Am. Coll. Cardiol., 50(2), 149-156.
86. Orn, S.; Manhenke, C.; Anand, I.S.; Squire, I.; Nagel, E., Edvardsen, T. and Dickstein, K. (2007) Am. J. Cardiol., 99(8), 1109-1114.
87. Pfeffer, M.A. and Braunwald, E. (1990) Circulation, 81(4), 1161-1172.
88. Kim, C.B. and Braunwald, E. (1993) Circulation, 88(5 Pt 1), 2426-2436.
89. Braunwald, E. and Kloner, R.A. (1982) Circulation, 66(6), 1146-1149.
90. Rogers, W.J.; Bowlby, L.J.; Chandra, N.C.; French, W.J.; Gore, J.M.; Lambrew, C.T.; Rubison, R.M.; Tiefenbrunn, A.J. and Weaver, W.D. (1994) Circulation, 90(4), 2103-2114.
91. Bolli, R. (1990) Circulation, 82(3), 723-738.
92. Jugdutt, B.I. Angiotensin II receptor blockers. (1998) in 1998 Cardiology Clinics Annual of Drug Therapy, (Crawford, M.H., Ed.), W.B. Saunders, Philadelphia, pp. 1-17.
93. Zughaib, M.E.; Sun, J.Z. and Bolli, R. (1993) Basic. Res. Cardiol., 88(Suppl 1), 155-67.
94. Pfeffer, J.M., Pfeffer, M.A. and Braunwald, E. (1985) Circ. Res., 57(1), 84-95.
95. Pfeffer, M.A.; Lamas, G.A.; Vaughan, D.E.; Parisi, A.F. and Braunwald, E. (1988) N. Engl. J. Med., 319(2), 80-86.
96. Sharpe, N.; Murphy, J.; Smith, H. and Hannan, S. (1988) Lancet, 1(8580), 255-259.
97. Pfeffer, M.A.; Braunwald, E.; Moye, L.A.; Basta, L., Brown, E.J. Jr.; Cuddy, T.E.; Davis, B.R., Geltman, E.M.; Goldman, S. and Flaker, G.C. (1992) The SAVE Investigators. N. Engl. J. Med., 327(10), 669-677.
98. St John Sutton, M.; Pfeffer, M.A.; Plappert, T.; Rouleau, J.L.; Moye, L.A.; Dagenais, G.R.; Lamas, G.A.; Klein, M.; Sussex, B. and Goldman, S. The SAVE Investigators. (1994) Circulation, 89(1), 68-75.
99. Gruppo Italiano per to Studio delta Soprav-vivenza nell' Infarcto Miocardico. (1994) Lancet, 343(8906), 1115-1122.
100. ISIS-4 (Fourth International Study of Infarct Survival) Collaborative Group. (1995) Lancet, 345(8951), 669-685.
101. Pfeffer, M.A.; Greaves, S.C.; Arnold, J.M., Glynn, R.J., LaMotte, F.S.; Lee, R.T., Menapace, F.J. Jr.; Rapaport, E.; Ridker, P.M.; Rouleau, J.L.; Solomon, S.D. and Hennekens, C.H. (1997) Circulation, 95(12), 2643-2651.
102. Przyklenk, K. and Kloner, R.A. (1993) Basic Res. Cardiol., 88(Suppl 1), 139-154.
103. Urata, H., Healy, B.; Stewart, R. W.; Bumpus, F.M. and Husain, A. (1990) Circ. Res., 66(4), 883-890.
104. Jugdutt, B.I. and Butler, C. (2007) J. Am. Coll. Cardiol., 49(11), 1175-1177.
105. Jugdutt, B.I. (2005) in Progress in Coronary Artery Disease, Proceedings 6th International Congress on Coronary Artery Disease: From Prevention to Intervention. Monduzzi Editore, Bologna, Italy, pp. 47-51.
106. Schieffer, B.; Wirger, A.; Meybrunn, M.; Seitz, S.; Holtz, J.; Riede, U.N. and Drexler, H. (1994) Circulation, 89(11), 2273-2282.
107. Yoshiyama, M.; Kim, S.; Yamagishi, H.; Omura, T.; Tani, T.; Yanagi, S.; Toda, I.; Teragaki, M.; Akioka, K. and Takeuchi, K. (1994) Am. Heart J., 128(1), 1-6.
108. Kitakaze, M.; Minamino, T.; Node, K.; Komamura, K.; Shinozaki, Y.; Mori, H.; Kosaka, H.; Inoue, M.; Hori, M. and Kamada, T. (1995) Circulation, 92(4), 950-961.
109. Werrmann, J.G. and Cohen, S.M. (1994) J. Cardiovasc. Pharmacol., 24(4), 573-586.
110. Yang, B.C.; Phillips, M.I.; Ambuehl, P.E.; Shen, L.P.; Mehta, P. and Mehta, J.L. (1997) Circulation, 96(3), 922-926.
111. Yang, B.C.; Phillips, M.I.; Zhang, Y.C.; Kimura, B.; Shen, L.P. Mehta, P. and Mehta, J.L. (1998) Circ. Res., 83(5), 552-559.
112. Ford, W.R.; Clanachan, A.S. and Jugdutt, B.I. (1996) Circulation, 94(12), 3087-3089.
113. Ford, W.R.; Clanachan, A.S.; Lopaschuk, G.D.; Schulz, R. and Jugdutt, B.I. (1998) Am. J. Physiol., 274(5 Pt 2), H1524-H1531.
114. Kohya, T.; Yokoshiki, H.; Tohse, N.; Kanno, M., Nakaya, H.; Saito, H. and Kitabatake, A. (1995) Circ. Res., 76(5), 892-899.
115. Wiemer, G.; Scholkens, B.A.; Wagner, A.; Heitsch, H. and Linz, W. (1993) J. Hypertens, 11(5), S234-S235.
116. Thomas, G.P.; Ferrier, G.R. and Howlett, S.E. (1996) J. Pharmacol. Exp. Ther., 278(3), 1090-1097.
117. Ford, W.R., Khan, M.I. and Jugdutt, B.I. (1998) Can. J. Cardiol., 14(1), 73-80.
118. Schwarz, E.R.; Montino, H.; Fleischhauer, J.; Klues, H.G.; vom Dahl, J. and Hanrath, P. (1997) Cardiovasc. Drugs Ther., 11(5), 687-695.
119. Jalowy, A.; Schulz, R.; Dorge, H.; Behrends, M. and Heusch, G. (1998) J. Am. Coll. Cardiol., 32(6), 1787-1796.
120. Liu. Y.H.; Yang, X.P.; Sharov, V.G.; Sigmon, D.H.; Sabbath, H.N. and Carretero, O.A. (1996) Hypertension, 27(1), 7-13.
121. Sladek, T.; Sladkova, J.; Kolar, F.; Papousek, F.; Cicutti, N.; Korecky, B. and Rakusan, K. (1996) Cardiovasc. Res., 31(4), 568-576.
122. Stauss, H.M.; Zhu, Y.C.; Redlich, T.; Adamiak, D.; Mott, A.; Kregel, K.C. and Unger, T. (1994) J. Cardiovasc. Risk, 1(3), 255-262.
