-
1
-
-
25844443895
-
History of genetic disease: The molecular genetics of Huntington disease - A history
-
Bates GP (2005) History of genetic disease: the molecular genetics of Huntington disease-a history. Nat Rev Genet 6:766-773
-
(2005)
Nat Rev Genet
, vol.6
, pp. 766-773
-
-
Bates, G.P.1
-
2
-
-
25844506224
-
Therapeutics development for triplet repeat expansion diseases
-
Di Prospero NA, Fischbeck KH (2005) Therapeutics development for triplet repeat expansion diseases. Nat Rev Genet 6:756-765
-
(2005)
Nat Rev Genet
, vol.6
, pp. 756-765
-
-
Di Prospero, N.A.1
Fischbeck, K.H.2
-
3
-
-
25844487226
-
Diseases of unstable repeat expansion: Mechanisms and common principles
-
Gatchel JR, Zoghbi HY (2005) Diseases of unstable repeat expansion: mechanisms and common principles. Nat Rev Genet 6:743-755
-
(2005)
Nat Rev Genet
, vol.6
, pp. 743-755
-
-
Gatchel, J.R.1
Zoghbi, H.Y.2
-
4
-
-
0037292586
-
Dysfunction of wild-type huntingtin in Huntington disease
-
Cattaneo E (2003) Dysfunction of wild-type huntingtin in Huntington disease. News Physiol Sci 18:34-37
-
(2003)
News Physiol Sci
, vol.18
, pp. 34-37
-
-
Cattaneo, E.1
-
5
-
-
0742304252
-
Wild-type huntingtin plays a role in brain development and neuronal survival
-
Reiner A, Dragatsis I, Zeitlin S, Goldowitz D (2003) Wild-type huntingtin plays a role in brain development and neuronal survival. Mol Neurobiol 28:259-276
-
(2003)
Mol Neurobiol
, vol.28
, pp. 259-276
-
-
Reiner, A.1
Dragatsis, I.2
Zeitlin, S.3
Goldowitz, D.4
-
6
-
-
0034571171
-
Huntington's disease: The challenge for cell biologists
-
Tobin AJ, Signer ER (2000) Huntington's disease: the challenge for cell biologists. Trends Cell Biol 10:531-536
-
(2000)
Trends Cell Biol
, vol.10
, pp. 531-536
-
-
Tobin, A.J.1
Signer, E.R.2
-
9
-
-
0031838352
-
Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1
-
Cummings CJ, Mancini MA, Antalffy B, DeFranco DB, Orr HT, Zoghbi HY (1998) Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1. Nat Genet 19:148-154
-
(1998)
Nat Genet
, vol.19
, pp. 148-154
-
-
Cummings, C.J.1
Mancini, M.A.2
Antalffy, B.3
Defranco, D.B.4
Orr, H.T.5
Zoghbi, H.Y.6
-
10
-
-
0033499931
-
Analysis of the role of heat shock protein (hsp) molecular chaperones in polyglutamine disease
-
Chai Y, Koppenhafer SL, Bonini NM, Paulson HL (1999) Analysis of the role of heat shock protein (hsp) molecular chaperones in polyglutamine disease. J Neurosci19:10338-10347
-
(1999)
J
, vol.19
, pp. 10338-10347
-
-
Chai, Y.1
Koppenhafer, S.L.2
Bonini, N.M.3
Paulson, H.L.4
-
11
-
-
0034641589
-
Polyglutamine length-dependent interaction of Hsp40 and Hsp70 family chaperones with truncated N-terminal huntingtin: Their role in suppression of aggregation and cellular toxicity
-
Jana NR, Tanaka M, Wang G, Nukina N (2000) Polyglutamine length-dependent interaction of Hsp40 and Hsp70 family chaperones with truncated N-terminal huntingtin: their role in suppression of aggregation and cellular toxicity. Hum Mol Genet 9:2009-2018
-
(2000)
Hum Mol Genet
, vol.9
, pp. 2009-2018
-
-
Jana, N.R.1
Tanaka, M.2
Wang, G.3
Nukina, N.4
-
12
-
-
23344432914
-
Role of molecular chaperones in neurodegenerative disorders
-
Meriin AB, Sherman MY (2005) Role of molecular chaperones in neurodegenerative disorders. Int J Hyperthermia 21:403-419
-
(2005)
Int J Hyperthermia
, vol.21
, pp. 403-419
-
-
Meriin, A.B.1
Sherman, M.Y.2
-
13
-
-
0035394668
