-
1
-
-
0034976119
-
Islet cell tumors of the pancreas: The medical oncologist's perspective
-
Brentjens R, Saltz L 2001 Islet cell tumors of the pancreas: the medical oncologist's perspective. Surg Clin North Am 81:527-542
-
(2001)
Surg Clin North Am
, vol.81
, pp. 527-542
-
-
Brentjens, R.1
Saltz, L.2
-
3
-
-
0033016291
-
The ubiquitin-proteasome pathway and pathogenesis of human diseases
-
Schwartz AL, Ciechanover A 1999 The ubiquitin-proteasome pathway and pathogenesis of human diseases. Annu Rev Med 50:57-74
-
(1999)
Annu Rev Med
, vol.50
, pp. 57-74
-
-
Schwartz, A.L.1
Ciechanover, A.2
-
4
-
-
0032919345
-
The role of the ubiquitin-proteasome pathway in apoptosis
-
Orlowski RZ 1999 The role of the ubiquitin-proteasome pathway in apoptosis. Cell Death Differ 6:303-313
-
(1999)
Cell Death Differ
, vol.6
, pp. 303-313
-
-
Orlowski, R.Z.1
-
5
-
-
0036240701
-
The proteasome: A novel target for cancer chemotherapy
-
Almond JB, Cohen GM 2002 The proteasome: a novel target for cancer chemotherapy. Leukemia 16:433-443
-
(2002)
Leukemia
, vol.16
, pp. 433-443
-
-
Almond, J.B.1
Cohen, G.M.2
-
7
-
-
0036023407
-
A phase I trial of the novel proteasome inhibitor PS341 in advanced solid tumor malignancies
-
Aghajanian C, Soignet S, Dizon DS, Pien CS, Adams J, Elliott PJ, Sabbatini P, Miller V, Hensley ML, Pezzulli S, Canales C, Daud A, Spriggs DR 2002 A phase I trial of the novel proteasome inhibitor PS341 in advanced solid tumor malignancies. Clin Cancer Res 8:2505-2511
-
(2002)
Clin Cancer Res
, vol.8
, pp. 2505-2511
-
-
Aghajanian, C.1
Soignet, S.2
Dizon, D.S.3
Pien, C.S.4
Adams, J.5
Elliott, P.J.6
Sabbatini, P.7
Miller, V.8
Hensley, M.L.9
Pezzulli, S.10
Canales, C.11
Daud, A.12
Spriggs, D.R.13
-
8
-
-
0037111832
-
Phase I trial of the proteasome inhibitor PS-341 in patients with refractory hematologic malignancies
-
Orlowski RZ, Stinchcombe TE, Mitchell BS, Shea TC, Baldwin AS, Stahl S, Adams J, Esseltine DL, Elliott PJ, Pien CS, Guerciolini R, Anderson JK, Depcik-Smith ND, Bhagat R, Lehman MJ, Novick SC, O'Connor OA, Soignet SL 2002 Phase I trial of the proteasome inhibitor PS-341 in patients with refractory hematologic malignancies. J Clin Oncol 20:4420-4427
-
(2002)
J Clin Oncol
, vol.20
, pp. 4420-4427
-
-
Orlowski, R.Z.1
Stinchcombe, T.E.2
Mitchell, B.S.3
Shea, T.C.4
Baldwin, A.S.5
Stahl, S.6
Adams, J.7
Esseltine, D.L.8
Elliott, P.J.9
Pien, C.S.10
Guerciolini, R.11
Anderson, J.K.12
Depcik-Smith, N.D.13
Bhagat, R.14
Lehman, M.J.15
Novick, S.C.16
O'Connor, O.A.17
Soignet, S.L.18
-
9
-
-
0037973279
-
A phase 2 study of bortezomib in relapsed, refractory myeloma
-
Richardson PG, Barlogie B, Berenson J, Singhal S, Jagannath S, Irwin D, Rajkumar SV, Srkalovic G, Alsina M, Alexanian R, Siegel D, Orlowski RZ, Kuter D, Limentani SA, Lee S, Hideshima T, Esseltine DL, Kauffman M, Adams J, Schenkein DP, Anderson KC 2003 A phase 2 study of bortezomib in relapsed, refractory myeloma. N Engl J Med 348:2609-2617
-
(2003)
N Engl J Med
, vol.348
, pp. 2609-2617
-
-
Richardson, P.G.1
Barlogie, B.2
Berenson, J.3
Singhal, S.4
Jagannath, S.5
Irwin, D.6
Rajkumar, S.V.7
Srkalovic, G.8
Alsina, M.9
Alexanian, R.10
Siegel, D.11
Orlowski, R.Z.12
Kuter, D.13
Limentani, S.A.14
Lee, S.15
Hideshima, T.16
Esseltine, D.L.17
Kauffman, M.18
Adams, J.19
Schenkein, D.P.20
Anderson, K.C.21
more..
