메뉴 건너뛰기




Volumn 121, Issue 4, 2008, Pages 803-809

Therapeutic approaches for control of transcription factors in allergic disease

Author keywords

asthma; atopic dermatitis; GATA3; glucocorticoid receptor; nuclear factor B; nuclear factor of activated T cells; signal transducer and activator of transcription 6; TH2; Transcription factors

Indexed keywords

CYCLOSPORIN A; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; STAT6 PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GATA 3; TRANSCRIPTION FACTOR NFAT;

EID: 41449107295     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2008.02.008     Document Type: Review
Times cited : (37)

References (101)
  • 1
    • 0037338904 scopus 로고    scopus 로고
    • The role of T lymphocytes in the pathogenesis of asthma
    • Larche M., Robinson D.S., and Kay A.B. The role of T lymphocytes in the pathogenesis of asthma. J Allergy Clin Immunol 111 (2003) 450-463
    • (2003) J Allergy Clin Immunol , vol.111 , pp. 450-463
    • Larche, M.1    Robinson, D.S.2    Kay, A.B.3
  • 3
    • 0037775352 scopus 로고    scopus 로고
    • IL-13 effector functions
    • Wynn T.A. IL-13 effector functions. Annu Rev Immunol 21 (2003) 425-456
    • (2003) Annu Rev Immunol , vol.21 , pp. 425-456
    • Wynn, T.A.1
  • 5
    • 33646196946 scopus 로고    scopus 로고
    • Regulation of Th2 differentiation and Il4 locus accessibility
    • Ansel K.M., Djuretic I., Tanasa B., and Rao A. Regulation of Th2 differentiation and Il4 locus accessibility. Annu Rev Immunol 24 (2006) 607-656
    • (2006) Annu Rev Immunol , vol.24 , pp. 607-656
    • Ansel, K.M.1    Djuretic, I.2    Tanasa, B.3    Rao, A.4
  • 6
    • 9644262463 scopus 로고    scopus 로고
    • Signaling pathways in Th2 development
    • Mowen K.A., and Glimcher L.H. Signaling pathways in Th2 development. Immunol Rev 202 (2004) 203-222
    • (2004) Immunol Rev , vol.202 , pp. 203-222
    • Mowen, K.A.1    Glimcher, L.H.2
  • 7
    • 0036721797 scopus 로고    scopus 로고
    • Cytokine coexpression during human TH1/TH2 cell differentiation: direct evidence for coordinated expression of th2 cytokines
    • Cousins D.J., Lee T.H., and Staynov D.Z. Cytokine coexpression during human TH1/TH2 cell differentiation: direct evidence for coordinated expression of th2 cytokines. J Immunol 169 (2002) 2498-2506
    • (2002) J Immunol , vol.169 , pp. 2498-2506
    • Cousins, D.J.1    Lee, T.H.2    Staynov, D.Z.3
  • 9
    • 0037236203 scopus 로고    scopus 로고
    • Memory and flexibility of cytokine gene expression as separable properties of human T(H)1 and T(H)2 lymphocytes
    • Messi M., Giacchetto I., Nagata K., Lanzavecchia A., Natoli G., and Sallusto F. Memory and flexibility of cytokine gene expression as separable properties of human T(H)1 and T(H)2 lymphocytes. Nat Immunol 4 (2003) 78-86
    • (2003) Nat Immunol , vol.4 , pp. 78-86
    • Messi, M.1    Giacchetto, I.2    Nagata, K.3    Lanzavecchia, A.4    Natoli, G.5    Sallusto, F.6
  • 10
    • 0037103140 scopus 로고    scopus 로고
    • DNA methylation changes at human Th2 cytokine genes coincide with DNase I hypersensitive site formation during CD4(+) T cell differentiation
    • Santangelo S., Cousins D.J., Winkelmann N.E., and Staynov D.Z. DNA methylation changes at human Th2 cytokine genes coincide with DNase I hypersensitive site formation during CD4(+) T cell differentiation. J Immunol 69 (2002) 1893-1903
    • (2002) J Immunol , vol.69 , pp. 1893-1903
    • Santangelo, S.1    Cousins, D.J.2    Winkelmann, N.E.3    Staynov, D.Z.4
  • 11
    • 0029876629 scopus 로고    scopus 로고
    • Stat6 is required for mediating responses to IL-4 and for development of Th2 cells
    • Kaplan M.H., Schindler U., Smiley S.T., and Grusby M.J. Stat6 is required for mediating responses to IL-4 and for development of Th2 cells. Immunity 4 (1996) 313-319
    • (1996) Immunity , vol.4 , pp. 313-319
    • Kaplan, M.H.1    Schindler, U.2    Smiley, S.T.3    Grusby, M.J.4
  • 12
    • 15844374279 scopus 로고    scopus 로고
    • Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene
    • Shimoda K., van Deursen J., Sangster M.Y., Sarawar S.R., Carson R.T., Tripp R.A., et al. Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene. Nature 380 (1996) 630-633
    • (1996) Nature , vol.380 , pp. 630-633
    • Shimoda, K.1    van Deursen, J.2    Sangster, M.Y.3    Sarawar, S.R.4    Carson, R.T.5    Tripp, R.A.6
  • 14
    • 0032482159 scopus 로고    scopus 로고
    • Abrogation of bronchial eosinophilic inflammation and airway hyperreactivity in signal transducers and activators of transcription (STAT)6-deficient mice
    • Akimoto T., Numata F., Tamura M., Takata Y., Higashida N., Takashi T., et al. Abrogation of bronchial eosinophilic inflammation and airway hyperreactivity in signal transducers and activators of transcription (STAT)6-deficient mice. J Exp Med 187 (1998) 1537-1542
    • (1998) J Exp Med , vol.187 , pp. 1537-1542
    • Akimoto, T.1    Numata, F.2    Tamura, M.3    Takata, Y.4    Higashida, N.5    Takashi, T.6
  • 15
    • 0032536837 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription factor 6 (Stat6)-deficient mice are protected from antigen-induced airway hyperresponsiveness and mucus production
