Aza-peptidyl Michael acceptors. A new class of potent and selective inhibitors of asparaginyl endopeptidases (legumains) from evolutionarily diverse pathogens

Journal of Medicinal Chemistry

Volumn 51, Issue 9, 2008, Pages 2816-2832

  Götz, Marion G ^a,d   James, Karen Ellis ^a   Hansell, Elizabeth ^b   Dvořák, Jan ^b   Seshaadri, Amritha ^b   Sojka, Daniel ^b,c   Kopáček, Petr ^c   McKerrow, James H ^b   Caffrey, Conor R ^b   Powers, James C ^a  

^a GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c INSTITUTE OF PARASITOLOGY   (Czech Republic)

^d WHITMAN COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE; APC 3316; AZA PEPTIDE MICHAEL ACCEPTOR; CRA 3316; FUMARIC ACID; HOMOPHENYL ALANINE VINYL SULFONE; K 11777; LEGUMAIN; RUPRINTIVIR;

ARTICLE; DRUG SYNTHESIS; EVOLUTION; IC 50; IXODES RICINUS; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PHYLOGENY; SCHISTOSOMA MANSONI; STRUCTURE ACTIVITY RELATION; TOPOGRAPHY; TRICHOMONAS VAGINALIS;

ANIMALS; AZA COMPOUNDS; BIOTIN; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; DITHIOTHREITOL; INHIBITORY CONCENTRATION 50; IXODES; OLIGOPEPTIDES; SCHISTOSOMA MANSONI; STRUCTURE-ACTIVITY RELATIONSHIP; SULFHYDRYL COMPOUNDS; TRICHOMONAS VAGINALIS;

EID: 42949122012     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm701311r     Document Type: Article

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