-
Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice
-
Cummings CJ, Sun Y, Opal P, Antalffy B, Mestril R, Orr HT, Dillmann WH, Zoghbi HY (2001) Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice. Hum Mol Genet 10:1511-1518
-
(2001)
Hum Mol Genet
, vol.10
, pp. 1511-1518
-
-
Cummings, C.J.1
Sun, Y.2
Opal, P.3
Antalffy, B.4
Mestril, R.5
Orr, H.T.6
Dillmann, W.H.7
Zoghbi, H.Y.8
-
14
-
-
0032727617
-
Suppression of polyglutamine-mediated neurodegeneration in drosophila by the molecular chaperone Hsp70
-
Warrick JM, Chan HYE, Gray-Board GL, Chai Y, Paulson HL, Bonini NM (1999) Suppression of polyglutamine-mediated neurodegeneration in drosophila by the molecular chaperone Hsp70. Nature Genet 23:425-428
-
(1999)
Nature Genet
, vol.23
, pp. 425-428
-
-
Warrick, J.M.1
Chan, H.Y.E.2
Gray-Board, G.L.3
Chai, Y.4
Paulson, H.L.5
Bonini, N.M.6
-
15
-
-
0037444446
-
Heat shock protein 70 chaperone overexpression ameliorates phenotypes of the spinal and bulbar muscular atrophy transgenic mouse model by reducing nuclear-localized mutant androgen receptor protein
-
Adachi H, Katsuno M, Minamiyama M, Sang C, Pagoulatos G, Angelidis C, Kusakabe M, Yoshiki A, Kobayashi Y, Doyu M, Sobue G (2003) Heat shock protein 70 chaperone overexpression ameliorates phenotypes of the spinal and bulbar muscular atrophy transgenic mouse model by reducing nuclear-localized mutant androgen receptor protein. J Neurosci 23:2203-2211
-
(2003)
J Neurosci
, vol.23
, pp. 2203-2211
-
-
Adachi, H.1
Katsuno, M.2
Minamiyama, M.3
Sang, C.4
Pagoulatos, G.5
Angelidis, C.6
Kusakabe, M.7
Yoshiki, A.8
Kobayashi, Y.9
Doyu, M.10
Sobue, G.11
-
16
-
-
0036566675
-
Heat shock protein 27 prevents cellular polyglutamine toxicity and suppresses the increase of reactive oxygen species caused by huntingtin
-
Wyttenbach A, Sauvageot O, Carmichael J, Diaz-Latoud C, Arrigo AP, Rubinsztein DC (2002) Heat shock protein 27 prevents cellular polyglutamine toxicity and suppresses the increase of reactive oxygen species caused by huntingtin. Hum Mol Genet 11:1131-1151
-
(2002)
Hum Mol Genet
, vol.11
, pp. 1131-1151
-
-
Wyttenbach, A.1
Sauvageot, O.2
Carmichael, J.3
Diaz-Latoud, C.4
Arrigo, A.P.5
Rubinsztein, D.C.6
-
17
-
-
33749177252
-
The chaperonin TRiC controls polyglutamine aggregation and toxicity through subunit-specific interactions
-
Tam S, Geller R, Spiess C, Frydman J (2006) The chaperonin TRiC controls polyglutamine aggregation and toxicity through subunit-specific interactions. Nat Cell Biol 8:1155-1162
-
(2006)
Nat Cell Biol
, vol.8
, pp. 1155-1162
-
-
Tam, S.1
Geller, R.2
Spiess, C.3
Frydman, J.4
-
18
-
-
33749176269
-
Cytosolic chaperonin prevents polyglutamine toxicity with altering the aggregation state
-
Kitamura A, Kubota H, Pack CG, Matsumoto G, Hirayama S, Takahashi Y, Kimura H, Kinjo M, Morimoto RI, Nagata K (2006) Cytosolic chaperonin prevents polyglutamine toxicity with altering the aggregation state. Nat Cell Biol 8:1163-1170
-
(2006)
Nat Cell Biol
, vol.8
, pp. 1163-1170
-
-
Kitamura, A.1
Kubota, H.2
Pack, C.G.3
Matsumoto, G.4
Hirayama, S.5
Takahashi, Y.6
Kimura, H.7
Kinjo, M.8
Morimoto, R.I.9
Nagata, K.10
-
20
-
-
33646127577
-
Molecular chaperones and protein quality control
-
Bukau B, Weissman J, Horwich A (2006) Molecular chaperones and protein quality control. Cell 125:443-451
-
(2006)
Cell
, vol.125
, pp. 443-451
-
-
Bukau, B.1
Weissman, J.2
