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Volumn 25, Issue 23, 2005, Pages 5544-5552

α-synuclein phosphorylation enhances eosinophilic cytoplasmic inclusion formation in SH-SY5Y cells

Author keywords

synuclein; Eosinophilic inclusion; Lewy body; Parkin; Parkinson's disease; Synphilin 1; Ubiquitin

Indexed keywords

5,6 DICHLOROBENZIMIDAZOLE RIBOSIDE; ALANINE; ALPHA SYNUCLEIN; CASEIN KINASE II; PARKIN;

EID: 20444416315     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0482-05.2005     Document Type: Article
Times cited : (228)

References (53)
  • 1
    • 0027511827 scopus 로고
    • Casein kinase II phosphorylates the synaptic vesicle protein p65
    • Bennett MK, Miller KG, Scheller RH (1993) Casein kinase II phosphorylates the synaptic vesicle protein p65. J Neurosci 13:1701-1707.
    • (1993) J Neurosci , vol.13 , pp. 1701-1707
    • Bennett, M.K.1    Miller, K.G.2    Scheller, R.H.3
  • 4
    • 0034776095 scopus 로고    scopus 로고
    • Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: Implications for Lewy-body formation in Parkinson disease
    • Chung KK, Zhang Y, Lim KL, Tanaka Y, Huang H, Gao J, Ross CA, Dawson VL, Dawson TM (2001a) Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease. Nat Med 7:1144-1150.
    • (2001) Nat Med , vol.7 , pp. 1144-1150
    • Chung, K.K.1    Zhang, Y.2    Lim, K.L.3    Tanaka, Y.4    Huang, H.5    Gao, J.6    Ross, C.A.7    Dawson, V.L.8    Dawson, T.M.9
  • 5
    • 2942618660 scopus 로고    scopus 로고
    • The role of the ubiquitin-proteasomal pathway in Parkinson's disease and other neurodegenerative disorders
    • Chung KK, Dawson VL, Dawson TM (2001b) The role of the ubiquitin-proteasomal pathway in Parkinson's disease and other neurodegenerative disorders. Trends Neurosci 24:37-14.
    • (2001) Trends Neurosci , vol.24 , pp. 37-14
    • Chung, K.K.1    Dawson, V.L.2    Dawson, T.M.3
  • 6
    • 0242363670 scopus 로고    scopus 로고
    • Molecular pathways of neurodegeneration in Parkinson's disease
    • Dawson TM, Dawson VL (2003) Molecular pathways of neurodegeneration in Parkinson's disease. Science 302:819-822.
    • (2003) Science , vol.302 , pp. 819-822
    • Dawson, T.M.1    Dawson, V.L.2
  • 7
    • 0028916490 scopus 로고
    • Phosphorylation of DARPP-32, a dopamine- and cAMP-regulated phosphoprotein, by casein kinase I in vitro and in vivo
    • Desdouits F, Cohen D, Nairn AC, Greengard P, Girault JA (1995) Phosphorylation of DARPP-32, a dopamine- and cAMP-regulated phosphoprotein, by casein kinase I in vitro and in vivo. J Biol Chem 270:8772-8778.
    • (1995) J Biol Chem , vol.270 , pp. 8772-8778
    • Desdouits, F.1    Cohen, D.2    Nairn, A.C.3    Greengard, P.4    Girault, J.A.5
  • 8
    • 0038460184 scopus 로고    scopus 로고
    • Part II: Alpha-synuclein and its molecular pathophysiological role in neurodegenerative disease
    • Dev KK, Hofele K, Barbieri S, Buchman VL, van der PH (2003) Part II: alpha-synuclein and its molecular pathophysiological role in neurodegenerative disease. Neuropharmacology 45:14-44.
    • (2003) Neuropharmacology , vol.45 , pp. 14-44
    • Dev, K.K.1    Hofele, K.2    Barbieri, S.3    Buchman, V.L.4    Van Der, P.H.5
  • 12
    • 0034626735 scopus 로고    scopus 로고
    • Oxidants, oxidative stress and the biology of ageing
    • Finkel T, Holbrook NJ (2000) Oxidants, oxidative stress and the biology of ageing. Nature 408:239-247.
    • (2000) Nature , vol.408 , pp. 239-247
    • Finkel, T.1    Holbrook, N.J.2
  • 13
    • 7044238416 scopus 로고    scopus 로고
    • Neurodegenerative diseases: A decade of discoveries paves the way for therapeutic breakthroughs
    • Forman MS, Trojanowski JQ, Lee VM (2004) Neurodegenerative diseases: a decade of discoveries paves the way for therapeutic breakthroughs. Nat Med 10:1055-1063.
    • (2004) Nat Med , vol.10 , pp. 1055-1063
