-
1
-
-
0024593744
-
Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability
-
Hidalgo IJ, Raub TJ, Borchardt RT. 1989. Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability. Gastroenterology 96:736-749.
-
(1989)
Gastroenterology
, vol.96
, pp. 736-749
-
-
Hidalgo, I.J.1
Raub, T.J.2
Borchardt, R.T.3
-
2
-
-
0017412603
-
One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice
-
Fogh J, Fogh JM, Orfeo T. 1977. One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice. J Natl Cancer Inst 59:221-225.
-
(1977)
J Natl Cancer Inst
, vol.59
, pp. 221-225
-
-
Fogh, J.1
Fogh, J.M.2
Orfeo, T.3
-
3
-
-
0021490671
-
Epithelial properties of human colonic carcinoma cell line Caco-2: Electrical parameters
-
Grasset E, Pinto M, Dussaulx E, Zweibaum A, Desjeux JF. 1984. Epithelial properties of human colonic carcinoma cell line Caco-2: Electrical parameters. Am J Physiol 247:C260-C267.
-
(1984)
Am J Physiol
, vol.247
-
-
Grasset, E.1
Pinto, M.2
Dussaulx, E.3
Zweibaum, A.4
Desjeux, J.F.5
-
4
-
-
0021067619
-
Enterocyte-like differentiation and polarization of the human colon carcinoma cell line Caco-2 in culture
-
Pinto M, Robin-Leon S, Appay MD, Kedinger M, Triadou N, Dussaulx E, Lacroix B, Simon-Assman P, Haffen K, Fogh J, Zweibaum A. 1983. Enterocyte-like differentiation and polarization of the human colon carcinoma cell line Caco-2 in culture. Biol Cell 47:323-330.
-
(1983)
Biol Cell
, vol.47
, pp. 323-330
-
-
Pinto, M.1
Robin-Leon, S.2
Appay, M.D.3
Kedinger, M.4
Triadou, N.5
Dussaulx, E.6
Lacroix, B.7
Simon-Assman, P.8
Haffen, K.9
Fogh, J.10
Zweibaum, A.11
-
5
-
-
0023925328
-
Epithelial polarity, villin expression and enterocytic differentiation of cultured human colon carcinoma cells: A survey of twenty cell lines
-
Chantret I, Barbat A, Dussaulx E, Brattain MG, Zweibaum A. 1988. Epithelial polarity, villin expression and enterocytic differentiation of cultured human colon carcinoma cells: A survey of twenty cell lines. Cancer Res 48:1936-1942.
-
(1988)
Cancer Res
, vol.48
, pp. 1936-1942
-
-
Chantret, I.1
Barbat, A.2
Dussaulx, E.3
Brattain, M.G.4
Zweibaum, A.5
-
6
-
-
0031952285
-
Caco-2 cells express a combination of colonocyte and enterocyte phenotypes
-
Engle MJ, Goetz GS, Alpers DH. 1998. Caco-2 cells express a combination of colonocyte and enterocyte phenotypes. J Cell Physiol 174:362-369.
-
(1998)
J Cell Physiol
, vol.174
, pp. 362-369
-
-
Engle, M.J.1
Goetz, G.S.2
Alpers, D.H.3
-
7
-
-
0029142558
-
Heterogeneity in the human intestinal cell line Caco-2 leads to differences in transepithelial transport
-
Walter E, Kissel T. 1995. Heterogeneity in the human intestinal cell line Caco-2 leads to differences in transepithelial transport. Eur J Pharm Sci 3:215-230.
-
(1995)
Eur J Pharm Sci
, vol.3
, pp. 215-230
-
-
Walter, E.1
Kissel, T.2
-
9
-
-
0029998275
-
Comparative studies of drug-metabolizing enzymes in dog, monkey, and human small intestines, and in Caco-2 cells
-
Prueksaritanont T, Gorham LM, Hochman JH, Tran LO, Vyas KP. 1996 Comparative studies of drug-metabolizing enzymes in dog, monkey, and human small intestines, and in Caco-2 cells. Drug Metab Dispos 24:634-642.
-
(1996)
Drug Metab Dispos
, vol.24
, pp. 634-642
-
-
Prueksaritanont, T.1
Gorham, L.M.2
Hochman, J.H.3
Tran, L.O.4
Vyas, K.P.5
-
10
-
-
0029896241
-
Age-dependent expression of P-glycoprotein gp170 in Caco-2 cell monolayers
-
Hosoya HI, Kim KJ, Lee VHL. 1996. Age-dependent expression of P-glycoprotein gp170 in Caco-2 cell monolayers. Pharm Res 13:885-890.
-
(1996)
Pharm Res
, vol.13
, pp. 885-890
-
-
Hosoya, H.I.1
Kim, K.J.2
Lee, V.H.L.3
-
11
-
-
0042626576
-
Influence of drugs and nutrients on transporter gene expression levels in Caco-2 and LS180 intestinal epithelial cell lines
-
Li Q, Sai Y, Kato Y, Tamai I, Tsuji A. 2003. Influence of drugs and nutrients on transporter gene expression levels in Caco-2 and LS180 intestinal epithelial cell lines. Pharm Res 20:1119-1124.
-
(2003)
Pharm Res
, vol.20
, pp. 1119-1124
-
-
Li, Q.1
Sai, Y.2
Kato, Y.3
Tamai, I.4
Tsuji, A.5
-
12
-
-
0027181852
-
Functional expression of P-glycoprotein in apical membranes of human intestinal Caco-2 cells. Kinetics of vinblastine secretion and interaction with modulators
-
Hunter J, Jepson MA, Tsuruo T, Simmons NL, Hirst BH. 1993. Functional expression of P-glycoprotein in apical membranes of human intestinal Caco-2 cells. Kinetics of vinblastine secretion and interaction with modulators. J Biol Chem 268: 14991-14997.
-
(1993)
J Biol Chem
, vol.268
, pp. 14991-14997
-
-
Hunter, J.1
Jepson, M.A.2
Tsuruo, T.3
Simmons, N.L.4
Hirst, B.H.5
-
13
-
-
0034811602
-
Correlation of gene expression of ten efflux proteins of the ATP-binding cassette transporter family in normal human jejunum and in human intestinal epithelial Caco-2 cell monolayers
-
Taipalensuu J, Tornblom H, Lindberg G, Einarsson C, Sjoqvist F, Melhus H, Garberg P, Sjostrom B, Lundgren B, Artursson P. 2001. Correlation of gene expression of ten efflux proteins of the ATP-binding cassette transporter family in normal human jejunum and in human intestinal epithelial Caco-2 cell monolayers. J Pharmacol Exp Ther 299:164-170.
-
(2001)
J Pharmacol Exp Ther
, vol.299
, pp. 164-170
-
-
Taipalensuu, J.1
Tornblom, H.2
Lindberg, G.3
Einarsson, C.4
Sjoqvist, F.5
Melhus, H.6
Garberg, P.7
Sjostrom, B.8
Lundgren, B.9
Artursson, P.10
-
14
-
-
33750181267
-
Regional levels of drug transporters along the human intestinal tract: Co-expression of ABC and SLC transporters and comparison with Caco-2 cells
-
Englund G, Rorsman F, Rönnblom A, Karlbom U, Lazorval L, Gråsjö J, Kindmark A, Artursson P. 2006. Regional levels of drug transporters along the human intestinal tract: Co-expression of ABC and SLC transporters and comparison with Caco-2 cells. Eur J Pharm Sci 29:269-277.
