Intronic ANG II type 2 receptor gene polymorphism 1675 G/A modulates receptor protein expression but not mRNA splicing

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 289, Issue 6 58-6, 2005, Pages

  Warnecke, Christina ^a,b   Mugrauer, Peter ^a   Sürder, Daniel ^a   Erdmann, Jeanette ^a,c   Schubert, Carola ^a   Regitz Zagrosek, Vera ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^c UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

Author keywords

Angiotensin II; Gene expression; Single nucleotide polymorphism; Splicing

Indexed keywords

ANGIOTENSIN; ANGIOTENSIN 2 RECEPTOR; MESSENGER RNA; RECEPTOR PROTEIN;

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL TYPE; CODON; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; ENZYME ACTIVITY; GENE CONSTRUCT; GENE EXPRESSION; GENE SEQUENCE; GENETIC POLYMORPHISM; GENETIC TRANSFECTION; GENOTYPE; HEART MUSCLE ISCHEMIA; HEART VENTRICLE HYPERTROPHY; HEMIZYGOSITY; HETEROZYGOTE; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; RAT; RECEPTOR GENE; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VASCULAR SMOOTH MUSCLE;

ANIMALS; CELLS, CULTURED; FEMALE; GENE EXPRESSION REGULATION; HUMANS; INTRONS; MALE; MYOCARDIUM; POLYMORPHISM, GENETIC; RATS; RECEPTOR, ANGIOTENSIN, TYPE 2; RNA SPLICING; RNA, MESSENGER;

EID: 27844468601     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.00385.2005     Document Type: Article

References (46)

