The imidazoline RX871024 induces death of proliferating insulin-secreting cells by activation of c-jun N-terminal kinase

Cellular and Molecular Life Sciences

Volumn 65, Issue 7-8, 2008, Pages 1248-1255

  Zaitseva, I I ^a   Storling J ^b   Mandrup Poulsen, T ^a,b   Berggren, P O ^a   Zaitsev, S V ^a,c  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b STENO DIABETES CENTER   (Denmark)

^c MOSCOW STATE UNIVERSITY   (Russian Federation)

Author keywords

Apoptosis; Caspase; Cytokine; Imidazoline; Insulin secreting cell; MAPK

Indexed keywords

CASPASE 3; CASPASE 8; CASPASE 9; CYTOKINE; EFAROXAN; GAMMA INTERFERON; IMIDAZOLINE; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; NITRIC OXIDE; RX 871024; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; CELL DEATH; CELL LINE; CELL PROLIFERATION; CELL SURVIVAL; DIABETES MELLITUS; ENZYME ACTIVATION; ENZYME ACTIVITY; INSULIN LIKE ACTIVITY; PANCREAS ISLET BETA CELL;

ANIMALS; BENZOFURANS; CASPASES; CELL DEATH; CELL LINE; CELL PROLIFERATION; CYTOKINES; ENZYME ACTIVATION; HUMANS; IMIDAZOLES; INDOLES; INSULIN-SECRETING CELLS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MICE; NITRIC OXIDE;

EID: 42449134021     PISSN: 1420682X     EISSN: 15691632     Source Type: Journal    
DOI: 10.1007/s00018-008-7564-x     Document Type: Article

References (48)

