NKG2D recriuts two distinct adapters to trigger NK cell activation and costimulation

Nature Immunology

Volumn 3, Issue 12, 2002, Pages 1150-1155

  Gilfillan, Susan ^a   Ho, Emily L ^b   Cella, Marina ^a   Yokohama, Wayne M ^b   Colonna, Marco ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; KILLER CELL ACTIVATING RECEPTOR ASSOCIATED PROTEIN; LYMPHOCYTE RECEPTOR; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; NATURAL KILLER CELL RECEPTOR NKG2D; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN DAP; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG; HCST PROTEIN, MOUSE; HLA ANTIGEN CLASS 1; IMMUNOGLOBULIN RECEPTOR; MEMBRANE PROTEIN; NATURAL KILLER CELL ACTIVATING RECEPTORS; TYROBP PROTEIN, HUMAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; IMMUNE RESPONSE; IN VITRO STUDY; LYMPHOCYTE ACTIVATION; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING; VIRUS INFECTION; ANIMAL; CYTOTOXICITY; GENETICS; IMMUNOLOGY; MUTATION; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

ANIMALS; CYTOTOXICITY, IMMUNOLOGIC; HISTOCOMPATIBILITY ANTIGENS CLASS I; KILLER CELLS, NATURAL; LYMPHOCYTE ACTIVATION; MEMBRANE PROTEINS; MICE; MUTATION; RECEPTORS, IMMUNOLOGIC; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 0036910991     PISSN: 15292908     EISSN: None     Source Type: Journal    
DOI: 10.1038/ni857     Document Type: Article

References (33)

