Remote mutations alter transition-state structure of human purine nucleoside phosphorylase

Biochemistry

Volumn 47, Issue 8, 2008, Pages 2565-2576

  Luo, Minkui ^a   Li, Lei ^a   Schramm, Vern L ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; DENSITY FUNCTIONAL THEORY; NITROGEN COMPOUNDS; NUCLEOPHILES; PROTONATION;

BOVINES; PHOSPHOROLYSIS;

ENZYME ACTIVITY;

ARGININE; GLUTAMIC ACID; HYPOXANTHINE; PHOSPHATE; PURINE NUCLEOSIDE PHOSPHORYLASE; RIBOSE;

AMINO ACID SEQUENCE; ARTICLE; CALCULATION; CATALYSIS; CHEMICAL BOND; CRYSTAL STRUCTURE; DEPHOSPHORYLATION; ENZYME ACTIVE SITE; ENZYME STRUCTURE; MATHEMATICAL MODEL; MUTATION; PRIORITY JOURNAL; PROTON TRANSPORT; STEADY STATE;

CATALYSIS; ENZYME ACTIVATION; HUMANS; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTATION; PROTEIN STRUCTURE, SECONDARY; PURINE-NUCLEOSIDE PHOSPHORYLASE; RECOMBINANT PROTEINS; TRANSITION TEMPERATURE;

BOVINAE;

EID: 39749124957     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi702133x     Document Type: Article

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