Structure-based design of a parallel synthetic array directed toward the discovery of irreversible inhibitors of human rhinovirus 3C protease

Journal of Medicinal Chemistry

Volumn 45, Issue 10, 2002, Pages 2016-2023

  Johnson, Theodore O ^a   Hua, Ye ^a   Luu, Hiep T ^a   Brown, Edward L ^a   Chan, Fora ^b   Chu, Shao Song ^a   Dragovich, Peter S ^a   Eastman, Brian W ^c   Ferre, Rose Ann ^a   Fuhrman, Shella A ^a   Hendrickson, Thomas F ^d   Maldonado, Fausto C ^a   Matthews, David A ^a   Meador III, James W ^a   Patick, Amy K ^a   Reich, Siegfried H ^a   Skalitzky, Donald J ^a   Worland, Stephen T ^e   Yang, Michelle ^a   Zalman, Leora S ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^b Quorex Pharmaceuticals   (United States)

^c MERCK RESEARCH LABORATORIES   (United States)

^d SCHRÖDINGER INC   (United States)

^e F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEINASE INHIBITOR;

ARTICLE; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INACTIVATION; ENZYME INHIBITION; HELA CELL; HUMAN; HUMAN CELL; NONHUMAN; RHINOVIRUS; VIRUS INACTIVATION;

ANTIVIRAL AGENTS; COMBINATORIAL CHEMISTRY TECHNIQUES; CRYSTALLOGRAPHY, X-RAY; CYSTEINE ENDOPEPTIDASES; ENZYME INHIBITORS; HELA CELLS; HUMANS; PROTEIN BINDING; RHINOVIRUS; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL PROTEINS;

EID: 0037046546     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010435c     Document Type: Article

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