-
(2006)
Eur J Pharm Sci
, vol.29
, pp. 269-277
-
-
Englund, G.1
Rorsman, F.2
Rönnblom, A.3
Karlbom, U.4
Lazorval, L.5
Gråsjö, J.6
Kindmark, A.7
Artursson, P.8
-
16
-
-
0028293986
-
Presence and differential expression of SGLT1, GLUT1, GLUT2, GLUT3 and GLUT5 hexose transporter mRNAs in Caco-2 clones in relation to cell growth and glucose consumption
-
Mahraoui L, Rodolosse A, Barbat A, Dussaulx E, Zweibaum A, Rousset M, Brot-Laroche E. 1994. Presence and differential expression of SGLT1, GLUT1, GLUT2, GLUT3 and GLUT5 hexose transporter mRNAs in Caco-2 clones in relation to cell growth and glucose consumption. Biochem J 298:629-633.
-
(1994)
Biochem J
, vol.298
, pp. 629-633
-
-
Mahraoui, L.1
Rodolosse, A.2
Barbat, A.3
Dussaulx, E.4
Zweibaum, A.5
Rousset, M.6
Brot-Laroche, E.7
-
17
-
-
0025358551
-
Transport of bile acids in a human intestinal epithelial cell line, Caco-2
-
Hidalgo IJ, Borchardt RT. 1990. Transport of bile acids in a human intestinal epithelial cell line, Caco-2. Biochim Biophys Acta 1035:97-103.
-
(1990)
Biochim Biophys Acta
, vol.1035
, pp. 97-103
-
-
Hidalgo, I.J.1
Borchardt, R.T.2
-
18
-
-
0025668535
-
Mechanism of L-alpha-methyldopa transport through a monolayer of polarized human intestinal epithelial cells (Caco-2)
-
Hu M, Borchardt RT. 1990. Mechanism of L-alpha-methyldopa transport through a monolayer of polarized human intestinal epithelial cells (Caco-2). Pharm Res 7:1313-1319.
-
(1990)
Pharm Res
, vol.7
, pp. 1313-1319
-
-
Hu, M.1
Borchardt, R.T.2
-
19
-
-
0025118126
-
Transport of a large neutral amino acid (phenylalanine) in a human intestinal epithelial cell line: Caco-2
-
Hidalgo IJ, Borchardt RT. 1990. Transport of a large neutral amino acid (phenylalanine) in a human intestinal epithelial cell line: Caco-2. Biochim Biophys Acta 1028:25-30.
-
(1990)
Biochim Biophys Acta
, vol.1028
, pp. 25-30
-
-
Hidalgo, I.J.1
Borchardt, R.T.2
-
20
-
-
0028787081
-
The transport of acidic amino acids and their analogues across monolayers of human intestinal absorptive (Caco-2) cells in vitro
-
Nicklin PL, Irwin WJ, Hassan IF, Mackay M, Dixon HB. 1995. The transport of acidic amino acids and their analogues across monolayers of human intestinal absorptive (Caco-2) cells in vitro. Biochim Biophys Acta 1269:176-186.
-
(1995)
Biochim Biophys Acta
, vol.1269
, pp. 176-186
-
-
Nicklin, P.L.1
Irwin, W.J.2
Hassan, I.F.3
Mackay, M.4
Dixon, H.B.5
-
21
-
-
0025376172
-
Carrier affinity as a mechanism for the pH-dependence of folate transport in the small intestine
-
Mason JB, Shoda R, Haskell M, Selhub J, Rosenberg IH. 1990. Carrier affinity as a mechanism for the pH-dependence of folate transport in the small intestine. Biochim Biophys Acta 1024:331-335.
-
(1990)
Biochim Biophys Acta
, vol.1024
, pp. 331-335
-
-
Mason, J.B.1
Shoda, R.2
Haskell, M.3
Selhub, J.4
Rosenberg, I.H.5
-
22
-
-
0027328245
-
Biotin transport in a human intestinal epithelial cell line (Caco-2)
-
Ng KY, Borchardt RT. 1993. Biotin transport in a human intestinal epithelial cell line (Caco-2). Life Sci 53:1121-1127.
-
(1993)
Life Sci
, vol.53
, pp. 1121-1127
-
-
Ng, K.Y.1
Borchardt, R.T.2
-
23
-
-
0027319297
-
Dipeptide transporters in apical and basolateral membranes of the human intestinal cell line Caco-2
-
Saito H, Inui K. 1993. Dipeptide transporters in apical and basolateral membranes of the human intestinal cell line Caco-2. Am J Physiol 265:G289-G294.
-
(1993)
Am J Physiol
, vol.265
-
-
Saito, H.1
Inui, K.2
-
25
-
-
0025046860
-
Uptake of the cephalosporin, cephalexin, by a dipeptide transport carrier in the human intestinal cell line, Caco-2
-
Dantzig AH, Bergin L. 1990. Uptake of the cephalosporin, cephalexin, by a dipeptide transport carrier in the human intestinal cell line, Caco-2. Biochim Biophys Acta 1027:211-217.
-
(1990)
Biochim Biophys Acta
, vol.1027
, pp. 211-217
-
-
Dantzig, A.H.1
Bergin, L.2
-
26
-
-
0027422902
-
Comparison of uptake characteristics of thymidine and zidovudine in a human intestinal epithelial model system
-
Hu M. 1993. Comparison of uptake characteristics of thymidine and zidovudine in a human intestinal epithelial model system. J Pharm Sci 82:829-833.
-
(1993)
J Pharm Sci
, vol.82
, pp. 829-833
-
-
Hu, M.1
-
27
-
-
0033058435
-
+-independent transport systems in T84 and Caco-2 cells
-
+-independent transport systems in T84 and Caco-2 cells. Biochim Biophys Acta 1419: 15-22.
-
(1999)
Biochim Biophys Acta
, vol.1419
, pp. 15-22
-
-
Ward, J.L.1
Tse, C.M.2
-
28
-
-
0028358657
-
pH-dependent and carrier-mediated transport of salicylic acid across Caco-2 cells
-
Takanaga H, Tamai I, Tsuji A. 1994. pH-dependent and carrier-mediated transport of salicylic acid across Caco-2 cells. J Pharm Pharmacol 46: 567-570.
-
(1994)
J Pharm Pharmacol
, vol.46
, pp. 567-570
-
-
Takanaga, H.1
Tamai, I.2
Tsuji, A.3
-
29
-
-
0037338515
-
Sulfate conjugating and transport functions of MDCK distal tubular cells
-
Ng KH, Lim BG, Wong KP. 2003. Sulfate conjugating and transport functions of MDCK distal tubular cells. Kidney Int 63:976-986.