1. AbdAlla S, Lother H, Abdel-tawab AM, and Quitterer U. The angiotensin II AT2 receptor is an AT1 receptor antagonist. J Biol Chem 276: 39721-39726, 2001.
2. Akishita M, Iwai M, Wu L, Zhang L, Ouchi Y, Dzau VJ, and Horiuchi M. Inhibitory effect of angiotensin II type 2 receptor on coronary arterial remodeling after aortic banding in mice. Circulation 102: 1684-1689, 2000.
3. Alfakih K, Maqbool A, Sivananthan M, Walters K, Bainbridge G, Ridgway J, Balmforth AJ, and Hall AS. Left ventricle mass index and the common, functional, X-linked angiotensin II type-2 receptor gene polymorphism (-1332 G/A) in patients with systemic hypertension. Hypertension 43: 1189-1194, 2004.
4. Bartunek J, Weinberg EO, Tajima M, Rohrbach S, and Lorell BH. Angiotensin II type 2 receptor blockade amplifies the early signals of cardiac growth response to angiotensin II in hypertrophied hearts. Circulation 99: 22-25, 1999.
5. Blume A, Kaschina E, and Unger T. Angiotensin II type 2 receptors: signalling and pathophysiological role. Curr Opin Nephrol Hypertens 10: 239-246, 2001.
6. Booz GW and Baker KM. Role of type 1 and type 2 angiotensin receptors in angiotensin II-induced cardiomyocyte hypertrophy. Hypertension 28: 635-640, 1996.
7. Cech TR. The generality of self-splicing RNA: relationship to nuclear mRNA splicing. Cell 44: 207-210, 1986.
8. Chamley-Campbell J, Campbell GR, and Ross R. The smooth muscle cell in culture. Physiol Rev 59: 1-61, 1979.
9. Erdmann J, Guse M, Kallisch H, Fleck E, and Regitz-Zagrosek V. Novel intronic polymorphism (+1675G/A) in the human angiotensin II subtype 2 receptor gene. Hum Mutat 15: 487, 2000.
10. Fischer m Hengstenberg C, Holmer S, Regitz-Zagrosek V, Riegger GAJ, Schunkert H, Erdmann J. The human AT2 (+1675G/A) polymorphism influences left ventricular structure in hypertensives males, but not in females (Abstract). 24th European Society of Cardiology Congress (Aug. 15-Sept. 4). Poster P1536, 2002.
11. Gohlke P, Pees C, and Unger T. AT2 receptor stimulation increases aortic cyclic GMP in SHRSP by a kinin-dependent mechanism. Hypertension 31: 349-355, 1998.
12. Green MR. Pre-mRNA splicing. Annu Rev Genet 20: 671-708, 1986.
13. Hamer DH and Leder P. Splicing and the formation of stable RNA. Cell 18: 1299-1302, 1979.
14. Hein L, Barsh GS, Pratt RE, Dzau VJ, and Kobilka BK. Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor in mice. Nature 377: 744-747, 1995.
15. Herrmann SM, Nicaud V, Schmidt-Petersen K, Pfeifer J, Erdmann J, McDonagh T, Dargie HJ, Paul M, and Regitz-Zagrosek V. Angiotensin II type 2 receptor gene polymorphism and cardiovascular phenotypes: the GLAECO and GLAOLD studies. Eur J Heart Fail 4: 707-712, 2002.
16. Hiraoka M, Taniguchi T, Nakai H, Kino M, Okada Y, Tanizawa A, Tsukahara H, Ohshima Y, Muramatsu I, and Mayumi M. No evidence for AT2R gene derangement in human urinary tract anomalies. Kidney Int 59: 1244-1249, 2001.
17. Ichihara S, Senbonmatsu T, Price E Jr, Ichiki T, Gaffney FA, and Inagami T. Targeted deletion of angiotensin II type 2 receptor caused cardiac rupture after acute myocardial infarction. Circulation 106: 2244-2249, 2002.
18. Ichihara S, Senbonmatsu T, Price E Jr, Ichiki T, Gaffney FA, and Inagami T. Angiotensin II type 2 receptor is essential for left ventricular hypertrophy and cardiac fibrosis in chronic angiotensin II-induced hypertension. Circulation 104: 346-351, 2001.
19. Ichiki T, Labosky PA, Shiota C, Okuyama S, Imagawa Y, Fogo A, Niimura F, Ichikawa I, Hogan BL, and Inagami T. Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor. Nature 377: 748-750, 1995.
20. Janiak P, Pillon A, Frost JF, and Vilaine JP. Role of angiotensin subtype 2 receptor in neointima formation after vascular injury. Hypertension 20: 737-745, 1992.
21. Jin XQ, Fukuda N, Su JZ, Lai YM, Suzuki R, Tahira Y, Takagi H, Ikeda Y, Kanmatsuse K, and Miyazaki H. Angiotensin II type 2 receptor gene transfer downregulates angiotensin II type 1a receptor in vascular smooth muscle cells. Hypertension 39: 1021-1027, 2002.
22. Jones A, Dhamrait SS, Payne JR, Hawe E, Li P, Toor IS, Luong L, Wootton PTE, Miller GJ, Humphries SE, and Montgomery HE. Genetic variants of angiotensin II receptors and cardiovascular risk in hypertension. Hypertension 42: 500-506, 2003.
23. Kurisu S, Ozono R, Oshima T, Kambe M, Ishida T, Sugino H, Matsuura H, Chayama K, Teranishi Y, Iba O, Amano K, and Matsubara H. Cardiac angiotensin II type 2 receptor activates the kinin/NO system and inhibits fibrosis. Hypertension 41: 99-107, 2003.
24. Kuznetsova T, Staessen JA, Thijs L, Kunath C, Olszanecka A, Ryabikov A, Tikhonoff V, Stolarz K, Bianchi G, Casiglia E, Fagard R, Brand-Herrmann SM, Kawecka-Jaszcz K, Malyutina S, Nikitin Y, and Brand E. Left ventricular mass in relation to genetic variation in angiotensin II receptors, renin system genes, and sodium excretion. Circulation 110: 2644-2650, 2004.
25. Lévy BI. Can angiotensin II type 2 receptors have deleterious effects in cardiovascular disease?; Implications for therapeutic blockade of the rennin-angiotensin system. Circulation 109: 8-13, 2004.
26. Martin MM and Elton TS. The sequence and genomic organization of the human type 2 angiotensin II receptor. Biochem Biophys Res Commun 209: 554-562, 1995.