Horwich, A.3
-
21
-
-
0035947372
-
Impairment of the ubiquitin-proteasome system by protein aggregation
-
Bence NF, Sampat RM, Kopito RR (2001) Impairment of the ubiquitin-proteasome system by protein aggregation. Science 292:1552-1555
-
(2001)
Science
, vol.292
, pp. 1552-1555
-
-
Bence, N.F.1
Sampat, R.M.2
Kopito, R.R.3
-
22
-
-
0037108725
-
Aggregate formation inhibits proteasomal degradation of polyglutamine proteins
-
Verhoef LG, Lindsten K, Masucci MG, Dantuma NP (2002) Aggregate formation inhibits proteasomal degradation of polyglutamine proteins. Hum Mol Genet 11:2689-2700
-
(2002)
Hum Mol Genet
, vol.11
, pp. 2689-2700
-
-
Verhoef, L.G.1
Lindsten, K.2
Masucci, M.G.3
Dantuma, N.P.4
-
23
-
-
13244258435
-
Global impairment of the ubiquitin-proteasome system by nuclear or cytoplasmic protein aggregates precedes inclusion body formation
-
Bennett EJ, Bence NF, Jayakumar R, Kopito RR (2005) Global impairment of the ubiquitin-proteasome system by nuclear or cytoplasmic protein aggregates precedes inclusion body formation. Mol Cell 17:351-365
-
(2005)
Mol Cell
, vol.17
, pp. 351-365
-
-
Bennett, E.J.1
Bence, N.F.2
Jayakumar, R.3
Kopito, R.R.4
-
24
-
-
0034578389
-
Aggresomes, inclusion bodies and protein aggregation
-
Kopito RR (2000) Aggresomes, inclusion bodies and protein aggregation. Trends Cell Biol 10:524-530
-
(2000)
Trends Cell Biol
, vol.10
, pp. 524-530
-
-
Kopito, R.R.1
-
25
-
-
0035139109
-
Cellular defenses against unfolded proteins: A cell biologist thinks about neurodegenerative diseases
-
Sherman MY, Goldberg AL (2001) Cellular defenses against unfolded proteins: a cell biologist thinks about neurodegenerative diseases. Neuron 29:15-32
-
(2001)
Neuron
, vol.29
, pp. 15-32
-
-
Sherman, M.Y.1
Goldberg, A.L.2
-
27
-
-
0035336658
-
Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release
-
Jana NR, Zemskov EA, Wang G, Nukina N (2001) Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release. Hum Mol Genet 10:1049-1059
-
(2001)
Hum Mol Genet
, vol.10
, pp. 1049-1059
-
-
Jana, N.R.1
Zemskov, E.A.2
Wang, G.3
Nukina, N.4
-
28
-
-
0033391428
-
Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 mice
-
Cummings CJ, Reinstein E, Sun Y, Antalffy B, Jiang Y, Ciechanover A, Orr HT, Beaudet AL, Zoghbi HY (1999) Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 mice. Neuron 24:879-892
-
(1999)
Neuron
, vol.24
, pp. 879-892
-
-
Cummings, C.J.1
Reinstein, E.2
Sun, Y.3
Antalffy, B.4
Jiang, Y.5
Ciechanover, A.6
Orr, H.T.7
Beaudet, A.L.8
Zoghbi, H.Y.9
-
29
-
-
0034737299
-
Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease
-
Yamamoto A, Lucas JJ, Hen R (2000) Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease. Cell 101:57-66
-
(2000)
Cell
, vol.101
, pp. 57-66
-
-
Yamamoto, A.1
Lucas, J.J.2
Hen, R.3
-
30
-
-
0035889973
-
Proteasomal-dependent aggregate reversal and absence of cell death in a conditional mouse model of Huntington's disease
-
Martin-Aparicio E, Yamamoto A, Hernandez F, Hen R, Avila J, Lucas JJ (2001) Proteasomal-dependent aggregate reversal and absence of cell death in a conditional mouse model of Huntington's disease. J Neurosci 21:8772-8781
-
(2001)
J Neurosci
, vol.21
, pp. 8772-8781
-
-
Martin-Aparicio, E.1
Yamamoto, A.2
Hernandez, F.3
Hen, R.4
Avila, J.5
Lucas, J.J.6
-
31
-
-
1842766144
-
Eukaryotic proteasomes cannot digest polyglutamine sequences and release them during degradation of polyglutamine-containing proteins