-
10
-
-
0034644522
-
Signal transduction by the JNK group of MAP kinases
-
Davis RJ 2000 Signal transduction by the JNK group of MAP kinases. Cell 103:239-252
-
(2000)
Cell
, vol.103
, pp. 239-252
-
-
Davis, R.J.1
-
11
-
-
0035282334
-
Mammalian MAP kinase signalling cascades
-
Chang L, Karin M 2001 Mammalian MAP kinase signalling cascades. Nature 410:37-40
-
(2001)
Nature
, vol.410
, pp. 37-40
-
-
Chang, L.1
Karin, M.2
-
12
-
-
15644381250
-
Bcl-2 undergoes phosphorylarion by c-Jun N-terminal kinase/stress- activated protein kinases in the presence of the constitutively active GTP-binding protein Rac1
-
Maundrell K, Antonsson B, Magnenat E, Camps M, Muda M, Chabert C, Gillieron C, Boschert U, Vial-Knecht E, Martinou JC, Arkinstall S 1997 Bcl-2 undergoes phosphorylarion by c-Jun N-terminal kinase/stress-activated protein kinases in the presence of the constitutively active GTP-binding protein Rac1. J Biol Chem 272:25238-25242
-
(1997)
J Biol Chem
, vol.272
, pp. 25238-25242
-
-
Maundrell, K.1
Antonsson, B.2
Magnenat, E.3
Camps, M.4
Muda, M.5
Chabert, C.6
Gillieron, C.7
Boschert, U.8
Vial-Knecht, E.9
Martinou, J.C.10
Arkinstall, S.11
-
13
-
-
0034614658
-
Translation of SAPK/JNK to mitochondria and interaction with Bcl-x(L) in response to DNA damage
-
Kharbanda S, Saxena S, Yoshida K, Pandey P, Kaneki M, Wang Q, Cheng K, Chen YN, Campbell A, Sudha T, Yuan ZM, Narula J, Weichselbaum R, Nalin C, Kufe D 2000 Translation of SAPK/JNK to mitochondria and interaction with Bcl-x(L) in response to DNA damage. J Biol Chem 275:322-327
-
(2000)
J Biol Chem
, vol.275
, pp. 322-327
-
-
Kharbanda, S.1
Saxena, S.2
Yoshida, K.3
Pandey, P.4
Kaneki, M.5
Wang, Q.6
Cheng, K.7
Chen, Y.N.8
Campbell, A.9
Sudha, T.10
Yuan, Z.M.11
Narula, J.12
Weichselbaum, R.13
Nalin, C.14
Kufe, D.15
-
14
-
-
0033850451
-
The c-Jun amino-terminal kinase pathway is preferentially activated by interleukin-1 and controls apoptosis in differentiating pancreatic β-cells
-
Ammendrup A, Maillard A, Nielsen K, Andersen NA, Serup P, Madsen OD, Mandrup-Poulsen T, Bonny C 2000 The c-Jun amino-terminal kinase pathway is preferentially activated by interleukin-1 and controls apoptosis in differentiating pancreatic β-cells. Diabetes 49:1468-1476
-
(2000)
Diabetes
, vol.49
, pp. 1468-1476
-
-
Ammendrup, A.1
Maillard, A.2
Nielsen, K.3
Andersen, N.A.4
Serup, P.5
Madsen, O.D.6
Mandrup-Poulsen, T.7
Bonny, C.8
-
15
-
-
0034596017
-
IB1 reduces cytokine-induced apoptosis of insulin-secreting cells
-
Bonny C, Oberson A, Steinmann M, Schorderet DF, Nicod P, Waeber G 2000 IB1 reduces cytokine-induced apoptosis of insulin-secreting cells. J Biol Chem 275:16466-16472
-
(2000)
J Biol Chem
, vol.275
, pp. 16466-16472
-
-
Bonny, C.1
Oberson, A.2
Steinmann, M.3
Schorderet, D.F.4
Nicod, P.5
Waeber, G.6
-
16
-
-
0031915453
-
IB1, a JIP-1-related nuclear protein present in insulin-secreting cells
-
Bonny C, Nicod P, Waeber G 1998 IB1, a JIP-1-related nuclear protein present in insulin-secreting cells. J Biol Chem 273:1843-1846
-
(1998)
J Biol Chem
, vol.273
, pp. 1843-1846
-
-
Bonny, C.1
Nicod, P.2
Waeber, G.3
-
17
-
-
0032984806
-
