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Volumn 169, Issue 9, 2002, Pages 5294-5299

A small molecule inhibitor of redox-regulated NF-κB and activator protein-1 transcription blocks allergic airway inflammation in a mouse asthma model

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; METHYL 4 HYDROXY 4 (8 METHYL 1,2 DIOXO 2 PHENYL 2,3,5,8 TETRAHYDRO 1H [1,2,4]TRIAZOLO[1,2 A]PYRIDAZIN 5 YL) 2 BUTYNOATE; NEUROPEPTIDE; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG;

EID: 0036839618     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.169.9.5294     Document Type: Article
Times cited : (109)

References (54)
  • 1
    • 0030632409 scopus 로고    scopus 로고
    • T cells as orchestrators of the asthmatic response
    • Kay, A. B. 1997. T cells as orchestrators of the asthmatic response. Ciba Found. Symp. 206:56.
    • (1997) Ciba Found. Symp. , vol.206 , pp. 56
    • Kay, A.B.1
  • 3
    • 0023263523 scopus 로고
    • Normal alveolar epithelial lining fluid contains high levels of glutathione
    • Cantin, A. M., S. L. North, R. C. Hubbard, and R. G. Crystal. 1987. Normal alveolar epithelial lining fluid contains high levels of glutathione. J. Appl. Physiol. 63:152.
    • (1987) J. Appl. Physiol. , vol.63 , pp. 152
    • Cantin, A.M.1    North, S.L.2    Hubbard, R.C.3    Crystal, R.G.4
  • 5
    • 0030271387 scopus 로고    scopus 로고
    • NF-κB: Ten years after
    • Baeuerle, P. A., and D. Baltimore. 1996. NF-κB: Ten years after. Cell 87:13.
    • (1996) Cell , vol.87 , pp. 13
    • Baeuerle, P.A.1    Baltimore, D.2
  • 6
    • 0029874138 scopus 로고    scopus 로고
    • The NF-κB and IκB proteins: New discoveries and insights
    • Baldwin, A. S., Jr. 1996. The NF-κB and IκB proteins: New discoveries and insights. Annu. Rev. Immunol. 14:649.
    • (1996) Annu. Rev. Immunol. , vol.14 , pp. 649
    • Baldwin A.S., Jr.1
  • 7
    • 0033595892 scopus 로고    scopus 로고
    • The Rel/NF-κB signal transduction pathway: Introduction
    • Gilmore, T. D. 1999. The Rel/NF-κB signal transduction pathway: Introduction. Oncogene 18:6842.
    • (1999) Oncogene , vol.18 , pp. 6842
    • Gilmore, T.D.1
  • 9
    • 0345062267 scopus 로고    scopus 로고
    • Functional synergism of STAT6 with either NF-κB or PU.I to mediate IL-4-induced activation of IgE germline gene transcription
    • Stutz, A. M., and M. Woisetschlager. 1999. Functional synergism of STAT6 with either NF-κB or PU.I to mediate IL-4-induced activation of IgE germline gene transcription. J. Immunol 163:4383.
    • (1999) J. Immunol. , vol.63 , pp. 4383
    • Stutz, A.M.1    Woisetschlager, M.2
  • 10
    • 0033059554 scopus 로고    scopus 로고
    • Transcriptional control of the IL-5 gene by human helper T cells: IL-5 synthesis is regulated independently from IL-2 or IL-4 synthesis
    • Mori, A., O. Kaminuma, T. Mikami, S. Inoue. Y. Okumura, K. Akiyama, and H. Okudaira. 1999. Transcriptional control of the IL-5 gene by human helper T cells: IL-5 synthesis is regulated independently from IL-2 or IL-4 synthesis. J. Allergy Clin. Immunol. 103:429.
    • (1999) J. Allergy Clin. Immunol. , vol.103 , pp. 429
    • Mori, A.1    Kaminuma, O.2    Mikami, T.3    Inoue, S.4    Okumura, Y.5    Akiyama, K.6    Okudaira, H.7
  • 11
    • 0031080138 scopus 로고    scopus 로고
    • NF-κB: A pivotal role in asthma and a new target for therapy
    • Barnes, P. J., and I. M. Adcock. 1997. NF-κB: A pivotal role in asthma and a new target for therapy. Trends Pharmacol. Sci. 18:46.
