In vivo transfection of a cis element 'decoy' against signal transducers and activators of transcription 6 (STAT6)-binding site ameliorates IgE-mediated late-phase reaction in an atopic dermatitis mouse model

Gene Therapy

Volumn 11, Issue 24, 2004, Pages 1753-1762

  Yokozeki, H ^a   Wu, M H ^a   Sumi, K ^a   Awad, Sherif ^a   Satoh, T ^a   Katayama, I ^b   Takeda, K ^c   Akira, S ^c   Kaneda, Y ^d   Nishioka, K ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b NAGASAKI UNIVERSITY   (Japan)

^c OSAKA UNIVERSITY   (Japan)

^d OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Atopic dermatitis; IgE; Mast cells; STAT6 decoy; Th2

Indexed keywords

1 FLUORO 2,4 DINITROBENZENE; DOUBLE STRANDED DNA; HISTAMINE; IMMUNOGLOBULIN E; IMMUNOGLOBULIN E RECEPTOR; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 6; LIPOSOME; MONOCLONAL ANTIBODY; OLIGONUCLEOTIDE; STAT6 PROTEIN; SYNTHETIC DNA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATOPIC DERMATITIS; BINDING AFFINITY; BINDING SITE; CELL CULTURE; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE COURSE; DRUG EFFICACY; DRUG MECHANISM; EDEMA; EOSINOPHIL; GENE ACTIVATION; GENETIC TRANSFECTION; HISTAMINE RELEASE; HISTOPATHOLOGY; HYPOTHESIS; IN VITRO STUDY; IN VIVO STUDY; MALE; MAST CELL; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN BINDING; SKIN SENSITIZATION; SKIN TEST; TRANSACTIVATION;

EID: 19944390511     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3302341     Document Type: Article

References (31)

1. Michell EB et al. Basophils in allergen-induced patch test sites in atopic dermatitis. Lancet 1982; 1: 127-130.
2. Uehara M, Ofuji S. Patch test reactions to human skin dander in atopic dermatits. Arch Deramtol 1976; 112: 951.
3. Adinoff AD, Tellez P, Clark AF. Atopic dermatitis and aeroallergen in contact sensitivity. J Allergy Clin Immunol 1988; 81: 736-742.
4. Bruijzeel PL et al. The involvement of eosinophils in the patch test reaction to aeroallergens in atopic dermatitis: its relevance for the pathogenesis of atopic dermatitis. Clin Exp Allergy 1993; 23: 97-109.
5. Sampson HA. The role of food allergy and mediator release in atopic dermatitis. J Allergy Clin Immunol 1988; 81: 635-645.
6. Pathomechanism RG. Genetic and immunological factors. In: Essential Aspects of Atopic Deramatitis. Springer-Verlag: Tokyo, 1988, pp 108-111.
7. Katayama I, Tanei R, Nishioka K, Dohi Y. Induction of eczematous skin reaction in experimentally induced hyperplastic skin of BALB/c mice by monoclonal anti-DNP-IgE antibody: possible implication for skin lesion formation in atopic dermatitis. Int Arch Allergy Appl Immunol 1990; 93: 148-154.
8. Katayama I, Minatohara K, Yokozeki H, Nishioka K. Topical vitamin D3 downregulates IgE-mediated murine biphasic cutaneous reaction. Int Arch Allergy Immunol 1996; 111: 71-76.
9. Katayama I, Otoyama K, Yokozeki H, Nishioka K. Effect of mast cell modulators on IgE-mediated murine biphasic cutaneous reaction. Int Arch Allergy Immunol 1996; 109: 390-397.
10. Yokozeki H et al. Signal transducer and activator of Transcription 6 is essential in the induction of contact hypersensitivity. J Exp Med 2000; 191: 995-1004.
11. Takeda K et al. Essential role of Stat6 in IL-4 signaling. Nature 1996; 380: 627-630.
12. Taked K et al. Impaired IL-13-mediated functions of macrophages in STAT6-deficient mice. J Immunol 1996; 157: 3220-3222.
13. Morishita R et al. A gene therapy strategy using a transcription factor decoy of the E2F binding site inhibits smooth proliferation in vivo. Proc Natl Acad Sci USA 1995; 92: 5855-5859.
14. Morishita R et al. Role of transcriptional cis elements, angiotensinogen gene-activating element, of angiotensinogen gene in blood pressure regulation. Hypertension 1996; 27: 502-507.
15. Morishita R et al. In vivo transfection of cis element 'decoy' against nuclear factor-κB binding site prevents myocardial infection. Nature Med 1997; 3: 894-899.
16. Nakamura H et al. Prevention and regulation of atopic dermatitis by ointment containing NF-κB decoy oligodeoxynucleotides in NC/Nga atopic mouse model. Gene Therapy 2002; 9: 1221-1229.
17. Abeyama K, Eng W, Jester JV, Vink AA. A role for NF-κB-dependent gene transaction in sunburn. J Clin Invest 2000; 105: 1751-1759.
18. Wang LH et al. Targeted disruption of Stat6 DNA binding activity by an oligonucleotide decoy blocks IL-4-deriven Th2 cell response. Blood 2000; 95: 1249-1257.
19. Malaviya R, Uckun MF. Role of STAT6 in IgE receptor/FcERI-mediated late phase allergic response of mast cells. J Immunol 2002; 168: 421-426.
20. Yagi R et al. Development of atopic dermatitis-like lesions in STAT6-deficient NC/Nga mice. J Immunol 2002; 168: 2020-2027.
21. Kaneda Y, Iwaki K, Uchida T. Introduction of the human insulin gene in adult rat liver. J Biol Chem 1989; 264: 12126-12129.
22. Hoeck J, Woisetshlager M. Activation of Eotaxin-3/CCL26 gene expression in human dermal fibroblast is mediated by stat6. J Immunol 2001; 167: 3216-3222.
23. Hoeck J, Woisetshlager M. STAT6 mediates eotaxin-1 expression in IL-4 or TNF-α-induced fibroblasts. J Immunol 2001; 166: 4507-4515.
24. Wershil BK, Wang ZS, Gordon JR, Gall J. Recruitment of neutrophils during IgE-dependent cutaneous late phase reactions in the mouse is mast cell-dependent: partial inhibition of the reaction with antiserum against tumor necrosis factor-α. J Clin Invest 2001; 87: 446.
25. Kitaura J et al. Akt-dependent cytokine production in mast cells. J Exp Med 2000; 192: 729-739.
26. Saeki Y et al. Development and characterization of cationic liposomes conjugated with HVJ (Sendai virus): reciprocal effect of cationic lipid for in vitro and in vivo gene transfer. Hum Gene Ther 1997; 8: 2133-2141.
27. Molitor JA et al. NF-κB: a family of inducible and differentially expressed enhancer-binding proteins in human T cells. Proc Natl Acad Sci USA 1990; 87: 10028-10032.
28. Schreiber EP, Matthais MM, Schaffner W. Rapid detection of octameric binding proteins with 'mini-extracts' prepared from a small number of cells. Nucleic Acids Res 1989; 17: 6419.
29. Ferguson T, Dube P, Griffith TS. Regulation of contact hypersensitivity by interleukin 10. J Exp Med 1994; 179: 1597-1674.
30. Malaviya. R, Chen CL, Dibirdik I, Uckun FM. Targeting Janus kinase 3 in mast cells prevents immediate hypersensitivity reaction and anaphylaxis. J Biol Chem 1999; 274: 27028-27038.
31. Malaviya R, Abraham SN. Interaction of bacteria with mast cells. Methods Enzymol 1995; 253: 27-43.