Lentivirus-mediated Bcl-2 expression in βTC-tet cells improves resistance to hypoxia and cytokine-induced apoptosis while preserving in vitro and in vivo control of insulin secretion
-
Dupraz P, Rinsch C, Pralong WF, Rolland E, Zufferey R, Trono D, Thorens B 1999 Lentivirus-mediated Bcl-2 expression in βTC-tet cells improves resistance to hypoxia and cytokine-induced apoptosis while preserving in vitro and in vivo control of insulin secretion. Gene Ther 6:1160-1169
-
(1999)
Gene Ther
, vol.6
, pp. 1160-1169
-
-
Dupraz, P.1
Rinsch, C.2
Pralong, W.F.3
Rolland, E.4
Zufferey, R.5
Trono, D.6
Thorens, B.7
-
18
-
-
12444335255
-
The JNK binding domain of islet-brain 1 inhibits IL-1 induced JNK activity and apoptosis but not the transcription of key proapoptotic or protective genes in insulin-secreting cell lines
-
Nikulina MA, Sandhu N, Shamim Z, Andersen NA, Oberson A, Dupraz P, Thorens B, Karlsen AE, Bonny C, Mandrup-Poulsen T 2003 The JNK binding domain of islet-brain 1 inhibits IL-1 induced JNK activity and apoptosis but not the transcription of key proapoptotic or protective genes in insulin-secreting cell lines. Cytokine 24:13-24
-
(2003)
Cytokine
, vol.24
, pp. 13-24
-
-
Nikulina, M.A.1
Sandhu, N.2
Shamim, Z.3
Andersen, N.A.4
Oberson, A.5
Dupraz, P.6
Thorens, B.7
Karlsen, A.E.8
Bonny, C.9
Mandrup-Poulsen, T.10
-
19
-
-
0024586904
-
Growth hormone is a growth factor for the differentiated pancreatic β-cell
-
Nielsen JH, Linde S, Welinder BS, Billestrup N, Madsen OD 1989 Growth hormone is a growth factor for the differentiated pancreatic β-cell. Mol Endocrinol 3:165-173
-
(1989)
Mol Endocrinol
, vol.3
, pp. 165-173
-
-
Nielsen, J.H.1
Linde, S.2
Welinder, B.S.3
Billestrup, N.4
Madsen, O.D.5
-
20
-
-
0033511648
-
β-cell maturation leads to in vitro sensitivity to cytotoxins
-
Nielsen K, Karlsen AE, Deckert M, Madsen OD, Serup P, Mandrup-Poulsen T, Nerup J 1999 β-Cell maturation leads to in vitro sensitivity to cytotoxins. Diabetes 48:2324-2332
-
(1999)
Diabetes
, vol.48
, pp. 2324-2332
-
-
Nielsen, K.1
Karlsen, A.E.2
Deckert, M.3
Madsen, O.D.4
Serup, P.5
Mandrup-Poulsen, T.6
Nerup, J.7
-
21
-
-
0032513215
-
Proteasome inhibitors activate stress kinases and induce Hsp72. Diverse effects on apoptosis
-
Meriin AB, Gabai VL, Yaglom J, Shifrin VI, Sherman MY 1998 Proteasome inhibitors activate stress kinases and induce Hsp72. Diverse effects on apoptosis. J Biol Chem 273:6373-6379
-
(1998)
J Biol Chem
, vol.273
, pp. 6373-6379
-
-
Meriin, A.B.1
Gabai, V.L.2
Yaglom, J.3
Shifrin, V.I.4
Sherman, M.Y.5
-
22
-
-
0034658384
-
JNK (c-Jun N-terminal kinase) and p38 activation in receptor-mediated and chemically-induced apoptosis of T-cells: Differential requirements for caspase activation
-
MacFarlane M, Cohen GM, Dickens M 2000 JNK (c-Jun N-terminal kinase) and p38 activation in receptor-mediated and chemically-induced apoptosis of T-cells: differential requirements for caspase activation. Biochem J 348(Pt 1): 93-101
-
(2000)
Biochem J
, vol.348
, Issue.PART 1
, pp. 93-101
-
-
MacFarlane, M.1
Cohen, G.M.2
Dickens, M.3
-
23
-
-
0030826412
-
A cytoplasmic inhibitor of the JNK signal transduction pathway
-
Dickens M, Rogers JS, Cavanagh J, Raitano A, Xia Z, Halpern JR, Greenberg ME, Sawyers CL, Davis RJ 1997 A cytoplasmic inhibitor of the JNK signal transduction pathway. Science 277:693-696