    • Kuperman D., Schofield B., Wills-Karp M., and Grusby M.J. Signal transducer and activator of transcription factor 6 (Stat6)-deficient mice are protected from antigen-induced airway hyperresponsiveness and mucus production. J Exp Med 187 (1998) 939-948
    • (1998) J Exp Med , vol.187 , pp. 939-948
    • Kuperman, D.1    Schofield, B.2    Wills-Karp, M.3    Grusby, M.J.4
  • 16
    • 0034689032 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 6 is essential in the induction of contact hypersensitivity
    • Yokozeki H., Ghoreishi M., Takagawa S., Takayama K., Satoh T., Katayama I., et al. Signal transducer and activator of transcription 6 is essential in the induction of contact hypersensitivity. J Exp Med 191 (2000) 995-1004
    • (2000) J Exp Med , vol.191 , pp. 995-1004
    • Yokozeki, H.1    Ghoreishi, M.2    Takagawa, S.3    Takayama, K.4    Satoh, T.5    Katayama, I.6
  • 17
    • 19944390511 scopus 로고    scopus 로고
    • In vivo transfection of a cis element "decoy" against signal transducers and activators of transcription 6 (STAT6)-binding site ameliorates IgE-mediated late-phase reaction in an atopic dermatitis mouse model
    • Yokozeki H., Wu M.H., Sumi K., Awad S., Satoh T., Katayama I., et al. In vivo transfection of a cis element "decoy" against signal transducers and activators of transcription 6 (STAT6)-binding site ameliorates IgE-mediated late-phase reaction in an atopic dermatitis mouse model. Gene Ther 11 (2004) 1753-1762
    • (2004) Gene Ther , vol.11 , pp. 1753-1762
    • Yokozeki, H.1    Wu, M.H.2    Sumi, K.3    Awad, S.4    Satoh, T.5    Katayama, I.6
  • 18
    • 0036344597 scopus 로고    scopus 로고
    • Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma
    • Kuperman D.A., Huang X., Koth L.L., Chang G.H., Dolganov G.M., Zhu Z., et al. Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma. Nat Med 8 (2002) 885-889
    • (2002) Nat Med , vol.8 , pp. 885-889
    • Kuperman, D.A.1    Huang, X.2    Koth, L.L.3    Chang, G.H.4    Dolganov, G.M.5    Zhu, Z.6
  • 19
    • 0035821221 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 6 controls chemokine production and T helper cell type 2 cell trafficking in allergic pulmonary inflammation
    • Mathew A., MacLean J.A., DeHaan E., Tager A.M., Green F.H., and Luster A.D. Signal transducer and activator of transcription 6 controls chemokine production and T helper cell type 2 cell trafficking in allergic pulmonary inflammation. J Exp Med 193 (2001) 1087-1096
    • (2001) J Exp Med , vol.193 , pp. 1087-1096
    • Mathew, A.1    MacLean, J.A.2    DeHaan, E.3    Tager, A.M.4    Green, F.H.5    Luster, A.D.6
  • 20
    • 5044251100 scopus 로고    scopus 로고
    • STAT6-mediated signaling in Th2-dependent allergic asthma: critical role for the development of eosinophilia, airway hyper-responsiveness and mucus hypersecretion, distinct from its role in Th2 differentiation
    • Hoshino A., Tsuji T., Matsuzaki J., Jinushi T., Ashino S., Teramura T., et al. STAT6-mediated signaling in Th2-dependent allergic asthma: critical role for the development of eosinophilia, airway hyper-responsiveness and mucus hypersecretion, distinct from its role in Th2 differentiation. Int Immunol 16 (2004) 1497-1505
    • (2004) Int Immunol , vol.16 , pp. 1497-1505
    • Hoshino, A.1    Tsuji, T.2    Matsuzaki, J.3    Jinushi, T.4    Ashino, S.5    Teramura, T.6
  • 21
    • 0033257957 scopus 로고    scopus 로고
    • Homologous human and murine antisense oligonucleotides targeting stat6. Functional effects on germline cepsilon transcript
    • Hill S., Herlaar E., Le Cardinal A., van Heeke G., and Nicklin P. Homologous human and murine antisense oligonucleotides targeting stat6. Functional effects on germline cepsilon transcript. Am J Respir Cell Mol Biol 21 (1999) 728-737
    • (1999) Am J Respir Cell Mol Biol , vol.21 , pp. 728-737
    • Hill, S.1    Herlaar, E.2    Le Cardinal, A.3    van Heeke, G.4    Nicklin, P.5
  • 22
    • 1442325348 scopus 로고    scopus 로고
    • Signaling pathways regulating interleukin-13-stimulated chemokine release from airway smooth muscle
    • Peng Q., Matsuda T., and Hirst S.J. Signaling pathways regulating interleukin-13-stimulated chemokine release from airway smooth muscle. Am J Respir Crit Care Med 169 (2004) 596-603
    • (2004) Am J Respir Crit Care Med , vol.169 , pp. 596-603
    • Peng, Q.1    Matsuda, T.2    Hirst, S.J.3
  • 23
    • 11144265894 scopus 로고    scopus 로고
    • Gene silencing with STAT6 specific siRNAs blocks eotaxin release in IL-4/TNFalpha stimulated human epithelial cells
    • Rippmann J.F., Schnapp A., Weith A., and Hobbie S. Gene silencing with STAT6 specific siRNAs blocks eotaxin release in IL-4/TNFalpha stimulated human epithelial cells. FEBS Lett 579 (2005) 173-178
    • (2005) FEBS Lett , vol.579 , pp. 173-178
    • Rippmann, J.F.1    Schnapp, A.2    Weith, A.3    Hobbie, S.4
  • 24
    • 0035725741 scopus 로고    scopus 로고
    • Specific inhibition of interleukin-4-dependent Stat6 activation by an intracellularly delivered peptide
    • Stolzenberger S., Haake M., and Duschl A. Specific inhibition of interleukin-4-dependent Stat6 activation by an intracellularly delivered peptide. Eur J Biochem 268 (2001) 4809-4814
    • (2001) Eur J Biochem , vol.268 , pp. 4809-4814
    • Stolzenberger, S.1    Haake, M.2    Duschl, A.3
  • 25
    • 34848848833 scopus 로고    scopus 로고
