Application of crystallographic and modeling methods in the design of purine nucleoside phosphorylase inhibitors

Proceedings of the National Academy of Sciences of the United States of America

Volumn 88, Issue 24, 1991, Pages 11540-11544

  Ealick, Steven E ^a   Babu, Y Sudhakar ^b   Bugg, Charles E ^a,b   Erion, Mark D ^c   Guida, Wayne C ^c   Montgomery, John A ^b,d   Secrist III, John A ^d  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b BIOCRYST PHARMACEUTICALS INC   (United States)

^c NOVARTIS PHARMA AG   (Switzerland)

^d SOUTHERN RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR;

ARTICLE; DRUG DESIGN; PRIORITY JOURNAL; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; BINDING SITES; DRUG DESIGN; ENZYME INHIBITORS; HUMAN; KINETICS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MONTE CARLO METHOD; PROTEIN CONFORMATION; PURINE-NUCLEOSIDE PHOSPHORYLASE; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, NON-P.H.S.; SUPPORT, U.S. GOV'T, P.H.S.; X-RAY DIFFRACTION;

EID: 0026349524     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.88.24.11540     Document Type: Article

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