    • (1997) Trends Pharmacol. Sci. , vol.18 , pp. 46
    • Barnes, P.J.1    Adcock, I.M.2
  • 12
    • 0029949409 scopus 로고    scopus 로고
    • Multiple transcription factors are required for activation of human interleukin 9 gene in T cells
    • Zhu, Y. X., L. Y. Kang, W. Luo, C. C. H. Li, L. Yang, and Y. C. Yang. 1996. Multiple transcription factors are required for activation of human interleukin 9 gene in T cells. J. Biol. Chem. 271:15815.
    • (1996) J. Biol. Chem. , vol.271 , pp. 15815
    • Zhu, Y.X.1    Kang, L.Y.2    Luo, W.3    Li, C.C.H.4    Yang, L.5    Yang, Y.C.6
  • 13
    • 0031596858 scopus 로고    scopus 로고
    • The NF-κB binding site is essential for transcriptional activation of the IL-15 gene
    • Washizu, J., H. Nishimura, N. Nakamura, Y. Nimura, and Y. Yoshikai. 1998. The NF-κB binding site is essential for transcriptional activation of the IL-15 gene. Immunogenetics 48:1.
    • (1998) Immunogenetics , vol.48 , pp. 1
    • Washizu, J.1    Nishimura, H.2    Nakamura, N.3    Nimura, Y.4    Yoshikai, Y.5
  • 14
    • 0034128090 scopus 로고    scopus 로고
    • The role of nuclear factor-κB in pulmonary diseases
    • Christman, J. W., R. T. Sadikot, and T. S. Blackwell. 2000. The role of nuclear factor-κB in pulmonary diseases. Chest 117:1482.
    • (2000) Chest , vol.117 , pp. 1482
    • Christman, J.W.1    Sadikot, R.T.2    Blackwell, T.S.3
  • 15
    • 0029836595 scopus 로고    scopus 로고
    • The NF-κB/Rel and I κB gene families: Mediators of immune response and inflammation
    • Wulczyn, F. G., D. Krappmann, and C. Scheidereit. 1996. The NF-κB/Rel and I κB gene families: Mediators of immune response and inflammation. J. Mol. Med. 74:749.
    • (1996) J. Mol. Med. , vol.74 , pp. 749
    • Wulczyn, F.G.1    Krappmann, D.2    Scheidereit, C.3
  • 16
    • 0032476742 scopus 로고    scopus 로고
    • Essential role of nuclear factor κB in the induction of eosinophilia in allergic airway inflammation
    • Yang, L., L. Cohn, D. H. Zhang, R. Homer, A. Ray, and P. Ray, 1998. Essential role of nuclear factor κB in the induction of eosinophilia in allergic airway inflammation. J. Exp. Med. 188:1739.
    • (1998) J. Exp. Med. , vol.188 , pp. 1739
    • Yang, L.1    Cohn, L.2    Zhang, D.H.3    Homer, R.4    Ray, A.5    Ray, P.6
  • 17
    • 0025720735 scopus 로고
    • The role of Jun. Fos and the AP-1 complex in cell-proliferation and transformation
    • Angel, P., and M. Karin. 1991. The role of Jun. Fos and the AP-1 complex in cell-proliferation and transformation. Biochim. Biophys. Acta 1072:129.
    • (1991) Biochim. Biophys. Acta , vol.1072 , pp. 129
    • Angel, P.1    Karin, M.2
  • 18
    • 0023611441 scopus 로고
    • Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements
    • Lee, W., P. Mitchell, and R. Tjian. 1987. Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements. Cell 49:741.
    • (1987) Cell , vol.49 , pp. 741
    • Lee, W.1    Mitchell, P.2    Tjian, R.3
  • 20
    • 0029079269 scopus 로고
    • The effect of active oxygen generated by xanthine/xanthine oxidase on genes and signal transduction in mouse epidermal JB6 cells
    • Singh, N., and S. Aggarwal. 1995. The effect of active oxygen generated by xanthine/xanthine oxidase on genes and signal transduction in mouse epidermal JB6 cells. Int. J. Cancer 62:107.
    • (1995) Int. J. Cancer , vol.62 , pp. 107
    • Singh, N.1    Aggarwal, S.2
  • 21
    • 14444270850 scopus 로고    scopus 로고
    • Oxidative stress regulates the expression and activity of transcription factor activator protein-1 in rat conceptus
    • Ozolins, T. R., and B. F. Hales, 1997. Oxidative stress regulates the expression and activity of transcription factor activator protein-1 in rat conceptus. J. Pharmacol. Exp. Ther. 280:1085.
