ULBP1, 2, 3: Novel MHC class I-related molecules that bind to human cytomegalovirus glycoprotein UL16, activate NK cells

European Journal of Immunology

Volumn 31, Issue 5, 2001, Pages 1428-1437

  Kubin, Marek ^a   Cassiano, Linda ^a   Chalupny, Jan ^a   Chin, Wilson ^a   Cosman, David ^a   Fanslow, William ^a   Müllberg, Jürgen ^a,b   Rousseau, Anne Marie ^a   Ulrich, Dawn ^a   Armitage, Richard ^a  

^a AMGEN INC   (United States)

^b Target Quest BV   (Netherlands)

Author keywords

Activation receptor; Cytomegalovirus; NK cell

Indexed keywords

CHEMOKINE; CYTOKINE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; RECOMBINANT PROTEIN; RECOMBINANT UL 16 PROTEIN; UL 16 BINDING PROTEIN 1; UL 16 BINDING PROTEIN 2; UL 16 BINDING PROTEIN 3; UNCLASSIFIED DRUG; VIRUS GLYCOPROTEIN;

ANIMAL CELL; ARTICLE; ASSAY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY; HOST; HUMAN; HUMAN CELL; HUMAN CYTOMEGALOVIRUS; IMMUNE SYSTEM; LYMPHOCYTE ACTIVATION; MOLECULAR BIOLOGY; MOUSE; NATURAL KILLER CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; SEQUENCE HOMOLOGY; SOLUBILITY;

ANIMALS; BINDING, COMPETITIVE; CARRIER PROTEINS; CELL DIVISION; CELLS, CULTURED; CHEMOKINES; CYTOKINES; CYTOMEGALOVIRUS; CYTOTOXICITY, IMMUNOLOGIC; FLOW CYTOMETRY; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; IMMUNOGLOBULIN G; INTERLEUKIN-15; KILLER CELLS, NATURAL; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COUNT; MICE; MICE, SCID; PROTEIN BINDING; SOLUBILITY; SPLEEN; T-LYMPHOCYTES, CYTOTOXIC; VIRAL ENVELOPE PROTEINS;

EID: 0034998410     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200105)31:5<1428::AID-IMMU1428>3.0.CO;2-4     Document Type: Article

References (35)