-
(2003)
Kidney Int
, vol.63
, pp. 976-986
-
-
Ng, K.H.1
Lim, B.G.2
Wong, K.P.3
-
31
-
-
0029989719
-
The cytosolic glutathione S-transferase isoenzymes in the dog kidney cortex as compared with the corresponding MDCK renal cell line
-
Bohets HH, Nouwen EJ, De Broe ME, Diereckx PJ. 1996. The cytosolic glutathione S-transferase isoenzymes in the dog kidney cortex as compared with the corresponding MDCK renal cell line. Biochim Biophys Acta 1311:93-101.
-
(1996)
Biochim Biophys Acta
, vol.1311
, pp. 93-101
-
-
Bohets, H.H.1
Nouwen, E.J.2
De Broe, M.E.3
Diereckx, P.J.4
-
32
-
-
0036891989
-
Functional characterization of monocarboxylix acid, large neutral amino acid, bile acid and peptide transporters, and P-glycoprotein in MDCK and Cao-2 cells
-
Putman W, Ramanathan S, Pan L, Takahashi L, Benet LZ. 2002. Functional characterization of monocarboxylix acid, large neutral amino acid, bile acid and peptide transporters, and P-glycoprotein in MDCK and Cao-2 cells. J Pharm Sci 91:2622-2635.
-
(2002)
J Pharm Sci
, vol.91
, pp. 2622-2635
-
-
Putman, W.1
Ramanathan, S.2
Pan, L.3
Takahashi, L.4
Benet, L.Z.5
-
33
-
-
0027368043
-
Transepithelial secretion, cellular accumulation, and cytotoxicity of vinblastine in defined MDCK cell strains
-
Hunter J, Hirst BH, Simmons NL. 1993. Transepithelial secretion, cellular accumulation, and cytotoxicity of vinblastine in defined MDCK cell strains. Biochim Biophys Acta 1179:1-10.
-
(1993)
Biochim Biophys Acta
, vol.1179
, pp. 1-10
-
-
Hunter, J.1
Hirst, B.H.2
Simmons, N.L.3
-
34
-
-
0024449848
-
Transepithelial transport of drugs by the multidrug transporter in cultured Madin-Darby canine kidney cell epithelia
-
Horio M, Chin KV, Currier SJ, Goldenburg S, Williams C, Pastan J, Gottesman MM, Handler J. 1989. Transepithelial transport of drugs by the multidrug transporter in cultured Madin-Darby canine kidney cell epithelia. J Biol Chem 264: 14880-14884.
-
(1989)
J Biol Chem
, vol.264
, pp. 14880-14884
-
-
Horio, M.1
Chin, K.V.2
Currier, S.J.3
Goldenburg, S.4
Williams, C.5
Pastan, J.6
Gottesman, M.M.7
Handler, J.8
-
35
-
-
0034816905
-
Functional characteristics and steroid-hormone mediated regulation of an organic cation transporter in Madin-Darby canine kidney cells
-
Shu Y, Bello CL, Mangravite LM, Feng B, Giacomini KM. 2001. Functional characteristics and steroid-hormone mediated regulation of an organic cation transporter in Madin-Darby canine kidney cells. J Pharmacol Exp Ther 299:392-398.
-
(2001)
J Pharmacol Exp Ther
, vol.299
, pp. 392-398
-
-
Shu, Y.1
Bello, C.L.2
Mangravite, L.M.3
Feng, B.4
Giacomini, K.M.5
-
36
-
-
0028937583
-
+-peptide cotransportation in Madin-Darby canine kidney cells: Expression and calmodulin-dependent regulation
-
+-peptide cotransportation in Madin-Darby canine kidney cells: Expression and calmodulin-dependent regulation. Am J Physiol 268:F391-F397.
-
(1995)
Am J Physiol
, vol.268
-
-
Brandsch, M.1
Ganapathy, V.2
Leibach, F.H.3
-
37
-
-
0033696967
-
Functional expression of novel peptide transporter in renal basolateral membranes
-
Terada T, Sawada K, Ito T, Saito H, Hashimoto Y, Inui KI. 2000. Functional expression of novel peptide transporter in renal basolateral membranes. Am J Physiol 279:F851-F857.
-
(2000)
Am J Physiol
, vol.279
-
-
Terada, T.1
Sawada, K.2
Ito, T.3
Saito, H.4
Hashimoto, Y.5
Inui, K.I.6
-
38
-
-
0025804183
-
Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells
-
Artursson P, Karlsson J. 1991. Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells. Biochem Biophys Res Commun 175:880-885.
-
(1991)
Biochem Biophys Res Commun
, vol.175
, pp. 880-885
-
-
Artursson, P.1
Karlsson, J.2
-
39
-
-
0030023536
-
Comparison between active and passive drug transport in human intestinal epithelial (Caco-2) cells in vitro and human jejunum in vivo
-
Lennernas H, Palm K, Fagerholm U, Artursson P. 1996. Comparison between active and passive drug transport in human intestinal epithelial (Caco-2) cells in vitro and human jejunum in vivo. Intl J Pharm 127:103-107.
-
(1996)
Intl J Pharm
, vol.127
, pp. 103-107
-
-
Lennernas, H.1
Palm, K.2
Fagerholm, U.3
Artursson, P.4
-
40
-
-
0031780682
-
Correlation between oral drug absorption in humans, and apparent drug permeability in TC-7 cells, a human epithelial intestinal cell line: Comparison with the parental Caco-2 cell line
-
Grès MC, Julian B, Bourrié M, Meunier V, Roques C, Berger M, Boulenc X, Berger Y, Fabre G. 1998. Correlation between oral drug absorption in humans, and apparent drug permeability in TC-7 cells, a human epithelial intestinal cell line: Comparison with the parental Caco-2 cell line. Pharm Res 15:726-733.
-
(1998)
Pharm Res
, vol.15
, pp. 726-733
-
-
Grès, M.C.1
Julian, B.2
Bourrié, M.3
Meunier, V.4
Roques, C.5
Berger, M.6
Boulenc, X.7
Berger, Y.8
Fabre, G.9
-
41
-
-
0032826794
-
Use of Caco-2 cell culture model for the characterization of intestinal absorption of antibiotics
-
Biganzoli E, Cavenaghi LA, Rossi R, Brunati MC, Nolli ML. 1999. Use of Caco-2 cell culture model for the characterization of intestinal absorption of antibiotics. Il Farmaco 54:594-599.
-
(1999)
Il Farmaco
, vol.54
, pp. 594-599
-
-
Biganzoli, E.1
Cavenaghi, L.A.2
Rossi, R.3
Brunati, M.C.4
Nolli, M.L.5
-
42
-
-
33646139261
-
Method suitability of a Caco-2 cell model for drug permeability classification
-
abstract 425
-
Volpe DA, Ciavarella AB, Asafu-Adjaye EB, Ellison CD, Faustino PJ, Yu LX. 2001. Method suitability of a Caco-2 cell model for drug permeability classification. AAPS PharmSci 3: abstract 425.