123. Liu, Y.; Tsuchida, A.; Cohen, M.V. and Downey, J.M. (1995) J. Mol. Cell Cardiol., 27(3), 883-892.
124. Diaz, R.J. and Wilson, G.J. (1997) J. Mol. Cell Cardiol., 29(1), 129-139.
125. Richard, V.; Ghaleh, B.; Berdeaux, A. and Giudicelli, J-F. (1993) Br. J. Pharmacol., 110(3), 969-974.
126. McDonald, K.M.; Garr, M.; Carlyle, P.F.; Francis, G.S.; Hauer, K.; Hunter, D.W.; Parish, T.; Stillman, A. and Cohn, J.N. (1994) Circulation, 90(6), 3034-3046.
127. Hartman, J.C.; Hullinger, T.G.; Wall, T.M. and Shebuski, R.J. (1993) Eur. J. Pharmacol., 234(2-3), 229-236.
128. Liu, Y.H.; Yang, X.P.; Sharov, V.G.; Nass, O.; Sabbah, H.N.; Peterson, E. and Carretero, O.A. (1997) J. Clin. Invest., 99(8), 1926-1935.
129. Milavetz, J.J.; Raya, T.E.; Johnson, C.S.; Morkin, E. and Goldman, S. (1996) J. Am. Coll. Cardiol., 27(3), 714-719.
130. Richer, C.; Fornes, P.; Cazaubon, C.; Domergue, V.; Nisato, D. and Giudicelli, J.F. (1999) Cardiovasc. Res., 41(8), 100-108.
131. Pitt, B.; Segal, R.; Martinez, F.A.; Meurers, G.; Cowley, A.J.; Thomas, I.; Deedwania, P.C.; Ney, D.E., Snavely, D.B. and Chang, P.I. (1997) Lancet, 349(9054), 747-752.
132. Bastien, N.R.; Juneau, A-V.; Ouellette, J. and Lambert, C. (1999) Cardiovasc. Res., 43(1), 77-85.
133. Yusuf, S. Maggioni, A.P. and Rouleau, J.L. (1997) Circulation, 96 (Suppl I), 1-452.
134. Oparil, S., Guthrie, R.; Lewin, A.J.; Marbury, T.; Reilly, K.; Triscari, J. and Witcher, J.A. (1998) Clin. Ther., 20(3), 399-409.
135. Vanderheyden, P.M.; Fierens, F.L.; De Backer, J.P.; Fraeyman, N. and Vauquelin, G. (1999) Br. J. Pharmacol., 126(4), 1057-65.
136. Inoue, Y.; Nakamura, N. and Inagami, T. (1997) J. Hypertens, 15(7), 703-714.
137. Johnston, C.I. and Risvanis, J. (1997) Am. J. Hypertens, 10(12 Pt 2), 306S-310S.
138. Jugdutt, B.I.; Xu, Y.; Balghith, M.; Moudgil, R. and Menon, V. (2000) J. Cardiovasc. Pharmacol. Therapeut., 5(4), 301-311.
139. Xu, Y.; Menon, V. and Jugdutt, B.I. (2000) J Renin-Angiotensin-Aldosterone Syst., 1(2), 184-195.
140. Sawicki, G. and Jugdutt, B.I. (2004) Proteomics, 4(7), 2195-2202.
141. Sawicki, G. and Jugdutt, B.I. (2007) Proteomics, 42(12), 2100-2110.
142. Jugdutt, B.I.; Idikio, H. and Uwiera, R. (2007) Mol. Cell Biochem., 303(1-2), 27-38.
143. Jugdutt, B.I.; Idikio, H. and Uwiera, R. (2007) Mol. Cell Biochem., 304(1-2), 79-91.
144. Jugdutt, B.I. (2006) J. Vasc. Health Risk Management, 2(2), 125-138.
145. Ferrario, C.M.; Jessup, J.; Chappell, M.C.; Averill, D.B.; Brosnihan, K.B.. Tallant, E.A.; Diz, D.I. and Gallagher, P.E. (2005) Circulation, 111(20), 2605-2610.
146. Peng, H.; Carretero, O.A.; Vuljaj, N.; Liao, T.D.; Motivala, A.; Peterson, E.L. and Rhaleb, N.E. (2005) Circulation, 112(16), 2436-2445.
147. Campbell, D.J.; Krum, H. and Ester, M.D. (2005) Circulation, 111(3), 315-320.
148. Seyedi, N.; Xu, X.; Nasjlett,i A. and Hintze, T.H. (1995) Hypertension, 26(20), 164-170.
149. Jugdutt, B.I. and Balghith, M. (2001) J. Renin Angiotensin Aldosterone Syst., 2(2), 134-140.
150. Ferrario, C.M. and Chappell, M.C. (2004) Cell Mol. Life Sci., 61(21), 2720-2727.
151. Ferrario, C.M.; Trask, A.J. and Jessup, J.A. (2005) Am. J. Physiol., Heart Circ. Physiol., 289(6), H2281-H2290.
152. Igase, M., Strawn, W.B.; Gallagher, P.E., Geary, R.L. and Ferrario, C.M. (2005) Am. J. Physiol., Heart Circ. Physiol., 289(3), H1013-H1019.
153. Benter, I.F.; Yousif, M.H.; Cojocel, C.; Al-Maghrebi, M. and Diz, D.I. (2007) Am. J. Physiol., Heart Circ. Physiol., 292(1), H666-H672.
154. Benter, I.F.; Yousif, M.H.; Anim, J.T.; Cojocel, C. and Diz, D.I. (2006) Am. J. Physiol., Heart Circ. Physiol., 290(2), H684-H691.
155. Yousif, M.H., Kehinde, E.O. and Benter, I.F. (2007) Pharmacol. Res., 56(3), 209-216.
156. Comini, L.; Bachetti, T.; Cargnoni, A.; Bastianon, D.; Gitti, G.L.; Ceconi, C. and Ferrari, R. (2007) Pharmacol. Res., 56(1), 42-48.
157. Yu, C.M.; Tipoe, G.L.; Wing-Hon Lai, K. and Lau, C.P. (2001) J. Am. Coll. Cardiol., 38(4), 1207-1215.
158. Perry, G.J.; Wei, C.C.; Hankes, G.H.; Dillon, S.R., Rynders, P.; Mukherjee, R.; Spinale, F.G. and Dell'Italia, L.J. (2002) J. Am. Coll. Cardiol., 39(8), 1374-1379.
159. Dell'Italia, L.J. Balcells, E.; Meng, Q.C.; Su, X.; Schultz, D. Bishop, S.P.; Machida, N.; Straeter-Knowlen, I.M.; Hankes, G.H.; Dillon, R.; Cartee, R.E. and Oparil, S. (1997) Am. J. Physiol., Heart Circ. Physiol., 273(2 Pt 2), H961-H970.
160. Ryan, T.D.; Rothstein, E.C.; Aban, I.; Tallaj, J.A.; Husain, A.; Lucchesi, P.A. and Dell'Italia, L.J. (2007) J. Am. Coll. Cardiol., 49(7), 811-821.
161. Onishi, K.; Dohi, K.; Koji, T., Funabiki, K.; Kitamura, T.; Imanaka-Yoshida, K.; Ito, M.; Nobori, T. and Nakano, T. (2004) J. Cardiovasc. Pharmacol., 43(6): 860-867.
