Type-2 IGF receptor: A multi-ligand binding protein

Hormone and Metabolic Research

Volumn 31, Issue 2-3, 1999, Pages 242-246

  Braulke, Thomas ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

Binding sites; Cytoplasmic signals; Development; Imprinting; Mannose 6 phosphate receptor; Mutations; Recycling; Tumor; Type 2 IGF receptors (IGF2R)

Indexed keywords

BINDING PROTEIN; CASEIN KINASE II; GLYCOPROTEIN; GROWTH FACTOR; GUANOSINE TRIPHOSPHATASE; LYSOSOME ENZYME; MANNOSE 6 PHOSPHATE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOPROTEIN PHOSPHATASE 1; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN KINASE C; RETINOIC ACID; SOMATOMEDIN B; SOMATOMEDIN B RECEPTOR; UROKINASE RECEPTOR;

ARTICLE; BINDING SITE; CARCINOGENESIS; CELLULAR DISTRIBUTION; ENDOCYTOSIS; GENE; HUMAN; LIGAND BINDING; LYSOSOME; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TUMOR;

MAMMALIA; RODENTIA;

EID: 0032930759     PISSN: 00185043     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-978725     Document Type: Article

References (60)

1. 1. LeRoith D, Werner H, Beitner-Johnson D, Roberts CT. Molecular and cellular aspects of the insulin-like growth factor I receptor. Endocrine Rev 1995; 16: 143-63
2. 2. Louvi A, Accili D, Efstratiadis A. Growth-promoting interaction of IGF-II with the insulin receptor during mouse embryonic development. Dev Biol 1997; 189: 33-48
3. 3. Kornfeld S. Structure and function of the mannose 6-phosphate/ insulin-like growth factor II receptors. Ann Rev Biochem 1992; 61:307-30
4. 4. Ludwig T, LeBorgne R, Hoflack B. Roles for mannose-6-phosphate receptors in lysosomal enzyme sorting, IGF-II biding and clathrin-coat assembly. Trends Cell Biol 1995; 5: 202-6
5. 5. Braulke T. Origin of lysosomal proteins. In: Lloyd JB, Mason RW (eds). Subcellular Biochemistry: Biology of the lysosome. New York, Plenum Press, 1996; 27: 15-49
6. 6. DeSouza AT, Yamada T, Mills JJ, Jirtle RL. Imprinted genes in liver carcinogenesis. FASEB J 1997; 11: 60-7
7. 7. Szebenyl G, Rotwein P. The mouse insulin-like growth factor II/ cation-independent mannose 6-phosphate receptor gene: molecular cloning and genomic organization. Genomics 1994; 19: 120-9
8. 8. Dahms NM, Rose PA, Molkentin JD, Zhang Y, Brzycki MA. The bcvine mannose 6-phosphate/insulin-like growth factor II receptor. The role of arginine residues in mannose 6-phosphate binding. J Biol Chem 1993; 268: 5457-63
9. 9. Schmidt B, Kiecke-Siemsen C, Waheed A, Braulke T, von Figura K. Localization of the insulin-like growth factor II binding site to aminoacid 1508-1566 in repeat 11 of the mannose 6-phosphate/insulin-like growth factor II receptor. J Biol Chem 1995; 270: 14975-82
10. 10. Garmroudi F, Devi G, Slentz DH, Schaffer BS, MacDonald RG. Truncated forms of the insulin-like growth factor II (IGF-II)/ mannose 6-phosphate receptor encompassing the IGF-II binding site: characterization of a point mutation that abolishes ICF-II binding. Mol Endocrinol 1996; 10: 642-51
11. 11. Zhou M, Ma Z, Sly WS. Cloning and expression of the cDNA of chicken cation-independent mannose-6-phosphate receptor. Proc Nat Acad Sci USA 1995; 92: 9762-6
12. 12. Kiess W, Greenstein LA, Lee L, Thomas C, Nissley SP. Biosynthesis of the insulin-like growth factor II (IGF II)/mannose 6-phosphate receptor in rat C6 glial cells. The role of N-linked glycosylation in binding IGF-II to the receptor. Mol Endocrinol 1991; 5: 282-91
