RX871024 reduces NO production but does not protect against pancreatic β-cell death induced by proinflammatory cytokines

Biochemical and Biophysical Research Communications

Volumn 347, Issue 4, 2006, Pages 1121-1128

  Zaitseva, Irina I ^a,b   Sharoyko, Vladimir ^a   Størling, Joachim ^d   Efendic, Suad ^a   Guerin, Christopher ^c   Mandrup Poulsen, Thomas ^a,d   Nicotera, Pierluigi ^c   Berggren, Per Olof ^a   Zaitsev, Sergei V ^a,b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b MOSCOW STATE UNIVERSITY   (Russian Federation)

^c UNIVERSITY OF LEICESTER   (United Kingdom)

^d STENO DIABETES CENTER   (Denmark)

Author keywords

Apoptosis; Cytokine; Imidazoline; Insulin; Islet of langerhans; MAPK; TUNEL labelling

Indexed keywords

CYTOKINE; EFAROXAN; GAMMA INTERFERON; IMIDAZOLINE DERIVATIVE; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; RX 871024; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CULTURE; CELL PROTECTION; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG EFFECT; ENZYME PHOSPHORYLATION; INHIBITION KINETICS; INSULIN DEPENDENT DIABETES MELLITUS; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL;

ANIMALS; BENZOFURANS; CELL DEATH; CELLS, CULTURED; CYTOKINES; IMIDAZOLES; INDOLES; INSULIN; INSULIN-SECRETING CELLS; INTERFERON TYPE II; INTERLEUKIN-1; MICE; MICE, OBESE; NITRIC OXIDE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 33746343031     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2006.06.197     Document Type: Article

References (43)

