Autophagy: A novel protective mechanism in chronic ischemia

Cell Cycle

Volumn 5, Issue 11, 2006, Pages 1175-1177

  Yan, Lin ^a   Sadoshima, Junichi ^a   Vatner, Dorothy E ^a   Vatner, Stephen F ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

Apoptosis; Autophagy; Cardioprotection; Chronic myocardial ischemia

Indexed keywords

3 METHYLADENINE; CATHEPSIN B; CATHEPSIN D; CYTOCHROME C; CYTOPLASM PROTEIN; RAPAMYCIN;

APOPTOSIS; AUTOPHAGY; CAENORHABDITIS ELEGANS; CELL DEATH; CELL STRAIN; CELL STRAIN COS7; CELL SURVIVAL; CORONARY ARTERY OBSTRUCTION; HEART MUSCLE ISCHEMIA; IMMUNOHISTOCHEMISTRY; NONHUMAN; ORGANISM; PROTEIN DEGRADATION; REVIEW; STRESS; SWINE;

CAENORHABDITIS ELEGANS; SUIDAE;

EID: 33744905803     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.5.11.2787     Document Type: Review

References (45)

1. Anversa P, Kajstura J, Leri A, Bolli R. Life and death of cardiac stem cells: A paradigm shift in cardiac biology. Circulation 2006; 113:1451-63.
2. Narula J, Haider N, Virmani R, DiSalvo TG, Kolodgie FD, Hajjar RJ, Schmidt U, Semigran MJ, Dec GW, Khaw BA. Apoptosis in myocytes in end-stage heart failure. N Engl J Med 1996; 335:1182-9.
3. Olivetti G, Abbi R, Quaini F, Kajstura J, Cheng W, Nitahara JA, Quaini E, Di Loreto C, Beltrami CA, Krajewski S, Reed JC, Anversa P. Apoptosis in the failing human heart. N Engl J Med 1997; 336:1131-41.
4. Mani K, Kitsis RN. Myocyte apoptosis: Programming ventricular remodeling. J Am Coll Cardiol 2003; 41:761-4.
5. Elsasser A, Vogt AM, Nef H, Kostin S, Mollmann H, Skwara W, Bode C, Hamm C, Schaper J. Human hibernating myocardium is jeopardized by apoptotic and autophagic cell death. J Am Coll Cardiol 2004; 43:2191-9.
6. Yan L, Vatner DE, Kim SJ, Ge H, Masurekar M, Massover WH, Yang G, Matsui Y, Sadoshima J, Vatner SF. Autophagy in chronically ischemic myocardium. Proc Natl Acad Sci USA 2005; 102:13807-12.
7. Kajstura J, Bolli R, Sonnenblick EH, Anversa P, Leri A. Cause of death: Suicide. J Mol Cell Cardiol 2006; 40:425-37.
8. Leist M, Jaattela M. Four deaths and a funeral: From caspases to alternative mechanisms. Nat Rev Mol Cell Biol 2001; 2:589-98.
9. Ren G, Dewald O, Frangogiannis NG. Inflammatory mechanisms in myocardial infarction. Curr Drug Targets Inflamm Allergy 2003; 2:242-56.
10. Depre C, Kim SJ, John AS, Huang Y, Rimoldi OE, Pepper JR, Dreyfus GD, Gaussin V, Pennell DJ, Vatner DE, Camici PG, Vatner SF. Program of cell survival underlying human and experimental hibernating myocardium. Circ Res 2004; 95:433-40.
11. Williams RS, Benjamin IJ. Protective responses in the ischemic myocardium. J Clin Invest 2000; 106:813-8.
12. Depre C, Tomlinson JE, Kudej RK, Gaussin V, Thompson E, Kim SJ, Vatner DE, Topper JN, Vatner SF. Gene program for cardiac cell survival induced by transient ischemia in conscious pigs. PNAS 2001; 98:9336-41.
13. Klionsky DJ. Cell biology: Regulated self-cannibalism. Nature 2004; 431:31-2.
14. Levine B, Klionsky DJ. Development by self-digestion: Molecular mechanisms and biological functions of autophagy. Dev Cell 2004; 6:463-77.
15. Mizushima N, Ohsumi Y, Yoshimori T. Autophagosome formation in mammalian cells. Cell Struct Funct 2002; 27:421-9.
16. Shintani T, Klionsky DJ. Autophagy in health and disease: A double-edged sword. Science 2004; 306:990-5.
17. Ahlberg J, Marzella L, Glaumann H. Uptake and degradation of proteins by isolated rat liver lysosomes. Suggestion of a microautophagic pathway of proteolysis. Lab Invest 1982; 47:523-32.
18. Bursch W. The autophagosomal-lysosomal compartment in programmed cell death. Cell Death Differ 2001; 8:569-81.
19. Cuervo AM, Dice JF. Lysosomes, a meeting point of proteins, chaperones, and proteases. J Mol Med 1998; 76:6-12.
20. Stromhaug PE, Klionsky DJ. Approaching the molecular mechanism of autophagy. Traffic 2001; 2:524-31.
21. Tolkovsky AM, Xue L, Fletcher GC, Borutaite V. Mitochondrial disappearance from cells: A clue to the role of autophagy in programmed cell death and disease? Biochimie 2002; 84:233-40.