-
(2001)
AAPS PharmSci
, vol.3
-
-
Volpe, D.A.1
Ciavarella, A.B.2
Asafu-Adjaye, E.B.3
Ellison, C.D.4
Faustino, P.J.5
Yu, L.X.6
-
43
-
-
0032949615
-
MDCK (Madin-Darby canine kidney) cells: A tool for membrane permeability screening
-
Irvine JD, Takahashi L, Lockhart K, Cheong J, Tolan JW, Selick HE, Grove JR. 1999. MDCK (Madin-Darby canine kidney) cells: A tool for membrane permeability screening. J Pharm Sci 88: 28-33.
-
(1999)
J Pharm Sci
, vol.88
, pp. 28-33
-
-
Irvine, J.D.1
Takahashi, L.2
Lockhart, K.3
Cheong, J.4
Tolan, J.W.5
Selick, H.E.6
Grove, J.R.7
-
44
-
-
0024505075
-
The Madin Darby canine kidney (MDCK) epithelial cell monolayer as a model cellular transport barrier
-
Cho MJ, Thompson DP, Cramer CT, Vidmar TJ, Scieszka JF. 1989. The Madin Darby canine kidney (MDCK) epithelial cell monolayer as a model cellular transport barrier. Pharm Res 6:71-77.
-
(1989)
Pharm Res
, vol.6
, pp. 71-77
-
-
Cho, M.J.1
Thompson, D.P.2
Cramer, C.T.3
Vidmar, T.J.4
Scieszka, J.F.5
-
46
-
-
0017891781
-
Polarized monolayers formed by epithelial cells on a permeable and translucent support
-
Cereijido M, Robbins ES, Dolan WJ, Rotunno CA, Sabatini DD. 1978. Polarized monolayers formed by epithelial cells on a permeable and translucent support. J Cell Biol 77:853-880.
-
(1978)
J Cell Biol
, vol.77
, pp. 853-880
-
-
Cereijido, M.1
Robbins, E.S.2
Dolan, W.J.3
Rotunno, C.A.4
Sabatini, D.D.5
-
47
-
-
0019957042
-
Cultured monolayers of MDCK cells: A novel model system for the study of epithelial development and function
-
Simmons NL. 1982. Cultured monolayers of MDCK cells: A novel model system for the study of epithelial development and function. Gen Pharmacol 13:287-291.
-
(1982)
Gen Pharmacol
, vol.13
, pp. 287-291
-
-
Simmons, N.L.1
-
48
-
-
0031824307
-
MDCK cell cultures as an epithelial in vitro model: Cytoskeleton and tight junction as indicators for the definition of age-related stages by confocal microscopy
-
Rothen-Rutishauser B, Krämer SD, Braun A, Günthert M, Wunderli-Allenspach H. 1998. MDCK cell cultures as an epithelial in vitro model: Cytoskeleton and tight junction as indicators for the definition of age-related stages by confocal microscopy. Pharm Res 15:964-971.
-
(1998)
Pharm Res
, vol.15
, pp. 964-971
-
-
Rothen-Rutishauser, B.1
Krämer, S.D.2
Braun, A.3
Günthert, M.4
Wunderli-Allenspach, H.5
-
49
-
-
0022531159
-
Variability of functional characteristics of MDCK cells
-
Husted R, Welsh M, Stokes J. 1986. Variability of functional characteristics of MDCK cells. Am J Physiol 250:C214-C221.
-
(1986)
Am J Physiol
, vol.250
-
-
Husted, R.1
Welsh, M.2
Stokes, J.3
-
50
-
-
0033692842
-
The MDCK cell line is made up of populations of cells with diverse resistive and transport properties
-
Arthur JM. 2000. The MDCK cell line is made up of populations of cells with diverse resistive and transport properties. Tissue Cell 32:446-450.
-
(2000)
Tissue Cell
, vol.32
, pp. 446-450
-
-
Arthur, J.M.1
-
51
-
-
39749179144
-
Examination of the MDCK-II cell as an intestinal model for permeability screening
-
abstract 2224
-
Spicer N, Yu H, Janosky B, Doan VK, Wei D, Laws K, Rooney M, Hardy LW, Chan OH. 2002. Examination of the MDCK-II cell as an intestinal model for permeability screening. AAPS PharmSci 4: abstract 2224.
-
(2002)
AAPS PharmSci
, vol.4
-
-
Spicer, N.1
Yu, H.2
Janosky, B.3
Doan, V.K.4
Wei, D.5
Laws, K.6
Rooney, M.7
Hardy, L.W.8
Chan, O.H.9
-
52
-
-
12244290744
-
Towards standardization of an in vitro method of drug absorption
-
Volpe DA, Faustino PJ, Yu LX, Hussain AS. 2001. Towards standardization of an in vitro method of drug absorption. Pharm Forum 27:2916-2922.
-
(2001)
Pharm Forum
, vol.27
, pp. 2916-2922
-
-
Volpe, D.A.1
Faustino, P.J.2
Yu, L.X.3
Hussain, A.S.4
-
54
-
-
0028215390
-
Rational delivery strategies for the design of peptides with enhanced oral delivery
-
Borchardt RT. 1994. Rational delivery strategies for the design of peptides with enhanced oral delivery. Drug Dev Ind Pharm 20:469-483.
-
(1994)
Drug Dev Ind Pharm
, vol.20
, pp. 469-483
-
-
Borchardt, R.T.1
-
55
-
-
0028786481
-
The human intestinal epithelial cell line Caco-2; pharmacological and pharmacokinetic applications
-
Meunier V, Bourrié M, Berger Y, Fabre G. 1995. The human intestinal epithelial cell line Caco-2; pharmacological and pharmacokinetic applications. Cell Biol Toxicol 11:187-194.
-
(1995)
Cell Biol Toxicol
, vol.11
, pp. 187-194
-
-
Meunier, V.1
Bourrié, M.2
Berger, Y.3
Fabre, G.4
-
56
-
-
0025102678
-
The use of cultured epithelial and endothelial cells for drug transport and metabolism studies
-
Audus KL, Bartel RL, Hidalgo IJ, Borchardt RT. 1990. The use of cultured epithelial and endothelial cells for drug transport and metabolism studies. Pharm Res 7:435-451.
-
(1990)
Pharm Res
, vol.7
, pp. 435-451
-
-
Audus, K.L.1
Bartel, R.L.2
Hidalgo, I.J.3
Borchardt, R.T.4
-
57
-
-
0030588644
-
The use of the intestinal epithelial cell culture model, Caco-2, in pharmaceutical development
-
Bailey CA, Bryla P, Malick AW. 1996. The use of the intestinal epithelial cell culture model, Caco-2, in pharmaceutical development. Adv Drug Deliv Rev 22:85-103.
-
(1996)
Adv Drug Deliv Rev
, vol.22
, pp. 85-103
-
-
Bailey, C.A.1
Bryla, P.2
Malick, A.W.3
-
58
-
-
0030787532
-
A human colonic cell line sharing similarities with enterocytes as a model to examine oral absorption: Advantages and limitations of the Caco-2 model
-
Delie F, Rubas W. 1997. A human colonic cell line sharing similarities with enterocytes as a model to examine oral absorption: Advantages and limitations of the Caco-2 model. Crit Rev Ther Drug Carrier Syst 14:221-286.
