β-Cell toxicity of ATP-sensitive K+ channel-blocking insulin secretagogues

Biochemical Pharmacology

Volumn 67, Issue 9, 2004, Pages 1733-1741

  Rustenbeck, Ingo ^a   Krautheim, Andrea ^b,d   Jörns, Anne ^c   Steinfelder, Hans Jürgen ^b  

^a TECHNICAL UNIVERSITY OF BRAUNSCHWEIG   (Germany)

^b UNIVERSITY OF GÖTTINGEN   (Germany)

^c HANNOVER MEDICAL SCHOOL   (Germany)

^d OTTO VON GUERICKE UNIVERSITY   (Germany)

Author keywords

3 (4,5 dimethylthiazol 2 yl) 2,5 diphenyltetrazolium bromide; Apoptosis; ATP dependent K+ channels; HIT cells; Imidazolines; KATP channels; MTT; Necrosis; Pancreatic islets; Tolbutamide

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALINIDINE; CALCIUM CHANNEL L TYPE; CASPASE; DNA FRAGMENT; EFAROXAN; GALLOPAMIL; IDAZOXAN; IMIDAZOLINE DERIVATIVE; INSULIN DERIVATIVE; PHENTOLAMINE; POTASSIUM CHANNEL BLOCKING AGENT; QUININE DERIVATIVE; SULFONYLUREA DERIVATIVE; TOLBUTAMIDE;

ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; ELECTRON MICROSCOPY; ENZYME ACTIVATION; HAMSTER; INSULINOMA; MORPHOLOGY; MOUSE; NECROSIS; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL;

ANIMALS; APOPTOSIS; BIOLOGICAL TRANSPORT; CALCIUM; CASPASES; CELL SURVIVAL; DNA FRAGMENTATION; INSULIN; ISLETS OF LANGERHANS; MEMBRANE PROTEINS; MICE; POTASSIUM CHANNELS; TOLBUTAMIDE;

EID: 1842634570     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2004.01.016     Document Type: Article

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