1. Trinchieri, G., Biology of natural killer cells. Adv. Immunol. 1989. 47: 187-376.
2. Fehniger, T. A., Shah, M. H., Turner, M. J., VanDeusen, J. B., Whitman, S. P., Cooper, M. A., Suzuki, K., Wechser, M., Goodsaid, F. and Caligiuri, M. A., Differential cytokine and chemokine gene expression by human NK cells following activation with IL-18 or IL-15 in combination with IL-12: implications for the innate immune response. J. Immunol. 1999. 162: 4511-4520.
3. + in Fc gamma R (CD16)-induced transcription and expression of lymphokine genes. J. Exp. Med. 1989. 169: 549-567.
4. Lanier, L. L., Natural killer cell receptors and MHC class I interactions. Curr. Opin. Immunol. 1997. 9: 126-131.
5. Bauer, S., Groh, V., Wu, J., Steinle, A., Phillips, J. H., Lanier, L. L. and Spies, T., Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. Science 1999. 285: 727-729.
6. Kubin, M. Z., Parshley, D. L., Din, W., Waugh, J. Y., Davis-Smith, T., Smith, C. A., Macduff, B. M., Armitage, R. J., Chin, W., Cassiano, L., Borges, L., Petersen, M., Trinchieri, G. and Goodwin, R. G., Molecular cloning and biological characterization of NK cell activation-inducing ligand, a counterstructure for CD48. Eur. J. Immunol. 1999. 29: 3466-3477.
7. Moretta, A., Biassoni, R., Bottino, C., Mingari, M. C. and Moretta, L., Natural cytotoxicity receptors that trigger human NK-cell-mediated cytolysis. Immunol. Today 2000. 21: 228-234.
8. Wu, J., Song, Y., Bakker, A. B., Bauer, S., Spies, T., Lanier, L. L. and Phillips, J. H., An activating immunoreceptor complex formed by NKG2D and DAP10. Science 1999. 285: 730-732.
9. Alcamí, A., Symons, J. A., Collins, P. D., Williams, T. J. and Smith, G. L., Blockade of chemokine activity by a soluble chemokine binding protein from vaccinia virus. J. Immunol. 1998. 160: 624-633.
10. Born, T. L., Morrison, L. A., Esteban, D. J., VandenBos, T., Thebeau, L. G., Chen, N., Spriggs, M. K., Sims, J. E. and Buller, R. M., A poxvirus protein that binds to and inactivates IL-18, and inhibits NK cell response. J. Immunol. 2000. 164: 3246-3254.
11. Cosman, D., Fanger, N., Borges, L., Kubin, M., Chin, W., Peterson, L. and Hsu, M.-L., A novel immunoglobulin superfamily receptor for cellular and viral MHC class I molecules. Immunity 1997. 7: 273-282.
12. Parry, C. M., Simas, J. P., Smith, V. P., Stewart, C. A., Minson, A. C., Efstathiou, S. and Alcami, A., A broad spectrum secreted chemokine binding protein encoded by a herpesvirus. J. Exp. Med, 2000. 191: 573-578.
13. Smith, C. A., Smith, T. D., Smolak, P. J., Friend, D., Hagen, H., Gerhart, M., Park, L., Pickup, D. J., Torrance, D., Monier, K., Schooley, K. and Goodwin, R. G., Poxvirus genomes encode a secreted, soluble protein that completely inhibits β chemokine activity yet lacks sequence homology to known chemokine receptors. Virology 1997. 236: 316-327.
14. Spriggs, M. K., One step ahead of the game: viral immunomodulatory molecules. Annu. Rev. Immunol. 1996. 14: 101-130.
15. Thome, M., Schneider, P., Hofmann, K., Fickenscher, H., Meinl, E., Neipel, F., Mattmann, C., Burns, K., Bodmer, J.-L., Schröter, M., Scaffidi, C., Krammer, P. H., Peter, M. E. and Tschopp, J., Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors. Nature 1997. 386: 517-521.
16. Biron, C. A., Nguyen, K. B., Pien, G. C., Cousens, L. P. and Salazar-Mather, T. P., Natural killer cells in antiviral defense: function and regulation by innate cytokines. Annu. Rev. Immunol. 1999. 17: 189-220.
17. Farrell, H. E., Degli-Esposti, M. A. and Davis-Poynter, N. J., Cytomegalovirus evasion of natural killer cell responses, Immunol. Rev. 1999. 168: 187-197.
18. Krosky, P. M., Underwood, M. R., Turk, S. R., Feng, K. W., Jain, R. K., Ptak, R. G., Westerman, A. C., Biron, K. K., Townsend, L. B. and Drach, J. C., Resistance of human cytomegalovirus to benzimidazole ribonucleosides maps to two open reading frames: UL89 and UL56. J. Virol. 1998. 72: 4721-4728.