    • Inhibition of experimental allergic airways disease by local application of a cell-penetrating dominant-negative STAT-6 peptide
    • McCusker C.T., Wang Y., Shan J., Kinyanjui M.W., Villeneuve A., Michael H., et al. Inhibition of experimental allergic airways disease by local application of a cell-penetrating dominant-negative STAT-6 peptide. J Immunol 179 (2007) 2556-2564
    • (2007) J Immunol , vol.179 , pp. 2556-2564
    • McCusker, C.T.1    Wang, Y.2    Shan, J.3    Kinyanjui, M.W.4    Villeneuve, A.5    Michael, H.6
  • 26
    • 0030810155 scopus 로고    scopus 로고
    • The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells
    • Zheng W., and Flavell R.A. The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell 89 (1997) 587-596
    • (1997) Cell , vol.89 , pp. 587-596
    • Zheng, W.1    Flavell, R.A.2
  • 27
    • 0000344022 scopus 로고    scopus 로고
    • GATA-3 induces T helper cell type 2 (Th2) cytokine expression and chromatin remodeling in committed Th1 cells
    • Lee H.J., Takemoto N., Kurata H., Kamogawa Y., Miyatake S., O'Garra A., et al. GATA-3 induces T helper cell type 2 (Th2) cytokine expression and chromatin remodeling in committed Th1 cells. J Exp Med 192 (2000) 105-116
    • (2000) J Exp Med , vol.192 , pp. 105-116
    • Lee, H.J.1    Takemoto, N.2    Kurata, H.3    Kamogawa, Y.4    Miyatake, S.5    O'Garra, A.6
  • 28
    • 0141920622 scopus 로고    scopus 로고
    • Genetic reprogramming of primary human T cells reveals functional plasticity in Th cell differentiation
    • Sundrud M.S., Grill S.M., Ni D., Nagata K., Alkan S.S., Subramaniam A., et al. Genetic reprogramming of primary human T cells reveals functional plasticity in Th cell differentiation. J Immunol 171 (2003) 3542-3549
    • (2003) J Immunol , vol.171 , pp. 3542-3549
    • Sundrud, M.S.1    Grill, S.M.2    Ni, D.3    Nagata, K.4    Alkan, S.S.5    Subramaniam, A.6
  • 29
    • 1242274405 scopus 로고    scopus 로고
    • GATA-3 deficiency abrogates the development and maintenance of T helper type 2 cells
    • Pai S.Y., Truitt M.L., and Ho I.C. GATA-3 deficiency abrogates the development and maintenance of T helper type 2 cells. Proc Natl Acad Sci U S A 101 (2004) 1993-1998
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 1993-1998
    • Pai, S.Y.1    Truitt, M.L.2    Ho, I.C.3
  • 30
    • 9244263631 scopus 로고    scopus 로고
    • Conditional deletion of Gata3 shows its essential function in T(H)1-T(H)2 responses
    • Zhu J., Min B., Hu-Li J., Watson C.J., Grinberg A., Wang Q., et al. Conditional deletion of Gata3 shows its essential function in T(H)1-T(H)2 responses. Nat Immunol 5 (2004) 1157-1165
    • (2004) Nat Immunol , vol.5 , pp. 1157-1165
    • Zhu, J.1    Min, B.2    Hu-Li, J.3    Watson, C.J.4    Grinberg, A.5    Wang, Q.6
  • 32
    • 4344607622 scopus 로고    scopus 로고
    • Transgenic mice which overproduce Th2 cytokines develop spontaneous atopic dermatitis and asthma
    • Lee G.R., and Flavell R.A. Transgenic mice which overproduce Th2 cytokines develop spontaneous atopic dermatitis and asthma. Int Immunol 16 (2004) 1155-1160
    • (2004) Int Immunol , vol.16 , pp. 1155-1160
    • Lee, G.R.1    Flavell, R.A.2
  • 33
    • 0033916858 scopus 로고    scopus 로고
    • Upregulation of the transcription factor GATA-3 in upper airway mucosa after in vivo and in vitro allergen challenge
    • Nakamura Y., Christodoulopoulos P., Cameron L., Wright E., Lavigne F., Toda M., et al. Upregulation of the transcription factor GATA-3 in upper airway mucosa after in vivo and in vitro allergen challenge. J Allergy Clin Immunol 105 (2000) 1146-1152
    • (2000) J Allergy Clin Immunol , vol.105 , pp. 1146-1152
    • Nakamura, Y.1    Christodoulopoulos, P.2    Cameron, L.3    Wright, E.4    Lavigne, F.5    Toda, M.6
  • 37
    • 0035806279 scopus 로고    scopus 로고
    • Treatment of allergic airway inflammation and hyperresponsiveness by antisense-induced local blockade of GATA-3 expression
    • Finotto S., De Sanctis G.T., Lehr H.A., Herz U., Buerke M., Schipp M., et al. Treatment of allergic airway inflammation and hyperresponsiveness by antisense-induced local blockade of GATA-3 expression. J Exp Med 193 (2001) 1247-1260
    • (2001) J Exp Med , vol.193 , pp. 1247-1260
    • Finotto, S.1    De Sanctis, G.T.2    Lehr, H.A.3    Herz, U.4    Buerke, M.5    Schipp, M.6
  • 38
    • 37549010258 scopus 로고    scopus 로고
    • Lentiviral-mediated GATA-3 RNAi decreases allergic airway inflammation and hyperresponsiveness
    • Lee C.C., Huang H.Y., and Chiang B.L. Lentiviral-mediated GATA-3 RNAi decreases allergic airway inflammation and hyperresponsiveness. Mol Ther 16 (2008) 60-65
    • (2008) Mol Ther , vol.16 , pp. 60-65
    • Lee, C.C.1    Huang, H.Y.2    Chiang, B.L.3
  • 39
    • 33846935457 scopus 로고    scopus 로고
    • Regulation of Th2 cytokine genes by p38 MAPK-mediated phosphorylation of GATA-3
    • Maneechotesuwan K., Xin Y., Ito K., Jazrawi E., Lee K.Y., Usmani O.S., et al. Regulation of Th2 cytokine genes by p38 MAPK-mediated phosphorylation of GATA-3. J Immunol 178 (2007) 2491-2498
    • (2007) J Immunol , vol.178 , pp. 2491-2498
    • Maneechotesuwan, K.1    Xin, Y.2    Ito, K.3    Jazrawi, E.4    Lee, K.Y.5    Usmani, O.S.6
  • 40
    • 14944350956 scopus 로고    scopus 로고
    • Inhaled p38alpha mitogen-activated protein kinase antisense oligonucleotide attenuates asthma in mice
