Autoimmunity and β cell regeneration in mouse and human type 1 diabetes: The peace is not enough

Annals of the New York Academy of Sciences

Volumn 1103, Issue , 2007, Pages 19-32

  Ablamunits, Vitaly ^a   Sherry, Nicole A ^b   Kushner, Jake A ^c   Herold, Kevan C ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Immune therapy; Type 1 diabetes; cell regeneration

Indexed keywords

MONOCLONAL ANTIBODY CD3;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNITY; CELL DIVISION; CELL GROWTH; CELL LOSS; CELL REGENERATION; CELLULAR IMMUNITY; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOTHERAPY; INSULIN DEPENDENT DIABETES MELLITUS; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL;

ANIMALIA;

EID: 34249012115     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1394.006     Document Type: Article

References (47)

1. BONNER-WEIR, S. 2000. Islet growth and development in the adult. J. Mol. Endocrinol. 24: 297-302.
2. RYAN, E.A., B.W. PATY, P.A. SENIOR, et al. 2005. Five-year follow-up after clinical islet transplantation. Diabetes 54: 2060-2069.
3. HEROLD, K.C., S.E. GITELMAN, U. MASHARANI, et al. 2005. A single course of anti-CD3 monoclonal antibody hOKT3{gamma}1(Ala-Ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes. Diabetes 54: 1763-1769.
4. HEROLD, K.C., W. HAGOPIAN, J.A. AUGER, et al. 2002. Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus. N. Engl. J. Med. 346: 1692-1698.
5. KEYMEULEN, B., E. VANDEMEULEBROUCKE, A.G. ZIEGLER, et al. 2005. Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes. N. Engl. J. Med. 352: 2598-2608.
6. FINEGOOD, D.T., L. SCAGLIA & S. BONNER-WEIR. 1995. Dynamics of beta-cell mass in the growing rat pancreas. Estimation with a simple mathematical model. Diabetes 44: 249-256.
7. BONNER-WEIR, S. 2000. Perspective: postnatal pancreatic beta cell growth. Endocrinology 141: 1926-1929.
8. TETA, M., S.Y. LONG, L.M. WARTSCHOW, et al. 2005. Very slow turnover of beta-cells in aged adult mice. Diabetes 54: 2557-2567
9. TRUDEAU, J.D., J.P. DUTZ, E. ARANY, et al. 2000. Neonatal beta-cell apoptosis: a trigger for autoimmune diabetes? Diabetes 49: 1-7.
10. O'BRIEN, B.A., Y. HUANG, X. GENG, et al. 2002. Phagocytosis of apoptotic cells by macrophages from NOD mice is reduced. Diabetes 51: 2481-2488.
11. TSAI, E.B., N.A. SHERRY, J.P. PALMER & K.C. HEROLD. 2006. The rise and fall of insulin secretion in type 1 diabetes mellitus. Diabetologia 49: 261-270.
12. PALMER, J.P., G.A. FLEMING, C.J. GREENBAUM, et al. 2004. C-peptide is the appropriate outcome measure for type 1(diabetes clinical trials to preserve beta-cell function): report of an ADA workshop, 21-22 October 2001. Diabetes 53: 250-264.
13. SHERRY, N.A., J.A. KUSHNER, M. GLANDT, et al. 2006. Effects of autoimmunity and immune therapy on {beta}-cell turnover in type 1 diabetes. Diabetes 55: 3238-3245.
14. SARVETNICK, N.E. & D. GU. 1992. Regeneration of pancreatic endocrine cells in interferon-gamma transgenic mice. Adv. Exp. Med. Biol. 321: 85-89. [discussion, pp. 91-83].
15. SREENAN, S., A.J. PICK, M. LEVISETTI, et al. 1999. Increased beta-cell proliferation and reduced mass before diabetes onset in the nonobese diabetic mouse. Diabetes 48: 989-996.
16. LUO, X., H. YANG, I.S. KIM, et al. 2005. Systemic transforming growth factor-beta1 gene therapy induces Foxp3+ regulatory cells, restores self-tolerance, and facilitates regeneration of beta cell function in overtly diabetic nonobese diabetic mice. Transplantation 79: 1091-1096.
17. HEBROK, M., S.K. KIM, B. ST. JACQUES, et al. 2000. Regulation of pancreas development by hedgehog signaling. Development 127: 4905-4913.
18. DKHISSI, F., S. RAYNAL & D.A. LAWRENCE. 1999. Altered complex formation between p21waf, p27kip and their partner G1 cyclins determines the stimulatory or inhibitory transforming growth factor-beta1 growth response of human fibroblasts. Int. J. Oncol. 14: 905-910.
19. VUKKADAPU, S.S., J.M. BELLI, K. ISHII, et al. 2005. Dynamic interaction between T cell-mediated beta-cell damage and beta-cell repair in the run up to autoimmune diabetes of the NOD mouse. Physiol. Genomics 21: 201-211.
20. TERAZONO, K., H. YAMAMOTO, S. TAKASAWA, et al. 1988. A novel gene activated in regenerating islets. J. Biol. Chem. 263: 2111-2114.
21. UNNO, M., K. NATA, N. NOGUCHI, et al. 2002. Production and characterization of Reg knockout mice: reduced proliferation of pancreatic beta-cells in Reg knockout mice. Diabetes 51(Suppl. 3): S478-S483.