    • Forman, M.S.1    Trojanowski, J.Q.2    Lee, V.M.3
  • 17
    • 0025976482 scopus 로고
    • Neuronal inclusions of Parkinson's disease
    • Gibb WR, Scott T, Lees AJ (1991) Neuronal inclusions of Parkinson's disease. Mov Disord 6:2-11.
    • (1991) Mov Disord , vol.6 , pp. 2-11
    • Gibb, W.R.1    Scott, T.2    Lees, A.J.3
  • 19
    • 0029086047 scopus 로고
    • A phosphatidylinositol 4,5-bisphosphate-sensitive casein kinase I alpha associates with synaptic vesicles and phosphorylates a subset of vesicle proteins
    • Gross SD, Hoffman DP, Fisette PL, Baas P, Anderson RA (1995) A phosphatidylinositol 4,5-bisphosphate-sensitive casein kinase I alpha associates with synaptic vesicles and phosphorylates a subset of vesicle proteins. J Cell Biol 130:711-724.
    • (1995) J Cell Biol , vol.130 , pp. 711-724
    • Gross, S.D.1    Hoffman, D.P.2    Fisette, P.L.3    Baas, P.4    Anderson, R.A.5
  • 21
    • 0033577159 scopus 로고    scopus 로고
    • Oxidative stress induces amyloid-like aggregate formation of NACP/alpha-synudein in vitro
    • Hashimoto M, Hsu LJ, Xia Y, Takeda A, Sisk A, Sundsmo M, Masliah E (1999) Oxidative stress induces amyloid-like aggregate formation of NACP/alpha-synudein in vitro. NeuroReport 10:717-721.
    • (1999) NeuroReport , vol.10 , pp. 717-721
    • Hashimoto, M.1    Hsu, L.J.2    Xia, Y.3    Takeda, A.4    Sisk, A.5    Sundsmo, M.6    Masliah, E.7
  • 22
    • 0037118247 scopus 로고    scopus 로고
    • Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila
    • Jackson GR, Wiedau-Pazos M, Sang TK, Wagle N, Brown CA, Massachi S, Geschwind DH (2002) Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila. Neuron 34:509-519.
    • (2002) Neuron , vol.34 , pp. 509-519
    • Jackson, G.R.1    Wiedau-Pazos, M.2    Sang, T.K.3    Wagle, N.4    Brown, C.A.5    Massachi, S.6    Geschwind, D.H.7
  • 25
    • 0034008852 scopus 로고    scopus 로고
    • Enhanced vulnerability to oxidative stress by alpha-synuclein mutations and C-terminal truncation
    • Kanda S, Bishop JF, Eglitis MA, Yang Y, Mouradian MM (2000) Enhanced vulnerability to oxidative stress by alpha-synuclein mutations and C-terminal truncation. Neuroscience 97:279-284.
    • (2000) Neuroscience , vol.97 , pp. 279-284
    • Kanda, S.1    Bishop, J.F.2    Eglitis, M.A.3    Yang, Y.4    Mouradian, M.M.5
  • 28
    • 1342325420 scopus 로고    scopus 로고
    • Casein kinase II-mediated phosphorylation regulates alpha-synuclein/ synphilin-1 interaction and inclusion body formation
    • Lee G, Tanaka M, Park K, Lee SS, Kim YM, Junn E, Lee SH, Mouradian MM (2004) Casein kinase II-mediated phosphorylation regulates alpha-synuclein/ synphilin-1 interaction and inclusion body formation. J Biol Chem 279:6834-6839.
    • (2004) J Biol Chem , vol.279 , pp. 6834-6839
    • Lee, G.1    Tanaka, M.2    Park, K.3    Lee, S.S.4    Kim, Y.M.5    Junn, E.6    Lee, S.H.7    Mouradian, M.M.8
  • 29
    • 0037085288 scopus 로고    scopus 로고
    • Formation and removal of alpha-synuclein aggregates in cells exposed to mitochondrial inhibitors
    • Lee HJ, Shin SY, Choi C, Lee YH, Lee SJ (2002) Formation and removal of alpha-synuclein aggregates in cells exposed to mitochondrial inhibitors. J Biol Chem 277:5411-5417.
    • (2002) J Biol Chem , vol.277 , pp. 5411-5417
    • Lee, H.J.1    Shin, S.Y.2    Choi, C.3    Lee, Y.H.4    Lee, S.J.5
  • 32
    • 0035863188 scopus 로고    scopus 로고
    • Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice
    • Lucas JJ, Hernandez F, Gomez-Ramos P, Moran MA, Hen R, Avila J (2001) Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice. EMBO J 20:27-39.
    • (2001) EMBO J , vol.20 , pp. 27-39
    • Lucas, J.J.1    Hernandez, F.2    Gomez-Ramos, P.3    Moran, M.A.4    Hen, R.5    Avila, J.6
  • 37
    • 0034714204 scopus 로고    scopus 로고
    • Synucleins are a novel class of substrates for G protein-coupled receptor kinases