    • Duan W., Chan J.H., McKay K., Crosby J.R., Choo H.H., Leung B.P., et al. Inhaled p38alpha mitogen-activated protein kinase antisense oligonucleotide attenuates asthma in mice. Am J Respir Crit Care Med 171 (2005) 571-578
    • (2005) Am J Respir Crit Care Med , vol.171 , pp. 571-578
    • Duan, W.1    Chan, J.H.2    McKay, K.3    Crosby, J.R.4    Choo, H.H.5    Leung, B.P.6
  • 41
    • 18544406054 scopus 로고    scopus 로고
    • SB 239063, a potent p38 MAP kinase inhibitor, reduces inflammatory cytokine production, airways eosinophil infiltration, and persistence
    • Underwood D.C., Osborn R.R., Kotzer C.J., Adams J.L., Lee J.C., Webb E.F., et al. SB 239063, a potent p38 MAP kinase inhibitor, reduces inflammatory cytokine production, airways eosinophil infiltration, and persistence. J Pharmacol Exp Ther 293 (2000) 281-288
    • (2000) J Pharmacol Exp Ther , vol.293 , pp. 281-288
    • Underwood, D.C.1    Osborn, R.R.2    Kotzer, C.J.3    Adams, J.L.4    Lee, J.C.5    Webb, E.F.6
  • 42
    • 0141483523 scopus 로고    scopus 로고
    • Transcriptional regulation by calcium, calcineurin, and NFAT
    • Hogan P.G., Chen L., Nardone J., and Rao A. Transcriptional regulation by calcium, calcineurin, and NFAT. Genes Dev 17 (2003) 2205-2232
    • (2003) Genes Dev , vol.17 , pp. 2205-2232
    • Hogan, P.G.1    Chen, L.2    Nardone, J.3    Rao, A.4
  • 43
    • 0036234543 scopus 로고    scopus 로고
    • NFAT signaling: choreographing the social lives of cells
    • Crabtree G.R., and Olson E.N. NFAT signaling: choreographing the social lives of cells. Cell 109 suppl (2002) S67-S79
    • (2002) Cell , vol.109 , Issue.SUPPL
    • Crabtree, G.R.1    Olson, E.N.2
  • 44
    • 20644466433 scopus 로고    scopus 로고
    • NFAT proteins: key regulators of T-cell development and function
    • Macian F. NFAT proteins: key regulators of T-cell development and function. Nat Rev Immunol 5 (2005) 472-484
    • (2005) Nat Rev Immunol , vol.5 , pp. 472-484
    • Macian, F.1
  • 45
    • 0035129248 scopus 로고    scopus 로고
    • NFATc1 and NFATc2 together control both T and B cell activation and differentiation
    • Peng S.L., Gerth A.J., Ranger A.M., and Glimcher L.H. NFATc1 and NFATc2 together control both T and B cell activation and differentiation. Immunity 14 (2001) 13-20
    • (2001) Immunity , vol.14 , pp. 13-20
    • Peng, S.L.1    Gerth, A.J.2    Ranger, A.M.3    Glimcher, L.H.4
  • 47
    • 20444506718 scopus 로고    scopus 로고
    • Report of the Topical Calcineurin Inhibitor Task Force of the American College of Allergy, Asthma and Immunology and the American Academy of Allergy, Asthma and Immunology
    • Fonacier L., Spergel J., Charlesworth E.N., Weldon D., Beltrani V., Bernhisel-Broadbent J., et al. Report of the Topical Calcineurin Inhibitor Task Force of the American College of Allergy, Asthma and Immunology and the American Academy of Allergy, Asthma and Immunology. J Allergy Clin Immunol 115 (2005) 1249-1253
    • (2005) J Allergy Clin Immunol , vol.115 , pp. 1249-1253
    • Fonacier, L.1    Spergel, J.2    Charlesworth, E.N.3    Weldon, D.4    Beltrani, V.5    Bernhisel-Broadbent, J.6
  • 48
    • 0042387830 scopus 로고    scopus 로고
    • Asthma refractory to glucocorticoids: the role of newer immunosuppressants
    • Corrigan C.J. Asthma refractory to glucocorticoids: the role of newer immunosuppressants. Am J Respir Med 1 (2002) 47-54
    • (2002) Am J Respir Med , vol.1 , pp. 47-54
    • Corrigan, C.J.1
  • 49
    • 0033773992 scopus 로고    scopus 로고
    • Attenuation of the allergen-induced late asthmatic reaction by cyclosporin A is associated with inhibition of bronchial eosinophils, interleukin-5, granulocyte macrophage colony-stimulating factor, and eotaxin
    • Khan L.N., Kon O.M., Macfarlane A.J., Meng Q., Ying S., Barnes N.C., et al. Attenuation of the allergen-induced late asthmatic reaction by cyclosporin A is associated with inhibition of bronchial eosinophils, interleukin-5, granulocyte macrophage colony-stimulating factor, and eotaxin. Am J Respir Crit Care Med 162 (2000) 1377-1382
    • (2000) Am J Respir Crit Care Med , vol.162 , pp. 1377-1382
    • Khan, L.N.1    Kon, O.M.2    Macfarlane, A.J.3    Meng, Q.4    Ying, S.5    Barnes, N.C.6
  • 50
    • 4544269656 scopus 로고    scopus 로고
    • A locally active antiinflammatory macrolide (MLD987) for inhalation therapy of asthma
    • Hersperger R., Buchheit K.H., Cammisuli S., Enz A., Lohse O., Ponelle M., et al. A locally active antiinflammatory macrolide (MLD987) for inhalation therapy of asthma. J Med Chem 47 (2004) 4950-4957
    • (2004) J Med Chem , vol.47 , pp. 4950-4957
    • Hersperger, R.1    Buchheit, K.H.2    Cammisuli, S.3    Enz, A.4    Lohse, O.5    Ponelle, M.6
  • 51
    • 0033803718 scopus 로고    scopus 로고
    • Neurotoxicity of calcineurin inhibitors: impact and clinical management
    • Bechstein W.O. Neurotoxicity of calcineurin inhibitors: impact and clinical management. Transpl Int 13 (2000) 313-326
    • (2000) Transpl Int , vol.13 , pp. 313-326
    • Bechstein, W.O.1
  • 52
    • 0035659395 scopus 로고    scopus 로고
    • Nephrotoxicity of immunosuppressive drugs: new insight and preventive strategies
    • Olyaei A.J., de Mattos A.M., and Bennett W.M. Nephrotoxicity of immunosuppressive drugs: new insight and preventive strategies. Curr Opin Crit Care 7 (2001) 384-389