-
Venkatraman P, Wetzel R, Tanaka M, Nukina N, Goldberg AL (2004) Eukaryotic proteasomes cannot digest polyglutamine sequences and release them during degradation of polyglutamine-containing proteins. Mol Cell 14:95-104
-
(2004)
Mol Cell
, vol.14
, pp. 95-104
-
-
Venkatraman, P.1
Wetzel, R.2
Tanaka, M.3
Nukina, N.4
Goldberg, A.L.5
-
32
-
-
34247365603
-
Aggregation and proteasome: The case of elongated polyglutamine aggregation in spinal and bulbar muscular atrophy
-
Rusmini P, Sau D, Crippa V, Palazzolo I, Simonini F, Onesto E, Martini L, Poletti A (2007) Aggregation and proteasome: the case of elongated polyglutamine aggregation in spinal and bulbar muscular atrophy. Neurobiol Aging 28:1099-1111
-
(2007)
Neurobiol Aging
, vol.28
, pp. 1099-1111
-
-
Rusmini, P.1
Sau, D.2
Crippa, V.3
Palazzolo, I.4
Simonini, F.5
Onesto, E.6
Martini, L.7
Poletti, A.8
-
33
-
-
2542436167
-
Modulating huntingtin half-life alters polyglutamine-dependent aggregate formation and cell toxicity
-
Kaytor MD, Wilkinson KD, Warren ST (2004) Modulating huntingtin half-life alters polyglutamine-dependent aggregate formation and cell toxicity. J Neurochem 89:962-973
-
(2004)
J Neurochem
, vol.89
, pp. 962-973
-
-
Kaytor, M.D.1
Wilkinson, K.D.2
Warren, S.T.3
-
34
-
-
33845898194
-
Ubiquitin-conjugating enzyme E2-25K increases aggregate formation and cell death in polyglutamine diseases
-
de Pril R, Fischer DF, Roos RA, van Leeuwen FW (2007) Ubiquitin-conjugating enzyme E2-25K increases aggregate formation and cell death in polyglutamine diseases. Mol Cell Neurosci 34:10-19
-
(2007)
Mol Cell Neurosci
, vol.34
, pp. 10-19
-
-
De Pril, R.1
Fischer, D.F.2
Roos, R.A.3
Van Leeuwen, F.W.4
-
35
-
-
32644433693
-
A novel GTPase, CRAG, mediates promyelocytic leukemia protein-associated nuclear body formation and degradation of expanded polyglutamine protein
-
Qin Q, Inatome R, Hotta A, Kojima M, Yamamura H, Hirai H, Yoshizawa T, Tanaka H, Fukami K, Yanagi S (2006) A novel GTPase, CRAG, mediates promyelocytic leukemia protein-associated nuclear body formation and degradation of expanded polyglutamine protein. J Cell Biol 172:497-504
-
(2006)
J Cell Biol
, vol.172
, pp. 497-504
-
-
Qin, Q.1
Inatome, R.2
Hotta, A.3
Kojima, M.4
Yamamura, H.5
Hirai, H.6
Yoshizawa, T.7
Tanaka, H.8
Fukami, K.9
Yanagi, S.10
-
36
-
-
0036083396
-
The ubiquitin-proteasome proteolytic pathway: Destruction for the sake of construction
-
Glickman MH, Ciechanover A (2002) The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. Physiol Rev 82:373-428
-
(2002)
Physiol Rev
, vol.82
, pp. 373-428
-
-
Glickman, M.H.1
Ciechanover, A.2
-
37
-
-
0033013126
-
Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions
-
Ballinger CA, Connell P, Wu Y, Hu Z, Thompson LJ, Yin LY, Patterson C (1999) Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions. Mol Cell Biol 19:4535-4545
-
(1999)
Mol Cell Biol
, vol.19
, pp. 4535-4545
-
-
Ballinger, C.A.1
Connell, P.2
Wu, Y.3
Hu, Z.4
Thompson, L.J.5
Yin, L.Y.6
Patterson, C.7
-
38
-
-
0035900793
-
CHIP is a U-box-dependent E3 ubiquitin ligase: Identification of Hsc70 as a target for ubiquitylation
-
Jiang J, Ballinger CA, Wu Y, Dai Q, Cyr DM, Hohfeld J, Patterson C (2001) CHIP is a U-box-dependent E3 ubiquitin ligase: identification of Hsc70 as a target for ubiquitylation. J Biol Chem 276:42938-42944
-
(2001)
J Biol Chem