-
(1997)
Crit Rev Ther Drug Carrier Syst
, vol.14
, pp. 221-286
-
-
Delie, F.1
Rubas, W.2
-
59
-
-
0030909506
-
The influence of culture time and passage number on the morphological and physiological development of Caco-2 cells
-
Briske-Anderson MJ, Finley JW, Newman SM. 1997. The influence of culture time and passage number on the morphological and physiological development of Caco-2 cells. Proc Soc Expt Biol Med 214:248-257.
-
(1997)
Proc Soc Expt Biol Med
, vol.214
, pp. 248-257
-
-
Briske-Anderson, M.J.1
Finley, J.W.2
Newman, S.M.3
-
60
-
-
0035524138
-
Assessing the absorption of new pharmaceuticals
-
Hidalgo IJ. 2001. Assessing the absorption of new pharmaceuticals. Curr Topics Med Chem 1:385-401.
-
(2001)
Curr Topics Med Chem
, vol.1
, pp. 385-401
-
-
Hidalgo, I.J.1
-
61
-
-
0028859318
-
In vitro systems for studying intestinal drug absorption
-
Hillgren KM, Kato A, Borchardt RT. 1995. In vitro systems for studying intestinal drug absorption. Med Res Rev 15:83-109.
-
(1995)
Med Res Rev
, vol.15
, pp. 83-109
-
-
Hillgren, K.M.1
Kato, A.2
Borchardt, R.T.3
-
62
-
-
0026631750
-
Transient mosaic patterns of morphological and functional differentiation in the Caco-2 cell line
-
Vachon PH, Beaulieu JF. 1992. Transient mosaic patterns of morphological and functional differentiation in the Caco-2 cell line. Gastroenterology 103:414-423.
-
(1992)
Gastroenterology
, vol.103
, pp. 414-423
-
-
Vachon, P.H.1
Beaulieu, J.F.2
-
63
-
-
0026321138
-
Cell cultures as models for drug absorption across the intestinal mucosa
-
Artursson P. 1991. Cell cultures as models for drug absorption across the intestinal mucosa. Crit Rev Ther Drug Carrier Syst 8:305-330.
-
(1991)
Crit Rev Ther Drug Carrier Syst
, vol.8
, pp. 305-330
-
-
Artursson, P.1
-
64
-
-
0026750080
-
Permeable support type influences the transport of compounds across Caco-2 cells
-
Nicklin P, Irwin B, Hassan I, Williamson I, Mackay M. 1992. Permeable support type influences the transport of compounds across Caco-2 cells. Intl J Pharm 83:197-209.
-
(1992)
Intl J Pharm
, vol.83
, pp. 197-209
-
-
Nicklin, P.1
Irwin, B.2
Hassan, I.3
Williamson, I.4
Mackay, M.5
-
65
-
-
85031451528
-
Isolation and characterization of Caco-2 cells expressing high and low levels of P-glycoprotein
-
abstract 1383
-
Kumpf SL, Ribabeneira MD, Sharpe D, Link J, Huber R, Burton C, Aungst B. 2001. Isolation and characterization of Caco-2 cells expressing high and low levels of P-glycoprotein. AAPS PharmSci 3: abstract 1383.
-
(2001)
AAPS PharmSci
, vol.3
-
-
Kumpf, S.L.1
Ribabeneira, M.D.2
Sharpe, D.3
Link, J.4
Huber, R.5
Burton, C.6
Aungst, B.7
-
66
-
-
3042597717
-
Variation of peptide transporter (PepT1 and HPT1) expression in Caco-2 cells as a function of cell origin
-
Behrens I, Kamm W, Dantzig AH, Kissel T. 2004. Variation of peptide transporter (PepT1 and HPT1) expression in Caco-2 cells as a function of cell origin. J Pharm Sci 93:1743-1754.
-
(2004)
J Pharm Sci
, vol.93
, pp. 1743-1754
-
-
Behrens, I.1
Kamm, W.2
Dantzig, A.H.3
Kissel, T.4
-
67
-
-
0019456040
-
Identification of two strains of MDCK cells which resemble separate nephron tubule segments
-
Richardson JCW, Scalera V, Simmons NL. 1981. Identification of two strains of MDCK cells which resemble separate nephron tubule segments. Biochim Biophys Acta 673:26-36.
-
(1981)
Biochim Biophys Acta
, vol.673
, pp. 26-36
-
-
Richardson, J.C.W.1
Scalera, V.2
Simmons, N.L.3
-
68
-
-
0030963896
-
Evidence for diminished functional expression of intestinal transporters in Caco-2 cell monolayers at high passages
-
Yu H, Cook TJ, Sinko PJ. 1997. Evidence for diminished functional expression of intestinal transporters in Caco-2 cell monolayers at high passages. Pharm Res 14:757-762.
-
(1997)
Pharm Res
, vol.14
, pp. 757-762
-
-
Yu, H.1
Cook, T.J.2
Sinko, P.J.3
-
69
-
-
0029927801
-
Transport properties are not altered across Caco-2 cells with heightened TEER despite underlying physiological and ultrastructural changes
-
Lu S, Gough AW, Bobrowski WF, Stewart BH. 1996. Transport properties are not altered across Caco-2 cells with heightened TEER despite underlying physiological and ultrastructural changes. J Pharm Sci 85:270-273.
-
(1996)
J Pharm Sci
, vol.85
, pp. 270-273
-
-
Lu, S.1
Gough, A.W.2
Bobrowski, W.F.3
Stewart, B.H.4
-
70
-
-
0034712893
-
Development of a more rapid, reduced serum culture system for Caco-2 monolayers and application to the biopharmaceutics classification system
-
Lentz KA, Hayashi J, Lucisano LJ, Polli JE. 2000. Development of a more rapid, reduced serum culture system for Caco-2 monolayers and application to the biopharmaceutics classification system. Int J Pharm 200:41-51.
-
(2000)
Int J Pharm
, vol.200
, pp. 41-51
-
-
Lentz, K.A.1
Hayashi, J.2
Lucisano, L.J.3
Polli, J.E.4
-
71
-
-
0347989382
-
In-depth evaluation of Gly-Sar transport parameters as a function of culture time in the Caco-2 cell model
-
Bravo SA, Nielsen CU, Amstrup J, Frokjaer S, Bodin B. 2004. In-depth evaluation of Gly-Sar transport parameters as a function of culture time in the Caco-2 cell model. Eur J Pharm Sci 21:77-86.
-
(2004)
Eur J Pharm Sci
, vol.21
, pp. 77-86
-
-
Bravo, S.A.1
Nielsen, C.U.2
Amstrup, J.3
Frokjaer, S.4
Bodin, B.5
-
72
-
-
0031834404
-
P-glycoprotein (P-gp) mediated efflux in Caco-2 cell monolayers: The influence of culturing conditions and drug exposure on P-gp expression levels
-
Anderle P, Niederer E, Rubas W, Hilgendorf C, Spahn-Langguth H, Wunderli-Allenspach H, Merkle HP, Langguth P. 1998. P-glycoprotein (P-gp) mediated efflux in Caco-2 cell monolayers: The influence of culturing conditions and drug exposure on P-gp expression levels. J Pharm Sci 87: 757-762.