22. Uchiyama Y. Autophagic cell death and its execution by lysosomal cathepsins. Arch Histol Cytol 2001; 64:233-46.
23. Tsujimoto Y, Shimizu S. Another way to die: Autophagic programmed cell death. Cell Death Differ 2005; 121528-34.
24. Kroemer G, El-Deiry WS, Golstein P, Peter ME, Vaux D, Vandenabeele P, Zhivotovsky B, Blagosklonny MV, Malorni W, Knight RA, Piacentini M, Nagata S, Melino G. Classification of cell death: Recommendations of the nomenclature committee on cell death. Cell Death Differ 2005; 121463-7.
25. Yu L, Alva A, Su H, Dutt P, Freundt E, Welsh S, Baehrecke EH, Lenardo MJ. Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8. Science 2004; 304:1500-2.
26. Yu L, Lenardo MJ, Baehrecke EH. Autophagy and caspases: A new cell death program. Cell Cycle 2004; 3:1124-6.
27. Cuervo AM. Autophagy: In sickness and in health. Trends in Cell Biol 2004; 14:70-7.
28. Larsen KE, Sulzer D. Autophagy in neurons: A review. Histol Histopathol 2002; 17:897-908.
29. Bergamini E, Cavallini G, Donati A, Gori Z. The role of macroautophagy in the ageing process, anti-ageing intervention and age-associated diseases. Int J Biochem Cell Biol 2004; 36:2392-404.
30. Gozuacik D, Kimchi A. Autophagy as a cell death and tumor suppressor mechanism. Oncogene 2004; 23:2891-906.
31. Yue Z, Jin S, Yang C, Levine AJ, Heintz N. Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc Natl Acad Sci USA 2003; 100:15077-82.
32. Levine B, Yuan J. Autophagy in cell death: An innocent convict? J Clin Invest 2005; 115:2679-88.
33. Lum JJ, DeBerardinis RJ, Thompson CB. Autophagy in metazoans: Cell survival in the land of plenty. Nat Rev Mol Cell Biol 2005; 6:439-48.
34. Kim SJ, Peppas A, Hong SK, Yang G, Huang Y, Diaz G, Sadoshima J, Vatner DE, Vatner SF. Persistent stunning induces myocardial hibernation and protection: Flow/function and metabolic mechanisms. Circ Res 2003; 92:1233-9.
35. Boya P, Gonzalez-Polo RA, Casares N, Perfettini JL, Dessen P, Larochette N, Metivier D, Meley D, Souquere S, Yoshimori T, Pierron G, Codogno P, Kroemer G. Inhibition of macroautophagy triggers apoptosis. Mol Cell Biol 2005; 25:1025-40.
36. Seglen PO, Gordon PB. 3-Methyladenine: Specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes. Proc Natl Acad Sci USA 1982; 79:1889-92.
37. Ravikumar B, Berger Z, Vacher C, O'Kane CJ, Rubinsztein DC. Rapamycin pretreatment protects against apoptosis. Hum Mol Genet 2006; 15:1209-16.
38. Ollinger K. Inhibition of cathepsin D prevents free-radical-induced apoptosis in rat cardiomyocytes. Arch Biochem Biophys 2000; 373:346-51.
39. Roberg K, Johansson U, Ollinger K. Lysosomal release of cathepsin D precedes relocation of cytochrome c and loss of mitochondrial transmembrane potential during apoptosis induced by oxidative stress. Free Radic Biol Med 1999; 27:1228-37.
40. Turk B, Turk D, Turk V. Lysosomal cysteine proteases: More than scavengers. Biochim Biophys Acta 2000; 1477:98-111.
41. Vancompernolle K, Van Herreweghe F, Pynaert G, Van de Craen M, De Vos K, Totty N, Sterling A, Fiers W, Vandenabeele P, Grooten J. Atractyloside-induced release of cathepsin B, a protease with caspase-processing activity. FEBS Lett 1998; 438:150-8.
42. Layton GT, Harris SJ, Bland FA, Lee SR, Fearn S, Kaleta J, Wood ML, Bond A, Ward G. Therapeutic effects of cysteine protease inhibition in allergic lung inflammation: Inhibition of allergen-specific T lymphocyte migration. Inflamm Res 2001; 50:400-8.
43. Wagner BM, Smith RA, Coles PJ, Copp LJ, Ernest MJ, Krantz A. In vivo inhibition of cathepsin B by peptidyl (acyloxy)methyl ketones. J Med Chem 1994; 37:1833-40.
44. Paglin S, Lee NY, Nakar C, Fitzgerald M, Plotkin J, Deuel B, Hackett N, McMahill M, Sphicas E, Lampen N, Yahalom J. Rapamycin-sensitive pathway regulates mitochondrial membrane potential, autophagy, and survival in irradiated MCF-7 cells. Cancer Res 2005; 65:11061-70.
45. Melendez A, Talloczy Z, Seaman M, Eskelinen EL, Hall DH, Levine B. Autophagy genes are essential for dauer development and life-span extension in C. elegans. Science 2003; 301:1387-91.