162. Pinaud, F.; Bocquet, A.; Dumont, O.; Retailleau, K. I Baufreton, C.; Andriantsitohaina, R.; Loufrani, L. and Henrion, D. (2007) Hypertension, 50(1), 96-102.
163. Carey, R.M. (2007) Hypertension, 50(1), 33-34.
164. Strauss, M.H. and Hall, A.S. (2006) Circulation, 114(8), 838-854.
165. Regitz-Zagrosek, V.; Friedel, N., Heymann, A.; Bauer, P.; Neuss, M.; Rolfs, A.; Steffen, C.; Hildebrandt, A.; Hetzer, R. and Fleck, E. (1995) Circulation, 91(5), 1461-1471.
166. Wharton, J.; Morgan, K.; Rutherford, R.A.; Catravas, J.D.; Chester, A.; Whitehead, B.F.; De Leval, M.R.; Yacoub, M.H. and Polak, J.M. (1998) J. Pharmacol. Exp. Ther., 284(1), 323-336.
167. Alfakih, K.; Brown, B.; Lawrance, R.A., Warburton, P.; Maqbool, A.; Walters, K., Samani, N.J.; Ball, S.G.; Balmforth, A.J. and Hall, A.S. (2007) Atherosclerosis. doi:10.1016/j.atheroscierosis.2007.01.028.
168. Savoia, C.; Touyz, R.M., Volpe, M. and Schiffrin, E.L. (2007) Hypertension. 49(2), 341-346.
169. Verdecchia, P.; Angeli, F.; Gattobigio, R. and Reboldi, G.P. (2005) Eur. Heart J., 26(22), 2381-2386.
170. Ichihara, S.; Senbonmatsu, T.; Price, E. Jr.; Ichiki, T., Gaffrey, F.A. and Inagami, T. (2002) Circulation, 106(17), 2244-2249.
171. Senbonmatsu, T.; Ichihara, S.; Price, E. Jr.; Gaffney, F.A. and Inagami, T. (2000) J Clin Invest., 106(3), R25-R29.
172. Nakayama, M.; Yan, X.; Price, R.L.; Borg, T.K.; Ito, K.; Sanbe, A.; Robbins, J. and Lorel, B.H. (2005) Am. J. Physiol., Heart Circ. Physiol., 288(1), H317-H327.
173. Kim, M.P.; Zhou, M. and Wahl, L.M. (2005) J. Leukoc. Biol., 78(1), 195-201.
174. Warnecke, C.; Mugrauer, P.; Surder, D.; Erdmann, J., Schubert, C. and Regitz-Zagrosek, V. (2005) Am. J Physiol., Regul. Integr. Comp. Physiol., 289(6), R1729-R1735.
175. McKelvie, R.S., Yusuf, S.; Pericak, D., Avezum, A.; Burns, R.J.; Probstfield, J.; Tsuyuki, R.T.; White, M.; Rouleau, J.; Latini, R.; Maggioni, A.; Young, J. and Pogue, J. (1999) Circulation, 100(10), 1056-1064.
176. Suzuki, G.; Morita, H.; Mishima, T., Sharov, V.G.; Todor, A.; Tanhehco, E.J.; Rudolph, A.E.; McMahon, E.G.; Goldstein, S. and Sabbah, H.N. (2002) Circulation, 106(23), 2967-2972.
177. Modena, M.G.; Aveta, P.; Menozzi, A. and Rossi, R. (2001) Am. Heart J., 141(1), 41-4.
178. Pitt, B.; Zannad, F.; Remme, W.J.; Cody, R; Castaigne, A., Perez, A.; Palensky, J. and Wittes, J. (1999) N. Engl. J. Med., 341(10), 709-717.
179. Pitt, B.; Remme, W.; Zannad, F.; Neaton, J.; Martinez, F., Roniker, B.; Bittman, R.; Hurley, S.; Kleiman, J. and Gatlin, M.; Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study Investigators. (2003) N. Engl. J. Med., 348(22), 1309-1321.
180. Zannad, F.; Alla, F.; Dousset, B.; Perez, A. and Pitt, B. (2000) Circulation, 102(22), 27002706.
181. Rocha, R., Rudolph, A.E.; Frierdich, G.E.; Nachowiak, D.A.; Kekec, B.K.; Blomme, E.A.; McMahon, E.G. and Delyani, J.A. (2002) Am. J. Physiol., Heart Circ. Physiol., 283(5), H1802-H1810.
182. Rocha, R., Martin-Berger, C.L.; Yang, P.; Scherrer, R.; Delyani, J. and McMahon, E. (2002) Endocrinology, 143(12), 4828-4836.
183. Silvestre, J.S.; Heymes, C.; Oubenaissa, A.; Robert, V.; Aupetit-Faisant, B.; Carayon, A.; Swynghedauw, B. and Delcayre, C. (1999) Circulation, 99(20), 2694-2701.
184. Fraccarollo, D.; Galuppo, P.; Hildemann, S.; Christ M.; Ertl, G. and Bauersachs, J. (2003) J. Am. Coll. Cardiol., 42(9), 1666-1673.
185. Li, D.; Shinagawa, K., Pang, L.; Leung, T.K.; Cardin, S.; Wang, Z. and Nattel. S. (2001) Circulation, 104(21), 2608-2614.
186. Ehrlich, JR.; Hohnloser, S.H. and Nattel, S. (2006) Eur. Heart J., 27(5), 512-518.
187. Kumagai, K.; Nakashima, H.; Urata, H.; Gondo, N.; Arakawa, K. and Saku, K. (2003) J. Am. Coll. Cardiol., 41(12), 2197-2204.
188. Milliez, P.; Deangelis, N.; Rucker-Martin, C., Leenhardt, A.; Vicaut, E.; Robidel, K; Beauffis, P.; Delcayre, C. and Hatem, S.N. (2005) Eur. Heart J., 26(20), 2193-2199.
189. Danser, A.H. (2007) J. Cardiovasc. Pharmacol., 50(2), 105-111.
190. Sepehrdad, R., Frishman, W.H.; Stier, C.T. Jr. and Sica, D.A. (2007) Cardiol., Rev., 15(5), 242-256.
191. van Kats, J,P.; Sassen, L.M.; Danser, A.H.; Polak, M.P.; Soei, L.K. Derkx, F.H.; Schalekamp, M.A. and Verdouw, P.D. (1996) Br. J. Pharmacol., 117(5), 891-901.
192. Oparil, S.; Yarows, S.A.; Patel, S.; Fang, H.; Zhang, J. and Satlin, A. (2007) Lancet, 370(9583), 221-229.
193. Gundersen, T.; Abrahamsen, A.M.; Kjekshus, J. and Ronnevik, P.K. (1982) Circulation, 66(6), 1179-84.
194. The MIAMI Trial Research Group. (1985) Eur. Heart J., 6(3): 199-226.
195. First International Study of Infarct Survival Collaborative Group. (1986) Lancet, 2(8498), 57-66.
196. Hjalmarson, A.; Elmfeldt, D.; Herlitz, J.; Holmberg, S.; Málek, I.; Nyberg, G.; Rydén, L.; Swedberg, K.; Vedin, A.; Waagstein, F.; Waldenstrom, A.; Waldenstrom, J., Wedel, H.; Wilhelmsen, L. and Wilhelmsson, C. (1981) Lancet, 2(8251): 823-827.