-
(1998)
J Pharm Sci
, vol.87
, pp. 757-762
-
-
Anderle, P.1
Niederer, E.2
Rubas, W.3
Hilgendorf, C.4
Spahn-Langguth, H.5
Wunderli-Allenspach, H.6
Merkle, H.P.7
Langguth, P.8
-
73
-
-
0346670288
-
High glucose concentration in isotonic media alters Caco-2 cell permeability
-
article
-
D'Souza VM, Shertzer HG, Menon AG, Pauletti GM. 2003. High glucose concentration in isotonic media alters Caco-2 cell permeability. AAPS PharmSci 5: article 24.
-
(2003)
AAPS PharmSci
, vol.5
, pp. 24
-
-
D'Souza, V.M.1
Shertzer, H.G.2
Menon, A.G.3
Pauletti, G.M.4
-
74
-
-
0037369936
-
Extracellular glucose concentration alters functional activity of intestinal oligopeptide transporter (PepT-1) in Caco-2 cells
-
D'Souza VM, Buckley DJ, Buckley AR, Pauletti GM. 2003. Extracellular glucose concentration alters functional activity of intestinal oligopeptide transporter (PepT-1) in Caco-2 cells. J Pharm Sci 92:594-603.
-
(2003)
J Pharm Sci
, vol.92
, pp. 594-603
-
-
D'Souza, V.M.1
Buckley, D.J.2
Buckley, A.R.3
Pauletti, G.M.4
-
75
-
-
0038267446
-
Glutamine and barrier function in cultured Caco-2 epithelial cell monolayers
-
DeMarco VG, Li N, Thomas J, West CM, Neu J. 2003. Glutamine and barrier function in cultured Caco-2 epithelial cell monolayers. J Nutr 133: 2176-2179.
-
(2003)
J Nutr
, vol.133
, pp. 2176-2179
-
-
DeMarco, V.G.1
Li, N.2
Thomas, J.3
West, C.M.4
Neu, J.5
-
76
-
-
0035080160
-
Alteration of culture regime modifies antioxidant defenses independent of intracellular reactive oxygen levels and resistance to severe oxidative stress within confluent Caco-2 "intestinal cells
-
Bestwick CS, Milne L. 2001. Alteration of culture regime modifies antioxidant defenses independent of intracellular reactive oxygen levels and resistance to severe oxidative stress within confluent Caco-2 "intestinal cells". Dig Dis Sci 46:417-423.
-
(2001)
Dig Dis Sci
, vol.46
, pp. 417-423
-
-
Bestwick, C.S.1
Milne, L.2
-
77
-
-
0242298619
-
Permeability characteristics of parental and clonal human intestinal Caco-2 cell lines differentiated in serum-supplemented and serum-free media
-
Ranaldi G, Consalvo R, Sambuy Y, Scarino ML. 2003. Permeability characteristics of parental and clonal human intestinal Caco-2 cell lines differentiated in serum-supplemented and serum-free media. Toxicol In Vitro 17:761-767.
-
(2003)
Toxicol In Vitro
, vol.17
, pp. 761-767
-
-
Ranaldi, G.1
Consalvo, R.2
Sambuy, Y.3
Scarino, M.L.4
-
78
-
-
0027185816
-
Changes of proliferative activity and phenotypes in spontaneous differentiation of a colon cancer cell line
-
Hara A, Hibi T, Toda K, Watanabe N, Hayashi A, Iwao Y, Saito H, Watanabe J, Tsuchiya M. 1993. Changes of proliferative activity and phenotypes in spontaneous differentiation of a colon cancer cell line. Jpn J Cancer Res 84:625-632.
-
(1993)
Jpn J Cancer Res
, vol.84
, pp. 625-632
-
-
Hara, A.1
Hibi, T.2
Toda, K.3
Watanabe, N.4
Hayashi, A.5
Iwao, Y.6
Saito, H.7
Watanabe, J.8
Tsuchiya, M.9
-
79
-
-
0043092355
-
Do cell culture conditions influence the carrier-mediated transport of peptides in Caco-2 cell monolayers?
-
Behrens I, Kissel T. 2003. Do cell culture conditions influence the carrier-mediated transport of peptides in Caco-2 cell monolayers? Eur J Pharm Sci 19:433-442.
-
(2003)
Eur J Pharm Sci
, vol.19
, pp. 433-442
-
-
Behrens, I.1
Kissel, T.2
-
80
-
-
85031434583
-
The MDCK monolayer as an in vitro model for membrane permeability screening
-
abstract 1606
-
Yuan J, Reyner EL, Stewart BH, Chan OH. 2000. The MDCK monolayer as an in vitro model for membrane permeability screening. AAPS PharmSci 2: abstract 1606.
-
(2000)
AAPS PharmSci
, vol.2
-
-
Yuan, J.1
Reyner, E.L.2
Stewart, B.H.3
Chan, O.H.4
-
81
-
-
0141819197
-
The effect of cell culture conditions on saquinavir transport through, and interactions with, MDCKII cells overexpressing hM DR1
-
Williams GC, Knipp GT, Sinko PJ. 2003. The effect of cell culture conditions on saquinavir transport through, and interactions with, MDCKII cells overexpressing hM DR1. J Pharm Sci 92:1957-1967.
-
(2003)
J Pharm Sci
, vol.92
, pp. 1957-1967
-
-
Williams, G.C.1
Knipp, G.T.2
Sinko, P.J.3
-
82
-
-
0031458877
-
Influence of the microporous substratum and hydrodynamics on resistances of drug transport in cell culture systems: Calculations of intrinsic transport parameters
-
Yu H, Sinko P. 1997. Influence of the microporous substratum and hydrodynamics on resistances of drug transport in cell culture systems: Calculations of intrinsic transport parameters. J Pharm Sci 86:1448-1456.
-
(1997)
J Pharm Sci
, vol.86
, pp. 1448-1456
-
-
Yu, H.1
Sinko, P.2
-
83
-
-
0034040837
-
Formation of multilayers in the Caco-2 cell culture model: A confocal laser scanning microscopy study
-
Rothen-Rutishauser B, Braun A, Günthert M, Wunderli-Allenspach H. 2000. Formation of multilayers in the Caco-2 cell culture model: A confocal laser scanning microscopy study. Pharm Res 17: 460-465.
-
(2000)
Pharm Res
, vol.17
, pp. 460-465
-
-
Rothen-Rutishauser, B.1
Braun, A.2
Günthert, M.3
Wunderli-Allenspach, H.4
-
84
-
-
0025311288
-
Epithelial transport of drugs in cell cultures: A model for studying the passive diffusion of drugs over intestinal absorptive (Caco-2) cells
-
Artursson P. 1990. Epithelial transport of drugs in cell cultures: A model for studying the passive diffusion of drugs over intestinal absorptive (Caco-2) cells. J Pharm Sci 79:476-482.