13. 13. Tong PY, Gregory W, Kornfeld S. Ligand interactions of the cation-independent mannose 6-phosphate receptor. J Biol Chem 1989; 264: 7962-9
14. 14. MacDonald RG, Pfeffer SR, Coussens L, Tepper MA, Brocklebank CM, Mole JE, Anderson JK, Chen E, Czech MP, Ullrich A. A single receptor binds both insulin-like growth factor II and mannose 6-phosphate. Science 1988; 239: 1134-7
15. 15. Waheed A, Braulke T, Junghans U, von Figura K. Mannose 6-phosphate/insulin-like growth factor II receptor: the two types of ligands bind simultaneously to one receptor at different sites. Biochem Biophys Res Commun 1988; 152: 1248-54
16. 16. Kiess W, Blickenstaff GD, Sklar MM, Thomas CL, Nissley SP, Sahagian GG. Biochemical evidence that the type II insulin-like growth factor receptor is identical to the cation-independent mannose 6-phosphate receptor. J Biol Chem 1988; 263: 9339-44
17. 17. Valenzano KJ, Remmler J, Lobel P. Soluble insulin-like growth factor II/mannose 6-phosphate receptor carries multiple high molecular weight forms of insulin-like growth factor II in fetal bovine serum. J Biol Chem 1995; 270: 16441-8
18. 18. Kang JX, Li Y, Leaf A. Mannose-6-phosphate/insulin-like growth factor-II receptor is a receptor for retinoic acid. Proc Natl Acad Sci USA 1997; 95: 13671-6
19. 19. Nykjaer A, Christensen EL, Vorum H, Hager H, Petersen CM, Roigaard H, Min HY, Vilhardt F, Moller LB, Kornfeld S, Gliemann J. Mannose 6-phosphate/insulin-like growth factor-II receptor targets the urokinase receptor to lysosomes via a novel binding interaction. J Cell Biol 1998; 141: 815-28
20. 20. Köster A, von Figura K, Pohlmann R. Mistargeting of lysosomal enzymes in Mr 46000 mannose 6-phosphate receptor-deficient mice is compensated by carbohydrate-specific endocytotic receptors. Eur J Biochem 1994; 224: 685-9
21. 21. Schmitz F, Bresciani R, Hartmann H, Braulke T. Effect of insulin-like growth factor II on uptake of arylsulfatase A by cultured rat hepatocytes and Kupffer cells. J Hepatol 1995; 22: 356-63
22. 22. O'Brien DA, Welch JE, Fulcher KD, Eddy EM. Expression of mannose-6-phosphate receptor messenger ribonucleic acids in mouse spermatogenic and Sertoli cells. Biol Reprod 1994; 50: 429-35
23. 23. Dennis PA, Rifkin DB. Cellular activation of latent transforming growth factor β requires binding to the cation-independent mannose 6-phosphate/insulin-like growth factor type II receptor. Proc Natl Acad Sci USA 1991 ; 88: 580-4
24. 24. Lee SJ, Nathans D. Proliferin secreted by cultured cells bind to mannose 6-phosphate receptors. J Biol Chem 1988; 263: 3521-7
25. 25. van Kesteren CA, Danser AH, Derkx FH, Dekkers DH, Lamers JM, Saxena PR, Schalekamp MA. Mannose 6-phosphate receptor-mediated internalization and activation of prorenin by cardiac cells. Hypertension 1997; 30: 1389-96
26. 26. Wang ZQ, Fung MR, Barlow DP, Wagner EF. Regulation of embryonic growth and lysosomal targeting by the imprinted Igf2/ Mpr gene. Nature 1994; 372: 464-7
27. 27. Lau MMH, Stewart CEH, Liu Z, Bhatt H, Rotwein P, Stewart CL. Loss of the imprinted IGF2/cation-independent mannose 6-phosphate receptor results in fetal overgrowth and perinatal lethality. Genes Dev 1994; 8: 2953-63
28. 28. Ludwig T, EggenschwilerJ, Fisher P, D'Ercole AJ, Davenport ML, Efstratiadis A. Mouse mutants lacking the type 2 IGF receptor (IGF2R) are rescued from perinatal lethality in Igf2 and Igf1r null backgrounds. Dev Biol 1996; 177: 517-35
