Ageing and wound healing

Biogerontology

Volumn 3, Issue 6, 2002, Pages 337-345

  Ashcroft, Gillian S ^a   Mills, Stuart J ^a   Ashworth, Jason J ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

collagen; fibroblast; inflammation; skin; wound

Indexed keywords

AGING; ANGIOGENESIS; EXTRACELLULAR MATRIX; HUMAN; INFLAMMATION; PHYSIOLOGY; REVIEW; WOUND HEALING;

AGING; EXTRACELLULAR MATRIX; HUMANS; INFLAMMATION; NEOVASCULARIZATION, PHYSIOLOGIC; WOUND HEALING;

EID: 0041343131     PISSN: 13895729     EISSN: 15736768     Source Type: Journal    
DOI: 10.1023/A:1021399228395     Document Type: Review

References (79)

1. Aimes RT and Quigley JP (1995) Matrix metalloprotease 2 is an interstitial collagenase. J Biol Chem 270: 5872-5876 DOI: 10.1074/jbc.270.11.5872
2. Albini A, Pontz B, Pulz M, Allavena G, Mensing H and Muller PK (1988) decline of fibroblast chemotaxis with the age of donor and cell passage number. Coll Relat Res 8: 23-37
3. Arbogast BW, Berry DL and Newell CL (1984) Injury of arterial endothelial cells in diabetic, sucrose-fed and aged rats. Atherosclerosis 51: 31-45 DOI: 10.1016/0021-9150(84)90142-4
4. Ashcroft GS, Horan MA and Ferguson MWJ (1997a) The effects of ageing on wound healing: immunolocalisation of growth factors and their receptors in a murine incisional model. J Anat 190: 351-365 DOI: 10.1046/j.1469-7580.1997.19030351.x
5. Ashcroft GS, Horan MA and Ferguson MWJ (1997b) Ageing is associated with reduced deposition of specific extracellular matrix components, an up-regulation of angiogenesis, and an altered inflammatory response in a murine incisional wound healing model. J Invest Derm 108: 430-437 DOI: 10.1111/1523-1747.ep12289705
6. Ashcroft GS, Kielty CM, Horan MA and Ferguson MWJ (1997c) Age-related changes in the temporal and spatial distributions of fibrillin and elastin mRNAs and proteins in acute cutaneous wounds of healthy humans. J Pathol 183: 80-89 DOI: 10.1002/(SICI)1096-9896(199709)183:1<80::AID-PATH1104>3.0.CO;2-N
7. Ashcroft GS, Herrick SE, Tarnuzzer RW, Horan MA, Schultz GS and Ferguson MWJ (1997d) Age-related changes in the differ344 ential regulation of tissue inhibitor of matrix metalloproteinases (TIMP)-1 and-2 protein and mRNA in acute healing wounds of healthy humans. J Pathol 183: 169-176 DOI: 10.1002/(SICI)1096-9896(199710)183:2<169::AID-PATH915>3.0.CO;2-Q
8. Ashcroft GS, Horan MA, Herrick SE, Tarnuzzer RW, Schultz GS and Ferguson MWJ (1997e) Age-related differences in the temporal and spatial regulation of matrix metalloproteinases (MMPs) in normal skin and acute cutaneous wounds of healthy humans. Cell Tiss Res 290: 581-591 DOI: 10.1007/s004410050963
9. Ashcroft GS, Dodsworth J, Boxtel E, Tarnuzzer R, Horan MA, Schultz GS and Ferguson MWJ (1997f) Estrogen accelerates cutaneous wound healing associated with an increase in TGF-?1 levels. Nat Med 3: 11, 1209-1215 DOI: 10.1038/nm1197-1209
10. Ashcroft GS, Horan MA and Ferguson MWJ (1998) Ageing alters the inflammatory and endothelial cell adhesion molecule profiles during human cutaneous wound healing. Lab Invest 78: 47-58
11. Ashcroft GS, Yang X, Glick AB, Weinstein M, Letterio JJ, Mizel DE, Anzano M, Greenwell-Wild T, Wahl SM, Deng C and Roberts AB (1999a) Mice lacking smad3 show accelerated wound healing and an impaired local inflammatory response. Nat Cell Biol 1: 260-266 DOI: 10.1038/12971