22. JOHANSSON, M., G. MATTSSON, A. ANDERSSON, et al. 2006. Islet endothelial cells and pancreatic beta-cell proliferation: studies in vitro and during pregnancy in adult rats. Endocrinology 147: 2315-2324.
23. LAMMERT, E., O. CLEAVER & D. MELTON. 2001. Induction of pancreatic differentiation by signals from blood vessels. Science 294: 564-567.
24. MATHEWS, V., P.T. HANSON, E. FORD, et al. 2004. Recruitment of bone marrow-derived endothelial cells to sites of pancreatic beta-cell injury. Diabetes 53: 91-98.
25. LIPSETT, M. & D.T. FINEGOOD. 2002. Beta-cell neogenesis during prolonged hyperglycemia in rats. Diabetes 51: 1834-1841.
26. STEIL, G.M., N. TRIVEDI, J.C. JONAS, et al. 2001. Adaptation of beta-cell mass to substrate oversupply: enhanced function with normal gene expression. Am. J. Physiol. Endocrinol. Metab. 280: E788-E796.
27. BONNER-WEIR, S. & A. SHARMA. 2002. Pancreatic stem cells. J. Pathol. 197: 519-526.
28. PECK, A.B., J.G. CORNELIUS, D. SCHATZ & V.K. RAMIYA. 2002. Generation of islets of Langerhans from adult pancreatic stem cells. J. Hepatobiliary Pancreat. Surg. 9: 704-709.
29. BONNER-WEIR, S., M. TANEJA, G.C. WEIR, et al. 2000. In vitro cultivation of human islets from expanded ductal tissue. Proc. Natl. Acad. Sci. USA 97: 7999-8004.
30. DOR, Y., J. BROWN, O.I. MARTINEZ & D.A. MELTON. 2004. Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature 429: 41-46.
31. SANDER, M. & M.S. GERMAN. 1997. The beta cell transcription factors and development of the pancreas. J. Mol. Med. 75: 327-340.
32. GU, G., J.R. BROWN & D.A. MELTON. 2003. Direct lineage tracing reveals the ontogeny of pancreatic cell fates during mouse embryogenesis. Mech. Dev. 120: 35-43.
33. OKAMOTO, H., M.L. HRIBAL, H.V. BIN, et al. 2006. Role of the forkhead protein FoxO1 in beta cell compensation to insulin resistance. J. Clin. Invest. 116:775-782.
34. KODAMA, S., W. KUHTREIBER, S. FUJIMURA, et al. 2003. Islet regeneration during the reversal of autoimmune diabetes in NOD mice. Science 302: 1223-1227.
35. IANUS, A., G.G. HOLZ, N.D. THEISE & M.A. HUSSAIN. 2003. In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion. J. Clin. Invest. 111: 843-850.
36. ZORINA, T.D., V.M. SUBBOTIN, S. BERTERA, et al. 2003. Recovery of the endogenous beta cell function in the NOD model of autoimmune diabetes. Stem Cells 21: 377-388.
37. CHOI, J.B., H. UCHINO, K. AZUMA, et al. 2003. Little evidence of transdifferentiation of bone marrow-derived cells into pancreatic beta cells. Diabetologia 46: 1366-1374.
38. RAJAGOPAL, J., W.J. ANDERSON, S. KUME, et al. 2003. Insulin staining of ES cell progeny from insulin uptake. Science 299: 363.
39. CHONG, A.S., J. SHEN, J. TAO, et al. 2006. Reversal of diabetes in non-obese diabetic mice without spleen cell-derived beta cell regeneration. Science 311: 1774-1775.
40. NISHIO, J., J.L. GAGLIA, S.E. TURVEY, et al. 2006. Islet recovery and reversal of murine type 1 diabetes in the absence of any infused spleen cell contribution. Science 311: 1775-1778.
41. SURI, A., B. CALDERON, T.J. ESPARZA, et al. 2006. Immunological reversal of autoimmune diabetes without hematopoietic replacement of beta cells. Science 311: 1778-1780.
42. PINKSE, G.G., O.H. TYSMA, C.A. BERGEN, et al. 2005. Autoreactive CD8 T cells associated with beta cell destruction in type 1 diabetes. Proc. Natl. Acad. Sci. USA 102: 18425-18430.
43. CHATENOUD, L., E. THERVET, J. PRIMO & J.F. BACH. 1994. Anti-CD3 antibody induces long-term remission of overt autoimmunity in nonobese diabetic mice. Proc. Natl. Acad. Sci. USA 91: 123-127.
44. BELGHITH, M., J.A. BLUESTONE, S. BARRIOT, et al. 2003. TGF-beta-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes. Nat. Med. 9: 1202-1208.
45. TUCH, B.E., A.M. SIMPSON & I.L. CAMPBELL. 1991. Role of tumor necrosis factor-alpha and interferon-gamma as growth factors to the human fetal beta-cell. J. Clin. Endocrinol. Metab. 73: 1044-1050.
46. THE DIABETES CONTROL AND C OMPLICATIONS TRIAL RESEARCH GROUP. 1998. Effect of intensive therapy on residual beta-cell function in patients with type 1 diabetes in the diabetes control and complications trial. A randomized, controlled trial. Ann. Intern. Med. 128: 517-523.
47. DUSETTI, N.J., J.M. FRIGERIO, C. SZPIRER, et al. 2005. Cloning, expression, and chromosomal localization of the rat pancreatitis-associated protein III gene. Biochem. J. 307: 9-16.