Molecular dissection of 2B4 signaling: Implications for signal transduction by SLAM-related receptors

Molecular and Cellular Biology

Volumn 24, Issue 12, 2004, Pages 5144-5156

  Chen, Riyan ^a   Relouzat, Francis ^e   Roncagalli, Romain ^a,b   Aoukaty, Ala ^d   Tan, Rusung ^d   Latour, Sylvain ^e   Veillette, André ^a,b,c  

^a CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

^c MCGILL UNIVERSITY   (Canada)

^d UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^e HÔPITAL NECKER ENFANTS MALADES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CD84 ANTIGEN; CELL RECEPTOR; GAMMA INTERFERON; PROTEIN; PROTEIN 2B4; SLAM RELATED RECEPTOR; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; CELL IMMORTALIZATION; CELL KILLING; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; HUMAN; HUMAN CELL; LYMPHOPROLIFERATIVE DISEASE; NATURAL KILLER CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; RECEPTOR BINDING; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAIN; STRUCTURE ACTIVITY RELATION; T LYMPHOCYTE ACTIVATION; TISSUE SPECIFICITY;

ANIMALS; ANTIGENS, CD; CARRIER PROTEINS; CELL LINE; GLYCOPROTEINS; HUMANS; IMMUNOGLOBULINS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KILLER CELLS, NATURAL; LYMPHOPROLIFERATIVE DISORDERS; MEMBRANE GLYCOPROTEINS; MICE; MODELS, BIOLOGICAL; PHOSPHORYLATION; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, CELL SURFACE; RECEPTORS, IMMUNOLOGIC; SIGNAL TRANSDUCTION; TYROSINE;

EID: 2442445760     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.24.12.5144-5156.2004     Document Type: Article

References (35)