12. Ashcroft GS, Greenwell-Wild T, Horan MA, Wahl SM and Ferguson MWJ (1999b) Topical estrogen accelerates cutaneous wound healing in aged humans associated with an altered inflammatory response. Am J Pathol 155: 1137-1146
13. Ashcroft GS, Lei K, Jin W, Greenwell-Wild T, Longenecker G, McGrady S, Song X-Y and Wahl SM (2000) Secretory leukocyte protease inhibitor (SLPI) mediates non-redundant functions necessary for normal wound healing. Nat Med 1147-1153
14. Ballas CB and Davidson JM (2001) Delayed wound healing in aged rats is associated with increased collagen gel remodeling and contraction by skin fibroblasts, not with differences in apoptotic or myofibroblast cell populations. Wound Repair Reg 9: 223-237 DOI: 10.1046/j.1524-475x.2001.00223.x
15. Barrandon Y and Green H (1987) Cell migration is essential for sustained growth of keratinocyte colonies: the roles of transforming growth factor alpha and epidermal growth factor. Cell 50: 1131-1135 DOI: 10.1016/0092-8674(87)90179-6
16. Bauer EA, Silverman N, Busier DF, Kronberger A and Deuel TF (1986) Diminshed response of Werner's syndrome fibroblasts to growth factors PDGF and FGF. Science 234: 1240-1243
17. Beck LS, Deguzman L, Lee WP, Xu Y, Siegal MW and Amento EP (1993) one systemic administration of transforming growth factor-b1 reverses age-or glucocorticoid-impaired wound healing. J Clin Invest 92: 2841-2849 DOI: 10.1172/JCI116904
18. Bruce SA and Deamond SF (1991) Longitudinal study of in vivo wound repair and in vitro cellular senescence of dermal fibroblasts. Exp Gerontol 26: 17-27 DOI: 10.1016/0531-5565(91)90058-T
19. Bullen EC, Longaker M, Updike D, Benton R, Ladin D, Hou Z and Howard EW (1995) Tissue inhibitor of metalloproteinases-1 is decreased and activated gelatinases are increased in chronic wounds. J Invest Derm 104: 236-240 DOI: 10.1111/1523-1747.ep12612786
20. Butcher EO and Klingsberg J (1963) Age, gonadectomy and wound healing in palatal mucosa of the rat. Oral Surg 16: 482-492 DOI: 10.1016/0030-4220(63)90178-6
21. Butcher S, Chahal H, Nayak L, Sinclair A, Henriquez N, Sapey E, O'Mahony D and Lord J (2001) Senescence in innate immune responses: reduced neutrophil phagocytic capacity and CD16 expression in elderly humans. J Leuk Biol 6: 881-886
22. Chung HY, Kim HJ, Km JW and Yu B (2001) The inflammation hypothesis of aging: molecular modulation by calorie restriction. Ann NY Acad Sci 928: 327-335 DOI: 10.1111/j.1749-6632.2001.tb05662.x
23. Cohen BJ (1987) Accelerated wound repair in old deer mice (peromyscus maniculatus) and white-footed mice (peromyscus leucopus). J Gerontol 42: 302-307
24. Cohen BJ, Danon D and Roth GS (1987) Wound repair in mice as influenced by age and antimacrophage serum. J Gerontol 42: 295-301
25. Compton CC (1993) Wound healing potential of cultured epithelium. Wounds Compend Skin Res Pract 5: 97-111
26. Danon D, Kowatch MA and Roth G (1989) Promotion of wound repair in old mice by local injection of macrophages. PNAS (USA) 86: 2018-2020 DOI: 10.1073/pnas.86.6.2018
27. Ershler WB, Gamelli RL, Moore AL, Hacker MP and Blow AJ (1984) Experimental tumours and aging: local factors that may account for the observed age advantage in the b16 murine melanoma model. Exp Gerontol 19: 367-376 DOI: 10.1016/0531-5565(84)90046-9