, vol.276
, pp. 42938-42944
-
-
Jiang, J.1
Ballinger, C.A.2
Wu, Y.3
Dai, Q.4
Cyr, D.M.5
Hohfeld, J.6
Patterson, C.7
-
39
-
-
0035146685
-
The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins
-
Connell P, Ballinger CA, Jiang J, Wu Y, Thompson LJ, Hohfeld J, Patterson C (2001) The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins. Nat Cell Biol 3:93-96
-
(2001)
Nat Cell Biol
, vol.3
, pp. 93-96
-
-
Connell, P.1
Ballinger, C.A.2
Jiang, J.3
Wu, Y.4
Thompson, L.J.5
Hohfeld, J.6
Patterson, C.7
-
40
-
-
0035142877
-
The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation
-
Meacham GC, Patterson C, Zhang W, Younger JM, Cyr DM (2001) The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation. Nat Cell Biol 3:100-105
-
(2001)
Nat Cell Biol
, vol.3
, pp. 100-105
-
-
Meacham, G.C.1
Patterson, C.2
Zhang, W.3
Younger, J.M.4
Cyr, D.M.5
-
41
-
-
0035684430
-
CHIP is a chaperone-dependent E3 ligase that ubiquitylates unfolded protein
-
Murata S, Minami Y, Minami M, Chiba T, Tanaka K (2001) CHIP is a chaperone-dependent E3 ligase that ubiquitylates unfolded protein. EMBO Rep 2:1133-1138
-
(2001)
EMBO Rep
, vol.2
, pp. 1133-1138
-
-
Murata, S.1
Minami, Y.2
Minami, M.3
Chiba, T.4
Tanaka, K.5
-
42
-
-
1242291789
-
CHIP: A link between the chaperone and proteasome systems
-
McDonough H, Patterson C (2003) CHIP: a link between the chaperone and proteasome systems. Cell Stress Chaperones 8:303-308
-
(2003)
Cell Stress Chaperones
, vol.8
, pp. 303-308
-
-
McDonough, H.1
Patterson, C.2
-
43
-
-
3042817421
-
CHIP promotes proteasomal degradation of familial ALS-linked mutant SOD1 by ubiquitinating Hsp/Hsc70
-
Urushitani M, Kurisu J, Tateno M, Hatakeyama S, Nakayama K, Kato S, Takahashi R (2004) CHIP promotes proteasomal degradation of familial ALS-linked mutant SOD1 by ubiquitinating Hsp/Hsc70. J Neurochem 90:231-244
-
(2004)
J Neurochem
, vol.90
, pp. 231-244
-
-
Urushitani, M.1
Kurisu, J.2
Tateno, M.3
Hatakeyama, S.4
Nakayama, K.5
Kato, S.6
Takahashi, R.7
-
44
-
-
5444239863
-
U-box protein carboxyl terminus of Hsc70-interacting protein (CHIP) mediates poly-ubiquitylation preferentially on four-repeat Tau and is involved in neurodegeneration of tauopathy
-
Hatakeyama S, Matsumoto M, Kamura T, Murayama M, Chui DH, Planel E, Takahashi R, Nakayama KI, Takashima A (2004) U-box protein carboxyl terminus of Hsc70-interacting protein (CHIP) mediates poly-ubiquitylation preferentially on four-repeat Tau and is involved in neurodegeneration of tauopathy. J Neurochem 91:299-307
-
(2004)
J Neurochem
, vol.91
, pp. 299-307
-
-
Hatakeyama, S.1
Matsumoto, M.2
Kamura, T.3
Murayama, M.4
Chui, D.H.5
Planel, E.6
Takahashi, R.7
Nakayama, K.I.8
Takashima, A.9
-
45
-
-
11144356089
-
CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation
-
Petrucelli L, Dickson D, Kehoe K, Taylor J, Snyder H, Grover A, De Lucia M, McGowan E, Lewis J, Prihar G, Kim J, Dillmann WH, Browne SE, Hall A, Voellmy R, Tsuboi Y, Dawson TM, Wolozin B, Hardy J, Hutton M (2004) CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation. Hum Mol Genet 13:703-714
-
(2004)
Hum Mol Genet
, vol.13
, pp. 703-714
-
-
Petrucelli, L.1
Dickson, D.2
Kehoe, K.3
Taylor, J.4
Snyder, H.5
Grover, A.6
De Lucia, M.7
McGowan, E.8
Lewis, J.9
Prihar, G.10
Kim, J.11
Dillmann, W.H.12
Browne, S.E.13
Hall, A.14
Voellmy, R.15
Tsuboi, Y.16
Dawson, T.M.17
Wolozin, B.18
Hardy, J.19
Hutton, M.20
more..