197. Wei, S.; Chow, L.T. and Sanderson, J.E. (2000) J. Am. Coll. Cardiol., 36(1), 276-281.
198. Prabhu, S.D., Chandrasekar, B.; Murray, D.R. and Freeman, G.L. (2000) Circulation, 101(17), 2103-2109.
199. Buhler, F.R.; Laragh, J.H.; Baer, L.; Vaughan, E.D. Jr. and Brunner, H.R. (1972) N. Engl. J. Med., 287(24), 1209-1214.
200. Campbell, D.J., Aggarwal, A.; Ester, M. and Kaye, D. (2001) Lancet, 358(9293), 1609-1610.
201. Sharpe, N. (1999) Lancet, 353(9169), 1988-1989.
202. Jugdutt, B.I. (2007) In Procleedings, 13 World Congress on Heart Disease, Monduzzi Editore, Bologna, (In Press).
203. Tiefenbacher, C.P.; Kapitza, J.; Dietz, V.; Lee, C.H. and Niroomand, F. (2003) Am. J. Physiol., Heart Circ. Physiol., 285(1), H59-H64.
204. Bauersachs, J.; Galuppo, P.; Fraccarollo, D.; Christ M. and Ertl, G. (2001) Circulation, 104(9), 982-985.
205. Rosenson, R.S.; Tangney, C.C. and Casey, L.C. (1999) Lancet, 353(9157), 983-984.
206. Hayashidani, S,; Tsutsui, H.; Shiomi, T.; Suematsu, N.; Kinugawa, S.; Ide, T.; Wen, J. and Takeshita, A. (2002) Circulation, 105(7), 868-873.
207. Habibi, J.; Whaley-Connell, A.; Qazi, M.A.; Hayden, M.R.; Cooper, S.A.; Tramontano, A.; Thyfault, J.; Stump, C.; Ferrario, C.; Muniyappa, R. and Sowers, J.R. (2007) Endocrinology, 148(5), 2181-2188.
208. Bulhak, A.; Roy, J.; Hedin, U., Sjoquist, P.O. and Pernow, J. (2007) Am. J. Physiol., Heart Circ. Physiol., 292(6), H3158-H3163.
209. Aronow, W.S.; Frishman, W.H. and Cheng-Lai, A. (2007) Cardiol., Rev., 15(4):195-215.
210. Jugdutt, B.I. (2007) Circulation, 115(3): 288-291.
211. Timmers, L.; Sluijter, J.P., Verlaan, C.W.; Steendijk, P.; Cramer, M.J. Emons, M.; Strijder, C.; Grundeman, P.F.; Sze, S.K.; Hua, L.; Piek:,J.J., Borst C., Pasterkamp, G. and de Kleijn, D.P. (2007) Circulation, 115(3), 326-332.
212. Antman, E.M.; Bennett, J.S.; Daugherty, A.; Furberg, C.; Roberts, H. and Taubert, K.A.; American Heart Association. (2007) Circulation, 115(12), 1634-1642.
213. Jugdutt, B.I. (2007) in Proceedings, 7th International Congress on Coronary Artery Disease: From Prevention to Intervention. Monduzzi Editore, Bologna, pp 345-349.
214. Center on Aging Society. Obesity among older Americans. 2003, 10, 1-6. http://ihcrp.georgetown.edu/agingsociety/pdfs/0besity2.pdf
215. Mensah, G.A. and Brown, D.W. (2007) Health Aff., 26(1), 38-48.
216. Iwasaka, T.; Takahashi, N.; Nakamura, S.; Sugiura, T., Tarumi, N.; Kimura, Y.; Okubo, N.; Taniguchi, H.; Matsui, Y. and Inada, M. (1992) Diabetes Care, 15(11), 1522-1526.
217. Campbell, I.W. (2005) Curr. Mol. Med., 5(3), 349-363.
218. Singh, S.; Loke, Y.K. and Furberg, C.D. (2007) Diabetes Care, 30(8), 2148-2153.
219. Nissen, S.E. and Wolski, K. (2007) N. Engl. J. Med., 356(24), 2457-2471.
220. Lincoff, A.M.; Wolski, K.; Nicholls, S.J. and Nissen, S.E. (2007) JAMA, 298(10), 1180-1188.
221. Shiomi, T.; Tsutsui, H,; Hayashidani, S.; Suematsu, N.; Ikeuchi, M.; Wen, J., Ishibashi, M.; Kubota, T.; Egashira, K. and Takeshita, A. (2002) Circulation, 106(24), 3126-3132.
222. Frantz, S.; Hu, K.; Widder, J.; Bayer, B.; Witzel, C.C., Schmidt, I.; Galuppo, P.; Strotmann, J.; Ertl, G. and Bauersachs, J. (2004) Br. J. Pharmacol., 141(1), 9-14.
223. Lygate, C.A.; Hulbert, K.; Monfared, M.; Cole, M.A., Clarke, K. and Neubauer, S. (2003) Cardiovasc. Res., 58(3), 632-637.
224. Yue, T.L.; Chen, J.; Bao, W.; Narayanan, P.K.; Bril, A.; Jiang, W. Lysko, P.G.; Gu, J.L.; Boyce, R.; Zimmerman, D.M.; Hart, T.K.; Buckingham, R.E. and Ohlstein, E.H. (2001) Circulation, 104(21), 2588-2594.
225. Ye, Y.; Lin, Y.; Atar, S.; Huang, M.H.; Perez-Polo, J.R., Uretsky, B.F. and Birnbaum, Y. (2006) Am. J. Physiol., Heart Circ. Physiol., 291(3), H1158-H1169.
226. Cao, Z.; Ye, P.; Long, C.; Chen, K.; Li, X. and Wang, H. (2007) Pharmacology., 79(3), 184-192.
227. Birnbaum, Y.; Ye, Y.; Lin, Y.; Freeberg, S.Y., Nishi, S.P., Martinez, J.D.; Huang, M.H.; Uretsky, B.F. and Perez-Polo, J.R. (2006) Circulation, 114(9), 929-935.
228. Ricote, M.; Li, A.C.; Willson, T.M.; Kelly, C.S. and Glass, C.K. (1998) Nature, 391(6662), 79-82.
229. Macfarlane, D.P. and Fisher, M. (2006) Am. J Cardiovasc. Drugs, 6(5), 297-304
230. Yanagisawa, M.; Kurihara, H.; Kimura, S.; Tomobe, Y.; Kobayashi, M.; Mitsui, Y.; Yazaki, Y.; Goo, K.and Masaki, T. (1988) Nature, 332(6163), 411415.
231. Dzau, V.J. (1933) Curr. Opin. Nephrol. Hypertens, 2, 27-32.
232. Yorikane, R.; Sakai, S.; Miyauchi, T.; Sakurai, T.; Sugishita, Y.and Goto, K. (1993) FEBS, 332(1-2), 31-34.
233. Ito, H.; Hirata, Y.; Hiroe, M.; Tsujino, M.; Adachi, S.; Takamoto, T.; Nitta, M.; Taniguchi, F. and Marumo, F. (1991) Circ. Res., 69(1), 209-215.