1. Aoukaty, A., and R. Tan. 2002. Association of the X-linked lymphoproliferative disease gene product SAP/SH2D1A with 2B4, a natural killer cell-activating molecule, is dependent on phosphoinositide 3-kinase. J. Biol. Chem. 277:13331-13337.
2. Benoit, L., X. Wang, H. F. Pabst, J. Dutz, and R. Tan. 2000. Defective NK cell activation in X-linked lymphoproliferative disease. J. Immunol. 165. 3549-3553.
3. Bottino, C., R. Augugliaro, R. Castriconi, M. Nanni, R. Biassoni, L. Moretta, and A. Moretta. 2000. Analysis of the molecular mechanism involved in 2B4-mediated NK cell activation: evidence that human 2B4 is physically and functionally associated with the linker for activation of T cells. Eur. J. Immunol. 30:3718-3722.
4. Bottino, C., M. Falco, S. Parolini, E. Marcenaro, R. Augugliaro, S. Sivori, E. Landi, R. Biassoni, L. D. Notarangelo, L. Moretta, and A. Moretta. 2001. NTB-A, a novel SH2D1A-associated surface molecule contributing to the inability of natural killer cells to kill Epstein-Barr virus-infected B cells in X-linked lymphoproliferative disease. J. Exp. Med. 194:235-246.
5. Brown, M. H., K. Boles, P. A. van der Merwe, V. Kumar, P. A. Mathew, and A. N. Barclay. 1998. 2B4, the natural killer and T cell immunoglobulin superfamily surface protein, is a ligand for CD48. J. Exp. Med. 188:2083-2090.
6. Castro, A. G., T. M. Hauser, B. G. Cocks, J. Abrams, S. Zurawski, T. Churakova, F. Zonin, D. Robinson, S. G. Tangye, G. Aversa, K. E. Nichols, J. E. de Vries, L. L. Lanier, and A. O'Garra. 1999. Molecular and functional characterization of mouse signaling lymphocytic activation molecule (SLAM): differential expression and responsiveness in Th1 and Th2 cells. J. Immunol. 163:5860-5870.
7. Chan, B., A. Lanyi, H. K. Song, J. Griesbach, M. Simarro-Grande, F. Poy, D. Howie, J. Sumegi, C. Terhorst, and M. J. Eck. 2003. SAP couples Fyn to SLAM immune receptors. Nat. Cell Biol. 5:155-160.
8. Coffey, A. J., R. A. Brooksbank, O. Brandau, T. Oohashi, G. R. Howell, J. M. Bye, A. P. Cahn, J. Durham, P. Heath, P. Wray, R. Pavitt, J. Wilkinson, M. Leversha, E. Huckle, C. J. Shaw-Smith, A. Dunham, S. Rhodes, V. Schuster, G. Porta, L. Yin, P. Serafini, B. Sylla, M. Zollo, B. Franco, D. R. Bentley, et al. 1998. Host response to EBV infection in X-linked lymphoproliferative disease results from mutations in an SH2-domain encoding gene. Nat. Genet. 20:129-135.
9. Colucci, F., E. Rosmaraki, S. Bregenholt, S. I. Samson, B. Di, V., M. Turner, L. Vanes, V. Tybulewicz, and J. P. Di Santo. 2001. Functional dichotomy in natural killer cell signaling: Vav1-dependent and -independent mechanisms. J. Exp. Med. 193:1413-1424.
10. Davidson, D., L. M. Chow, M. Fournel, and A. Veillette. 1992. Differential regulation of T cell antigen responsiveness by isoforms of the src-related tyrosine protein kinase p59fyn. J. Exp Med. 175:1483-1492.
11. Dutz, J. P., L. Benoit, X. Wang, D. J. Demetrick, A. Junker, D. de Sa, and R. Tan. 2001. Lymphocytic vasculitis in X-linked lymphoproliferative disease. Blood 97:95-100.
12. Engel, P., M. J. Eck, and C. Terhorst. 2003. The SAP and SLAM families in immune responses and X-linked lymphoproliferative disease. Nat. Rev. Immunol. 3:813-821.
13. Garni-Wagner, B. A., A. Purohit, P. A. Mathew, M. Bennett, and V. Kumar. 1993. A novel function-associated molecule related to non-MHC-restricted cytotoxicity mediated by activated natural killer cells and T cells. J. Immunol. 151:60-70.
14. + T cell proliferation by 2B4/CD48 interactions. J. Immunol. 167:6706-6710.
15. Klem, J., P. C. Verrett, V. Kumar, and J. D. Schatzle. 2002. 2B4 is constitutively associated with linker for the activation of T cells in glycolipid-enriched microdomains: properties required for 2B4 lytic function. J. Immunol. 169:55-62.
16. Latchman, Y., P. F. McKay, and H. Reiser. 1998. Identification of the 2B4 molecule as a counter-receptor for CD48. J. Immunol. 161:5809-5812.
17. Latour, S., G. Gish, C. D. Helgason, R. K. Humphries, T. Pawson, and A. Veillette. 2001. Regulation of SLAM-mediated signal transduction by SAP, the X-linked lymphoproliferative gene product. Nat. Immunol. 2:681-690.