-
46
-
-
24144440041
-
In vivo evidence of CHIP up-regulation attenuating tau aggregation
-
Sahara N, Murayama M, Mizoroki T, Urushitani M, Imai Y, Takahashi R, Murata S, Tanaka K, Takashima A (2005) In vivo evidence of CHIP up-regulation attenuating tau aggregation. J Neurochem 94:1254-1263
-
(2005)
J Neurochem
, vol.94
, pp. 1254-1263
-
-
Sahara, N.1
Murayama, M.2
Mizoroki, T.3
Urushitani, M.4
Imai, Y.5
Takahashi, R.6
Murata, S.7
Tanaka, K.8
Takashima, A.9
-
47
-
-
21244499845
-
The co-chaperone carboxyl terminus of Hsp70-interacting protein (CHIP) mediates alpha-synuclein degradation decisions between proteasomal and lysosomal pathways
-
Shin Y, Klucken J, Patterson C, Hyman BT, McLean PJ (2005) The co-chaperone carboxyl terminus of Hsp70-interacting protein (CHIP) mediates alpha-synuclein degradation decisions between proteasomal and lysosomal pathways. J Biol Chem 280:23727-23734
-
(2005)
J Biol Chem
, vol.280
, pp. 23727-23734
-
-
Shin, Y.1
Klucken, J.2
Patterson, C.3
Hyman, B.T.4
McLean, P.J.5
-
48
-
-
33847369469
-
The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins
-
Dickey CA, Kamal A, Lundgren K, Klosak N, Bailey RM, Dunmore J, Ash P, Shoraka S, Zlatkovic J, Eckman CB, Patterson C, Dickson DW, Nahman NS Jr, Hutton M, Burrows F, Petrucelli L (2007) The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins. J Clin Invest 117:648-658
-
(2007)
J Clin Invest
, vol.117
, pp. 648-658
-
-
Dickey, C.A.1
Kamal, A.2
Lundgren, K.3
Klosak, N.4
Bailey, R.M.5
Dunmore, J.6
Ash, P.7
Shoraka, S.8
Zlatkovic, J.9
Eckman, C.B.10
Patterson, C.11
Dickson, D.W.12
Nahman Jr., N.S.13
Hutton, M.14
Burrows, F.15
Petrucelli, L.16
-
49
-
-
34447297017
-
CHIP and HSPs interact with {beta}-APP in a proteasome-dependent manner and influence A{beta} metabolism
-
Kumar P, Ambasta RK, Veereshwarayya V, Rosen KM, Kosik KS, Band H, Mestril R, Patterson C, Querfurth HW. (2007) CHIP and HSPs interact with {beta}-APP in a proteasome-dependent manner and influence A{beta} metabolism. Hum Mol Genet. 16:848-864
-
(2007)
Hum Mol Genet.
