Synphilin-1A: An aggregation-prone isoform of synphilin-1 that causes neuronal death and is present in aggregates from α-synucleinopathy patients

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 15, 2006, Pages 5917-5922

  Eyal, Allon ^a   Szargel, Raymonde ^a   Avraham, Eyal ^a   Liani, Esti ^a   Haskin, Joseph ^a   Rott, Ruth ^a   Engelender, Simone ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

synuclein; Cell death; Lewy body; Parkinson's disease

Indexed keywords

ALPHA SYNUCLEIN; BINDING PROTEIN; BRAIN PROTEIN; DETERGENT; ISOPROTEIN; SYNPHILIN 1; SYNPHILIN 1A; UNCLASSIFIED DRUG;

ALPHA SYNUCLEINOPATHY; ARTICLE; CELL INCLUSION; CELL STRAIN HEK293; CONTROLLED STUDY; DEGENERATIVE DISEASE; DOPAMINERGIC NERVE CELL; EXON; GENE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; LEWY BODY; NERVE CELL NECROSIS; NEUROTOXICITY; NUCLEOTIDE SEQUENCE; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN PROTEIN INTERACTION; RNA TRANSLATION; SNCAIP GENE;

ALPHA-SYNUCLEIN; BASE SEQUENCE; CARRIER PROTEINS; CELL DEATH; CELL LINE; CLONING, MOLECULAR; CODON; EXONS; HUMANS; KIDNEY; LEWY BODY DISEASE; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; NEURONS; PARKINSON DISEASE; PROTEIN ISOFORMS;

EID: 33645833646     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0509707103     Document Type: Article

References (20)

1. Maroteaux, L., Campanelli, J. T. & Scheller, R. H. (1988) J. Neurosci. 8, 2804-2815.
2. Polymeropoulos, M. H., Lavedan, C., Leroy, E., Ide, S. E., Dehejia, A., Dutra, A., Pike, B., Root, H., Rubenstein, J., Boyer, R., et al. (1997) Science 276, 2045-2047.
3. Kruger, R., Kuhn, W., Muller, T., Woitalla, D., Graeber, M., Kosel, S., Przuntek, H., Epplen. J. T., Schols, L. & Riess, O. (1998) Nat. Genet. 18, 106-108.
4. Zarranz, J. J., Alegre, J., Gomez-Esteban, J. C., Lezcano, E., Ros, R., Ampuero, I., Vidal, L., Hoenicka, J., Rodriguez, O., Atares, B., et al. (2004) Ann. Neurol. 55, 164-173.
5. Singleton, A. B., Farrer, M., Johnson, J., Singleton, A., Hague, S., Kachergus, J., Hulihan, M., Peuralinna, T., Dutra, A., Nussbaum, R., et al. (2003) Science 302, 841.
6. Spillantini, M. G., Schmidt, M. L., Lee, V. M., Trojanowski, J. Q., Jakes, R. & Goedert, M. (1997) Nature 388, 839-840.
7. Takeda, A., Mallory, M., Sundsmo, M., Honer, W., Hansen, L. & Masliah, E. (1998) Am. J. Pathol. 152, 367-372.
8. Engelender, S., Kaminsky, Z., Guo, X., Sharp, A. H., Amaravi, R. K., Kleiderlein, J. J., Margolis, R. L., Troncoso, J. C., Lanahan, A. A., Worley, P. F., et al. (1999) Nat. Genet. 22, 110-114.
9. Liani, E., Eyal, A., Avraham, E., Shemer, R., Szargel, R., Berg, D., Bornemann, A., Riess, O., Ross, C. A., Rott, R., et al. (2004) Proc. Natl. Acad. Sci. USA 101, 5500-5505.
10. Avraham, E., Szargel, R., Eyal, A., Rott, R. & Engelender, S. (2005) J. Biol. Chem. 280, 42877-42886.
11. Chung, K. K., Zhang, Y., Lim, K. L., Tanaka, Y., Huang, H., Gao, J., Ross, C. A., Dawson, V. L. & Dawson, T. M. (2001) Nat. Med. 7, 1144-1150.
12. Kitada, T., Asakawa, S., Hattori, N., Matsumine, H., Yamamura, Y., Minoshima, S., Yokochi, M., Mizuno, Y. & Shimizu, N. (1998) Nature 392, 605-608.
13. Wakabayashi, K., Engelender, S., Tanaka, Y., Yoshimoto, M., Mori, F., Tsuji, S., Ross, C. A. & Takahashi, H. (2002) Acta Neuropathol. (Berlin) 103, 209-214.
14. Marx, F. P., Holzmann, C., Strauss, K. M., Li, L., Eberhardt, O., Gerhardt, E., Cookson, M. R., Hernandez, D., Farter, M. J., Kachergus, J., et al. (2003) Hum. Mol. Genet. 12, 1223-1231.
15. Engelender, S., Wanner, T., Kleiderlein, J. J., Wakabayashi, K., Tsuji, S., Takahashi, H., Ashworth, R., Margolis, R. L. & Ross, C. A. (2000) Mamm. Genome 11, 763-766.
16. Mount, S. M. (1982) Nucleic Acids Res. 10, 459-472.
17. Strausberg, R. L, Feingold, E. A., Grouse, L. H., Derge, J. G., Klausner, R. D., Collins, F. S., Wagner, L., Shenmen, C. M., Schuler, G. D., Altschul, S. F., et al. (2002) Proc. Natl. Acad. Sci. USA 99, 16899-16903.
18. Maquat, L. E. (2004) Nat. Rev. Mol. Cell Biol. 5, 89-99.
19. Ribeiro, C. S., Carneiro, K., Ross, C. A., Menezes, J. R. & Engelender, S. (2002) J. Biol. Chem. 277, 23927-23933.
20. Watanabe, S. Y., Albsoul-Younes, A. M., Kawano, T., Itoh, H., Kaziro, Y., Nakajima, S. & Nakajima, Y. (1999) Neurosci. Res. 33, 71-78.