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0342266905
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Agouron Pharmaceuticals, Inc. WO 9957135
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Dragovich, P.S., Marakovits, J.T., Prins, T.J., Tikhe, J.G., Webber, S.E., Zhou, R., Johnson, T.O. (Agouron Pharmaceuticals, Inc.). Antipicornaviral cpds., their preparation and use. WO 9957135.
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Antipicornaviral cpds., Their Preparation and Use
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Dragovich, P.S.1
Marakovits, J.T.2
Prins, T.J.3
Tikhe, J.G.4
Webber, S.E.5
Zhou, R.6
Johnson, T.O.7
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2
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0033535579
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Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3c protease inhibitors. 3. Structure-activity studies of ketomethylene-containing peptidomimetics
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Dragovich, P.S., Prins, T.J., Zhou, R., Fuhrman, S.A., Patick, A.K., Matthews, D.A., Ford, C.E., Meador, J.W. III, Ferre, R.A., Worland, S.T. Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 3. Structure-activity studies of ketomethylene-containing peptidomimetics. J Med Chem 1999, 42: 1203-12.
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Dragovich, P.S.1
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Zhou, R.3
Fuhrman, S.A.4
Patick, A.K.5
Matthews, D.A.6
Ford, C.E.7
Meador J.W. III8
Ferre, R.A.9
Worland, S.T.10
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3
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0033535596
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Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 4. Incorporation of P1 lactam moieties as L-glutamine replacements
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Dragovich, P.S., Prins, T.J., Zhou, R. et al. Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 4. Incorporation of P1 lactam moieties as L-glutamine replacements. J Med Chem 1999, 42: 1213-24.
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Dragovich, P.S.1
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A comparative test of fifteen compounds against all known human rhinovirus serotypes as a basis fora more rational screening program
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Design of rhinovirus protease inhibitors for treatment of common cold
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in preparation
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Wang, Q.M. Design of rhinovirus protease inhibitors for treatment of common cold. Drugs Fut 2000, 25: in preparation.
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Wang, Q.M.1
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8
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0342266904
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Structure-based design of irreversible peptidyl and peptidomimetic human rhinovirus 3C protease inhibitors
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(March 21-25, Anaheim) Abst MEDI 264
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Dragovich, P.S., Webber, S.E., Fuhrman, S.A. et al. Structure-based design of irreversible peptidyl and peptidomimetic human rhinovirus 3C protease inhibitors. 217th ACS Natl Meet (March 21-25, Anaheim) 1999, Abst MEDI 264.
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217th ACS Natl Meet
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Dragovich, P.S.1
Webber, S.E.2
Fuhrman, S.A.3
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9
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13044300859
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Structure-assisted design of mechanism-based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypes
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Matthews, D.A., Dragovich, P.S., Webber, S.E. et al. Structure-assisted design of mechanism-based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypes. Proc Natl Acad Sci USA 1999, 96: 11000-7.
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(1999)
Proc Natl Acad Sci USA
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Matthews, D.A.1
Dragovich, P.S.2
Webber, S.E.3
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10
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0032870120
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In vitro antiviral activity of AG7088, a potent inhibitor of human rhinovirus 3C protease
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Patick, A.K., Binford, S.L., Brothers, M.A. et al. In vitro antiviral activity of AG7088, a potent inhibitor of human rhinovirus 3C protease. Antimicrob Agents Chemother 1999, 43: 2444-50.
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Antimicrob Agents Chemother
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Patick, A.K.1
Binford, S.L.2
Brothers, M.A.3
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11
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0343136320
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Comparative in vitro antirhinoviral activity of AG7088 and pleconaril
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(Sept 26-29, San Francisco) Abst H276
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Kaiser, L., Crump, C., Patick, A.K., Zalman, L.S., Hayden, F.G. Comparative in vitro antirhinoviral activity of AG7088 and pleconaril. 39th Intersci Conf Antimicrob Agents Chemother (Sept 26-29, San Francisco) 1999, Abst H276.