29. 29. Minniti CP, Kohn EC, GrubbJH, Sly WS, Oh Y, Müller HL, Rosenfeld RG, Helman LJ. The insulin-like growth factor II (IGF-II)/ mannose 6-phosphate receptor mediates IGF-II-induced motility in human rhabdomyosarcoma cells. J Biol Chem 1992; 267: 9000-4
30. 30. Volpert O, Jackson D, Bouck N, Linzer DI. The insulin-like growth factor II/mannose 6-phosphate receptor is required for proliferin-induced angiogenesis. Endocrinology 1996; 137: 3871-6
31. 31. Rosenthal SM, Hsiao D, Silverman LA. An insulin-like growth factor-II (IGF-II) analog with highly selective affinity for IGF-II receptors stimulates differentiation, but not IGF-I receptor down-regulation in muscle cells. Endocrinology 1994; 135: 38-44
32. 32. Nishimoto I. The IGF-II receptor sytem: a G protein-linked mechanism. Mol Reprod Dev 1993; 35: 398-407
33. 33. Körner C, Nürnberg B, Uhde M, Braulke T. Mannose 6-phosphate/lnsulin-like growth factor II receptor fails to interact with G-proteins. J Biol Chem 1995; 270: 287-95
34. 34. Zhang Q, Berggren P-O, Tally M. Glucose increases both the plasma membrane number and phosphorylation of insulin-like growth factor II/mannose 6-phosphate receptors. J Biol Chem 1997; 272: 23703-6
35. 35. Braulke T, Mieskes G. Role of protein phosphatases in insulin-like growth factor II (IGF II)-stimulated mannose 6-phosphate/ IGF II receptor redistribution. J Biol Chem 1992; 267: 17347-53
36. 36. Körner C, Braulke T. Inhibition of IGF II-induced redistribution of mannose 6-phosphate receptors by the phosphatidylinositol 3-kinase inhibitor, wortmannin. Mol Cell Endocrinol 1996; 118: 201-5
37. 37. LeBorgne R, Schmidt A, Mauxion F, Griffiths G, Hoflack B. Binding of AP-1 Golgi adaptors to membranes requires phosphorylated cytoplasmic domains of the mannose 6-phosphate/insulin-like growth factor II receptor. J Biol Chem 1993; 268: 22552-6
38. 38. LeBorgne R, Hoflack B. Mannose 6-phosphate receptors regulate the formation of clathrin-coated vesicles in the TGN. J Cell Biol 1997; 137: 335-45
39. 39. LeBorgne R, Griffiths G, Hoflack B. Mannose 6-phosphate receptors and ADP-ribosylation factors cooperate for high affinity interaction of the AP-1 Golgi assembly proteins with membranes. J Biol Chem 1996; 271: 2162-70
40. 40. Diaz E, Pfeffer SR. TIP-47: a cargo selection device for mannose 6-phosphate receptor trafficking. Cell 1998; 93: 433-43
41. 41. Riederer MA, Soldati T, Shapiro AD, Lin J, Pfeffer SR. Lysosome biogenesis requires rab 9 function and receptor recycling from endosomes to the trans-Golgi network. J Cell Biol 1994; 125: 573-82
42. 42. Kundra R, Kornfeld S. Wortmannin retards the movement of the mannose 6-phosphate/insulin-like growth factor II receptor and its ligand out of endosomes. J Biol Chem 1998; 273: 3848-53
43. 43. Rosorius O, Issinger O-G, Braulke T. Phosphorylation of the cytoplasmic tail of the 300 kDa mannose 6-phosphate receptor is required for the interaction with a cytosolic protein. J Biol Chem 1993; 268: 21470-3
44. 44. Sklar MM, Kiess W, Thomas CL, Nissley SP. Developmental expression of the tissue insulin-like growth factor II/mannose 6-phosphate receptor in the rat. J Biol Chem 1989; 264: 16733-8