234. Katwa, L.; Gurada, E. and Weber, K. (1993) Cardiovasc. Res., 27(12), 2125-2129.
235. Guarda, E.; Katwa, L.C.; Myers, P.R., Tyagi, S.C. and Weber, K.T. (1993) Cardiovasc. Res., 27(12), 2130-2134.
236. Margulies, K.B.; Hildebrand, F.L. Jr.; Lerman, A.; Perella, M.A. and Burnett, J.C. Jr. (1990) Circulation, 82(6), 2226-2230.
237. Loffler, B.M.; Roux, S.; Kalina, B. Clozel, M. and Clozel, J.P. (1993) J. Mol. Cell Cardiol.,2 5(4), 467-416.
238. Cohn, J.N. (1996) Circulation, 94(4 Suppl), 604-606.
239. Kiowski, W.; Sutsch, G., Hunziker, P.; Muller, P.; Kim, J.; Oechslin, E.; Schmitt, R., Jones, R. and Bertel, O. (1995) Lancet, 346(8977), 732-736.
240. Shimoyama, H.; Sabbab, H.N.; Borzak, S.; Tanimura, M.; Shevylyagin, S.; Scich, G. and Goldstein, S. (1996) Circulation, 94(4),779-784.
241. Modesti, P.A.; Vanni, S.; Paniccia, R. Bandinelli, B.; Bertolozzi, I.; Polidori, G.; Sani, G. and Neri Serneri, G.G. (1999) J. Cardiovasc. Pharmacol., 34(3), 333-339.
242. Ito, H.; Hiroe, M.; Hirata, Y.; Hiroyuki, F.; Susumu, A., Hajime, A.; Yoshiko, O. and Fumiaki, M. (1994) Circulation, 89(5), 2198-2203.
243. Shubeita, H.E.; McDonough, P.M. Harris, A.N.; Knowlton, K.U., Glembotski, C.C., Brown, J.H. and Chien, K.R. (1990) J. Biol. Chem., 265(33), 20555-20562.
244. Opie, L.H.; Commerford, P.J.; Gersh, B.J. and Pfeffer, M.A. (2006) Lancet, 367(9507), 356-367.
245. Kurihara, Y.; Kurihara, H.; Susuki, H.; Kodama, T.; Maemura, K.; Nagai, R.; Oda, H., Kuwaki, T.; Cao, W.H.; Kamada, N.; Jishage, K.; Ouchi, Y.; Azuma, S.; Toyoda, Y.; Ishikawa, T.; Kumada, M. and Yazaki, Y. (1994) Nature, 368(6473), 703-710.
246. Tsuji, S.; Sawamura, A.; Watanabe, H.; Takihara, K.; Park, S.E. and Azuma, J. (1992) Life Sci., 48, 1745-1749.
247. Brunner, F.; du-Toit, E.F. and Opie, L.H. (1992) J. Mol. Cell Cardiol., 24(11), 1291-1305.
248. Velasco, C.E.; Turner, M.; Inagami, T.; Atkinson, J.B.; Virmani, R.; Jackson, E.K.; Murray, J.J. and Forman, M.B. (1994) Am. Heart J., 128(3), 441-451.
249. McMurdo, L.; Sessa, W.C.; Thiemermann, C. and Vane, J.R. (1991) Br. J. Pharmacol., 104, 323P.
250. Neubauer, S.; Zimmermann, S.; Hisch, A.; Pulzer, F.; Tian, R.; Auer, W., Bauer, B. and Ertl, G. (1991) J. Mol. Cell Cardiol., 23(12), 1397-1409.
251. Saito, T.; Fushimi, E.; Abe, T.; Kimura, Y.; Takahashi, K.; Kudo, Y.; Nakagomi, A. and Miura, M. (1992) Jpn. Circ. J., 56(7), 657-670.
252. Zaugg, C.E., Hornstein, P.S.; Zhu, P.; Simper, D.; Lüscher, T.F.; Allegrini, P.R. and Buser, P.T. (1996) Circulation, 94(4), 742-747.
253. Zaugg, C.E.; Zhu, P.; Simper, D.; Lüscher, T.F.; Allegrini, P.R. and Buser, P.T. (1993) J. Cardiovasc. Pharmacol., 22(Suppl. 8), S367-S370.
254. Sakai, S.; Miyauchi, T.; Kobayashi, M.; Yamaguchi, I.; Goto, K. and Sugishita, Y. (1996) Nature, 384(6607):353-355.
255. Podesser, B.K.; Siwik, D.A.; Eberli, F.R.; Sam, F.; Ngoy, S.; Lambert, J.; Ngo, K.; Apstein, C.S. and Colucci, W.S. (2001) Am. J. Physiol., Heart Circ. Physiol., 280(3):H984-H991.
256. Clozel, M.; Qiu, C.; Qiu, C.S.; Hess, P. and Olozel, J.P. (2002) J. Am. Coll. Cardiol., 39(1):142-147.
257. Hu, K.; Gaudron, P.; Schmidt, T.J.; Hoffmann, K.D. and Ertl, G. (1998) J Cardiovasc. Pharmacol., 32(3):505-508.
258. Nguyen, Q.T.; Cernacek, P.; Sirois, M.G.; Calderone, A.; Lapointe, N.; Stewart, D.J. and Rouleau, J.L. (2001) Circulation, 104(17):2075-2081.
259. Fraccarollo, D.; Galuppo, P.; Bauersachs, J. and Ertl, G. (2002) Cardiovasc. Res., 54(3):559-567.
260. Fraccarollo, D.; Bauersachs, J.; Kollner, M.; Galuppo, P. and Ertl, G. (2002) Cardiovasc. Res., 54(1):85-94.
261. Anand, I.; McMurray, J.; Cohn, J.N.; Konstam, M.A.; Notter, T.; Quitzau, K.; Ruschitzka, F. and Luscher, T.F.; EARTH investigators. (2004) Lancet, 364(9431):347-354.
262. Arbab-Zadeh, A.; Dijk, E.; Prasad, A.; Fu, Q.; Torres, P.; Zhang, R.; Thomas, J.D.; Palmer, D. and Levine, B.D. (2004) Circulation, 110(13):1799-805.
263. Dinenno, F.A.; Tanaka,H.; Stauffer, B.L. and Seals, D.R. (2001) J. Physiol., 536(Pt 3):977-983.
264. Imaizumi, T.; Nejima, I.; Kiuchi, K.; Takeda, S.; Seino, Y.; Tanaka, K. and Takano, T. (2007) J. Nippon Med. Sch., 74(2):131-147.
265. Rohde, L.E., Ducharme, A.; Arroyo, L.H.; Aikawa, M.; Sukhova, G.H.; Lopez-Anaya, A., McClure, K.F.; Mitchell, P.G.; Libby, P.; Lee, R.T. (1999) Circulation, 99(23), 3063-3070.
266. Ikonomidis, J.S.; Hendrick, J.W.; Parkhurst, A.M.; Herron, A.R.; Escobar, P.G.; Dowdy, K.B.; Stroud, R.E.; Hapke, E.; Zile, M.R. and Spinale, F.G. (2005) Am. J. Physiol., Heart Circ. Physiol., 288(1), H149-H158.
267. Matsumura, S.; Iwanaga, S.; Mochizuki, S.; Okamoto, H.; Ogawa, S. and Okada, Y. (2005) J. Clin. Invest., 115(3), 599-609.