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(1999)
39th Intersci Conf Antimicrob Agents Chemother
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Kaiser, L.1
Crump, C.2
Patick, A.K.3
Zalman, L.S.4
Hayden, F.G.5
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12
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0342266903
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Novel anti-human rhinovirus compounds directed at 3C protease can inhibit cytokine production in infected cells
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(Sept 24-27, San Diego) Abst H-62
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Zalman, L.S., Brothers, M.A., Dragovich, P.S., Prins, T.J., Marakovits, J.T., Zhou, R., Tikhe, J., Webber, S.E., Worland, S.T., Patick, A.K. Novel anti-human rhinovirus compounds directed at 3C protease can inhibit cytokine production in infected cells. 38th Intersci Conf Antimicrob Agents Chemother (Sept 24-27, San Diego) 1998, Abst H-62.
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(1998)
38th Intersci Conf Antimicrob Agents Chemother
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Zalman, L.S.1
Brothers, M.A.2
Dragovich, P.S.3
Prins, T.J.4
Marakovits, J.T.5
Zhou, R.6
Tikhe, J.7
Webber, S.E.8
Worland, S.T.9
Patick, A.K.10
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13
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0007047183
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Phase I evaluation of the safety and pharmacokinetics of intranasal AG7088, a novel investigational 3C protease inhibitor
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(Sept 26-29, San Francisco) Abst H275
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Pithavala, Y.K., Hsyu, P.H., Gersten, M., Crampton, S., Penning, C.A., Daniels, R.G., Zhang, K., Paradiso, L., Kerr, B.M. Phase I evaluation of the safety and pharmacokinetics of intranasal AG7088, a novel investigational 3C protease inhibitor. 39th Intersci Conf Antimicrob Agents Chemother (Sept 26-29, San Francisco) 1999, Abst H275.
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(1999)
39th Intersci Conf Antimicrob Agents Chemother
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Pithavala, Y.K.1
Hsyu, P.H.2
Gersten, M.3
Crampton, S.4
Penning, C.A.5
Daniels, R.G.6
Zhang, K.7
Paradiso, L.8
Kerr, B.M.9
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14
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0342266901
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Nasal disposition of AG7088, a rhinovirus 3C protease inhibitor, after multiple intranasal doses in healthy volunteers
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(Nov 14-18, New Orleans) Abst 3636
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Hsyu, P., Pithavala, Y., Gersten, M., Crampton, S., Zhang, K., Paradiso, L., Buonarati, M. Nasal disposition of AG7088, a rhinovirus 3C protease inhibitor, after multiple intranasal doses in healthy volunteers. Annu Meet Am Assoc Pharm Sci (Nov 14-18, New Orleans) 1999, Abst 3636.
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(1999)
Annu Meet Am Assoc Pharm Sci
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Hsyu, P.1
Pithavala, Y.2
Gersten, M.3
Crampton, S.4
Zhang, K.5
Paradiso, L.6
Buonarati, M.7
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16
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0342702033
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Evaluation of the antiviral activity of irreversible inhibitors of human rhinovirus 3C protease, a novel target for antiviral intervention
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(Sept 24-27, San Diego) Abst H-61
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Patick, A.K., Ford, C.E., Brothers, M.A. et al. Evaluation of the antiviral activity of irreversible inhibitors of human rhinovirus 3C protease, a novel target for antiviral intervention. 38th Intersci Conf Antimicrob Agents Chemother (Sept 24-27, San Diego) 1998, Abst H-61.
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(1998)
38th Intersci Conf Antimicrob Agents Chemother
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Patick, A.K.1
Ford, C.E.2
Brothers, M.A.3
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17
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0342266562
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Agouron Pharmaceuticals, Inc. Company Communication Nov 23
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AG-7088 development status. Agouron Pharmaceuticals, Inc. Company Communication Nov 23, 1999.
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(1999)
AG-7088 Development Status
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