45. 45. Sklar MM, Thomas CL, Municchi G, Roberts CT, LeRoith D, Kiess W, Nissley P. Developmental expression of rat insuln-like growth factor II/mannose 6-phosphate receptor messenger ribonucleic acid. Endocrinology 1992; 130: 3484-91
46. 46. Senior PV, Byrne S, Brammar WJ, Beck F. Expression of the IGF II/ mannose 6-phosphate receptor mRNA and protein in the developing rat. Development 1990; 109: 67-73
47. 47. Matzner U, von Figura K, Pohlmann R. Expression of the two mannose 6-phosphate receptors is spatically and temporally different during mouse embryogenesis. Development 1992; 114: 965-72
48. 48. Kalscheuer VM, Mariman EC, Schepens MT, Rehder H, Ropers HH. The insulin-like growth factor type-2 receptor gene is imprinted in the mouse but not in humans. Nat Genet 1993; 5: 74-8
49. 49. Mills JJ, Falls JG, DeSouza AT, Jirtle RL Imprinted M6p/Igf2 receptor is mutated in rat liver tumors. Oncogene 1998; 16: 2797-2802
50. 50. Hu J-F, Oruganti H, Vu TH, Hoffman AR. Tissue-specific imprinting of the mouse insulin-like growth factor II receptor gene correlates with differential allele-specific DNA methylation. Mol Endocrinol 1998; 12: 220-32
51. 51. Liu Z, Mittanck DW, Kim S, Rotwein P. Control of insulin-like growth factor II/mannose 6-phosphate receptor gene transcription by proximal promotor elements. Mol Endocrinol 1995; 9: 1477-87
52. 52. Levy MJ, Hernandez ER, Adashi EY, Stillman RJ, Roberts CT, LeRoith D. Expression of the insulin-like growth factor (IGF)-I and II and the IGF-I and -II receptor genes during postnatal development of the rat ovary. Endocrinology 1992; 131: 1202-6
53. 53. Matzner U, Hille-Rehfeld A, von Figura K, Pohlmann R. Expression of mannose 6-phosphate receptors in chicken. Develop Dyn 1996; 207; 11-24
54. 54. Mathieu M, Vignon F, Capony F, Rochefort H. Estradiol down-regulates the mannose-6-phosphate/insulin-like growth factor-II receptor gene and induces cathepsin-D in breast cancer cells: a receptor saturation mechanism to increase the secretion of lysosomal proenzymes. Mol Endocrinol 1991; 5: 815-22
55. 55. Jirtle RL, Hankins CR, Reisenbichler H, Boyer IJ. Regulation of mannose 6-phosphate/insulin-like growth factor-II receptors and transforming growth factor beta during liver tumor promotion with phenobarbital. Carcinogenesis 1994; 15: 1473-8
56. 56. Sue SR, Chari RS, Kong FM, Mills JJ, Fine RL, Meyers WC. Transforming growth factor-beta receptors and mannose 6-phosphate/insulin-like growth factor-II receptor expression in human hepatocellular carcinoma. Ann Surg 1995; 222: 171-8
57. 57. Wang S, Souza RF, Kong D, Yin J, Smolinski KN, Zou TT, Frank T, Young J, Flanders KC, Sugimura H, Abraham JM, Meltzer SJ. Deficient transforming growth factor-beta 1 activation and excessive insulin-like growth factor II (IGF II) expression in IGF II receptor-mutant tumors. Cancer Res 1997; 57: 2543-6
58. 58. DeSouza AT, Hankins GR, Washington MK, Orton TC, Jirtle RL. M6P/1GF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity. Nat Genet 1995; 11: 447-9
59. 59. Hankins GR, DeSouza AT, Bentley RC, Patel MR, Marks JR, Iglehart JD, Jirtle RL M6P/IGF2 receptor: a candidate tumor suppressor gene. Oncogene 1996; 12: 2003-9
60. 60. Chappell SA, Walsh T, Walker RA, Shaw JA. Loss of heterozygosity at the mannose 6-phosphate insulin-like growth factor 2 receptor gene correlates with poor differentiation in early breast carcinomas. Br J Cancer 1997; 76: 1558-61