    • (2001) Curr Opin Crit Care , vol.7 , pp. 384-389
    • Olyaei, A.J.1    de Mattos, A.M.2    Bennett, W.M.3
  • 53
    • 2342526607 scopus 로고    scopus 로고
    • A new cell-permeable peptide allows successful allogeneic islet transplantation in mice
    • Noguchi H., Matsushita M., Okitsu T., Moriwaki A., Tomizawa K., Kang S., et al. A new cell-permeable peptide allows successful allogeneic islet transplantation in mice. Nat Med 10 (2004) 305-309
    • (2004) Nat Med , vol.10 , pp. 305-309
    • Noguchi, H.1    Matsushita, M.2    Okitsu, T.3    Moriwaki, A.4    Tomizawa, K.5    Kang, S.6
  • 54
    • 2442714017 scopus 로고    scopus 로고
    • Selective inhibition of calcineurin-NFAT signaling by blocking protein-protein interaction with small organic molecules
    • Roehrl M.H., Kang S., Aramburu J., Wagner G., Rao A., and Hogan P.G. Selective inhibition of calcineurin-NFAT signaling by blocking protein-protein interaction with small organic molecules. Proc Natl Acad Sci U S A 101 (2004) 7554-7559
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 7554-7559
    • Roehrl, M.H.1    Kang, S.2    Aramburu, J.3    Wagner, G.4    Rao, A.5    Hogan, P.G.6
  • 55
    • 2942632790 scopus 로고    scopus 로고
    • Chemical genetics to identify NFAT inhibitors: potential of targeting calcium mobilization in immunosuppression
    • Venkatesh N., Feng Y., DeDecker B., Yacono P., Golan D., Mitchison T., et al. Chemical genetics to identify NFAT inhibitors: potential of targeting calcium mobilization in immunosuppression. Proc Natl Acad Sci U S A 101 (2004) 8969-8974
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 8969-8974
    • Venkatesh, N.1    Feng, Y.2    DeDecker, B.3    Yacono, P.4    Golan, D.5    Mitchison, T.6
  • 56
    • 0032849010 scopus 로고    scopus 로고
    • Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A
    • Aramburu J., Yaffe M.B., Lopez-Rodriguez C., Cantley L.C., Hogan P.G., and Rao A. Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A. Science 285 (1999) 2129-2133
    • (1999) Science , vol.285 , pp. 2129-2133
    • Aramburu, J.1    Yaffe, M.B.2    Lopez-Rodriguez, C.3    Cantley, L.C.4    Hogan, P.G.5    Rao, A.6
  • 57
    • 33845768987 scopus 로고    scopus 로고
    • Integrating cell-signalling pathways with NF-kappaB and IKK function
    • Perkins N.D. Integrating cell-signalling pathways with NF-kappaB and IKK function. Nat Rev Mol Cell Biol 8 (2007) 49-62
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 49-62
    • Perkins, N.D.1
  • 58
    • 0034669926 scopus 로고    scopus 로고
    • Mechanisms of persistent NF-kappa B activity in the bronchi of an animal model of asthma
    • Bureau F., Delhalle S., Bonizzi G., Fievez L., Dogne S., Kirschvink N., et al. Mechanisms of persistent NF-kappa B activity in the bronchi of an animal model of asthma. J Immunol 165 (2000) 5822-5830
    • (2000) J Immunol , vol.165 , pp. 5822-5830
    • Bureau, F.1    Delhalle, S.2    Bonizzi, G.3    Fievez, L.4    Dogne, S.5    Kirschvink, N.6
  • 59
    • 0242459769 scopus 로고    scopus 로고
    • Persistent activation of nuclear factor-kappaB signaling pathway in severe uncontrolled asthma
    • Gagliardo R., Chanez P., Mathieu M., Bruno A., Costanzo G., Gougat C., et al. Persistent activation of nuclear factor-kappaB signaling pathway in severe uncontrolled asthma. Am J Respir Crit Care Med 168 (2003) 1190-1198
    • (2003) Am J Respir Crit Care Med , vol.168 , pp. 1190-1198
    • Gagliardo, R.1    Chanez, P.2    Mathieu, M.3    Bruno, A.4    Costanzo, G.5    Gougat, C.6
  • 61
    • 0036102865 scopus 로고    scopus 로고
    • Rapid activation of nuclear factor-kappaB in airway epithelium in a murine model of allergic airway inflammation
    • Poynter M.E., Irvin C.G., and Janssen-Heininger Y.M. Rapid activation of nuclear factor-kappaB in airway epithelium in a murine model of allergic airway inflammation. Am J Pathol 160 (2002) 1325-1334
    • (2002) Am J Pathol , vol.160 , pp. 1325-1334
    • Poynter, M.E.1    Irvin, C.G.2    Janssen-Heininger, Y.M.3
  • 62
    • 0032476742 scopus 로고    scopus 로고
    • Essential role of nuclear factor kappaB in the induction of eosinophilia in allergic airway inflammation
    • Yang L., Cohn L., Zhang D.H., Homer R., Ray A., and Ray P. Essential role of nuclear factor kappaB in the induction of eosinophilia in allergic airway inflammation. J Exp Med 188 (1998) 1739-1750
    • (1998) J Exp Med , vol.188 , pp. 1739-1750
    • Yang, L.1    Cohn, L.2    Zhang, D.H.3    Homer, R.4    Ray, A.5    Ray, P.6
  • 63
    • 0032740618 scopus 로고    scopus 로고
    • NF-kappa B/Rel transcription factors: c-Rel promotes airway hyperresponsiveness and allergic pulmonary inflammation
    • Donovan C.E., Mark D.A., He H.Z., Liou H.C., Kobzik L., Wang Y., et al. NF-kappa B/Rel transcription factors: c-Rel promotes airway hyperresponsiveness and allergic pulmonary inflammation. J Immunol 163 (1999) 6827-6833
    • (1999) J Immunol , vol.163 , pp. 6827-6833
    • Donovan, C.E.1    Mark, D.A.2    He, H.Z.3    Liou, H.C.4    Kobzik, L.5    Wang, Y.6
  • 64
    • 0035222187 scopus 로고    scopus 로고
    • A critical role for NF-kappa B in GATA3 expression and TH2 differentiation in allergic airway inflammation