1. Chandra J., Zhivotovsky B., Zaitsev S., Juntti-Berggren L., Berggren P.O., and Orrenius S. Role of apoptosis in pancreatic beta-cell death in diabetes. Diabetes 50 Suppl. 1 (2001) S44-S47
2. Mandrup-Poulsen T. beta-cell apoptosis: stimuli and signaling. Diabetes 50 Suppl. 1 (2001) S58-S63
3. Mandrup-Poulsen T. Beta cell death and protection. Ann. N. Y. Acad. Sci. 1005 (2003) 32-42
4. Yoon J.W., and Jun H.S. Cellular and molecular pathogenic mechanisms of insulin-dependent diabetes mellitus. Ann. N. Y. Acad. Sci. 928 (2001) 200-211
5. Mauricio D., and Mandrup-Poulsen T. Apoptosis and the pathogenesis of IDDM: a question of life and death. Diabetes 47 (1998) 1537-1543
6. Maedler K., Sergeev P., Ris F., Oberholzer J., Joller-Jemelka H.I., Spinas G.A., Kaiser N., Halban P.A., and Donath M.Y. Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets. J. Clin. Invest. 110 (2002) 851-860
7. Welsh N., Cnop M., Kharroubi I., Bugliani M., Lupi R., Marchetti P., and Eizirik D.L. Is there a role for locally produced interleukin-1 in the deleterious effects of high glucose or the type 2 diabetes milieu to human pancreatic islets?. Diabetes 54 (2005) 3238-3244
8. Corbett J.A., Sweetland M.A., Wang J.L., Lancaster Jr. J.R., and McDaniel M.L. Nitric oxide mediates cytokine-induced inhibition of insulin secretion by human islets of Langerhans. Proc. Natl. Acad. Sci. USA 90 (1993) 1731-1735
9. Chong M.M.W., Thomas H.E., and Kay T.W.H. Suppressor of cytokine signaling-1 regulates the sensitivity of pancreatic beta cells to tumor necrosis factor. J. Biol. Chem. 277 (2002) 27945-27952
10. Hoorens A., Stange G., Pavlovic D., and Pipeleers D. Distinction between interleukin-1-induced necrosis and apoptosis of islet cells. Diabetes 50 (2001) 551-557
11. Wu J.J., Chen X., Cao X.C., Baker M.S., and Kaufman D.B. Cytokine-induced metabolic dysfunction of MIN6 beta cells is nitric oxide independent. J. Surg. Res. 101 (2001) 190-195
12. Dupraz P., Cottet S., Hamburger F., Dolci W., Felley-Bosco E., and Thorens B. Dominant negative MyD88 proteins inhibit interleukin-1beta /interferon-gamma-mediated induction of nuclear factor kappa B-dependent nitrite production and apoptosis in beta cells. J. Biol. Chem. 275 (2000) 37672-37678
13. Cetkovic-Cvrlje M., and Eizirik D.L. TNF-alpha and IFN-gamma potentiate the deleterious effects of IL-1 beta on mouse pancreatic islets mainly via generation of nitric oxide. Cytokine 6 (1994) 399-406
14. Saldeen J. Cytokines induce both necrosis and apoptosis via a common Bcl-2-inhibitable pathway in rat insulin-producing cells. Endocrinology 141 (2000) 2003-2010
15. Piro S., Lupi R., Dotta F., Patane G., Rabuazzo M.A., Marselli L., Santangelo C., Realacci M., Del G.S., Purrello F., and Marchetti P. Bovine islets are less susceptible than human islets to damage by human cytokines. Transplantation (Baltimore) 71 (2001) 21-26
16. Hadjivassiliou V., Green M.H., James R.F., Swift S.M., Clayton H.A., and Green I.C. Insulin secretion, DNA damage, and apoptosis in human and rat islets of Langerhans following exposure to nitric oxide, peroxynitrite, and cytokines. Nitric Oxide 2 (1998) 429-441
17. Zaitsev S.V., Appelskog I.B., Kapelioukh I.L., Yang S.N., Kohler M., Efendic S., and Berggren P.O. Imidazoline compounds protect against interleukin 1beta-induced beta-cell apoptosis. Diabetes 50 Suppl. 1 (2001) S70-S76
18. Van de Casteele M., Kefas B.A., Ling Z., Heimberg H., and Pipeleers D.G. Specific expression of Bax-omega in pancreatic beta-cells is down-regulated by cytokines before the onset of apoptosis. Endocrinology 143 (2002) 320-326
19. Zumsteg U., Frigerio S., and Hollander G.A. Nitric oxide production and Fas surface expression mediate two independent pathways of cytokine-induced murine beta-cell damage. Diabetes 49 (2000) 39-47
20. Delaney C.A., Pavlovic D., Hoorens A., Pipeleers D.G., and Eizirik D.L. Cytokines induce deoxyribonucleic acid strand breaks and apoptosis in human pancreatic islet cells. Endocrinology 138 (1997) 2610-2614
21. Liu D., Pavlovic D., Chen M.C., Flodstrom M., Sandler S., and Eizirik D.L. Cytokines induce apoptosis in beta-cells isolated from mice lacking the inducible isoform of nitric oxide synthase (iNOS-/-). Diabetes 49 (2000) 1116-1122
22. Ostenson C.G., Cattaneo A.G., Doxey J.C., and Efendic S. Alpha-adrenoceptors and insulin release from pancreatic islets of normal and diabetic rats. Am. J. Physiol. 257 (1989) E439-E443
