Exploring the S4 and S1 prime subsite specificities in caspase-3 with aza-peptide epoxide inhibitors

Biochemistry

Volumn 45, Issue 30, 2006, Pages 9059-9067

  Ganesan, Rajkumar ^a   Jelakovic, Stjepan ^a   Campbell, Amy J ^b   Li, Zhao Zhao ^b   Asgian, Juliana L ^b   Powers, James C ^b   Grütter, Markus G ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CATALYSIS; CATALYSTS; CRYSTAL STRUCTURE; HYDROGEN BONDS; POLYPEPTIDES;

AZA-PEPTIDE EPOXIDE; CASPASE-3-AZA-PEPTIDE EPOXIDE; CATALYTIC HISTIDINE; NUCLEOPHILIC ATTACK;

PROTEINS;

ANION; ASPARTIC ACID; CASPASE 3; CASPASE INHIBITOR; CYSTEINE; CYSTEINE PROTEINASE; EPOXIDE; HISTIDINE; ISOLEUCINE;

ALKYLATION; AMINO TERMINAL SEQUENCE; APOPTOSIS; ARTICLE; BETA CHAIN; BINDING AFFINITY; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; HUMAN; HYDROGEN BOND; NONHUMAN; PRIORITY JOURNAL; PROTON TRANSPORT; RING OPENING;

AZA COMPOUNDS; BINDING SITES; CASPASE 3; CASPASES; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; EPOXY COMPOUNDS; HUMANS; OLIGOPEPTIDES; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY;

EID: 33746646754     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi060364p     Document Type: Article

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