28. Fagiolo U, Cossarizza A, Santacaterina S, Ortolani C, Monti D, Paganelli R and Franceschi C (1992) Aging and cellular defence mechanisms. Ann NY Acad Sci 663: 490-493
29. Fenske NA and Lober CW(1986) Structural and functional changes of normal aging skin. J Am Acad Derm 15: 571-585 DOI: 10.1016/S0190-9622(86)70208-9
30. Gibson JM, Milam SB and Klebe RJ (1989) Late passage cells display an increase in contractile behaviour. Mech Aging Dev 48: 101-110 DOI: 10.1016/0047-6374(89)90042-0
31. Gonzalez-Suarez E, Samper E, Ramirez A, Flores JM, Martin-Caballero J, Jorcano JL and Blasco MA (2001) Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mtert, in basal keratinocytes. EMBO J 20: 2619-2630 DOI: 10.1093/emboj/20.11.2619
32. Halasz NA (1968) Dehiscence of laparotomy wounds. Am J Surg 116: 210-214 DOI: 10.1016/0002-9610(68)90495-9
33. Hebda PA (1998) Stimulatory effects of transforming growth factorbeta and epidermal growth factor on epidermal cell outgrowth from porcine skin explant cultures. J Invest Derm 91: 440-445 DOI: 10.1111/1523-1747.ep12476480
34. Herrick S, Ashcroft GS, Ireland G, Horan M, McCollum C and Ferguson M (1996) Up-regulation of elastase in acute wounds of healthy aged humans and chronic venous leg ulcers is associated with matrix degradation. Lab Invest 77: 281-288
35. Holm-Pederson P and Zederfeldt B (1971) Strength development of skin incisions in young and old rats. Scand J Plast Rec Surg 5: 7-12
36. Holt DR, Kirk SJ, Regan MC, Hurson M, Lindblad WJ and Barbul A (1992) Effect of age on wound healing in healthy human beings. Surgery 112: 293-298
37. Iiyama M, Shimada Y, Kita T and Ito H (1992) Effect of aging on macrophage adherence to extracellular matrix proteins. Mech Aging Dev 66: 149-158 DOI: 10.1016/0047-6374(92)90132-W
38. Katsuda S, Okada Y, Okada Y, Imai K and Nakanishi I (1994) matrix metalloproteinase-9 can degrade arterial elastin. Am J Pathol 145: 1208-1218
39. Khorramizadeh MR, Tredget EE, Telasky C, Shen Q and Ghahary A (1999) Aging differentially modulates the expression of collagen and collagenase in dermal fibroblasts. Mol Cell Biochem 194: 99-108 DOI: 10.1023/A:1006909021352
40. Kondo H, Nomaguchi TA and Yonezawa Y (1989) Effects of serum from human subjects of different ages on migration in vitro of human fibroblasts. Mech Aging Dev 47: 25-37 DOI: 10.1016/0047-6374(89)90004-3
41. Kramer R, Fuh G, Bensch KG and Karasek M (1985) Synthesis of extracellular matrix glycoproteins by cultured microvascular endothelial cells isolated from the dermis of neonatal and adult skin. J Cell Physiol 123: 1-9 DOI: 10.1002/jcp.1041230102
42. Kurban RS and Bhavan J (1990) Histologic changes in skin associated with aging. J Derm Surg Oncol 16: 908-914
43. Kurkinen M, Vaheri A, Roberts P and Stenman S (1980) Sequential appearance of fibronectin and collagen in experimental granulation tissue. Lab Invest 43: 47-51
44. Lipschitz DA and Udupa K (1986) Influence of aging and protein deficiency on neutrophil function. J Gerontol 4: 690-694
45. Lombard N and Masse R (1987) Effect of in vivo ageing on the growth of rat fibroblasts in cells from cutaneous explants. Royal Soc Sci Biol 181: 267-273
46. McCartney-Francis N and Wahl SM (2001) TGF-beta and macrophages in the rise and fall of inflammation. In: Breit SN and Wahl SM (eds) TGF-beta and Related Cytokines in Inflammation, pp. 65-90. Birkhauser, Basel