    • Pronin AN, Morris AJ, Surguchov A, Benovic JL (2000) Synucleins are a novel class of substrates for G protein-coupled receptor kinases. J Biol Chem 275:26515-26522.
    • (2000) J Biol Chem , vol.275 , pp. 26515-26522
    • Pronin, A.N.1    Morris, A.J.2    Surguchov, A.3    Benovic, J.L.4
  • 38
    • 8744311814 scopus 로고    scopus 로고
    • alpha-Synuclein is required for the fibrillar nature of ubiquitinated inclusions induced by proteasomal inhibition in primary neurons
    • Rideout HJ, Dietrich P, Wang Q, Dauer WT, Stefanis L (2004) alpha-Synuclein is required for the fibrillar nature of ubiquitinated inclusions induced by proteasomal inhibition in primary neurons. J Biol Chem 279:46915-46920.
    • (2004) J Biol Chem , vol.279 , pp. 46915-46920
    • Rideout, H.J.1    Dietrich, P.2    Wang, Q.3    Dauer, W.T.4    Stefanis, L.5
  • 41
    • 0034531475 scopus 로고    scopus 로고
    • The alpha-synucleinopathies: Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy
    • Spillantini MG, Goedert M (2000) The alpha-synucleinopathies: Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. Ann NY Acad Sci 920;16-27:16-27.
    • (2000) Ann NY Acad Sci , vol.920 , pp. 16-27
    • Spillantini, M.G.1    Goedert, M.2
  • 43
    • 0032568534 scopus 로고    scopus 로고
    • alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies
    • Spillantini MG, Crowther RA, Jakes R, Hasegawa M, Goedert M (1998) alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc Natl Acad Sci USA 95:6469-6473.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 6469-6473
    • Spillantini, M.G.1    Crowther, R.A.2    Jakes, R.3    Hasegawa, M.4    Goedert, M.5
  • 44
    • 0037461582 scopus 로고    scopus 로고
    • Phosphorylation of alpha-synuclein characteristic of synucleinopathy lesions is recapitulated in alpha-synuclein transgenic Drosophila
    • Takahashi M, Kanuka H, Fujiwara H, Koyama A, Hasegawa M, Miura M, Iwatsubo T (2003) Phosphorylation of alpha-synuclein characteristic of synucleinopathy lesions is recapitulated in alpha-synuclein transgenic Drosophila. Neurosci Lett 336:155-158.
    • (2003) Neurosci Lett , vol.336 , pp. 155-158
    • Takahashi, M.1    Kanuka, H.2    Fujiwara, H.3    Koyama, A.4    Hasegawa, M.5    Miura, M.6    Iwatsubo, T.7
  • 45
  • 47
    • 0028290651 scopus 로고
    • Association of casein kinase 2 with nuclear matrix. Possible role in nuclear matrix protein phosphorylation
    • Tawfic S, Ahmed K (1994) Association of casein kinase 2 with nuclear matrix. Possible role in nuclear matrix protein phosphorylation. J Biol Chem 269:7489-7493.
    • (1994) J Biol Chem , vol.269 , pp. 7489-7493
    • Tawfic, S.1    Ahmed, K.2
  • 48
    • 0037077040 scopus 로고    scopus 로고
    • Toxic proteins in neurodegenerative disease
    • Taylor JP, Hardy J, Fischbeck KH (2002) Toxic proteins in neurodegenerative disease. Science 296:1991-1995.
    • (2002) Science , vol.296 , pp. 1991-1995
    • Taylor, J.P.1    Hardy, J.2    Fischbeck, K.H.3
  • 49
    • 0026039891 scopus 로고
    • Casein kinase I and II-multipotential serine protein kinases: Structure, function, and regulation
    • Tuazon PT, Traugh JA (1991) Casein kinase I and II-multipotential serine protein kinases: structure, function, and regulation. Adv Second Messenger Phosphoprotein Res 23:123-164.
    • (1991) Adv Second Messenger Phosphoprotein Res , vol.23 , pp. 123-164
    • Tuazon, P.T.1    Traugh, J.A.2
  • 53
    • 0033825627 scopus 로고    scopus 로고
    • Oxidative stress and genetics in the pathogenesis of Parkinson's disease
    • Zhang Y, Dawson VL, Dawson TM (2000) Oxidative stress and genetics in the pathogenesis of Parkinson's disease. Neurobiol Dis 7:240-250.
    • (2000) Neurobiol Dis , vol.7 , pp. 240-250
    • Zhang, Y.1    Dawson, V.L.2    Dawson, T.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.