-
(1990)
J Pharm Sci
, vol.79
, pp. 476-482
-
-
Artursson, P.1
-
85
-
-
0026784597
-
Migration of polarized epithelial cells through permeable membrane substrates of defined pore size
-
Tucker SP, Melsen LR, Compans RW. 1992. Migration of polarized epithelial cells through permeable membrane substrates of defined pore size. Eur J Cell Biol 58:280-290.
-
(1992)
Eur J Cell Biol
, vol.58
, pp. 280-290
-
-
Tucker, S.P.1
Melsen, L.R.2
Compans, R.W.3
-
86
-
-
0035724848
-
Optimizing Caco-2 cell monolayers to increase throughput in drug intestinal absorption analysis
-
Markowska M, Oberle R, Juzwin S, Hsu CP, Gryszkiewicz M, Streeter AJ. 2001. Optimizing Caco-2 cell monolayers to increase throughput in drug intestinal absorption analysis. J Pharmacol Toxicol Methods 46:51-55.
-
(2001)
J Pharmacol Toxicol Methods
, vol.46
, pp. 51-55
-
-
Markowska, M.1
Oberle, R.2
Juzwin, S.3
Hsu, C.P.4
Gryszkiewicz, M.5
Streeter, A.J.6
-
87
-
-
0029944964
-
In vitro measurement of drug transport using a new diffusion chamber compatible with Millicell® culture supports: Performance with Caco-2 monolayers
-
Kuhfeld MT, Stratford RE. 1996. In vitro measurement of drug transport using a new diffusion chamber compatible with Millicell® culture supports: Performance with Caco-2 monolayers. Int J Pharm 133:47-58.
-
(1996)
Int J Pharm
, vol.133
, pp. 47-58
-
-
Kuhfeld, M.T.1
Stratford, R.E.2
-
88
-
-
0026460479
-
Apical to basolateral surface area ratio and polarity of MDCK cells on different supports
-
Butor C, Davoust J. 1992. Apical to basolateral surface area ratio and polarity of MDCK cells on different supports. Exp Cell Res 203:115-127.
-
(1992)
Exp Cell Res
, vol.203
, pp. 115-127
-
-
Butor, C.1
Davoust, J.2
-
89
-
-
0030735258
-
Evaluation of tissue culture insert membrane compatibility in the fluorescein leakage assay
-
Ward RK, Mungall S, Carter J, Clothier RH. 1997. Evaluation of tissue culture insert membrane compatibility in the fluorescein leakage assay. Toxicol In Vitro 11:761-768.
-
(1997)
Toxicol In Vitro
, vol.11
, pp. 761-768
-
-
Ward, R.K.1
Mungall, S.2
Carter, J.3
Clothier, R.H.4
-
90
-
-
0025332938
-
Cell culture techniques for the study of drug transport
-
Wilson G. 1990. Cell culture techniques for the study of drug transport. Eur J Drug Metab Pharmacokinet 15:159-163.
-
(1990)
Eur J Drug Metab Pharmacokinet
, vol.15
, pp. 159-163
-
-
Wilson, G.1
-
91
-
-
0031974645
-
Validation of a Caco-2 cells monolayer culture for drug transport studies
-
Sulzbacher A, Jarosch A, Schüler R, Acerbi D, Ventura P, Puccini P, Woodcock BG. 1998. Validation of a Caco-2 cells monolayer culture for drug transport studies. Intl J Clin Pharmacol Ther 36:86-89.
-
(1998)
Intl J Clin Pharmacol Ther
, vol.36
, pp. 86-89
-
-
Sulzbacher, A.1
Jarosch, A.2
Schüler, R.3
Acerbi, D.4
Ventura, P.5
Puccini, P.6
Woodcock, B.G.7
-
92
-
-
0029102179
-
Passive diffusion of weak organic electrolytes across Caco-2 cell monolayers: Uncoupling the contributions of hydrodynamic, transcellular and paracellular barriers
-
Adson A, Burton PS, Raub TJ, Barshun CL, Audus KL, Ho NFH. 1995. Passive diffusion of weak organic electrolytes across Caco-2 cell monolayers: Uncoupling the contributions of hydrodynamic, transcellular and paracellular barriers. J Pharm Sci 84:1197-1204.
-
(1995)
J Pharm Sci
, vol.84
, pp. 1197-1204
-
-
Adson, A.1
Burton, P.S.2
Raub, T.J.3
Barshun, C.L.4
Audus, K.L.5
Ho, N.F.H.6
-
93
-
-
0030792730
-
Estimation of the relative contribution of the transcellular and paracellular pathway to the transport of passively absorbed drugs in the Caco-2 cell culture model
-
Pade V, Stavchansky S. 1997. Estimation of the relative contribution of the transcellular and paracellular pathway to the transport of passively absorbed drugs in the Caco-2 cell culture model. Pharm Res 14:1210-1215.
-
(1997)
Pharm Res
, vol.14
, pp. 1210-1215
-
-
Pade, V.1
Stavchansky, S.2
-
94
-
-
0034031969
-
Optimized conditions for prediction of intestinal drug permeability using Caco-2 cells
-
Yamashita S, Furubayashim T, Kataoka M, Sakane T, Sezaki H, Tokuda H. 2000. Optimized conditions for prediction of intestinal drug permeability using Caco-2 cells. Eur J Pharm Sci 10:195-204.
-
(2000)
Eur J Pharm Sci
, vol.10
, pp. 195-204
-
-
Yamashita, S.1
Furubayashim, T.2
Kataoka, M.3
Sakane, T.4
Sezaki, H.5
Tokuda, H.6
-
95
-
-
19444375300
-
Effect of experimental pH on the in vitro permeability in intact rabbit intestines and Caco-2 monolayer
-
Lee KJ, Johnson N, Castelo J, Sinko PJ, Grass G, Holme K, Lee YH. 2005. Effect of experimental pH on the in vitro permeability in intact rabbit intestines and Caco-2 monolayer. Eur J Pharm Sci 25: 193-200.
-
(2005)
Eur J Pharm Sci
, vol.25
, pp. 193-200
-
-
Lee, K.J.1
Johnson, N.2
Castelo, J.3
Sinko, P.J.4
Grass, G.5
Holme, K.6
Lee, Y.H.7
-
96
-
-
85031446641
-
2 incubation in Caco-2 cell
-
abstract 723
-
2 incubation in Caco-2 cell. AAPS PharmSci 3: abstract 723.
-
(2001)
AAPS PharmSci
, vol.3
-
-
Johnson, N.1
Lee, K.J.2
Castelo, J.3
Click, K.4
Christopher, R.5
Gordon, P.6
Hollenbeck, T.7
Moylan, D.8
Ereso, V.9
Holme, K.10
Grass, G.11
Sinko, P.J.12
Lee, Y.H.13
-
97
-
-
85031438616
-
-
Balimane P, Patel K, Chong S. 2004. Effect of pH on the bidirectional transport of some commonly used efflux (P-gp) substrates. AAPS J 6: abstract 2340.
-
Balimane P, Patel K, Chong S. 2004. Effect of pH on the bidirectional transport of some commonly used efflux (P-gp) substrates. AAPS J 6: abstract 2340.