    • (1997) J. Pharmacol. Exp. Ther. , vol.280 , pp. 1085
    • Ozolins, T.R.1    Hales, B.F.2
  • 22
    • 0025916445 scopus 로고
    • Transcriptional activation of early-response genes by hydrogen peroxide in a mouse osteoblastic cell line
    • Nose, K., M. Shibanuma, K. Kikucbi, H. Kageyama, S. Sakiyama, and T. Kuroki. 1991. Transcriptional activation of early-response genes by hydrogen peroxide in a mouse osteoblastic cell line. Eur. J Biochem. 201:99.
    • (1991) Eur. J Biochem. , vol.201 , pp. 99
    • Nose, K.1    Shibanuma, M.2    Kikucbi, K.3    Kageyama, H.4    Sakiyama, S.5    Kuroki, T.6
  • 23
    • 0025077481 scopus 로고
    • Redox regulation of fos and jun DNA-binding activity in vitro
    • Abate, C., L. Patel, F. J. Rauscher, and T. Curran. 1990. Redox regulation of fos and jun DNA-binding activity in vitro. Science 249:1157.
    • (1990) Science , vol.249 , pp. 1157
    • Abate, C.1    Patel, L.2    Rauscher, F.J.3    Curran, T.4
  • 24
    • 0028344541 scopus 로고
    • Distinct effects of thioredoxin and antioxidants on the activation of transcription factors NF-κB and AP-1
    • Schenk, H., M. Klein, W. Erdbrugger, W. Droge, and K. Schulze-Osthoff. 1994. Distinct effects of thioredoxin and antioxidants on the activation of transcription factors NF-κB and AP-1. Proc. Natl. Acad. Sci. USA 91:1672.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 1672
    • Schenk, H.1    Klein, M.2    Erdbrugger, W.3    Droge, W.4    Schulze-Osthoff, K.5
  • 27
    • 0034660633 scopus 로고    scopus 로고
    • Sequence of the 5′-flanking region and promoter activity of the human mucin gene MUC5B in different phenotypes of colon cancer cells
    • Van, S., I. M. Perrais, P. Pigny, N. Porchet, and J. P. Aubert. 2000. Sequence of the 5′-flanking region and promoter activity of the human mucin gene MUC5B in different phenotypes of colon cancer cells. Biochem. J. 3:675.
    • (2000) Biochem. J. , vol.3 , pp. 675
    • Van, S.1    Perrais, I.M.2    Pigny, P.3    Porchet, N.4    Aubert, J.P.5
  • 28
    • 0030030331 scopus 로고    scopus 로고
    • Polymorphic nuclectides within the human IL-4 promoter that mediate overexpression of the gene
    • Song, Z., V. Casolaro, R. Chen, S. N. Georas, D. Monos, and S. J. Ono. 1996. Polymorphic nuclectides within the human IL-4 promoter that mediate overexpression of the gene. J. Immunol. 156:424.
    • (1996) J. Immunol. , vol.156 , pp. 424
    • Song, Z.1    Casolaro, V.2    Chen, R.3    Georas, S.N.4    Monos, D.5    Ono, S.J.6
  • 30
    • 0033594506 scopus 로고    scopus 로고
    • Secondary structure peptide mimetics: Design, synthesis, and evaluation of β-strand mimetic thrombin inhibitors
    • Boatman, P. D., C. O. Ogbu, M. Eguchi, H. O. Kim, H. Nakanishi, B. Cao, J. P. Shea, and M. Kahn. 1999. Secondary structure peptide mimetics: Design, synthesis, and evaluation of β-strand mimetic thrombin inhibitors. J. Med. Chem. 42:1367.
    • (1999) J. Med. Chem. , vol.42 , pp. 1367
    • Boatman, P.D.1    Ogbu, C.O.2    Eguchi, M.3    Kim, H.O.4    Nakanishi, H.5    Cao, B.6    Shea, J.P.7    Kahn, M.8
  • 31
    • 0029671072 scopus 로고    scopus 로고
    • Replacement of Trp28 in Escherichia coli thioredoxin by site-directed mutagenesis affects thermodynamic stability but not function
    • Slaby, I., V. Cerna, M. F. Jeng, H. J. Dyson, and A. Holmgren. 1996. Replacement of Trp28 in Escherichia coli thioredoxin by site-directed mutagenesis affects thermodynamic stability but not function. J. Biol. Chem. 271:3091.