268. Peterson, J.T.; Hallak, H., Johnson, L.; Li, H.; O'Brien, P.M.; Sliskovic, D.R.; Bocan, T.M.; Coker, M.L.; Etoh, T. and Spinale, F.G. (2001) Circulation, 103(18), 2303-2309.
269. Spinale, F.G.; Coker ML, Krombach SR, Mukherjee R, Hallak H, Houck WV, Clair MJ, Kribbs SB, Johnson LL, Peterson JT, Zile MR. (1999) Circ. Res., 85(4), 364-376.
270. Mukherjee, R.; Brinsa, T.A.; Dowdy, K.B.; Scott, A.A.; Baskin, J.M.; Deschamps, A.M.; Lowry, A.S.; Escobar, G.P.; Lucas, D.G.; Yarbrough, W.M.; Zile, M.R. and Spinale, F.G. (2003) Circulation, 107(4):618-625.
271. Covell, J.W. (1990) Circulation, 81 (suppl III), III-15-III-158.
272. Li, Y.Y.; Feng, Y.; McTiernan, C.F.; Pei, W.; Moravec, C.S.; Wang, P.; Rosenblum, W.; Kormos, R.L. and Feldman, A.M. (2001) Circulation, 104(10), 1147-1152.
273. Ducharme, A.; Frantz, S.; Aikawa, M.; Rabkin, E., Lindsey, M.; Rohde, L.E.; Schoen, F.J.; Kelly, R.A.; Werb, Z.; Libby, P. and Lee, R. T. (2000) J. Clin. Invest., 106(1):55-62.
274. Lindsey, M.L. (2004) Heart Fail. Rev., 9(1), 7-19.
275. Peterson, J.T. (2004) Heart Fail. Rev., 9(1), 63-79.
276. Brown, P.D. (2000) Expert. Opin. Investig. Drugs, 9(9), 2167-2177.
277. Villarreal, F.J.; Griffin, M.; Omens, J.; Dillmann, W, Nguyen, J. and Covell, J. (2003) Circulation, 108(12), 1487-1492.
278. Cheung, P.Y.; Sawicki, G.; Wozniak, M.; Wang, W.; Radomski, M.W. and Schulz, R. (2000) Circulation, 101(15):1833-1839.
279. Lindsey, M.; Wedin, K.; Brown, M.D.; Keller, C.; Evans, A.J.; Smolen, J.; Burns, A.R.; Rossen, R.D.; Michael, L. and Entman, M. (2001) Circulation, 103(17), 2181-2187.
280. Li, Y.Y.; Feldman, A.M. Sun, Y. and McTiernan, C.F. (1998) Circulation, 98(17), 1728-1734.
281. Fedak, P.W.; Altamentova, S.M.; Weisel, R.D.; Nili, N.; Ohno, N.; Verma, S.; Lee, T.Y.; Kiani, C.; Mickle, D.A.; Strauss, B.H. and Li, R.K. (2003) Matrix remodeling in experimental and human heart failure: a possible regulatory role for TIMP-3. Am. J. Physiol. Heart Circ. Physiol., 284 (2): H626-H634.
282. Fedak, P.W.; Smookler, D.S. Kassiri, Z.; Ohno, N. Leco, K.J. Verma, S.; Mickle, D.A.; Watson, K.L.; Hojilla, C.V.; Cruz, W.; Weisel, R.D.; Li, R.K. and Khokha, R. (2004) Circulation, 110(16): 2401-2409.
283. Kaden, J.J.; Dempfle, C.E.; Sueselbeck, T.; Brueckmann, M.; Poerner, T.C.; Haghi, D.; Haase, K.K. and Borggrefe, M. (2003) Cardiology., 99(3), 140-144.
284. Wagner, D.R.; Delagardelle, C.; Ernens, I.; Rouy, D.; Vaillant, M. and Beissel, J. (2006) J. Card. Fail., 12(1), 66-72.
285. Jugdutt, B.I. (2006) J. Card. Fail., 12(1), 73-76.
286. Hudson, M.P., Armstrong, P.W.; Ruzyllo, W.; Brum, J., Cusmano, L. Krzeski, P.; Lyon, R.; Quinones, M.; Theroux, P.; Sydlowski, D.; Kim, H.E.; Garcia, M.J.; Jaber, W.A. and.Weaver, W.D. (2006) J. Am. Coll. Cardiol., 48(1), 15-20.
287. Zhang, Y.; DeWitt, D.L.; McNeely, T.B.; Wahl, S.M. and Wahl, L.M. (1997) J. Clin. Invest., 99(5), 894-900.
288. Ashcroft, G.S.; Lei, K.; Jin, W., Longenecker, G.; Kulkarni, A.B.; Greenwell-Wild, T.; Hale-Donze, H.; McGrady, G. Song, X.Y. and Wahl, S.M. (2000) Nat. Med., 6(10), 1147-1153.
289. Sano, C.; Shimizu, T.; Sato, K.; Kawauchi, H. and Tomioka, H. (2000) Clin. Exp. Immunol., 121(1), 77-85.
290. Thompson, R.C. and Ohlsson, K. (1986) Pro. Natl. Acad. Sci. U. S. A., 83(18), 6692-6696.
291. Stetler, G.; Brewer, M.T. and Thompson, R.C. (1986) Nucleic Acids Res., 14(20), 7883-7896.
292. Denhardt, D.T. and Guo, X. (1993) FASEB J., 7(15), 1475-1482.
293. Singh, K.; Sirokman, G.; Communal, C.; Robinson, K.G., Conrad, C.H.; Brooks, W.W.; Bing, O.H. and Colucci, W.S. (1999) Hypertension, 3(2), 663-670.
294. Giachelli, C.M.; Schwartz, S.M.; Liaw, L. (1995) Trends Cardiovasc. Med., 5(3), 88-95.
295. Singh, K.; Balligand, J.L.; Fischer, T.A.; Smith, T.W. and Kelly, R.A. (1995) J. Biol. Chem., 270(47), 28471-28478.
296. Ashizawa, N.; Graf, K.; Do, Y.S.; Nunohiro, T., Giachelli, C.M.; Meehan, W.P.; Tuan, T.L. and Hsueh. W.A. (1996) J. Clin. Invest. 98(10), 2218-2227.
297. Trueblood, N.A.; Xie, Z.; Communal, C.; Sam, F.; Ngoy, S.; Liaw, L.; Jenkins, A.W.; Wang, J.; Sawyer, D.B.; Bing, O.H., Apstein, C.S.; Colucci, W.S. and Singh, K. (2001) Circ. Res., 88(10), 1080-1087.
298. Liaw, L.; Birk, D.E.; Ballas, C.B., Whitsitt, J.S.; Davidson, J.M. and Hogan, B.L. (1998) J. Clin. Invest., 101(7), 1468-1478.
299. Graf, K.; Do, Y.S.; Ashizawa, N.; Meehan, W.P.; Giachelli, C.M., Marboe, C.C., Fleck, E. and Hsueh, W.A. (1997) Circulation, 96(9), 3063-3071.
300. Lane, T.F. and Sage, E.H. (1994) FASEB J., 8(2), 163-173.
301. Masson, S.; Arosio, B.; Luvara, G.; Gagliano, N.; Fiordaliso, F.; Santambrogio, D.; Vergani, C.; Latini, R. and Annoni, G. (1998) J. Mol. Cell Cardiol., 30(8), 1501-1514.