, vol.16
, pp. 848-864
-
-
Kumar, P.1
Ambasta, R.K.2
Veereshwarayya, V.3
Rosen, K.M.4
Kosik, K.S.5
Band, H.6
Mestril, R.7
Patterson, C.8
Querfurth, H.W.9
-
50
-
-
15744387323
-
Co-chaperone CHIP associates with expanded polyglutamine protein and promotes their degradation by proteasomes
-
Jana NR, Dikshit P, Goswami A, Kotliarova S, Murata S, Tanaka K, Nukina N (2005) Co-chaperone CHIP associates with expanded polyglutamine protein and promotes their degradation by proteasomes. J Biol Chem 280:11635-11640
-
(2005)
J Biol Chem
, vol.280
, pp. 11635-11640
-
-
Jana, N.R.1
Dikshit, P.2
Goswami, A.3
Kotliarova, S.4
Murata, S.5
Tanaka, K.6
Nukina, N.7
-
51
-
-
27144558034
-
CHIP suppresses polyglutamine aggregation and toxicity in vitro and in vivo
-
Miller VM, Nelson RF, Gouvion CM, Williams A, Rodriguez-Lebron E, Harper SQ, Davidson BL, Rebagliati MR, Paulson HL (2005) CHIP suppresses polyglutamine aggregation and toxicity in vitro and in vivo. J Neurosci 25:9152-9166
-
(2005)
J Neurosci
, vol.25
, pp. 9152-9166
-
-
Miller, V.M.1
Nelson, R.F.2
Gouvion, C.M.3
Williams, A.4
Rodriguez-Lebron, E.5
Harper, S.Q.6
Davidson, B.L.7
Rebagliati, M.R.8
Paulson, H.L.9
-
52
-
-
33748741301
-
CHIP protects from the neurotoxicity of expanded and wild-type ataxin-1 and promotes their ubiquitination and degradation
-
Al-Ramahi I, Lam YC, Chen HK, de Gouyon B, Zhang M, Perez AM, Branco J, de Haro M, Patterson C, Zoghbi HY, Botas J (2006) CHIP protects from the neurotoxicity of expanded and wild-type ataxin-1 and promotes their ubiquitination and degradation. J Biol Chem 281:26714-26724
-
(2006)
J Biol Chem
, vol.281
, pp. 26714-26724
-
-
Al-Ramahi, I.1
Lam, Y.C.2
Chen, H.K.3
De Gouyon, B.4
Zhang, M.5
Perez, A.M.6
Branco, J.7
De Haro, M.8
Patterson, C.9
Zoghbi, H.Y.10
Botas, J.11
-
53
-
-
34248327285
-
CHIP overexpression reduces mutant androgen receptor protein and ameliorates phenotypes of the spinal and bulbar muscular atrophy transgenic mouse model
-
Adachi H, Waza M, Tokui K, Katsuno M, Minamiyama M, Tanaka F, Doyu M, Sobue G (2007) CHIP overexpression reduces mutant androgen receptor protein and ameliorates phenotypes of the spinal and bulbar muscular atrophy transgenic mouse model. J Neurosci 27:5115-5126
-
(2007)
J Neurosci
, vol.27
, pp. 5115-5126
-
-
Adachi, H.1
Waza, M.2
Tokui, K.3
Katsuno, M.4
Minamiyama, M.5
Tanaka, F.6
Doyu, M.7
Sobue, G.8
-
54
-
-
0036345454
-
CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity
-
Imai Y, Soda M, Hatakeyama S, Akagi T, Hashikawa T, Nakayama KI, Takahashi R (2002) CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity. Mol Cell 10:55-67
-
(2002)
Mol Cell
, vol.10
, pp. 55-67
-
-
Imai, Y.1
Soda, M.2
Hatakeyama, S.3
Akagi, T.4
Hashikawa, T.5
Nakayama, K.I.6
Takahashi, R.7
-
55
-
-
34247490082
-
The co-chaperone CHIP is induced in various stresses and confers protection to cells
-
Dikshit P, Jana NR (2007) The co-chaperone CHIP is induced in various stresses and confers protection to cells. Biochem Biophys Res Commun 357:761-765
-
(2007)
Biochem Biophys Res Commun
, vol.357
, pp. 761-765
-
-
Dikshit, P.1
Jana, N.R.2
-
56
-
-
1442264782
-
Molecular clearance of ataxin-3 is regulated by a mammalian E4
-
Matsumoto M, Yada M, Hatakeyama S, Ishimoto H, Tanimura T, Tsuji S, Kakizuka A, Kitagawa M, Nakayama KI (2004) Molecular clearance of ataxin-3 is regulated by a mammalian E4. EMBO J 23:659-669
-
(2004)
EMBO J
, vol.23
, pp. 659-669
-
-
Matsumoto, M.1
Yada, M.2
Hatakeyama, S.3
Ishimoto, H.4
Tanimura, T.5
Tsuji, S.6
Kakizuka, A.7
Kitagawa, M.8
Nakayama, K.I.9
-
57
-
-
33747891213
-
Ataxin-3 binds VCP/p97 and regulates retrotranslocation of ERAD substrates