27. Masaki H, Kurihara T, Yamaki A, Inomata N, Nozawa Y, Mori Y, Murasawa S, Kizima K, Maruyama K, Horiuchi M, Dzau VJ, Takahashi H, Iwasaka T, Inada M, and Matsubara H. Cardiac-specific overexpression of angiotensin II AT2 receptor causes attenuated response to AT1 receptor-mediated presser and chronotropic effects. J Clin Invest 101: 527-535, 1998.
28. Nakajima M, Hutchinson HG, Fujinaga M, Hayashida W, Morishita R, Zhang L, Horiuchi M, Pratt RE, and Dzau VJ. The angiotensin II type 2 (AT2) receptor antagonizes the growth effects of the AT1 receptor: gain-of-function study using gene transfer. Proc Natl Acad Sci USA 92: 10663-10667, 1995.
29. Nishimura H, Yerkes E, Hohenfellner K, Miyazaki Y, Ma J, Hunley TE, Yoshida H, Ichiki T, Threadgill D, Phillips JA, 3rd Hogan BM, Fogo A, Brock JW 3rd, Inagami T, and Ichikawa I. Role of the angiotensin type 2 receptor gene in congenital anomalies of the kidney and urinary tract, CAKUT, of mice and men. Mol Cell 3: 1-10, 1999.
30. Nouet S and Nahmias C. Signal transduction from the angiotensin II AT2 receptor. Trends Endocrinol Metab 11: 1-6, 2000.
31. Ohkubo N, Matsubara H, Nozawa Y, Mori Y, Murasawa S, Kijima K, Maruyama K, Masaki H, Tsutumi Y, Shibazaki Y, Iwasaka T, and Inada M. Angiotensin type 2 receptors are reexpressed by cardiac fibroblasts from failing myopathic hamster hearts and inhibit cell growth and fibrillar collagen metabolism. Circulation 96: 3954-3962, 1997.
32. Oishi Y, Ozono R, Yano Y, Teranishi Y, Akishita M, Horiuchi M, Oshima T, and Kambe M.' Cardioprotective role of AT2 receptor in postinfarction left ventricular remodeling. Hypertension 41: 814-818, 2003.
33. Ruskin B, Greene JM, and Green MR. Cryptic branch point activation allows accurate in vitro splicing of human beta-globin intron mutants. Cell 41: 833-844, 1985.
34. Saavedra JM, Armando I, Terron JA, Falcon-Neri A, Johren O, Hauser W, and Inagami T. Increased AT(1) receptors in adrenal gland of AT(2) receptor gene-disrupted mice. Regul Pept 102: 41-47, 2001.
35. Saavedra JM, Hauser W, Ciuffo G, Egidy G, Hoe KL, Johren O, Sembonmatsu T, Inagami T, and Armando I. Increased AT(I) receptor expression and mRNA in kidney glomeruli of AT(2) receptor gene-disrupted mice. Am J Physiol Renal Physiol 280: F71-F78, 2001.
36. Schmieder RE, Erdmann J, Delies C, Jacobi J, Fleck E, Hilgers K, and Regitz-Zagrosek V. Effect of the angiotensin II type 2-receptor gene (+1675 G/A) on left ventricular structure in humans. J Am Coll Cardiol 37: 175-182, 2001.
37. Senbonmatsu T, Ichihara S, Price E Jr, Gaffney FA, and Inagami T. Evidence for angiotensin II type 2 receptor-mediated cardiac myocyte enlargement during in vivo pressure overload. J Clin Invest 106: R25-R29, 2000.
38. Siragy HM, Inagami T, Ichiki T, and Carey RM. Sustained hypersen-sitivity to angiotensin II and its mechanism in mice lacking the subtype-2 (AT2) angiotensin receptor. Proc Natl Acad Sci USA 96: 6506-6510, 1999.
39. Stoll M, Steckelings UM, Paul M, Bottari SP, Metzger R, and Unger T. The angiotensin AT2-receptor mediates inhibition of cell proliferation in coronary endothelial cells. J Clin Invest 95: 651-657, 1995.
40. Tsutsumi Y, Matsubara H, Masaki H, Kurihara H, Murasawa S, Takai S, Miyazaki M, Nozawa Y, Ozono R, Nakagawa K, Miwa T, Kawada N, Mori Y, Shibasaki Y, Tanaka Y, Fujiyama S, Koyama Y, Fujiyama A, Takahashi H, and Iwasaka T. Angiotensin II type 2 receptor overexpression activates the vascular kinin system and causes vasodilation. J Clin Invest 104: 925-935, 1999.
41. Tsutsumi Y, Matsubara H, Ohkubo N, Mori Y, Nozawa Y, Murasawa S, Kijima K, Maruyama K, Masaki H, Moriguchi Y, Shibasaki Y, Kamihata H, Inada M, and Iwasaka T. Angiotensin II type 2 receptor is upregulated in human heart with interstitial fibrosis, and cardiac fibroblasts are the major cell type for its expression. Circ Res 83: 1035-1046, 1998.
42. Warnecke C, Kaup D, Marienfeld U, Poller W, Yankah C, Grafe M, Fleck E, and Regitz-Zagrosek V. Adenovirus-mediated overexpression and stimulation of the human angiotensin Il type 2 receptor in porcine cardiac fibroblasts does not modulate proliferation, collagen I mRNA expression and ERK1/ERK2 activity, but inhibits protein tyrosine phosphatases. J Mol Med 79: 510-521, 2001.
43. Warnecke C, Surder D, Curth R, Fleck E, and and Regitz-Zagrosek V. Analysis and functional characterization of alternatively spliced angiotensin II type 1 and 2 receptor transcripts in the human heart. J Mol Med 77: 718-727, 1999.
44. Warnecke C, Willich T, Holzmeister J, Bottari SP, Fleck E, and Regitz-Zagrosek V. Efficient transcription of the human angiotensin II type 2 receptor gene requires intronic sequence elements. Biochem J 340: 17-24, 1999.
45. Wharton J, Morgan K, Rutherford RA, Catravas JD, Chester A, Whitehead BF, De Leval MR, Yacoub MH, and Polak JM. Differential distribution of angiotensin AT2 receptors in the normal and failing human heart. J Pharmacol Exp Ther 284: 323-336, 1998.
46. Yang Z, Bove CM, French BA, Epstein FH, Berr SS, DiMaria JM, Gibson JJ, Carey RM, and Kramer CM. Angiotensin II type 2 receptor overexpression preserves left ventricular function after myocardial infarction. Circulation 106: 106-111, 2002.