302. Wu, R.X.; Laser, M.; Han, H.; Varadarajulu, J.; Schuh, K.; Hallhuber, M.; Hu, K.; Ertl, G., Hauck, C.R. and Ritter, O. (2006) J. Mol. Med., 84(3), 241-252.
303. Komatsubara, I.; Murakami, T.; Kusachi, S., Nakamura, K.; Hirohata, S.; Hayashi, J.; Takemoto, S., Suezawa, C., Ninomiya, Y. and Shiratori, Y. (2003) Cardiovasc. Pathol., 12(4), 186-194
304. Stanton, L.W.; Garrard, L.J.; Damm, D.; Garrick, B.L.; Lam, A.; Kapoun, A.M.; Zheng, Q.; Protter, A.A.; Schreiner, G.F. and White, R.T. (2000) Circ. Res., 86(9), 939-945.
305. Reed, M.J.; Puolakkainen, P.; Lane, T.F.; Dickerson, D.; Bornstein, P. and Sage, E.H. (1993) J. Histochem. Cytochem., 41(10), 1467-1477.
306. Chandrasekaran, V.; Ambati, J.; Ambati, B.K. and Taylor, E.W. (2007) J. Mol. Graph. Model., doi:10.1016/j.jmgm.2007.05.001.
307. Charest, A.; Pepin, A.; Shetty, R.; Cote, C.; Voisine, P.; Dagenais, F.; Pibarot, P. and Mathieu, P. (2006) Heart, 92(12), 1844-1849.
308. Rocnik, E.F.; Liu, P.; Sato, K.; Walsh, K. and Vaziri, C. (2006) J. Biol. Chem., 281(32), 22855-22864.
309. Capell, B.C., Collins, F.S. and Nabel, E.G. (2007) Circ. Res., 101(1), 13-26.
310. Orlic, D.; Kajstura, J.; Chimenti, S.; Limana, F.; Jakoniuk, I.; Quaini, F. Nadal-Ginard, B.; Bodine, D.M.; Leri, A. and Anversa, P. (2001) Proc. Natl. Acad. Sci. U. S. A., 98(18), 10344-10349.
311. Minatoguchi, S.; Takemura, G.; Chen, X.H.; Wang, N.; Uno, Y.; Koda, M.; Arai, M.; Misao, Y.; Lu, C., Suzuki, K.; Goto, K.; Komada, A.; Takahashi, T.; Kosai, K.; Fujiwara, T. and Fujiwara, H. (2004). Circulation, 109(21), 2572-2580.
312. Norol, F.; Merlet, P.; Isnard, R.; Sebillon, P.; Bonnet, N.; Cailliot, C.; Carrion, C.; Ribeiro, M., Charlotte, F.; Pradeau, P.; Mayol, J.F.; Peinnequin, A., Drouet, M.; Safsafi, K.;.Vernant, J.P. and Herodin, F. (2003) Blood, 102(13), 4361-4368.
313. Wang, Y.; Tagil, K.; Ripa, R.S.; Nilsson, J.C.; Carstensen, S.; Jorgensen, E.; Sondergaard, L.; Hesse, B.; Johnsen, H.E. and Kastrup, J. (2005) Int. J. Cardiol., 100(3), 477-483.
314. Kuethe, F.; Figulla, H.R.; Herzau, M.; Voth, M.; Fritzenwanger, M.; Opfermann, T.; Pachmann, K.; Krack, A.; Sayer, H.G.; Gottschild, D. and Werner, G. S. (2005) Am. Heart J., 150(1), 115.
315. Ince, H.; Petzsch, M.; Kleine, H.D.; Schmidt H.; Rehders, T.; Korber, T.; Schumichen, C.; Freund, M. and Nienaber, C.A. (2005) Circulation, 112(20), 3097-3106.
316. Zohlnhofer, D.; Ott, I.; Mehilli, J.; Schomig, K.; Michalk, F.; Ibrahim, T.; Meisetschlager, G.; von Wedel, J.; Bollwein, H.; Seyfarth, M.; Dirschinger, J.; Schmitt, C.; Schwaiger, M.; Kastrati, A. and Schomig, A.; REVIVAL-2 Investigators. (2006) JAMA, 295(9), 1003-1010.
317. Lehrke, S.; Mazhari, R.; Durand, D.J.; Zheng, M.; Bedja, D.; Zimmet, J.M.; Schuleri, K.H.; Chi, A.S.; Gabrielson, K.L. and Hare, J.M. (2006) Circ. Res., 99(5), 553-560.
318. Blankesteijn, W.M.; Essers-Janssen, Y.P.; Verluyten, M.J.; Daemen, M.J. and Smits, J.F. (1997) Nat. Med,. 3(5), 541-544.
319. Cleutjens, J.P.; Kandala, J.C.; Guarda, E.; Guntaka, R.V. and Weber, K.T. (1995) J. Mol. Cell Cardiol., 27(6), 1281-1292.
320. Creemers, E.; Cleutjens, J.; Smits, J.; Heymans, S.; Moons, L.; Collen, D.; Daemen, M. and Carmeliet, P. (2000) Am. J. Pathol., 156(6), 1865-1873.
321. Birdsall, H.H.; Green, D.M.; Trial, J.; Youker, K.A.; Burns, A.R.; MacKay, C.R.; LaRosa, G.J.; Hawkins, H.K.; Smith, C.W.; Michael, L.H.; Entman, M.L. and Rossen, R.D. (1997) Circulation, 95(3), 684-692.
322. Ambrosio, G.; Weisman, H.F.; Mannisi, J.A. and Becker, L.C. (1989) Circulation, 80(6), 1846-1861.
323. Dewald, O.; Zymek, P.; Winkelmann, K.; Koerting, A.; Ren, G.; Abou-Khamis, T.; Michael, L.H.; Rollins, B.J.; Entman, M.L. and Frangogiannis, N.G. (2005) Circ. Res., 96(8), 881-889.
324. Frangogiannis, N.G.; Dewald, O.; Xia, Y.; Ken, G.; Haudek, S.; Leucker, T.; Kraemer, D.; Taffet, G.; Rollins, B.J. and Entman, M.L. (2007) Circulation, 115(5), 584-592.
325. Frangogiannis, N.G.; Ren, G.; Dewald, O.; Zymek, P.; Haudek, S.; Koerting, A.; Winkelmann, K.; Michael, L.H.; Lawler, J. and Entman, M.L. (2005) Circulation, 111(22), 2935-2942.
326. Baran, K.W.; Nguyen, M.; McKendall, G.R.; Lambrew, C.T.; Dykstra, G.; Palmeri, S.T.; Gibbons, R.J.; Borzak, S.; Sobel, B. E.; Gourlay, S.G.; Rundle, A.C.; Gibson, C.M. and Barron, H.V.; Limitation of Myocardial Infarction Following Thrombolysis in Acute Myocardial Infarction (LIMIT AMT) Study Group. (2001) Circulation, 104(23), 2778-2783.
327. APEX AMI Investigators, Armstrong, P.W.; Granger, C.B.; Adams, P.X.; Hamm, C.; Holmes, D. Jr.; O'Neill. W.W.; Todaro, T.G.; Vahanian, A. and Van de Werf, F. (2007) JAMA, 297(1), 43-51.