    • Das J., Chen C.H., Yang L., Cohn L., Ray P., and Ray A. A critical role for NF-kappa B in GATA3 expression and TH2 differentiation in allergic airway inflammation. Nat Immunol 2 (2001) 45-50
    • (2001) Nat Immunol , vol.2 , pp. 45-50
    • Das, J.1    Chen, C.H.2    Yang, L.3    Cohn, L.4    Ray, P.5    Ray, A.6
  • 65
    • 0033847001 scopus 로고    scopus 로고
    • Mice lacking the transcription factor RelB develop T cell-dependent skin lesions similar to human atopic dermatitis
    • Barton D., HogenEsch H., and Weih F. Mice lacking the transcription factor RelB develop T cell-dependent skin lesions similar to human atopic dermatitis. Eur J Immunol 30 (2000) 2323-2332
    • (2000) Eur J Immunol , vol.30 , pp. 2323-2332
    • Barton, D.1    HogenEsch, H.2    Weih, F.3
  • 66
    • 0031159205 scopus 로고    scopus 로고
    • Multifocal defects in immune responses in RelB-deficient mice
    • Weih F., Warr G., Yang H., and Bravo R. Multifocal defects in immune responses in RelB-deficient mice. J Immunol 158 (1997) 5211-5218
    • (1997) J Immunol , vol.158 , pp. 5211-5218
    • Weih, F.1    Warr, G.2    Yang, H.3    Bravo, R.4
  • 67
    • 11244320356 scopus 로고    scopus 로고
    • Targeted disruption of MAIL, a nuclear IkappaB protein, leads to severe atopic dermatitis-like disease
    • Shiina T., Konno A., Oonuma T., Kitamura H., Imaoka K., Takeda N., et al. Targeted disruption of MAIL, a nuclear IkappaB protein, leads to severe atopic dermatitis-like disease. J Biol Chem 279 (2004) 55493-55498
    • (2004) J Biol Chem , vol.279 , pp. 55493-55498
    • Shiina, T.1    Konno, A.2    Oonuma, T.3    Kitamura, H.4    Imaoka, K.5    Takeda, N.6
  • 68
    • 3142581432 scopus 로고    scopus 로고
    • Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkappaBzeta
    • Yamamoto M., Yamazaki S., Uematsu S., Sato S., Hemmi H., Hoshino K., et al. Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkappaBzeta. Nature 430 (2004) 218-222
    • (2004) Nature , vol.430 , pp. 218-222
    • Yamamoto, M.1    Yamazaki, S.2    Uematsu, S.3    Sato, S.4    Hemmi, H.5    Hoshino, K.6
  • 69
    • 8644259967 scopus 로고    scopus 로고
    • Administration of antisense phosphorothioate oligonucleotide to the p65 subunit of NF-kappaB inhibits established asthmatic reaction in mice
    • Choi I.W., Kim D.K., Ko H.M., and Lee H.K. Administration of antisense phosphorothioate oligonucleotide to the p65 subunit of NF-kappaB inhibits established asthmatic reaction in mice. Int Immunopharmacol 4 (2004) 1817-1828
    • (2004) Int Immunopharmacol , vol.4 , pp. 1817-1828
    • Choi, I.W.1    Kim, D.K.2    Ko, H.M.3    Lee, H.K.4
  • 70
    • 6344269852 scopus 로고    scopus 로고
    • Selective blockade of NF-kappa B activity in airway immune cells inhibits the effector phase of experimental asthma
    • Desmet C., Gosset P., Pajak B., Cataldo D., Bentires-Alj M., Lekeux P., et al. Selective blockade of NF-kappa B activity in airway immune cells inhibits the effector phase of experimental asthma. J Immunol 173 (2004) 5766-5775
    • (2004) J Immunol , vol.173 , pp. 5766-5775
    • Desmet, C.1    Gosset, P.2    Pajak, B.3    Cataldo, D.4    Bentires-Alj, M.5    Lekeux, P.6
  • 71
    • 0036839618 scopus 로고    scopus 로고
    • A small molecule inhibitor of redox-regulated NF-kappa B and activator protein-1 transcription blocks allergic airway inflammation in a mouse asthma model
    • Henderson Jr. W.R., Chi E.Y., Teo J.L., Nguyen C., and Kahn M. A small molecule inhibitor of redox-regulated NF-kappa B and activator protein-1 transcription blocks allergic airway inflammation in a mouse asthma model. J Immunol 169 (2002) 5294-5299
    • (2002) J Immunol , vol.169 , pp. 5294-5299
    • Henderson Jr., W.R.1    Chi, E.Y.2    Teo, J.L.3    Nguyen, C.4    Kahn, M.5
  • 72
    • 0035163864 scopus 로고    scopus 로고
    • A novel transcription factor inhibitor, SP100030, inhibits cytokine gene expression, but not airway eosinophilia or hyperresponsiveness in sensitized and allergen-exposed rat
    • Huang T.J., Adcock I.M., and Chung K.F. A novel transcription factor inhibitor, SP100030, inhibits cytokine gene expression, but not airway eosinophilia or hyperresponsiveness in sensitized and allergen-exposed rat. Br J Pharmacol 134 (2001) 1029-1036
    • (2001) Br J Pharmacol , vol.134 , pp. 1029-1036
    • Huang, T.J.1    Adcock, I.M.2    Chung, K.F.3
  • 73
    • 38449120549 scopus 로고    scopus 로고
    • Inhibition of NF-κB activation reduces the tissue effects of transgenic IL-13
    • Chapoval S.P., Al-Garawi A., Lora J.M., Strickland I., Ma B., Lee P.J., et al. Inhibition of NF-κB activation reduces the tissue effects of transgenic IL-13. J Immunol 179 (2007) 7030-7041
    • (2007) J Immunol , vol.179 , pp. 7030-7041
    • Chapoval, S.P.1    Al-Garawi, A.2    Lora, J.M.3    Strickland, I.4    Ma, B.5    Lee, P.J.6
  • 74
    • 26944472106 scopus 로고    scopus 로고
    • Glucocorticoids: effects on gene transcription
    • Adcock I.M., Ito K., and Barnes P.J. Glucocorticoids: effects on gene transcription. Proc Am Thorac Soc 1 (2004) 247-254
    • (2004) Proc Am Thorac Soc , vol.1 , pp. 247-254
    • Adcock, I.M.1    Ito, K.2    Barnes, P.J.3
  • 75
    • 34748920671 scopus 로고    scopus 로고
    • Separating transrepression and transactivation: a distressing divorce for the glucocorticoid receptor?
