Hepatocellular telomere shortening correlates with chromosomal instability and the development of human hepatoma

Hepatology

Volumn 40, Issue 1, 2004, Pages 80-86

  Plentz, Ruben R ^a   Caselitz, Martin ^b   Bleck, Joerg S ^a   Gebel, Michael ^a   Flemming, Peer ^a   Kubicka, Stefan ^a   Manns, Michael P ^a   Rudolph, K Lenhard ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b Klinikum Deggendorf   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGE; AGED; ANEUPLOIDY; ARTICLE; CANCER GRADING; CANCER GROWTH; CANCER RISK; CELL TYPE; CHROMOSOME ANALYSIS; CLINICAL ARTICLE; CONTROLLED STUDY; CYTODIAGNOSIS; CYTOPHOTOMETRY; DIPLOIDY; FEMALE; HISTOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER CELL; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LIVER NODULE; MALE; NEEDLE BIOPSY; PLOIDY; PRIORITY JOURNAL; TELOMERE;

ADULT; AGED; ANEUPLOIDY; BIOPSY, NEEDLE; CARCINOMA, HEPATOCELLULAR; CHROMOSOMAL INSTABILITY; FEMALE; HEPATOCYTES; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LIVER; LIVER CIRRHOSIS; LIVER NEOPLASMS; MALE; MIDDLE AGED; TELOMERE;

EID: 3042780966     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.20271     Document Type: Article

References (26)

1. Monto A, Wright TL. The epidemiology and prevention of hepatocellular carcinoma. Semin Oncol 2001;28:441-449.
2. Velazquez RF, Rodriguez M, Navascues CA, Linares A, Perez R, Sotorris NG, et al. Prospective analysis of risk factors for hepatocellular carcinoma in patients with liver cirrhosis. HEPATOLOGY 2003;37:520-527.
3. Longchampt E, Patriarche C, Fabre M. Accuracy of cytology vs. microbiopsy for the diagnosis of well-differentiated hepatocellular carcinoma and macroregenerative nodule. Definition of standardized criteria from a study of 100 cases. Acta Cytol 2000;44:515-523.
4. Lengauer C, Kinzler KW, Vogelstein B. Genetic instabilities in human cancers. Nature 1998;396:643-649.
5. Thorgeirsson SS, Grisham JW. Molecular pathogenesis of human hepatocellular carcinoma. Nat Genet 2002;31:339-346.
6. Maser RS, DePinho RA. Take care of your chromosomes lest cancer take care of you. Cancer Cell 2003;3:4-6.
7. Djojosubroto MW, Choi YS, Lee HW, Rudolph KL. Telomeres and telomerase in aging, regeneration and cancer. Mol Cells 2003;15:164-175.
8. Blackburn EH. Structure and function of telomeres. Nature 1991;350: 569-573.
9. Wright WE, Shay JW. The two-stage mechanism controlling cellular senescence and immortalization. Exp Gerontol 1992;27:383-389.
10. Harley CB, Futcher AB, Greider CW. Telomeres shorten during ageing of human fibroblasts. Nature 1990;345:458-460.
11. Wiemann SU, Satyanarayana A, Tsahuridu M, Tillmann HL, Zender L, Klempnauer J, et al. Hepatocyte telomere shortening and senescence are general markers of human liver cirrhosis. FASEB J 2002;16:935-942.
12. Blasco MA, Lee HW, Hande MP, Samper E, Lansdorp PM, DePinho RA, et al. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 1997;91:25-34.
13. Maser RS, DePinho RA. Connecting chromosomes, crisis, and cancer. Science 2002;297:565-569.
14. Artandi SE, Chang S, Lee SL, Alson S, Gottlieb GJ, Chin L, et al. Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice. Nature 2000;406:641-645.
15. Rudolph KL, Chang S, Lee HW, Blasco M, Gottlieb GJ, Greider C, et al. Longevity, stress response, and cancer in aging telomerase-deficient mice. Cell 1999;96:701-712.
16. Rudolph KL, Millard M, Bosenberg MW, DePinho RA. Telomere dysfunction and evolution of intestinal carcinoma in mice and humans. Nat Genet 2001;28:155-159.
17. Farazi PA, Glickman J, Jiang S, Yu A, Rudolph KL, DePinho RA. Differential impact of telomere dysfunction on initiation and progression of hepatocellular carcinoma. Cancer Res 2003;63:5021-5027.
18. Satyanarayana A, Manns M.P. Rudolph KL. Telomeres and telomerase:a dual role in hepatocarcinogenesis. HEPATOLOGY. In press.
19. Yokota T, Suda T, Igarashi M, Kuroiwa T, Waguri N, Kawai H, et al. Telomere length variation and maintenance in hepatocarcinogenesis. Cancer 2003;98:110-118.
20. Miura N, Horikawa I, Nishimoto A, Ohmura H, Ito H, Hirohashi S, et al. Progressive telomere shortening and telomerase reactivation during hepatocellular carcinogenesis. Cancer Genet Cytogenet 1997;93:56-62.
21. Kojima H, Yokosuka O, Imazeki F, Saisho H, Omata M. Telomerase activity and telomere length in hepatocellular carcinoma and chronic liver disease. Gastroenterology 1997;112:493-500.
22. Allsopp RC, Chang E, Kashefi-Aazam M, Rogaev EI, Piatyszek MA, Shay JW, et al. Telomere shortening is associated with cell division in vitro and in vivo. Exp Cell Res 1995;220:194-200.
23. Caselitz M, Masche N, Bleck JS, Gebel M, Atay Z, Stern C, et al. Increasing sensitivity of morphological diagnosis in hepatocellular carcinoma (HCC) by combination of cytological and fine-needle histological examination after ultrasound guided fine needle biopsy. Z Gastroenterol 2003;41:559-564.
24. Satyanarayana A, Wiemann SU, Buer J, Lauber J, Dittmar KE, Wustefeld T, et al. Telomere shortening impairs organ regeneration by inhibiting cell cycle re-entry of a subpopulation of cells. EMBO J 2003;22:4003-4013.
25. Wilkens L, Bredt M, Flemming A, Mengel M, Klempnauer J, Kreipe H, et al. Detection of chromosomal aberrations in well-differentiated hepatocellular carcinoma by bright-field in situ hybridization. Mod Radiol 2002;15:470-475.
26. Tannapfel A, Busse C, Weinans L, Benicke M, Katalinis A, Geissler F, et al. INK4a-ARF alterations and p53 mutations in hepatocellular carcinomas. Oncogene 2001;20:7104-7109.