23. Chan S.L., Pallett A.L., and Morgan N.G. Clotrimazole and efaroxan stimulate insulin secretion by different mechanisms in rat pancreatic islets. Naunyn Schmiedebergs Arch Pharmacol. 356 (1997) 763-768
24. Schulz A., and Hasselblatt A. An insulin-releasing property of imidazoline derivatives is not limited to compounds that block alpha-adrenoceptors. Naunyn Schmiedebergs Arch Pharmacol. 340 (1989) 321-327
25. Zaitsev S.V., Efanov A.M., Efanova I.B., Larsson O., Ostenson C.G., Gold G., Berggren P.O., and Efendic S. Imidazoline compounds stimulate insulin release by inhibition of K(ATP) channels and interaction with the exocytotic machinery. Diabetes 45 (1996) 1610-1618
26. 2+ from endoplasmic reticulum, and interaction with exocytotic machinery. Ann. N. Y. Acad. Sci. 881 (1999) 241-252
27. Efanov A.M., Hoy M., Branstrom R., Zaitsev S.V., Magnuson M.A., Efendic S., Gromada J., and Berggren P.O. The imidazoline RX871024 stimulates insulin secretion in pancreatic beta-cells from mice deficient in K(ATP) channel function. Biochem. Biophys. Res. Commun. 284 (2001) 918-922
28. Efanov A.M., Zaitsev S.V., Mest H.J., Raap A., Appelskog I.B., Larsson O., Berggren P.O., and Efendic S. The novel imidazoline compound BL11282 potentiates glucose-induced insulin secretion in pancreatic beta-cells in the absence of modulation of K(ATP) channel activity. Diabetes 50 (2001) 797-802
29. Efanov A.M., Appelskog I.B., Abdel-Halim S.M., Khan A., Branstrom R., Larsson O., Ostenson C.G., Mest H.J., Berggren P.O., Efendic S., and Zaitsev S.V. Insulinotropic activity of the imidazoline derivative RX871024 in the diabetic GK rat. Am. J. Physiol. Endocrinol. Metab. 282 (2002) E117-E124
30. Efendic S., Efanov A.M., Berggren P.O., and Zaitsev S.V. Two generations of insulinotropic imidazoline compounds. Diabetes 51 Suppl. 3 (2002) S448-S454
31. Berlin I., Rosenzweig P., Chalon S., Fuseau E., Landault C., Cesselin F., Blacker C., and Puech A.J. Reduction of hyperglycemia after oral glucose load by the new alpha 2-adrenergic receptor antagonist SL 84.0418 in healthy subjects. Clin. Pharmacol. Ther. 55 (1994) 338-345
32. Papaccio G., Nicoletti F., Pisanti F.A., Galdieri M., and Bendtzen K. An imidazoline compound completely counteracts interleukin-1[beta] toxic effects to rat pancreatic islet [beta] cells. Mol. Med. 8 (2002) 536-545
33. Lernmark A. The preparation of, and studies on, free cell suspensions from mouse pancreatic islets. Diabetologia 10 (1974) 431-438
34. 2+ concentration. J. Biol. Chem. 273 (1998) 33501-33507
35. Josefsen K., Stenvang J.P., Kindmark H., Berggren P.O., Horn T., Kjaer T., and Buschard K. Fluorescence-activated cell sorted rat islet cells and studies of the insulin secretory process. J. Endocrinol. 149 (1996) 145-154
36. Larsen C.M., Wadt K.A., Juhl L.F., Andersen H.U., Karlsen A.E., Su M.S., Seedorf K., Shapiro L., Dinarello C.A., and Mandrup-Poulsen T. Interleukin-1beta-induced rat pancreatic islet nitric oxide synthesis requires both the p38 and extracellular signal-regulated kinase 1/2 mitogen-activated protein kinases. J. Biol. Chem. 273 (1998) 15294-15300
37. Ammendrup A., Maillard A., Nielsen K., Aabenhus Andersen N., Serup P., Dragsbaek Madsen O., Mandrup-Poulsen T., and Bonny C. The c-Jun amino-terminal kinase pathway is preferentially activated by interleukin-1 and controls apoptosis in differentiating pancreatic beta-cells. Diabetes 49 (2000) 1468-1476
38. Bonny C., Oberson A., Steinmann M., Schorderet D.F., Nicod P., and Waeber G. IB1 reduces cytokine-induced apoptosis of insulin-secreting cells. J. Biol. Chem. 275 (2000) 16466-16472
39. Saldeen J., Lee J.C., and Welsh N. Role of p38 mitogen-activated protein kinase (p38 MAPK) in cytokine-induced rat islet cell apoptosis. Biochem. Pharmacol. 61 (2001) 1561-1569
40. + channel 6.2 (SUR/Kir6.2) selective potassium channel opener in human islets. Diabetes 53 (2004) 1706-1713
41. Storling J., Zaitsev S.V., Kapelioukh I.L., Karlsen A.E., Billestrup N., Berggren P.O., and Mandrup-Poulsen T. Calcium has a permissive role in interleukin-1beta-induced c-jun N-terminal kinase activation in insulin-secreting cells. Endocrinology 146 (2005) 3026-3036
42. Mandrup-Poulsen T. Apoptotic signal transduction pathways in diabetes. Biochem. Pharmacol. 66 (2003) 1433-1440
43. Suk K., Kim S., Kim Y.H., Kim K.A., Chang I., Yagita H., Shong M., and Lee M.S. IFN-gamma/TNF-alpha synergism as the final effector in autoimmune diabetes: a key role for STAT1/IFN regulatory factor-1 pathway in pancreatic beta cell death. J. Immunol. 166 (2001) 4481-4489