    • Newton R., and Holden N.S. Separating transrepression and transactivation: a distressing divorce for the glucocorticoid receptor?. Mol Pharmacol 72 (2007) 799-809
    • (2007) Mol Pharmacol , vol.72 , pp. 799-809
    • Newton, R.1    Holden, N.S.2
  • 76
    • 26844433194 scopus 로고    scopus 로고
    • Antiinflammatory action of glucocorticoids-new mechanisms for old drugs
    • Rhen T., and Cidlowski J.A. Antiinflammatory action of glucocorticoids-new mechanisms for old drugs. N Engl J Med 353 (2005) 1711-1723
    • (2005) N Engl J Med , vol.353 , pp. 1711-1723
    • Rhen, T.1    Cidlowski, J.A.2
  • 77
    • 0037126628 scopus 로고    scopus 로고
    • Glucocorticoids inhibit MAP kinase via increased expression and decreased degradation of MKP-1
    • Kassel O., Sancono A., Kratzschmar J., Kreft B., Stassen M., and Cato A.C. Glucocorticoids inhibit MAP kinase via increased expression and decreased degradation of MKP-1. EMBO J 20 (2001) 7108-7116
    • (2001) EMBO J , vol.20 , pp. 7108-7116
    • Kassel, O.1    Sancono, A.2    Kratzschmar, J.3    Kreft, B.4    Stassen, M.5    Cato, A.C.6
  • 78
    • 0036841288 scopus 로고    scopus 로고
    • Dexamethasone causes sustained expression of mitogen-activated protein kinase (MAPK) phosphatase 1 and phosphatase-mediated inhibition of MAPK p38
    • Lasa M., Abraham S.M., Boucheron C., Saklatvala J., and Clark A.R. Dexamethasone causes sustained expression of mitogen-activated protein kinase (MAPK) phosphatase 1 and phosphatase-mediated inhibition of MAPK p38. Mol Cell Biol 22 (2002) 7802-7811
    • (2002) Mol Cell Biol , vol.22 , pp. 7802-7811
    • Lasa, M.1    Abraham, S.M.2    Boucheron, C.3    Saklatvala, J.4    Clark, A.R.5
  • 79
    • 0031019877 scopus 로고    scopus 로고
    • Glucocorticoid induced the expression of mRNA and the secretion of lipocortin 1 in rat astrocytoma cells
    • Mizuno H., Uemura K., Moriyama A., Wada Y., Asai K., Kimura S., et al. Glucocorticoid induced the expression of mRNA and the secretion of lipocortin 1 in rat astrocytoma cells. Brain Res 746 (1997) 256-264
    • (1997) Brain Res , vol.746 , pp. 256-264
    • Mizuno, H.1    Uemura, K.2    Moriyama, A.3    Wada, Y.4    Asai, K.5    Kimura, S.6
  • 80
    • 0034731527 scopus 로고    scopus 로고
    • The glucocorticoid receptor and STAT6 physically and functionally interact in T-lymphocytes
    • Biola A., Andreau K., David M., Sturm M., Haake M., Bertoglio J., et al. The glucocorticoid receptor and STAT6 physically and functionally interact in T-lymphocytes. FEBS Lett 487 (2000) 229-233
    • (2000) FEBS Lett , vol.487 , pp. 229-233
    • Biola, A.1    Andreau, K.2    David, M.3    Sturm, M.4    Haake, M.5    Bertoglio, J.6
  • 81
    • 0028107237 scopus 로고
    • Physical association and functional antagonism between the p65 subunit of transcription factor NF-kappa B and the glucocorticoid receptor
    • Ray A., and Prefontaine K.E. Physical association and functional antagonism between the p65 subunit of transcription factor NF-kappa B and the glucocorticoid receptor. Proc Natl Acad Sci U S A 91 (1994) 752-756
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 752-756
    • Ray, A.1    Prefontaine, K.E.2
  • 82
    • 0025130179 scopus 로고
    • Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor
    • Schule R., Rangarajan P., Kliewer S., Ransone L.J., Bolado J., Yang N., et al. Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor. Cell 62 (1990) 1217-1226
    • (1990) Cell , vol.62 , pp. 1217-1226
    • Schule, R.1    Rangarajan, P.2    Kliewer, S.3    Ransone, L.J.4    Bolado, J.5    Yang, N.6
  • 83
    • 0028867899 scopus 로고
    • Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis
    • Auphan N., DiDonato J.A., Rosette C., Helmberg A., and Karin M. Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis. Science 270 (1995) 286-290
    • (1995) Science , vol.270 , pp. 286-290
    • Auphan, N.1    DiDonato, J.A.2    Rosette, C.3    Helmberg, A.4    Karin, M.5
  • 84
    • 20744443470 scopus 로고    scopus 로고
    • Repression of interleukin-5 transcription by the glucocorticoid receptor targets GATA3 signaling and involves histone deacetylase recruitment
    • Jee Y.K., Gilmour J., Kelly A., Bowen H., Richards D., Soh C., et al. Repression of interleukin-5 transcription by the glucocorticoid receptor targets GATA3 signaling and involves histone deacetylase recruitment. J Biol Chem 280 (2005) 23243-23250
    • (2005) J Biol Chem , vol.280 , pp. 23243-23250
    • Jee, Y.K.1    Gilmour, J.2    Kelly, A.3    Bowen, H.4    Richards, D.5    Soh, C.6
  • 85
    • 0035451086 scopus 로고    scopus 로고
    • Suppression of granulocyte-macrophage colony-stimulating factor expression by glucocorticoids involves inhibition of enhancer function by the glucocorticoid receptor binding to composite NF-AT/activator protein-1 elements
    • Smith P.J., Cousins D.J., Jee Y.K., Staynov D.Z., Lee T.H., and Lavender P. Suppression of granulocyte-macrophage colony-stimulating factor expression by glucocorticoids involves inhibition of enhancer function by the glucocorticoid receptor binding to composite NF-AT/activator protein-1 elements. J Immunol 167 (2001) 2502-2510
    • (2001) J Immunol , vol.167 , pp. 2502-2510
    • Smith, P.J.1    Cousins, D.J.2    Jee, Y.K.3    Staynov, D.Z.4    Lee, T.H.5    Lavender, P.6
  • 86
    • 0033821409 scopus 로고    scopus 로고
    • Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits interleukin-1beta-induced histone H4 acetylation on lysines 8 and 12
    • Ito K., Barnes P.J., and Adcock I.M. Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits interleukin-1beta-induced histone H4 acetylation on lysines 8 and 12. Mol Cell Biol 20 (2000) 6891-6903
    • (2000) Mol Cell Biol , vol.20 , pp. 6891-6903
    • Ito, K.1    Barnes, P.J.2    Adcock, I.M.3
  • 87
    • 33749239852 scopus 로고    scopus 로고
    • Glucocorticoids cause rapid dissociation of a T-cell-receptor-associated protein complex containing LCK and FYN
    • Lowenberg M., Verhaar A.P., Bilderbeek J., Marle J., Buttgereit F., Peppelenbosch M.P., et al. Glucocorticoids cause rapid dissociation of a T-cell-receptor-associated protein complex containing LCK and FYN. EMBO Rep 7 (2006) 1023-1029
    • (2006) EMBO Rep , vol.7 , pp. 1023-1029
    • Lowenberg, M.1    Verhaar, A.P.2    Bilderbeek, J.3    Marle, J.4    Buttgereit, F.5    Peppelenbosch, M.P.6
  • 88
    • 33845218654 scopus 로고    scopus 로고