47. Maier JA, Voulalas P, Roeder D and Maciag T (1990) Extension of the life-span of human endothelial cells by an interleukin-1 alpha antisense oligomer. Science 249: 1570-1574
48. Matrisian LM, Davis D and Magun BE (1987) Internalization and processing of epidermal growth factor in aging human fibroblasts in culture. Exp Gerontol 22: 81-89 DOI: 10.1016/0531-5565(87)90043-X
49. Mendez MV, Raffetto J, Phillips T, Menzoian J and Park H (1999) The proliferative capacity of neonatal skin fibroblasts is reduced after exposure to venous ulcer wound fluid: a potential mechanism for senescence in venous ulcers. J Vasc Surg 30: 734-743 DOI: 10.1016/S0741-5214(99)70113-8
50. Mogford J, Tawil N, Chen A, Gies D, Xia Y and Mustoe TA (2002) Effect of age and hypoxia on TGF beta1 receptor expression and signal transduction in human dermal fibroblasts: impact on cell migration. J Cell Physiol 190: 259-265 DOI: 10.1002/jcp.10060
51. Montagna W and Carlisle K (1990) Structural changes in ageing skin. Br J Derm 122: 61-70
52. Muggleton-Harris A, Reisert PS and Burghoff RL (1982) In vitro characterisation of the response to a stimulus (wounding) with regard to ageing in human skin fibroblasts. Mech Aging Dev 19: 37-43 DOI: 10.1016/0047-6374(82)90048-3
53. Peacocke M, Yaar M and Gilchrest BA (1989) Interferon and the epidermis: implications for cellular senescence. Exp Gerontol 24: 415-421 DOI: 10.1016/0531-5565(89)90048-X
54. Pienta KJ and Coffey DS (1990) characterisation of the subtypes of cell motility in ageing human skin fibroblasts. Mech Aging Dev 56: 99-105 DOI: 10.1016/0047-6374(90)90001-V
55. Pieraggi MJ, Bouissou H, Angelier C, Uhart D, Magnol J and Kokolo J (1985) Le fibroblaste. Ann Path 5: 65-76
56. Quirinia A and Viidik A (1991) The influence of age on the healing of normal and ischaemic incisional skin wounds. Mech Aging Dev 58: 221-232 DOI: 10.1016/0047-6374(91)90094-G
57. Raffetto J, Mendez M, Phillips T, Park H and Menzoian J (1999) The effect of passage number on fibroblast cellular senescence in patients with chronic venous insufficiency with and without ulcer. Am J Surg 178: 107-112 DOI: 10.1016/S0002-9610(99)00134-8
58. Rattan SIS and Derventzi A (1991) Altered cellular responsiveness during ageing. Bioessays 13: 601-606 DOI: 10.1002/bies.950131111
59. Reed MJ, Vernon RB, Abrass I and Sage EH (1994) TGF-beta 1 induces the expression of type I collagen and SPARC, and enhances contraction of collagen gels, by fibroblasts from young and aged donors. J Cell Physiol 158: 169-179 DOI: 10.1002/jcp.1041580121
60. Reed MJ, Ferara NS and Vernon RB (2001) Impaired migration, integrin function, and actin cytoskeletal organization in dermal fibroblasts from a subset of aged human donors. Mech Ageing Dev 122: 1203-1220 DOI: 10.1016/S0047-6374(01)00260-3
61. Reenstra W, Yaar M and Gilchrest BA (1993) effect of donor age on epidermal growth factor processing in man. Exp Cell Res 209: 118-122 DOI: 10.1006/excr.1993.1291
62. Richard S, Querleux B, Bittoun J, Jolivet OO, Idy-peretti I, Lacharriere O and Leveque J (1993) Characterisation of the skin in vivo by high resolution magnetic resonance imaging: water behaviour and age-related effects. J Invest Derm 100: 705-709 DOI: 10.1111/1523-1747.ep12472356
63. Rudolph K, Chang S, Lee H, Blasco M, Gottlieb G, Greider C and Depinho RA (1999) Longevity, stress response, and cancer in aging telomerase-deficient mice. Cell 96: 701-712 DOI: 10.1016/S0092-8674(00)80580-2