1. Lanier, L. L. NK cell receptors. Annu. Rev. Immunol. 16, 359-393 (1998).
2. Bauer, S. et al. Activation of NK cells and T cells by NKG2D, a receptor for stress- inducible MICA. Science 285, 727-729 (1999).
3. Cerwerka, A. et al. Retinoic acid early inducible genes define a ligand family for the activating NKG2D receptor in mice. Immunity 12, 721-727 (2000).
4. Diefenbach, A., Jamieson, A. M., Liu, S. D., Shastri, N. & Raulet, D. H. Ligands for the murine NKG2D receptor: expression by tumor cells and activation of NK cells and macrophages. Nature Immunol. I. 119-126 (2000).
5. Cosman, D. et al. ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor. Immunity 14, 123-133 (2001).
6. Sutherland, C. L. et al. UL16-binding proteins, novel MHC class I-related Proteins, bind to NKG2D and activate multiple signaling pathways in primary NK cells. J. Immunol. 168, 671-679 (2002).
7. Groh, V. et al. Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium. Proc. Natl. Acad. Sci. USA 93, 12445-12450 (1996).
8. Groh, V., Steinle, A., Bauer, S. & Spies, T Recognition of stress-induced MHC molecules by intestinal epithelial γδ T cells. Science 279, 1737-1740 (1998).
9. Diefenbach, A., Jensen, E. R., Jamieson, A. M. & Raulet, D. H. Rael and H60 ligands of the NKG2D receptor stimulate tumour immunity. Nature 413, 165-171 (2001).
10. Cerwenka, A., Baron, J. L. & Lanier, L. L. Ectopic expression of retinoic acid early inducible- I gene (RAE-1) permits natural killer cell-mediated rejection of a MHC class I-bearing tumor in vivo. Proc. Natl. Acad. Sci. USA 98, 11521-11526 (2001).
11. Girardi, M. et al. Regulation of cutaneous malignancy by γδ T cells. Science 294, 605-609 (2001).
12. Groh, V. et al. Costimulation of CD8αβ T cells by NKG2D via engagement by MIC induced on virus-infected cells. Nature Immunol. 2, 255-260 (2001).
13. Wu, J. et al. An activating immunoreceptor complex formed by NKG2D and DAP10. Science 285, 730-732 (1999).
14. Lanier, L. L. & Bakker A. B. The ITAM-bearing transmembrane adaptor DAP12 in lymphoid and myeloid cell function. Immunol. Today 21, 611-614 (2000).
15. Tomasello, E. et al. Gene structure, expression pattern, and biological activity of mouse killer cell activating receptor-associated protein (KARAP)/DAP-12. J. Biol. Chem. 273, 34115-34119 (1998).
16. McVicar D.W. et al. DAP12-mediated signal transduction in natural killer cells. A dominant role for the Syk protein-tyrosine kinase. J. Biol. Chem. 273, 32934-32942 (1998).
17. Tomasello, E., Blery, M., Vely, E. & Vivier, E. Signaling pathways engaged by NK cell receptors: double concerto for activating receptors, inhibitory receptors and NK cells. Semin. Immunol. 12, 139-147 (2000).
18. Chang, C. et al. Cutting edge: KAP10, a novel transmembrane adapter protein genetically linked to DAP12 but with unique signaling properties. J. Immunol. 163, 4651-4654 (1999).
19. Wu, J., Cherwinski, H., Spies, T., Phillips, J. H. & Lanier, L. L. DAP10 and DAP12 form distinct, but functionally cooperative, receptor complexes in natural killer cells. J. Exp. Med. 192, 1059-1068 (2000).
20. Pages, F. et al. Binding of phosphatidylinositol-3-OH kinase to CD28 is required for T-cell signalling. Nature 369, 327-329 (1994).
21. Prasad, K.V. et al. T-cell antigen CD28 interacts with the lipid kinase phosphaticylinositol 3-kinase by a cytoplasmic Tyr(P)-Met-Xaa-Met motif. Proc. Natl. Acad. Sci. USA 91, 2834-2838 (1994).
22. Schwenk, F., Baron, U. & Rajewsky, K. A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells. Nucleic Acids Res. 23, 5080-5081 (1995).
23. Ho, E. L. et al. Costimulation of multiple NK cell activation receptors by NKG2D. J. Immunol. 169, 3667-3675 (2002).
24. Karre, K., Ljunggren, H. G., Piontelk, G. & Kiessling, R. Selective rejection of H-2-deficient lymphoma variants suggests alternative immune defence strategy. Nature 319, 675-678 (1986).
25. Idris, A. H. et al. The natural killer gene complex genetic locus Chok encodes Ly-49D, a target recognition receptor that activates natural killing. Proc. Natl. Acad. Sci. USA 96, 6330-6335 (1999).
26. +T cells specific for transporter associated with antigen processing deficient cells. Proc. Natl. Acad. Sci. USA 94, 11496-11501 (1997).
27. Kelly J. M., Takeda, K., Darcy, P. K., Yagita, H. & Smyth, M. J. A role for IFN-γ in primary and secondary immunity generated by NK cell-sensitive tumor-expressing CD80 in vivo. J. Immunol. 168, 4472-4479 (2002).
28. Kelly J. M. et al. Induction of tumor-specific T cell memory by NK cell-mediated tumor rejection. Nature Immunol. 3, 83-90 (2002).
29. Roberts, A. I. et al. NKG2D receptors induced by IL-15 costimulate CD28-negative effector CTL in the tissue microenvironment. J. Immunol. 167, 5527-5530 (2001).
30. Diefenbach, A. et al. Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D. Nature Immunol.; published online II November 2002 (doi: 10.1038/ni858).
31. Long, E. O. Tumor cell recognition by natural killer cells. Semin. Cancer Biol. 12, 57-61 (2002).
32. Pende, D. et al. Role of NKG2D in tumor cell lysis mediated by human NK cells: cooperation with natural cytotoxicity receptors and capability of recognizing tumors of nonepithelial origin. Eur. J. Immunol. 31, 1076-1086 (2001).
33. Riegert, P. & Gilfillan, S. A conserved sequence block in the murine and human TCR Jα region: assessment of regulatory function in vivo. J. Immunol. 162, 3471-3480 (1999).