Identification of human asparaginyl endopeptidase (legumain) as an inhibitor of osteoclast formation and bone resorption

Journal of Biological Chemistry

Volumn 274, Issue 39, 1999, Pages 27747-27753

  Choi, Sun Jin ^a   Reddy, Sakamuri V ^a   Devlin, Rowena D ^a   Menaa, Cheikh ^a   Chung, Hoyeon ^a   Boyce, Brendan F ^a   Roodman, G David ^a,b  

^a Univ of Texas Health Science Center ^*  (United States)

^b SOUTH TEXAS VETERANS HEALTH CARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEINASE;

ANIMAL TISSUE; ARTICLE; BONE MARROW CULTURE; CONTROLLED STUDY; CULTURE MEDIUM; ENZYME ANALYSIS; ENZYME LOCALIZATION; HUMAN; HUMAN CELL; HUMAN TISSUE; MOUSE; NONHUMAN; NUDE MOUSE; OSTEOBLAST; OSTEOLYSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; TISSUE DISTRIBUTION;

ANIMALS; BONE MARROW CELLS; BONE RESORPTION; CALCITONIN; CALCITRIOL; CELLS, CULTURED; CULTURE MEDIA, CONDITIONED; CYSTEINE ENDOPEPTIDASES; FETUS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE LIBRARY; HUMANS; HYPERCALCEMIA; INTERLEUKIN-1; KINETICS; MICE; MICE, INBRED C57BL; ORGAN CULTURE TECHNIQUES; OSTEOCLASTS; OSTEOGENESIS; PARATHYROID HORMONE-RELATED PROTEIN; PLANT PROTEINS; PROTEINS; RATS; TRANSCRIPTION, GENETIC;

EID: 0001460158     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.39.27747     Document Type: Article

References (23)

1. Jee, W. S., and Nolan, P. D. (1963) Nature 200, 225-226
2. Takahashi, S., Reddy, S. V., Chirgwin, J. M., Devlin, R., Haipek, C., Anderson, J., and Roodman, G. D. (1994) J. Biol. Chem. 269, 28696-28701
3. Reddy, S. V., Devlin, R. D., Menaa, C., Nishimura, R., Choi, S. J., Dallas, M., Yoneda, T., and Roodman, G. D. (1998) J. Cell. Physiol. 177, 636-645
4. Choi, S. J., Devlin, R. D., Menaa, C., Chung, H., Roodman, G. D., and Reddy, S. V. (1998) J. Clin. Invest. 102, 1360-1368
5. Takahashi, N., Yamana, H., Yoshiki, S., Roodman, G. D., Mundy, G. R., Jones, S. J., Boyde, A., and Suda, T. (1987) Endocrinology 122, 1373-1382
6. Hughes, D. E., Dai, A., Tiffee, J. C., Li, H. H., Mundy, G. R., and Boyce, B. F. (1996) Nat. Med. 2, 1132-1136
7. MacDonald, B. R., Takahashi, N., McManus, L. M., Holahan, J., Mundy, G. R., and Roodman, G. D. (1987) Endocrinology 120, 2326-2333
8. Kurihara, N., Chenu, C., Miller, M., Civin, C., and Roodman, G. D. (1990) Endocrinology 126, 2733-2741
9. Raisz, L. G., and Niemann, I. (1969) Endocrinology 85, 446-462
10. Boyce, B. F., Yates, A. J., and Mundy, G. R. (1989) Endocrinology 125, 2780-2783
11. Boyce, B. F., Aufdemorte, T. B., Garrett, I. R., Yates, A. J., and Mundy, G. R. (1989) Endocrinology 125, 1142-1150
12. Boyce, B. F., Yoneda, T., Lowe, C., Soriano, P., and Mundy, G. R. (1992) J. Clin. Invest. 90, 1622-1627
13. Chen, J. M., Dando, P. M., Rawlings, N. D., Brown, M. A., Young, N. E., Stevens, R. A., Hewitt, E., Watt, C., and Barrett, A. J. (1997) J. Biol. Chem. 272, 8090-8098
14. Chen, J. M., Dando, P. M., Stevens, R. A., Fortunato, M., and Barrett, A. J. (1998) Biochem. J. 335, 111-117
15. Takeda, O., Miura, Y., Mitta, M., Matsushita, H., Kato, I., Abe, Y., Yokosawa, H., and Ishii, S. (1994) J. Biochem. (Tokyo) 116, 541-546
16. Mundy, G. R., and Roodman, G. D. (1987) in Bone and Mineral Research (Peck, W. A., ed) pp. 209-281, Elsevier Science Publishers, New York
17. Biskobing, D. M., Fan, X., and Rubin, J. (1995) J. Bone Miner. Res. 10, 1025-1032
18. Simonet, W. S., Lacey, D. L., Dunstan, C. R., Kelley, M., Chang, M. S., Luthy, R., Nguyen, H. Q., Wooden, S., Bennett, L., Boone, T., Shimomoto, G., De Rose, M., Elliott, R., Colombero, A., Tan, H.-L., Trail, G., Sullivan, J., Davy, E., Buray, N., Rensbaw-Gegg, L., Hughes, T. M., Hill, D., Pattison, W., Cambell, P., Sander, S., Van, G., Tarpley, J., Derby, P., Lee, R., and Boyle, W. J. (1997) Cell 89, 309-319
19. Hofbauer, L. C., Dunstan, C. R., Spelsberg, T. C., Riggs, B. L., and Khosla, S. (1998) Biochem. Biophys. Res. Commun. 250, 776-781
20. Brindley, P. J., Kalinna, B. H., Dalton, J. P., Day, S. R., Wong, J. Y., Smythe, M. L., and McManus, D. P. (1997) Mol. Biochem. Parasitol. 89, 1-9
21. Goldberg, D. E., Slater, A. F. G., Beavis, R., Chait, B., Cerami, A., and Henderson, G. B. (1991). J. Exp. Med. 173, 961-969
22. Kembhavi, A. A., Buttle, D. J., Knight, C. G., and Barret, A. J. (1993) Arch. Biochem. Biophys. 303, 208-213
23. Fisher, J. E., Caulfield, M. P., Sato, M., Quartuccio, H. A., Gould, R. J., Garsky, V. M., Rodan, G. A., and Rosenblatt, M. (1993) Endocrinology 132, 1411-1413