-
Zhong X, Pittman RN (2006) Ataxin-3 binds VCP/p97 and regulates retrotranslocation of ERAD substrates. Hum Mol Genet 15:2409-2420
-
(2006)
Hum Mol Genet
, vol.15
, pp. 2409-2420
-
-
Zhong, X.1
Pittman, R.N.2
-
58
-
-
0027358723
-
The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53
-
Scheffner M, Huibregtse JM, Vierstra RD, Howley PM (1993) The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53. Cell 75:495-505
-
(1993)
Cell
, vol.75
, pp. 495-505
-
-
Scheffner, M.1
Huibregtse, J.M.2
Vierstra, R.D.3
Howley, P.M.4
-
59
-
-
0027396829
-
Cloning and expression of the cDNA for E6-AP, a protein that mediates the interaction of the human papillomavirus E6 oncoprotein with p53
-
Huibregtse JM, Scheffner M, Howley PM (1993) Cloning and expression of the cDNA for E6-AP, a protein that mediates the interaction of the human papillomavirus E6 oncoprotein with p53. Mol Cell Biol 13:775-784
-
(1993)
Mol Cell Biol
, vol.13
, pp. 775-784
-
-
Huibregtse, J.M.1
Scheffner, M.2
Howley, P.M.3
-
60
-
-
0028898424
-
Protein ubiquitination involving an E1-E2-E3 enzyme ubiquitin thioester cascade
-
Scheffner M, Nuber U, Huibregtse JM (1995) Protein ubiquitination involving an E1-E2-E3 enzyme ubiquitin thioester cascade. Nature 373:81-83
-
(1995)
Nature
, vol.373
, pp. 81-83
-
-
Scheffner, M.1
Nuber, U.2
Huibregtse, J.M.3
-
61
-
-
0029036701
-
A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase
-
Huibregtse JM, Scheffner M, Beaudenon S, Howley PM (1995) A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase. Proc Natl Acad Sci USA 92:2563-2567
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 2563-2567
-
-
Huibregtse, J.M.1
Scheffner, M.2
Beaudenon, S.3
Howley, P.M.4
-
62
-
-
0032192481
-
Mutation of the Angelman ubiquitin ligase in mice causes increased cytoplasmic p53 and deficits of contextual learning and long-term potentiation
-
Jiang YH, Armstrong D, Albrecht U, Atkins CM, Noebels JL, Eichele G, Sweatt JD, Beaudet AL (1998) Mutation of the Angelman ubiquitin ligase in mice causes increased cytoplasmic p53 and deficits of contextual learning and long-term potentiation. Neuron 21:799-811
-
(1998)
Neuron
, vol.21
, pp. 799-811
-
-
Jiang, Y.H.1
Armstrong, D.2
Albrecht, U.3
Atkins, C.M.4
Noebels, J.L.5
Eichele, G.6
Sweatt, J.D.7
Beaudet, A.L.8
-
63
-
-
0038159253
-
Parkin facilitates the elimination of expanded polyglutamine proteins and leads to preservation of proteasome function
-
Tsai YC, Fishman PS, Thakor NV, Oyler GA (2003) Parkin facilitates the elimination of expanded polyglutamine proteins and leads to preservation of proteasome function. J Biol Chem 278:22044-22055
-
(2003)
J Biol Chem
, vol.278
, pp. 22044-22055
-
-
Tsai, Y.C.1
Fishman, P.S.2
Thakor, N.V.3
Oyler, G.A.4
-
64
-
-
0037672207
-
Neurodegeneration: How does parkin prevent Parkinson's disease?
-
Cookson MR (2003) Neurodegeneration: how does parkin prevent Parkinson's disease? Curr Biol13:522-524
-
(2003)
Curr
, vol.13
, pp. 522-524
-
-
Cookson, M.R.1
-
65
-
-
0035967883
-
An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin
-
Imai Y, Soda M, Inoue H, Hattori N, Mizuno Y, Takahashi R (2001) An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin. Cell 105:891-902
-
(2001)
Cell
, vol.105
, pp. 891-902
-
-
Imai, Y.1
Soda, M.2
Inoue, H.3
Hattori, N.4
Mizuno, Y.5
Takahashi, R.6
-
66
-
-
0034680913
-
Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity
-
Imai Y, Soda M, Takahashi R (2000) Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity. J Biol Chem 275:35661-33664
-
(2000)
J Biol Chem
, vol.275
, pp. 35661-33664
-
-
Imai, Y.1
Soda, M.2
Takahashi, R.3
|