    • Glucocorticoids regulate tristetraprolin synthesis and posttranscriptionally regulate tumor necrosis factor alpha inflammatory signaling
    • Smoak K., and Cidlowski J.A. Glucocorticoids regulate tristetraprolin synthesis and posttranscriptionally regulate tumor necrosis factor alpha inflammatory signaling. Mol Cell Biol 26 (2006) 9126-9135
    • (2006) Mol Cell Biol , vol.26 , pp. 9126-9135
    • Smoak, K.1    Cidlowski, J.A.2
  • 89
    • 20044388720 scopus 로고    scopus 로고
    • Involvement of microRNA in AU-rich element-mediated mRNA instability
    • Jing Q., Huang S., Guth S., Zarubin T., Motoyama A., Chen J., et al. Involvement of microRNA in AU-rich element-mediated mRNA instability. Cell 120 (2005) 623-634
    • (2005) Cell , vol.120 , pp. 623-634
    • Jing, Q.1    Huang, S.2    Guth, S.3    Zarubin, T.4    Motoyama, A.5    Chen, J.6
  • 90
    • 33751099074 scopus 로고    scopus 로고
    • Analysis of the dissociated steroid RU24858 does not exclude a role for inducible genes in the anti-inflammatory actions of glucocorticoids
    • Chivers J.E., Gong W., King E.M., Seybold J., Mak J.C., Donnelly L.E., et al. Analysis of the dissociated steroid RU24858 does not exclude a role for inducible genes in the anti-inflammatory actions of glucocorticoids. Mol Pharmacol 70 (2006) 2084-2095
    • (2006) Mol Pharmacol , vol.70 , pp. 2084-2095
    • Chivers, J.E.1    Gong, W.2    King, E.M.3    Seybold, J.4    Mak, J.C.5    Donnelly, L.E.6
  • 91
    • 0347719371 scopus 로고    scopus 로고
    • Dissociation of transactivation from transrepression by a selective glucocorticoid receptor agonist leads to separation of therapeutic effects from side effects
    • Schacke H., Schottelius A., Docke W.D., Strehlke P., Jaroch S., Schmees N., et al. Dissociation of transactivation from transrepression by a selective glucocorticoid receptor agonist leads to separation of therapeutic effects from side effects. Proc Natl Acad Sci U S A 101 (2004) 227-232
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 227-232
    • Schacke, H.1    Schottelius, A.2    Docke, W.D.3    Strehlke, P.4    Jaroch, S.5    Schmees, N.6
  • 92
    • 0035253604 scopus 로고    scopus 로고
    • Therapeutic benefit of a dissociated glucocorticoid and the relevance of in vitro separation of transrepression from transactivation activity
    • Belvisi M.G., Wicks S.L., Battram C.H., Bottoms S.E., Redford J.E., Woodman P., et al. Therapeutic benefit of a dissociated glucocorticoid and the relevance of in vitro separation of transrepression from transactivation activity. J Immunol 166 (2001) 1975-1982
    • (2001) J Immunol , vol.166 , pp. 1975-1982
    • Belvisi, M.G.1    Wicks, S.L.2    Battram, C.H.3    Bottoms, S.E.4    Redford, J.E.5    Woodman, P.6
  • 93
    • 34547887674 scopus 로고    scopus 로고
    • Selective glucocorticoid receptor agonists (SEGRAs): novel ligands with an improved therapeutic index
    • Schacke H., Berger M., Rehwinkel H., and Asadullah K. Selective glucocorticoid receptor agonists (SEGRAs): novel ligands with an improved therapeutic index. Mol Cell Endocrinol 275 (2007) 109-117
    • (2007) Mol Cell Endocrinol , vol.275 , pp. 109-117
    • Schacke, H.1    Berger, M.2    Rehwinkel, H.3    Asadullah, K.4
  • 94
    • 33244482536 scopus 로고    scopus 로고
    • Combinatorial roles of nuclear receptors in inflammation and immunity
    • Glass C.K., and Ogawa S. Combinatorial roles of nuclear receptors in inflammation and immunity. Nat Rev Immunol 6 (2006) 44-55
    • (2006) Nat Rev Immunol , vol.6 , pp. 44-55
    • Glass, C.K.1    Ogawa, S.2
  • 95
    • 0036183630 scopus 로고    scopus 로고
    • The mechanisms of action of PPARs
    • Berger J., and Moller D.E. The mechanisms of action of PPARs. Annu Rev Med 53 (2002) 409-435
    • (2002) Annu Rev Med , vol.53 , pp. 409-435
    • Berger, J.1    Moller, D.E.2
  • 96
    • 34547603895 scopus 로고    scopus 로고
    • PPARs and molecular mechanisms of transrepression
    • Ricote M., and Glass C.K. PPARs and molecular mechanisms of transrepression. Biochim Biophys Acta 1771 (2007) 926-935
    • (2007) Biochim Biophys Acta , vol.1771 , pp. 926-935
    • Ricote, M.1    Glass, C.K.2
  • 97
    • 34548591700 scopus 로고    scopus 로고
    • Peroxisome proliferator activated receptor ligands as regulators of airway inflammation and remodelling in chronic lung disease
    • Ward J.E., and Tan X. Peroxisome proliferator activated receptor ligands as regulators of airway inflammation and remodelling in chronic lung disease. PPAR Res 2007 (2007) 14983
    • (2007) PPAR Res , vol.2007 , pp. 14983
    • Ward, J.E.1    Tan, X.2
  • 98
    • 0042624848 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors alpha and gamma down-regulate allergic inflammation and eosinophil activation
    • Woerly G., Honda K., Loyens M., Papin J.P., Auwerx J., Staels B., et al. Peroxisome proliferator-activated receptors alpha and gamma down-regulate allergic inflammation and eosinophil activation. J Exp Med 198 (2003) 411-421
    • (2003) J Exp Med , vol.198 , pp. 411-421
    • Woerly, G.1    Honda, K.2    Loyens, M.3    Papin, J.P.4    Auwerx, J.5    Staels, B.6
  • 99
    • 41449115848 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha regulates skin inflammation and humoral response in atopic dermatitis
    • Feb 13 [epub ahead of print]
    • Staumont-Salle D., Abboud G., Brenuchon C., Kanda A., Roumier T., Lavogiez C., et al. Peroxisome proliferator-activated receptor alpha regulates skin inflammation and humoral response in atopic dermatitis. J Allergy Clin Immunol (2008) Feb 13 [epub ahead of print]
    • (2008) J Allergy Clin Immunol
    • Staumont-Salle, D.1    Abboud, G.2    Brenuchon, C.3    Kanda, A.4    Roumier, T.5    Lavogiez, C.6
  • 100
    • 0036961434 scopus 로고    scopus 로고
    • Respirable antisense oligonucleotides: a new, third drug class targeting respiratory disease
    • Nyce J. Respirable antisense oligonucleotides: a new, third drug class targeting respiratory disease. Curr Opin Allergy Clin Immunol 2 (2002) 533-536
    • (2002) Curr Opin Allergy Clin Immunol , vol.2 , pp. 533-536
    • Nyce, J.1
  • 101
    • 0031025249 scopus 로고    scopus 로고
    • DNA antisense therapy for asthma in an animal model
    • Nyce J.W., and Metzger W.J. DNA antisense therapy for asthma in an animal model. Nature 385 (1997) 721-725
    • (1997) Nature , vol.385 , pp. 721-725
    • Nyce, J.W.1    Metzger, W.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.