    • (1996) J. Biol. Chem. , vol.271 , pp. 3091
    • Slaby, I.1    Cerna, V.2    Jeng, M.F.3    Dyson, H.J.4    Holmgren, A.5
  • 33
    • 0343502999 scopus 로고    scopus 로고
    • Soluble IL-4 receptor inhibits airway inflammation following allergen challenge in a mouse model of asthma
    • Henderson, W. R., Jr., E. Y. Chi, and C. R. Maliszewski. 2000. Soluble IL-4 receptor inhibits airway inflammation following allergen challenge in a mouse model of asthma. J. Immunol. 164:1086.
    • (2000) J. Immunol. , vol.164 , pp. 1086
    • Henderson W.R., Jr.1    Chi, E.Y.2    Maliszewski, C.R.3
  • 36
    • 0023088975 scopus 로고
    • Adverse effects of acetylcysteine on human and guinea pig bronchial asthma in vivo and on human fibroblasts and leukocytes in vitro
    • Dorsch, W., E. Auch, and P. Powerlowicz. 1987. Adverse effects of acetylcysteine on human and guinea pig bronchial asthma in vivo and on human fibroblasts and leukocytes in vitro. Int. Arch. Allergy Immunol. 82.33.
    • (1987) Int. Arch. Allergy Immunol. , vol.82 , pp. 33
    • Dorsch, W.1    Auch, E.2    Powerlowicz, P.3
  • 37
    • 0033781522 scopus 로고    scopus 로고
    • Reduction of exercise-induced asthma oxidative stress by lycopene, a natural antioxidant
    • Neuman, I., H. Nahum, and A. Ben-Amotz. 2000. Reduction of exercise-induced asthma oxidative stress by lycopene, a natural antioxidant. Allergy 55:1184.
    • (2000) Allergy , vol.55 , pp. 1184
    • Neuman, I.1    Nahum, H.2    Ben-Amotz, A.3
  • 38
    • 0001432325 scopus 로고
    • Enzymatic synthesis of deoxyribonucleotides. IV. Isolation and characterization of thioredoxin, the hydrogen donor from Escherichia coli
    • Laurent, T. C., E. C. Moore, and P. Reichard. 1964. Enzymatic synthesis of deoxyribonucleotides. IV. Isolation and characterization of thioredoxin, the hydrogen donor from Escherichia coli B. J. Biol. Chem. 239:3426.
    • (1964) B. J. Biol. Chem. , vol.239 , pp. 3426
    • Laurent, T.C.1    Moore, E.C.2    Reichard, P.3
  • 39
    • 1842295744 scopus 로고    scopus 로고
    • Regulatory role for a novel human thioredoxin peroxidase in NF-κB activation
    • Jin, D. Y., H. Z. Chae, S. G. Rhee, and K. T. Jeang. 1997. Regulatory role for a novel human thioredoxin peroxidase in NF-κB activation. J. Biol. Chem. 272:30952.
    • (1997) J. Biol. Chem. , vol.272 , pp. 30952
    • Jin, D.Y.1    Chae, H.Z.2    Rhee, S.G.3    Jeang, K.T.4
  • 40
    • 0026741597 scopus 로고
    • Human thioredoxin/adult T cell leukemia-derived factor activates the enhancer binding protein of human immunodeficiency virus type 1 by thiol redox control mechanism
    • Okamoto, T., H. Ogiwara, T. Hayashi, A. Mitsui, T. Kawabe, and J. Yodoi. 1992. Human thioredoxin/adult T cell leukemia-derived factor activates the enhancer binding protein of human immunodeficiency virus type 1 by thiol redox control mechanism. Int. Immunol. 4:811.
    • (1992) Int. Immunol. , vol.4 , pp. 811
    • Okamoto, T.1    Ogiwara, H.2    Hayashi, T.3    Mitsui, A.4    Kawabe, T.5    Yodoi, J.6
  • 42
    • 0032481292 scopus 로고    scopus 로고
    • Molecular cloning and expression of a cDNA encoding a human thioredoxin-like protein
    • Miranda-Vizuete, A., J. A. Gustafsson, and G. Spyrou. 1998. Molecular cloning and expression of a cDNA encoding a human thioredoxin-like protein. Biochem. Biophys. Res. Commun. 243:284.