-
(1997)
Science
, vol.277
, pp. 693-696
-
-
Dickens, M.1
Rogers, J.S.2
Cavanagh, J.3
Raitano, A.4
Xia, Z.5
Halpern, J.R.6
Greenberg, M.E.7
Sawyers, C.L.8
Davis, R.J.9
-
24
-
-
0029033981
-
Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin
-
Fenteany G, Standaert RF, Lane WS, Choi S, Corey EJ, Schreiber SL 1995 Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin. Science 268:726-731
-
(1995)
Science
, vol.268
, pp. 726-731
-
-
Fenteany, G.1
Standaert, R.F.2
Lane, W.S.3
Choi, S.4
Corey, E.J.5
Schreiber, S.L.6
-
25
-
-
0028880026
-
The role of the calpain-calpastatin system in thyrotropin-releasing hormone-induced selective down-regulation of a protein kinase C isozyme, nPKC epsilon, in rat pituitary GH4C1 cells
-
Eto A, Akita Y, Saido TC, Suzuki K, Kawashima S 1995 The role of the calpain-calpastatin system in thyrotropin-releasing hormone-induced selective down-regulation of a protein kinase C isozyme, nPKC epsilon, in rat pituitary GH4C1 cells. J Biol Chem 270:25115-25120
-
(1995)
J Biol Chem
, vol.270
, pp. 25115-25120
-
-
Eto, A.1
Akita, Y.2
Saido, T.C.3
Suzuki, K.4
Kawashima, S.5
-
26
-
-
0038068111
-
The scaffold protein IB1/JIP-1 is a critical mediator of cytokine-induced apoptosis in pancreatic β cells
-
Haefliger JA, Tawadros T, Meylan L, Gurun SL, Roehrich ME, Martin D, Thorens B, Waeber G 2003 The scaffold protein IB1/JIP-1 is a critical mediator of cytokine-induced apoptosis in pancreatic β cells. J Cell Sci 116:1463-1469
-
(2003)
J Cell Sci
, vol.116
, pp. 1463-1469
-
-
Haefliger, J.A.1
Tawadros, T.2
Meylan, L.3
Gurun, S.L.4
Roehrich, M.E.5
Martin, D.6
Thorens, B.7
Waeber, G.8
-
27
-
-
0030962262
-
p53-dependent induction of apoptosis by proteasome inhibitors
-
Lopes UG, Erhardt P, Yao R, Cooper GM 1997 p53-dependent induction of apoptosis by proteasome inhibitors. J Biol Chem 272:12893-12896
-
(1997)
J Biol Chem
, vol.272
, pp. 12893-12896
-
-
Lopes, U.G.1
Erhardt, P.2
Yao, R.3
Cooper, G.M.4
-
28
-
-
0033623487
-
Proteasome inhibitors induced caspase-dependent apoptosis and accumulation of p21WAF1/Cip1 in human immature leukemic cells
-
Naujokat C, Sezer O, Zinke H, Leclere A, Hauptmann S, Possinger K 2000 Proteasome inhibitors induced caspase-dependent apoptosis and accumulation of p21WAF1/Cip1 in human immature leukemic cells. Eur J Haematol 65:221-236
-
(2000)
Eur J Haematol
, vol.65
, pp. 221-236
-
-
Naujokat, C.1
Sezer, O.2
Zinke, H.3
Leclere, A.4
Hauptmann, S.5
Possinger, K.6
-
29
-
-
0029564960
-
Lactacystin, a specific inhibitor of the proteasome, induces apoptosis in human monoblast U937 cells
-
Imajoh-Ohmi S, Kawaguchi T, Sugiyama S, Tanaka K, Omura S, Kikuchi H 1995 Lactacystin, a specific inhibitor of the proteasome, induces apoptosis in human monoblast U937 cells. Biochem Biophys Res Commun 217:1070-1077
-
(1995)
Biochem Biophys Res Commun
, vol.217
, pp. 1070-1077
-
-
Imajoh-Ohmi, S.1
Kawaguchi, T.2
Sugiyama, S.3
Tanaka, K.4
Omura, S.5
Kikuchi, H.6
-
30
-
-
0030016329
-
Apoptosis induction resulting from proteasome inhibition
-
Shinohara K, Tomioka M, Nakano H, Tone S, Ito H, Kawashima S 1996 Apoptosis induction resulting from proteasome inhibition. Biochemical J 317(Pt 2):385-388