328. Kloner, R.A.; Fishbein, M.C.; Lew, H.; Maroko, P.R. and Braunwald, E. (1978) Circulation, 57(1), 56-63.
329. Li, Y.Y.; Feng, Y.Q.; Kadokami, T.; McTiernan, C.F.; Draviam, R.; Watkins, S.C. and Feldman, A.M. (2000) Proc. Natl. Acad. Sci. U. S. A., 97(23), 12746-12751.
330. Stamm, C.; Frichs, I.; Cowan, D.B.; Moran, A.M.; Cao-Danh, H., Duebener, L.F.; del Nido, P.J. and McGowan, F.X. Jr. (2001) Circulation, 104(12 Suppl 1), I350-I355.
331. Bozkurt, B.; Torre-Amione, G.; Warren, M.S.; Whitmore, J.; Soran, OZ.; Feldman, A.M. and Mann, D.L. (2001) Circulation, 103(8), 1044-1047.
332. Louis, A.; Cleland, J.G.; Crabbe, S.; Ford, S.; Thackray, S.; Houghton, T. and Clark, A. (2001) Eur. J. Heart Fail., 3(3), 381-387.
333. Bujak, M. and Frangogiannis, N.G. (2007) Cardiovasc. Res., 74(2), 184-195.
334. Brooks, W.W. and Conrad, C.H. (2000) J. Mol. Cell Cardiol., 32(2), 187-195.
335. Rosenkranz, S.; Flesch, M.; Amann, K.; Haeuseler, C.; Kilter, H.; Seeland, U. Schluter, K.D. and Bohm, M. (2002) Am. J. Physiol., Heart Circ. Physiol., 283(3), H1253-H1262.
336. Nakajima, H.; Nakajima, H.O.; Salcher, O.; Dittie, A.S.; Dembowsky, K.; Jing, S. and Field, L.J. (2000) Circ. Res., 86(5), 571-579.
337. Blankesteijn, W.M.; van Gijn, M.E., Daemen, M.J.A.P., Wynshaw-Boris, A.; Smits, J.F.M. and Pratt, R.E. (1999) Circulation, 100(Suppl.), 156.
338. Schroen, B.; Heymans, S.; Sharma, U., Blankesteijn, W.M.; Pokharel, S. Cleutjens, J.P.; Porter, J.G.; Evelo, C.T. Duisters, R. van Leeuwen, R.E.; Janssen, B.J.; Debets, J.J.; Smits, J.F.; Daemen, M.J. Crijns, H.J.; Bornstein, P. and Pinto, Y.M. (2004) Circ. Res., 95(5), 515-522.
339. Oudit, G.Y.; Kassiri, Z.; Patel, M.P.; Chappell, M. Butany, J.; Backx, P.H.; Tsushima, R.G.; Scholey, J.W.; Khokha, R. and Penninger, J.M. (2007) Cardiovasc. Res., 75(1), 29-39.
340. Kuba, K.; Zhang, L.; Imai, Y.; Arab, S.; Chen, M.; Maekawa, Y.; Leschnik, M.; Leibbrandt, A.; Makovic, M.; Schwaighofer, J.; Beetz, N.; Musialek, R.; Neely, G.G.; Komnenovic, V.; Kolm, U.; Metzler, B.; Ricci, R.; Hara, H., Meixner, A.; Nghiem, M.; Chen, X.; Dawood, F.; Wong, K.M.; Sarao, R.; Cukerman, E.; Kimura, A.; Hein, L.; Thalhammer, J.; Liu, P.P. and Penninger, J.M. (2007) Circ. Res., 101(4), e32-e42.
341. Frantz, S.; Ducharme, A.; Sawyer, D.; Rohde, L.E.; Kobzik, L.; Fukazawa, R.; Tracey, D.; Allen, H.; Lee, R.T. and Kelly, R.A. (2003) J. Mol. Cell Cardio.,3 5(6), 685-694.
342. Yaoita, H.; Ogawa, K.; Maehara, K. and Maruyama, Y. (1998) Circulation, 97(3), 276-281.
343. Chandrashekhar, Y.; Sen, S.; Anway, R.; Shuros, A. and Anand, I. (2004) J. Am. Coll. Cardiol., 43(2), 295-301.
344. Sam, F.; Sawyer, D.B.; Xie, Z.; Chang, D.L.; Ngoy, S.; Brenner, D.A.; Siwik, D.A.; Singh, K.; Apstein, C.S. and Colucci, W.S. (2001) Circ. Res., 89(4), 351-356.
345. Dotson, V.; Horak, K., Alwardt, C. and Larson, D.F. (2004) J. Extra. Corpor. Technol., 36(2), 197-201.
346. Zymek, P.; Bujak, M.; Chatila, K.; Cieslak, A.; Thakker, G.; Entman, M.L. and Frangogiannis, N.G. (2006) J. Am. Coll. Cardiol., 48(11), 2315-2323.
347. Cai, D.; Xaymardan, M.; Holm, J.M.; Zheng, J.; Kizer, J.R. and Edelberg, J.M. (2003) Am. J. Physiol. Heart Circ. Physiol., 285(2), H463-H469.
348. Oka, T.; Xu, J.; Kaiser, R.A.; Melendez, J.; Hambleton, M.; Sargent, M.A.; Lorts, A.; Brunskill, E.W.; Dorn, G.W. 2nd.; Conway, S.J.; Aronow, B.J.; Robbins, J. and Molkentin, J.D. (2007) Circ. Res., 101(3), 313-321.
349. Kuhn, B.; del Monte, F., Hajjar, R.J.; Chang, Y.S.; Lebeche, D.; Arab, S. and Keating, M.T. (2007) Nat Med., 13(8), 962-969.
350. Xiao, C.Y.; Yuhki, K.; Hara, A.; Fujino, T.; Kuriyama, S.; Yamada, T., Takayama, K.; Takahata, O.; Karibe, H., Taniguchi, T.; Narumiya, S. and Ushikubi, F. (2004) Circulation, 109(20), 2462-2468.
351. Cheng, Y., Wang, M.; Yu, Y., Lawson, J.; Funk, C.D. and Fitzgerald, G.A. (2006) J. Clin. Invest., 116(5), 1391-1399.
352. Jugdutt, B.I. (2005) in, Progress in Coronary Artery Disease, Proceedings 6th International Congress on Coronary Artery Disease: From Prevention to Intervention. Monduzzi Editore, Bologna, Italy, pp. 131-136.
353. Jugdutt, B.I. (1988) Can. J. Physiol., Pharmacol., 66(4), 385-395.
354. Jugdutt, B.I.; Michorowski, B.L. and Kappagoda, T.C. (1988) J. Am. Coll. Cardiol., 12(2), 362-372.
355. Jugdutt, B.I.; Khan, M.I.; Jugdutt, S.J. and Blinston, G.E. (1995) Circulation, 91(3), 802-812.
356. Jugdutt, B.I. and Amy, R.W. (1986) J. Am. Coll. Cardiol., 7(1), 91-102.
357. Jugdutt, B.I.; Joljart, M.J. and Khan, M.I. (1996) Circulation, 94(1), 94-101.