19. Littler, E., Stuart, A. D. and Chee, M. S., Human cytomegalovirus UL97 open reading frame encodes a protein that phosphorylates the antiviral nucleoside analogue ganciclovir. Nature 1992. 358: 160-162.
20. Tomasec, P., Braud, V. M., Rickards, C., Powell, M. B., McSharry, B. P., Gadola, S., Cerundolo, V., Borysiewicz, L. K., McMichael, A. J. and Wilkinson, G. W., Surface expression of HLA-E, an inhibitor of natural killer cells, enhanced by human cytomegalovirus gpUL40. Science 2000. 287: 1031.
21. Kaye, J., Browne, H., Stoffel, M. and Minson, T., The UL16 gene of human cytomegalovirus encodes a glycoprotein that is dispensable for growth in vitro. J. Virol. 1992. 66: 6609-6615.
22. Cosman, D., Müllberg, J., Sutherland, C., Chin, W., Armitage, R. J., Fanslow, W. C., Kubin, M. and Chalupny, J., The ULBP, novel MHC class I-related molecules, bind to human cytomegalovirus glycoprotein, UL16, and to the NKG2D/DAP10 receptor, to stimulate NK cytotoxicity. Immunity, 2001, in press.
23. Flamand, L., Stefanescu, I. and Menezes, J., Human herpesvirus-6 enhances natural killer cell cytotoxicity via IL-15. J. Clin. Invest. 1996. 97: 1373-1381.
24. Armitage, R. J., Ulrich, D. T., Macduff, B. M., Zappone, J., Kubin, M. Z. and Fanslow, W. C., Induction of membrane-associated and soluble CD83 from B, T and dendritic cells. In Kishimoto, T. (Eds.) Leucocyte typing VI. Garland Publishing, New York 1997, p 593.
25. Melero, I., Johnston, J. V., Shufford, W. W., Mittler, R. S. and Chen, L., NK1.1 cells express 4-1BB (CDw137) costimulatory molecule and are required for tumor immunity elicited by anti-4-1BB monoclonal antibodies. Cell. Immunol. 1998. 190: 167-172.
26. Tan, J. T., Whitmire, J. K., Murali-Krishna, K., Ahmed, R., Altman, J. D., Mittler, R. S., Sette, A., Pearson, T. C. and Larsen, C. P., 4-1BB costimulation is required for protective anti-viral immunity after peptide vaccination. J. Immunol. 2000. 164: 2320-2325.
27. Trinchieri, G. and Scott, P., Interleukin-12: basic principles and clinical applications. Curr. Top. Microbiol. Immunol. 1999. 238: 57-78.
28. Cretney, E., Degli-Esposti, M. A., Densley, E. H., Parrell, H. E., Davis-Poynter, N. J. and Smyth, M. J., m144, a murine cytomegalovirus (MCMV)-encoded major histocompatibility complex class I homologue, confers tumor resistance to natural killer cell-mediated rejection. J. Exp. Med. 1999. 190: 435-444.
29. Davis-Poynter, N. J., Degli-Esposti, M. and Farrell, H. E., Murine cytomegalovirus homologues of cellular immunomodulatory genes. Intervirology 1999. 42: 331-341.
30. Morris, A. E., Remmele, R. L., Jr., Klinke, R., Macduff, B. M., Fanslow, W. C. and Armitage, R. J., Incorporation of an isoleucine zipper motif enhances the biological activity of soluble CD40L (CD154). J. Biol. Chem. 1999. 274: 418-423.
31. Kubin, M., Kamoun, M. and Trinchieri, G., Interleukin 12 synergizes with B7/CD28 interaction in inducing efficient proliferation and cytokine production of human T cells. J. Exp. Med. 1994. 180: 211-222.
32. Galibert, L., Tometsko, M. E., Anderson, D. M., Cosman, D. and Dougall, W. C., The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-κB, a member of the TNFR superfamily. J. Biol. Chem. 1998. 273: 34120-34127.
33. Griffith, T. S., Chin, W. A., Jackson, G. C., Lynch, D. H. and Kubin, M. Z., Intracellular regulation of TRAIL-induced apoptosis in human melanoma cells. J. Immunol. 1998. 161: 2833-2840.
34. Lyman, S. D., Escobar, S., Rousseau, A. M., Armstrong, A. and Fanslow, W. C., Identification of CD7 as a cognate of the human K12 (SECTM1) protein. J. Biol. Chem. 2000. 275: 3431-3437.
35. Alderson, M. R., Armitage, R. J., Maraskovsky, E., Tough, T. W., Roux, E., Schooley, K., Ramsdell, F. and Lynch, D. H., Fas transduces activation signals in normal human T lymphocytes. J. Exp. Med. 1993. 178: 2231-2235.