18. Latour, S., R. Roncagalli, R. Chen, M. Bakinowski, X. Shi, P. L. Schwartzberg, D. Davidson, and A. Veillette. 2003. Binding of SAP SH2 domain to FynT SH3 domain reveals a novel mechanism of receptor signalling in immune regulation. Nat. Cell Biol. 5:149-154.
19. Latour, S., and A. Veillette. 2003. Molecular and immunological basis of X-linked lymphoproliferative disease. Immunol. Rev. 192:212-224.
20. Latour, S., J. Zhang, R. P. Siraganian, and A. Veillette. 1998. A unique insert in the linker domain of Syk is necessary for its function in immunoreceptor signalling. EMBO J. 17:2584-2595.
21. Lee, K. M., S. Bhawan, T. Majima, H. Wei, M. I. Nishimura, H. Yagita, and V. Kumar. 2003. Cutting edge: the NK cell receptor 2B4 augments antigen-specific T cell cytotoxicity through CD48 ligation on neighboring T cells. J. Immunol. 170:4881-4885.
22. Li, S. C., G. Gish, D. Yang, A. J. Coffey, J. D. Forman-Kay, I. Ernberg, L. E. Kay, and T. Pawson. 1999. Novel mode of ligand binding by the SH2 domain of the human XLP disease gene product SAP/SH2D1A. Curr. Biol. 9:1355-1362.
23. Mathew, P. A., B. A. Garni-Wagner, K. Land, A. Takashima, E. Stoneman, M. Bennett, and V. Kumar. 1993. Cloning and characterization of the 2B4 gene encoding a molecule associated with non-MHC-restricted killing mediated by activated natural killer cells and T cells. J. Immunol. 151:5328-5337.
24. Moretta, A., C. Bottino, M. Vitale, D. Pende, C. Cantoni, M. C. Mingari, R. Biassoni, and L. Moretta. 2001. Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis. Annu. Rev. Immunol. 19:197-223.
25. Nakajima, H., M. Cella, A. Bouchon, H. L. Grierson, J. Lewis, C. S. Duckett, J. I. Cohen, and M. Colonna. 2000. Patients with X-linked lymphoproliferative disease have a defect in 2B4 receptor-mediated NK cell cytotoxicity. Eur. J. Immunol. 30:3309-3318.
26. Nichols, K. E., D. P. Harkin, S. Levitz, M. Krainer, K. A. Kolquist, C. Genovese, A. Bernard, M. Ferguson, L. Zuo, E. Snyder, A. J. Buckler, C. Wise, J. Ashley, M. Lovett, M. B. Valentine, A. T. Look, W. Gerald, D. E. Housman, and D. A. Haber. 1998. Inactivating mutations in an SH2 domain-encoding gene in X-linked lymphoproliferative syndrome. Proc. Natl. Acad. Sci. USA 95:13765-13770.
27. Parolini, S., C. Bottino, M. Falco, R. Augugliaro, S. Giliani, R. Franceschini, H. D. Ochs, H. Wolf, J. Y. Bonnefoy, R. Biassoni, L. Moretta, L. D. Notarangelo, and A. Moretta. 2000. X-linked lymphoproliferative disease. 2B4 molecules displaying inhibitory rather than activating function are responsible for the inability of natural killer cells to kill Epstein-Barr virus-infected cells. J. Exp. Med. 192:337-346.
28. Sayos, J., C. Wu, M. Morra, N. Wang, X. Zhang, D. Allen, S. van Schaik, L. Notarangelo, R. Geha, M. G. Roncarolo, H. Oettgen, J. E. de Vries, G. Aversa, and C. Terhorst. 1998. The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM. Nature 395:462-469.
29. Tangye, S. G., S. Lazetic, E. Woollatt, G. R. Sutherland, L. L. Lanier, and J. H. Phillips. 1999. Cutting edge: human 2B4, an activating NK cell receptor, recruits the protein tyrosine phosphatase SHP-2 and the adaptor signaling protein SAP. J. Immunol. 162:6981-6985.
30. Tangye, S. G., J. H. Phillips, L. L. Lanier, and K. E. Nichols. 2000. Functional requirement for SAP in 2B4-mediated activation of human natural killer cells as revealed by the X-linked lymphoproliferative syndrome. J. Immunol. 165:2932-2936.
31. Turner, M., and D. D. Billadeau. 2002. VAV proteins as signal integrators for multi-subunit immune-recognition receptors. Nat. Rev. Immunol. 2:476-486.
32. Valiante, N. M., and G. Trinchieri. 1993. Identification of a novel signal transduction surface molecule on human cytotoxic lymphocytes. J. Exp. Med. 178:1397-1406.
33. Veillette, A., M. A. Bookman, E. M. Horak, and J. B. Bolen. 1988. The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p561ck. Cell 55:301-308.
34. Veillette, A., and S. Latour. 2003. The SLAM family of immune-cell receptors. Curr. Opin. Immunol. 15:277-285.
35. Watzl, C., C. C. Stebbins, and E. O. Long. 2000. NK cell inhibitory receptors prevent tyrosine phosphorylation of the activation receptor 2B4 (CD244). J. Immunol. 165:3545-3548.