64. Sandblom P, Peterson P and Muren A (1953) Determination of the tensile strength of the healing wound as a clinical test. Acta Chir Scand 105: 252-257
65. Shevitz J, Jenkins C and Hatcher V (1986) Fibronectin synthesis and degradation in human fibroblasts with aging. Mech Aging Dev 35: 221-232 DOI: 10.1016/0047-6374(86)90125-9
66. Shimada Y, Ito H, Kaji K and Fukuda M (1990) Tumour necrosis factor reduces lifespan of human endothelial cells in vitro. Mech Aging Dev 55: 245-254 DOI: 10.1016/0047-6374(90)90152-6
67. Shiraha H, Gupta K, Drabik K and Wells A (2000) Aging fibroblasts present reduced epidermal growth factor (EGF) responsiveness due to preferential loss of EGF receptors. J Biol Chem 275: 19343-19351 DOI: 10.1074/jbc.M000008200
68. Silverman EM and Silverman AG (1977) Granulocyte adherence in the elderly. Am J Clin Path 67: 49-52
69. Stanulis-Praeger BM and Gilchrest BA (1986) Growth factor responsiveness declines during adulthood for human skinderived cells. Mech Aging Dev 35: 185-198 DOI: 10.1016/0047-6374(86)90009-6
70. Swift ME, Burns AL, Gray G and Dipietro LA (2001) Age-related alterations in the inflammatory response to dermal injury. J Invest Derm 117: 1027-1035 DOI: 10.1046/j.0022-202x.2001.01539.x
71. Takeda K, Gosiewska A and Peterkofsky B (1992) Similar, but not identical, modulation of expression of extracellular matrix components during in vitro and in vivo aging of human skin fibroblasts. J Cell Physiol 153: 450-459 DOI: 10.1002/jcp.1041530303
72. Vande Berg J, Rudolph R, Hollan C and Haywood-Reid P (1998) Fibroblast senescence in pressure ulcers. Wound Repair Regen 6: 38-49 DOI: 10.1046/j.1524-475X.1998.60107.x
73. Vitellaro-Zuccarello L, Cappelletti S, Dal Pozzo Rossi V and Sari-Gorla M (1994) Stereological analysis of collagen and elastic fibers in the normal human dermis: variability with age, sex, and body region. Anat Rec 238: 153-162 DOI: 10.1002/ar.1092380202
74. Wahl SM, Hunt DA, Wakefield L, McCartney-Francis N, Wahl LM, Roberts AB and Sporn MB (1987) Transforming growth factor type beta induces monocyte chemotaxis and growth factor production. PNAS (USA) 84: 5788-5792 DOI: 10.1073/pnas.84.16.5788
75. Werner S, Breeden M, Hubner G, Greenhalgh DG and Longaker M (1994) Induction of keratinocyte growth factor expression is reduced and delayed during wound healing in the genetically diabetic mouse. J Invest Derm 103: 469-473 DOI: 10.1111/1523-1747.ep12395564
76. Wysocki A, Staiano-Coico L and Grinnell F (1993) wound fluid from chronic leg ulcers contains elevated levels of metalloproteinases MMP-2 and MMP-9. J Invest Derm 101: 64-68 DOI: 10.1111/1523-1747.ep12359590
77. Xia YP, Zhao Y, Tyrone JW, Chen A and Mustoe TA (2001) Differential activation of migration by hypoxia in keratinocytes isolated from donors of increasing age: implication for chronic wounds in the elderly. J Invest Derm 116: 50-56 DOI: 10.1046/j.1523-1747.2001.00209.x
78. Yamaura H and Matsuzawa T (1980) Decrease in capillary growth during aging. Exp Gerontol 15: 145-150 DOI: 10.1016/0531-5565(80)90086-8
79. Yonezawa Y, Kondo H and Nomaguchi TA (1989) Age-related changes in serotonin content and its release reaction of rat platelets. Mech Aging Dev 47: 65-75 DOI: 10.1016/0047-6374(89)90008-0