Cutting edge: Functional requirement for SAP in 2B4-mediated activation of human natural killer cells as revealed by the X-linked lymphoproliferative syndrome

Journal of Immunology

Volumn 165, Issue 6, 2000, Pages 2932-2936

  Tangye, S G ^a   Phillips, J H ^a   Lanier, L L ^a   Nichols, K E ^a  

^a CENTENARY INSTITUTE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; HUMAN; HUMAN CELL; IMMUNOPATHOLOGY; LYMPHOPROLIFERATIVE DISEASE; NATURAL KILLER CELL; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; X CHROMOSOME LINKED DISORDER; ANIMAL; BIOSYNTHESIS; CELL CULTURE; CELL LINE; CYTOTOXICITY TEST; GENETIC LINKAGE; GENETICS; IMMUNE DEFICIENCY; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; MONONUCLEAR CELL; MOUSE; PHYSIOLOGY; SRC HOMOLOGY DOMAIN; SYNDROME; X CHROMOSOME;

CARRIER PROTEIN; CD150 ANTIGEN; CD244 PROTEIN, HUMAN; CD244 PROTEIN, MOUSE; CELL SURFACE RECEPTOR; GLYCOPROTEIN; IMMUNOGLOBULIN; IMMUNOGLOBULIN RECEPTOR; LEUKOCYTE ANTIGEN; MEMBRANE PROTEIN; MONOCLONAL ANTIBODY; SH2D1A PROTEIN, HUMAN; SH2D1A PROTEIN, MOUSE; SIGNAL PEPTIDE;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD; CARRIER PROTEINS; CELL LINE; CYTOTOXICITY TESTS, IMMUNOLOGIC; CYTOTOXICITY, IMMUNOLOGIC; GLYCOPROTEINS; HUMANS; IMMUNOGLOBULINS; IMMUNOLOGIC DEFICIENCY SYNDROMES; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KILLER CELLS, NATURAL; LEUKOCYTES, MONONUCLEAR; LINKAGE (GENETICS); LYMPHOCYTE ACTIVATION; LYMPHOPROLIFERATIVE DISORDERS; MEMBRANE GLYCOPROTEINS; MICE; RECEPTORS, CELL SURFACE; RECEPTORS, IMMUNOLOGIC; SRC HOMOLOGY DOMAINS; SYNDROME; TUMOR CELLS, CULTURED; X CHROMOSOME;

EID: 0034664724     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.165.6.2932     Document Type: Article

References (33)

1. Regulation of immune responses through inhibitory receptors
2. X-linked agam-maglobulinemia: New approaches to old questions based on the identification of the defective gene
3. ZAP-70 deficiency in an autosomal recessive form of severe combined immunodeficiency
4. Interleukin-2 receptor γ-chain mutation results in X-linked severe combined immunodeficiency in humans
5. An essential role for BLNK in human B cells
6. X-linked lymphoproliferative syndrome: Natural history of the immunodeficiency
7. The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM
8. Inactivating mutations in an SH2 domain-encoding gene in X-linked lymphoproliferative syndrome
9. Host response to EBV infection in X-linked lymphoproliferative disease results from mutations in an SH2-domain encoding gene
10. Cutting edge: Human 2B4, an activating natural killer cell receptor, recruits the protein tyrosine phosphatase SHP-2 and the adaptor signaling protein SAP
11. Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition
12. Molecular and functional characterization of mouse SLAM: Differential expression and responsiveness in Th1 and Th2 cells
13. Cloning and characterization of the 2B4 gene encoding a molecule associated with non-MHC-restricted killing mediated by activated natural killer cells and T cells
14. A novel receptor involved in T-cell activation
15. Activating interactions in human NK cell recognition: The role of 2B4-CD48
16. Protein tyrosine phosphatases in T-cell development, apoptosis and signalling
17. Identification of a novel signal transduction surface molecule on human cytotoxic lymphocytes
18. Expression of the Blast-1 activation/adhesion molecule and its identification as CD48
19. Generation and cloning of antigen-specific human T-cells
20. Serum-free medium for generation and propagation of functional human cytotoxic and helper T cell clones
21. Characterization of a cell line, NKL, derived from an aggressive human natural killer cell leukemia
22. Superantigendependent, cell-mediated cytotoxicity inhibited by MHC class I receptors on T lymphocytes
23. NK cell receptors
24. The CD2-subset of the Ig superfamily of cell surface molecules: Receptor-ligand pairs expressed by NK cells and other immune cells
25. A novel function-associated molecule related to non-MHC-restricted cytotoxicity mediated by activated natural killer cells and T cells
26. Characterization of a surface membrane molecule expressed by natural killer cells in most inbred mouse strains: Monoclonal antibody C9.1 identifies an allelic form of the 2B4 antigen
27. Engagement, of the signaling lymphocytic activation molecule (SLAM) on activated T cells results in IL-2-independent, cyclosporin A-sensitive T cell proliferation and IFN-γ production
28. 2B4, the natural killer and T cell immunoglobulin superfamily surface protein, is a ligand for CD48
29. The biology of Epstein-Barr virus: Lessons learned from the virus and the host
30. Epstein-Barr virus superinduces a new human B cell differentiation antigen (B-LAST 1) expressed on transformed lymphoblasts
31. The abnormal gene in X-linked lymphoproliferative syndrome
32. Patients with X-linked lymphoproliferative disease have a defect in 2B4 receptor-mediated NK cell cytotoxicity
33. X-linked lymphoproliferative disease: 2B4 molecules displaying inhibitory rather than activating function are responsible for the inability of natural killer cells to kill Epstein-Barr virus-infected cells