1. Mandrup-Poulsen, T. (2003) Beta cell death and protection. Ann. N. Y. Acad. Sci. 1005, 32 -42.
2. Flodstrom-Tullberg, M., Yadav, D., Hagerkvist, R., Tsai, D., Secrest, P., Stotland, A. and Sarvetnick, N. (2003) Target cell expression of suppressor of cytokine signaling-1 prevents diabetes in the NOD mouse. Diabetes 52, 2696-2700.
3. + T cell-mediated autoimmune destruction. J. Immunol. 172, 5714-5721.
4. Barral, A. M., Thomas, H. E., Ling, E. M., Darwiche, R., Rodrigo, E., Christen, U., Ejrnaes, M., Wolfe, T., Kay, T. W. and von Herrath, M. G. (2006) SOCS-1 protects from virally-induced CD8 T cell mediated type 1 diabetes. J. Autoimmun. 27, 166-173.
5. Eizirik, D. L. and Mandrup-Poulsen, T. (2001) A choice of death - The signal-transduction of immune-mediated beta-cell apoptosis. Diabetologia 44, 2115-2133.
6. Andersen, N. A., Larsen, C. M. and Mandrup-Poulsen, T. (2000) TNFalpha and IFNgamma potentiate IL-1beta induced mitogen activated protein kinase activity in rat pancreatic islets of Langerhans. Diabetologia 43, 1389-1396.
7. Ammendrup, A., Maillard, A., Nielsen, K., Aabenhus Andersen, N., Serup, P., Dragsbaek Madsen, O., Mandrup-Poulsen, T. and Bonny, C. (2000) The c-Jun amino-terminal kinase pathway is preferentially activated by interleukin-1 and controls apoptosis in differentiating pancreatic beta-cells. Diabetes 49, 1468-1476.
8. Larsen, L., Storling, J., Darville, M., Eizirik, D. L., Bonny, C., Billestrup, N. and Mandrup-Poulsen, T. (2005) Extracellular signal-regulated kinase is essential for interleukin-1-induced and nuclear factor kappaB-mediated gene expression in insulin-producing INS-1E cells. Diabetologia 48, 2582-2590.
9. Hadjivassiliou, V., Green, M. H., James, R. F., Swift, S. M., Clayton, H. A. and Green, I. C. (1998) Insulin secretion, DNA damage, and apoptosis in human and rat islets of Langerhans following exposure to nitric oxide, peroxynitrite, and cytokines. Nitric Oxide 2, 429-441.
10. Zaitsev, S. V., Appelskog, I. B., Kapelioukh, I. L., Yang, S. N., Kohler, M., Efendic, S. and Berggren, P. O. (2001) Imidazoline compounds protect against interleukin 1beta-induced beta-cell apoptosis. Diabetes 50 Suppl 1, S70-76.
11. Kohler, M., Zaitsev, S. V., Zaitseva, I. I., Leibiger, B., Leibiger, I. B., Turunen, M., Kapelioukh, I. L., Bakkman, L., Appelskog, I. B., deMonvel, J. B., Imreh, G. and Berggren, P. O. (2003) Online monitoring of apoptosis in insulin-secreting cells. Diabetes 52, 2943-2950.
12. Augstein, P., Bahr, J., Wachlin, G., Heinke, P., Berg, S., Salzsieder, E. and Harrison, L. C. (2004) Cytokines activate caspase-3 in insulinoma cells of diabetes-prone NOD mice directly and via upregulation of Fas. J. Autoimmun. 23, 301-309.
13. Chandra, J., Zhivotovsky, B., Zaitsev, S., Juntti-Berggren, L., Berggren, P. O. and Orrenius, S. (2001) Role of apoptosis in pancreatic beta-cell death in diabetes. Diabetes 50 Suppl. 1, S44-47.
14. Riedl, S. J. and Shi, Y. (2004) Molecular mechanisms of caspase regulation during apoptosis. Nat. Rev. Mol. Cell. Biol. 5, 897-907.
15. Butler, A. E., Janson, J., Bonner-Weir, S., Ritzel, R., Rizza, R. A. and Butler, P. C. (2003) Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes 52, 102-110.
16. 2+ concentration. J. Biol. Chem. 273, 33501-33507.
17. Zaitsev, S. V., Efanov, A. M., Efanova, I. B., Larsson, O., Ostenson, C. G., Gold, G., Berggren, P. O. and Efendic, S. (1996) Imidazoline compounds stimulate insulin release by inhibition of K(ATP) channels and interaction with the exocytotic machinery. Diabetes 45, 1610-1618.
18. 2+ from endoplasmic reticulum, and interaction with exocytotic machinery. Ann. N. Y. Acad. Sci. 881, 241-252.
19. Efendic, S., Efanov, A. M., Berggren, P. O. and Zaitsev, S. V. (2002) Two generations of insulinotropic imidazoline compounds. Diabetes 51 Suppl. 3, S448-454.
20. Rustenbeck, I., Kopp, M., Ratzka, P., Leupolt, L. and Hasselblatt, A. (1999) Imidazolines and the pancreatic B-cell. Actions and binding sites. Ann. N. Y. Acad. Sci. 881, 229-240.
21. Zaitseva, I. I., Sharoyko, V., Storling, J., Efendic, S., Guerin, C., Mandrup-Poulsen, T., Nicotera, P., Berggren, P. O. and Zaitsev, S. V. (2006) RX871024 reduces NO production but does not protect against pancreatic beta-cell death induced by proinflammatory cytokines. Biochem. Biophys. Res. Commun. 347, 1121-1128.
22. Nir, T., Melton, D. A. and Dor, Y. (2007) Recovery from diabetes in mice by beta cell regeneration. J. Clin. Invest. 117, 2553-2561.
23. Ackermann, A. M. and Gannon, M. (2007) Molecular regulation of pancreatic beta-cell mass development, maintenance, and expansion. J. Mol. Endocrinol. 38, 193-206.
24. Ablamunits, V., Sherry, N. A., Kushner, J. A. and Herold, K. C. (2007) Autoimmunity and beta cell regeneration in mouse and human type 1 diabetes: The peace is not enough. Ann. N. Y. Acad. Sci. 1103, 19-32.