    • (1998) Biochem. Biophys. Res. Commun. , vol.243 , pp. 284
    • Miranda-Vizuete, A.1    Gustafsson, J.A.2    Spyrou, G.3
  • 43
    • 0026583944 scopus 로고
    • Identification and characterization of Ref-1, a nuclear protein that facilitates AP-1 DNA-binding activity
    • Xanthoudakis, S., and T. Curran. 1992. Identification and characterization of Ref-1, a nuclear protein that facilitates AP-1 DNA-binding activity. EMBO J. 11:653.
    • (1992) EMBO J. , vol.11 , pp. 653
    • Xanthoudakis, S.1    Curran, T.2
  • 44
    • 0030936568 scopus 로고    scopus 로고
    • AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1
    • Hirota, K., M. Matsui, S. Iwata, A. Nishiyama, K. Mori, and J. Yodoi. 1997. AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1. Proc. Natl. Acad. Sci. USA 94:3633.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 3633
    • Hirota, K.1    Matsui, M.2    Iwata, S.3    Nishiyama, A.4    Mori, K.5    Yodoi, J.6
  • 45
    • 0030585150 scopus 로고    scopus 로고
    • The solution structure of human thioredoxin complexed with its target from Ref-1 reveals peptide chain reversal
    • Qin, J., G. M. Clore, W. P. Kennedy, J. Kuszewski, and A. M. Gronenborn. 1996. The solution structure of human thioredoxin complexed with its target from Ref-1 reveals peptide chain reversal. Structure 4:613.
    • (1996) Structure , vol.4 , pp. 613
    • Qin, J.1    Clore, G.M.2    Kennedy, W.P.3    Kuszewski, J.4    Gronenborn, A.M.5
  • 46
    • 0029644240 scopus 로고
    • Solution structure of human thioredoxin in a mixed disulfide intermediate complex with its target peptide from the transcription factor NF-κB
    • Qin, J., G. M. Clore, W. M. Kennedy, J. R. Huth, and A. M. Gronenborn. 1995. Solution structure of human thioredoxin in a mixed disulfide intermediate complex with its target peptide from the transcription factor NF-κB. Structure 3:289.
    • (1995) Structure , vol.3 , pp. 289
    • Qin, J.1    Clore, G.M.2    Kennedy, W.M.3    Huth, J.R.4    Gronenborn, A.M.5
  • 48
    • 0028979479 scopus 로고
    • Structure of NF-κB p50 homodimer bound to a κB site
    • Ghosh, G., G. van Duyne, S. Ghosh, and P. B. Sigler. 1995. Structure of NF-κB p50 homodimer bound to a κB site. Nature 373:303.
    • (1995) Nature , vol.373 , pp. 303
    • Ghosh, G.1    Van Duyne, G.2    Ghosh, S.3    Sigler, P.B.4
  • 50
    • 0035222187 scopus 로고    scopus 로고
    • A critical role for NF-κB in GATA-3 expression and Th2 differentiation in allergic airway inflammation
    • Das, J., C. H. Chen, L. Yang, L. Cohn, P. Ray, and A. Ray. 2001. A critical role for NF-κB in GATA-3 expression and Th2 differentiation in allergic airway inflammation. Nat. Immunol. 2:45.
    • (2001) Nat. Immunol. , vol.2 , pp. 45
    • Das, J.1    Chen, C.H.2    Yang, L.3    Cohn, L.4    Ray, P.5    Ray, A.6
  • 51
    • 0028956973 scopus 로고
    • Inhaled glucocorticoids for asthma
    • Barnes, P. J. 1995. Inhaled glucocorticoids for asthma. N. Engl. J. Med. 332:868.
    • (1995) N. Engl. J. Med. , vol.332 , pp. 868
    • Barnes, P.J.1
  • 52
    • 0034889129 scopus 로고    scopus 로고
    • Cross-talk between pro-inflammatory transcription factors and glucocorticoids
    • Adcock, I. M., and G. Caramori. 2001. Cross-talk between pro-inflammatory transcription factors and glucocorticoids. Immunol. Cell Biol. 79:376.
    • (2001) Immunol. Cell Biol. , vol.79 , pp. 376
    • Adcock, I.M.1    Caramori, G.2
  • 54
    • 0029741438 scopus 로고    scopus 로고
    • Steroid resistance in asthma: Molecular mechanisms
    • Adcock. I. M. 1996. Steroid resistance in asthma: Molecular mechanisms Am. J. Respir. Crit. Care Med. 154:S58-S61.
    • (1996) Am. J. Respir. Crit. Care Med. , vol.154
    • Adcock, I.M.1


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