-
(1996)
Biochemical J
, vol.317
, Issue.PART 2
, pp. 385-388
-
-
Shinohara, K.1
Tomioka, M.2
Nakano, H.3
Tone, S.4
Ito, H.5
Kawashima, S.6
-
31
-
-
0031034160
-
Activation of the cell death program by inhibition of proteasome function
-
Drexler HC 1997 Activation of the cell death program by inhibition of proteasome function. Proc Natl Acad Sci USA 94:855-860
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 855-860
-
-
Drexler, H.C.1
-
32
-
-
2342517449
-
Apoptosis induced in 11210 leukemia-cells by an inhibitor of the chymotrypsin-like activity of the proteasome
-
Wojcik C, Stoklosa T, Giermasz A, Golab J, Zagozdzon R, Kawiak J, Wilk S, Komar A, Kaca A, Malejczyk J, Jakobisiak M 1997 Apoptosis induced in 11210 leukemia-cells by an inhibitor of the chymotrypsin-like activity of the proteasome. Apoptosis 2:455-462
-
(1997)
Apoptosis
, vol.2
, pp. 455-462
-
-
Wojcik, C.1
Stoklosa, T.2
Giermasz, A.3
Golab, J.4
Zagozdzon, R.5
Kawiak, J.6
Wilk, S.7
Komar, A.8
Kaca, A.9
Malejczyk, J.10
Jakobisiak, M.11
-
33
-
-
1642486367
-
Proteasome inhibitor PS-341 induces growth arrest and apoptosis of non-small cell lung cancer cells via the JNK/c-Jun/AP-1 signaling
-
Yang Y, Ikezoe T, Saito T, Kobayashi M, Koeffler HP, Taguchi H 2004 Proteasome inhibitor PS-341 induces growth arrest and apoptosis of non-small cell lung cancer cells via the JNK/c-Jun/AP-1 signaling. Cancer Sci 95:176-180
-
(2004)
Cancer Sci
, vol.95
, pp. 176-180
-
-
Yang, Y.1
Ikezoe, T.2
Saito, T.3
Kobayashi, M.4
Koeffler, H.P.5
Taguchi, H.6
-
34
-
-
0037441760
-
Molecular mechanisms mediating antimyeloma activity of proteasome inhibitor PS-341
-
Hideshima T, Mitsiades C, Akiyama M, Hayashi T, Chauhan D, Richardson P, Schlossman R, Podar K, Munshi NC, Mitsiades N, Anderson KC 2003 Molecular mechanisms mediating antimyeloma activity of proteasome inhibitor PS-341. Blood 101:1530-1534
-
(2003)
Blood
, vol.101
, pp. 1530-1534
-
-
Hideshima, T.1
Mitsiades, C.2
Akiyama, M.3
Hayashi, T.4
Chauhan, D.5
Richardson, P.6
Schlossman, R.7
Podar, K.8
Munshi, N.C.9
Mitsiades, N.10
Anderson, K.C.11
-
35
-
-
0035668779
-
A choice of death-the signal-transduction of immune-mediated β-cell apoptosis
-
Eizirik DL, Mandrup-Poulsen T 2001 A choice of death-the signal-transduction of immune-mediated β-cell apoptosis. Diabetologia 44:2115-2133
-
(2001)
Diabetologia
, vol.44
, pp. 2115-2133
-
-
Eizirik, D.L.1
Mandrup-Poulsen, T.2
-
36
-
-
0041828484
-
Inflammatory mediators and islet β-cell failure: A link between type 1 and type 2 diabetes
-
Donath MY, Storling J, Maedler K, Mandrup-Poulsen T 2003 Inflammatory mediators and islet β-cell failure: a link between type 1 and type 2 diabetes. J Mol Med 81:455-470
-
(2003)
J Mol Med
, vol.81
, pp. 455-470
-
-
Donath, M.Y.1
Storling, J.2
Maedler, K.3
Mandrup-Poulsen, T.4
-
37
-
-
0030868909
-
The interleukin-1 receptor-associated kinase is degraded by proteasomes following its phosphorylation
-
Yamin TT, Miller DK 1997 The interleukin-1 receptor-associated kinase is degraded by proteasomes following its phosphorylation. J Biol Chem 272:21540-21547
-
(1997)
J Biol Chem
, vol.272
, pp. 21540-21547
-
-
Yamin, T.T.1
Miller, D.K.2
|