25. Sharoyko, V. V., Zaitseva, I. I., Varsanyi, M., Portwood, N., Leibiger, B., Leibiger, I., Berggren, P. O., Edendic, S. and Zaitsev, S. V. (2005) Monomeric G-protein, Rhes, is not an imidazoline-regulated protein in pancreatic beta-cells. Biochem. Biophys. Res. Commun. 338, 1455-1459.
26. + channel-blocking insulin secretagogues. Biochem. Pharmacol. 67, 1733-1741.
27. Mourtada, M., Elliott, J., Smith, S. A. and Morgan, N. G. (2000) Effects of imidazoline binding site ligands on the growth and viability of clonal pancreatic beta-cells. Naunyn Schmiedebergs Arch. Pharmacol. 361, 146-154.
28. Chan, S. L. and Morgan, N. G. (1990) Stimulation of insulin secretion by efaroxan may involve interaction with potassium channels. Eur. J. Pharmacol. 176, 97-101.
29. Larsen, C. M., Wadt, K. A., Juhl, L. F., Andersen, H. U., Karlsen, A. E., Su, M. S., Seedorf, K., Shapiro, L., Dinarello, C. A. and Mandrup-Poulsen, T. (1998) Interleukin-1beta-induced rat pancreatic islet nitric oxide synthesis requires both the p38 and extracellular signal-regulated kinase 1/2 mitogen-activated protein kinases. J. Biol. Chem. 273, 15294-15300.
30. Storling, J., Zaitsev, S. V., Kapelioukh, I. L., Karlsen, A. E., Billestrup, N., Berggren, P. O. and Mandrup-Poulsen, T. (2005) Calcium has a permissive role in interleukin-1beta-induced cjun N-terminal kinase activation in insulin-secreting cells. Endocrinology 146, 3026-3036.
31. Finegood, D. T., Scaglia, L. and Bonner-Weir, S. (1995) Dynamics of beta-cell mass in the growing rat pancreas. Estimation with a simple mathematical model. Diabetes 44, 249-256.
32. Miyazaki, J., Araki, K., Yamato, E., Ikegami, H., Asano, T., Shibasaki, Y., Oka, Y. and Yamamura, K. (1990) Establishment of a pancreatic beta cell line that retains glucose-inducible insulin secretion: special reference to expression of glucose transporter isoforms. Endocrinology 127, 126-132.
33. Muller, D., Jones, P. M. and Persaud, S. J. (2006) Autocrine antiapoptotic and proliferative effects of insulin in pancreatic beta-cells. FEBS Lett. 580, 6977-6980.
34. Papadimitriou, A., King, A. J., Jones, P. M. and Persaud, S. J. (2007) Anti-apoptotic effects of arachidonic acid and prostaglandin E2 in pancreatic beta-cells. Cell Physiol. Biochem. 20, 607-616.
35. Todaro, M., Di Gaudio, F., Lavitrano, M., Stassi, G. and Papaccio, G. (2003) Islet beta-cell apoptosis triggered in vivo by interleukin-1beta is not related to the inducible nitric oxide synthase pathway: Evidence for mitochondrial function impairment and lipoperoxidation. Endocrinology 144, 4264-4271.
36. Mandrup-Poulsen, T. (2003) Apoptotic signal transduction pathways in diabetes. Biochem. Pharmacol. 66, 1433-1440.
37. Karlsen, A. E., Pavlovic, D., Nielsen, K., Jensen, J., Andersen, H. U., Pociot, F., Mandrup-Poulsen, T., Eizirik, D. L. and Nerup, J. (2000) Interferon-gamma induces interleukin-1 converting enzyme expression in pancreatic islets by an interferon regulatory factor-1-dependent mechanism. J. Clin. Endocrinol. Metab. 85, 830-836.
38. Jin, Z. and El-Deiry, W. S. (2005) Overview of cell death signaling pathways. Cancer Biol. Ther. 4, 139-163.
39. Herr, I. and Debatin, K. M. (2001) Cellular stress response and apoptosis in cancer therapy. Blood 98, 2603-2614.
40. Nilsson, T., Arkhammar, P., Hallberg, A., Hellman, B. and Berggren, P. O. (1987) Characterization of the inositol 1,4,5-trisphosphate-induced Ca2+ release in pancreatic beta-cells. Biochem. J. 248, 329-336.
41. 2+ mobilization from thapsigargin-sensitive stores in mouse pancreatic beta-cells. Diabetes 47, 211-218.
42. Squires, P. E., Hills, C. E., Rogers, G. J., Garland, P., Farley, S. R. and Morgan, N. G. (2004) The putative imidazoline receptor agonist, harmane, promotes intracellular calcium mobilisation in pancreatic beta-cells. Eur. J. Pharmacol. 501, 31-39.
43. Zhang, S., Liu, J., Dragunow, M. and Cooper, G. J. (2003) Fibrillogenic amylin evokes islet beta-cell apoptosis through linked activation of a caspase cascade and JNK1. J. Biol. Chem. 278, 52810-52819.
44. Higuchi, H., Grambihler, A., Canbay, A., Bronk, S. F. and Gores, G. J. (2004) Bile acids up-regulate death receptor 5/TRAIL-receptor 2 expression via a c-Jun N-terminal kinase-dependent pathway involving Sp1. J. Biol. Chem. 279, 51-60.
45. Hui, H., Dotta, F., DiMario, U. and Perfetti, R. (2004) Role of caspases in the regulation of apoptotic pancreatic islet beta-cells death. J. Cell Physiol. 200, 177-200.
46. Rhodes, C. J. (2005) Type 2 diabetes-a matter of beta-cell life and death? Science 307, 380-384.
47. Maedler, K., Carr, R. D., Bosco, D., Zuellig, R. A., Berney, T. and Donath, M. Y. (2005) Sulfonylurea induced beta-cell apoptosis in cultured human islets. J. Clin. Endocrinol. Metab. 90, 501-506.
48. Storling, J., Allaman-Pillet, N., Karlsen, A. E., Billestrup, N., Bonny, C. and Mandrup-Poulsen, T. (2005) Antitumorigenic effect of proteasome inhibitors on insulinoma cells. Endocrinology 146, 1718-1726.