-
-
-
-
98
-
-
19444382806
-
pH-Dependent passive and active transport of acidic drugs across Caco-2 cell monolayers
-
Neuhoff S, Ungell AL, Zamora I, Artursson P. 2005. pH-Dependent passive and active transport of acidic drugs across Caco-2 cell monolayers. Eur J Pharm Sci 25:211-220.
-
(2005)
Eur J Pharm Sci
, vol.25
, pp. 211-220
-
-
Neuhoff, S.1
Ungell, A.L.2
Zamora, I.3
Artursson, P.4
-
99
-
-
39749162302
-
Evaluation of cocktail approach to standardise Caco-2 permeability experiments
-
Koljonen M, Hakala KS, Ahtola-Satila T, Laitinen L, Kostianen R, Kotiaho T, Kaukonen AM, Hirvonen J. 2006. Evaluation of cocktail approach to standardise Caco-2 permeability experiments. Eur J Pharm Biopharm 29:269-277.
-
(2006)
Eur J Pharm Biopharm
, vol.29
, pp. 269-277
-
-
Koljonen, M.1
Hakala, K.S.2
Ahtola-Satila, T.3
Laitinen, L.4
Kostianen, R.5
Kotiaho, T.6
Kaukonen, A.M.7
Hirvonen, J.8
-
100
-
-
85031448000
-
Real and fast efflux of weak basic drugs across Caco-2 monolayers
-
abstract 5056
-
Ungell AB, Zamora I, Neuhoff S, Artursson P. 2002. Real and fast efflux of weak basic drugs across Caco-2 monolayers. AAPS PharmSci 4: abstract 5056.
-
(2002)
AAPS PharmSci
, vol.4
-
-
Ungell, A.B.1
Zamora, I.2
Neuhoff, S.3
Artursson, P.4
-
101
-
-
0031830624
-
In vitro permeability of eight β-blockers through Caco-2 monolayers utilizing liquid chromatography/electrospray ionization mass spectrometry
-
Caldwell GW, Easlick SM, Gunnet J, Mausucci JA, Demarest K. 1998. In vitro permeability of eight β-blockers through Caco-2 monolayers utilizing liquid chromatography/electrospray ionization mass spectrometry. J Mass Spectrom 33:607-614.
-
(1998)
J Mass Spectrom
, vol.33
, pp. 607-614
-
-
Caldwell, G.W.1
Easlick, S.M.2
Gunnet, J.3
Mausucci, J.A.4
Demarest, K.5
-
102
-
-
77956631092
-
Quantitative approaches to delineate passive transport mechanisms in cell culture monolayers
-
Amidon GL, Lee PI, Topp EM, editors, NY: Marcel-Dekker, Inc, pp
-
Ho NFH, Raub TJ, Burton PS, Basuhn CL, Adson A, Audus KL, Borchardt RT. 2000. Quantitative approaches to delineate passive transport mechanisms in cell culture monolayers. In: Amidon GL, Lee PI, Topp EM, editors. Transport processes in pharmaceutical systems. NY: Marcel-Dekker, Inc., pp 219-316.
-
(2000)
Transport processes in pharmaceutical systems
, pp. 219-316
-
-
Ho, N.F.H.1
Raub, T.J.2
Burton, P.S.3
Basuhn, C.L.4
Adson, A.5
Audus, K.L.6
Borchardt, R.T.7
-
103
-
-
0026457774
-
A new diffusion chamber system for the determination of drug permeability coefficients across the human intestinal epithelium that are independent of the unstirred water layer
-
Karlsson J, Artursson P. 1992. A new diffusion chamber system for the determination of drug permeability coefficients across the human intestinal epithelium that are independent of the unstirred water layer. Biochim Biophy Acta 1111:204-210.
-
(1992)
Biochim Biophy Acta
, vol.1111
, pp. 204-210
-
-
Karlsson, J.1
Artursson, P.2
-
104
-
-
0025822090
-
Characterization of the unstirred water layer in Caco-2 cell monolayers using a novel diffusion apparatus
-
Hidalgo IJ, Hillgren KM, Grass GM, Borchardt RT. 1991. Characterization of the unstirred water layer in Caco-2 cell monolayers using a novel diffusion apparatus. Pharm Res 8:222-227.
-
(1991)
Pharm Res
, vol.8
, pp. 222-227
-
-
Hidalgo, I.J.1
Hillgren, K.M.2
Grass, G.M.3
Borchardt, R.T.4
-
105
-
-
33845229445
-
Characterization of the Caco-2 permeability model and rat intestinal perfusion model for use with the BCS
-
abstract 4056
-
Bourdage JS, Burton PS, Cole CJ, Conradi RA, Day JS, Hilgers AR, Pfund WP. 1999. Characterization of the Caco-2 permeability model and rat intestinal perfusion model for use with the BCS. AAPS PharmSci 1: abstract 4056.
-
(1999)
AAPS PharmSci
, vol.1
-
-
Bourdage, J.S.1
Burton, P.S.2
Cole, C.J.3
Conradi, R.A.4
Day, J.S.5
Hilgers, A.R.6
Pfund, W.P.7
-
106
-
-
12444346800
-
Method considerations for Caco-2 permeability assessments in the biopharmaceutics classification system
-
Tolle-Sander S, Polli J. 2002. Method considerations for Caco-2 permeability assessments in the biopharmaceutics classification system. Pharm Forum 28:164-172.
-
(2002)
Pharm Forum
, vol.28
, pp. 164-172
-
-
Tolle-Sander, S.1
Polli, J.2
-
107
-
-
0344983259
-
In vitro trans-monolayer permeability calculations: Often forgotten assumptions
-
Youdin KA, Avdeef A, Abbott NJ. 2003. In vitro trans-monolayer permeability calculations: Often forgotten assumptions. Drug Discov Today 8:997-1003.
-
(2003)
Drug Discov Today
, vol.8
, pp. 997-1003
-
-
Youdin, K.A.1
Avdeef, A.2
Abbott, N.J.3
-
108
-
-
33750071406
-
Drug adsorption to plastic containers and retention of drugs in cultured cells under in vitro conditions
-
Palmgrén JJ, Monkkonen J, Korjamo T, Hassinen A, Auriola S. 2006. Drug adsorption to plastic containers and retention of drugs in cultured cells under in vitro conditions. Eur J Pharm Biopharm 64:369-378.
-
(2006)
Eur J Pharm Biopharm
, vol.64
, pp. 369-378
-
-
Palmgrén, J.J.1
Monkkonen, J.2
Korjamo, T.3
Hassinen, A.4
Auriola, S.5
-
109
-
-
0036870731
-
-
Ingels FM, Deferme S, Delbar N, Oth M, Augustijns PF. 2002. Implementation of the Caco-2 cell culture model as a predictive tool for the oral absorption of drugs. In house evaluation procedures. J Pharm Belg 57:153-158.
-
Ingels FM, Deferme S, Delbar N, Oth M, Augustijns PF. 2002. Implementation of the Caco-2 cell culture model as a predictive tool for the oral absorption of drugs. In house evaluation procedures. J Pharm Belg 57:153-158.
-
-
-
-
110
-
-
0030588714
-
Caco-2 monolayers in experimental and theoretical predictions of drug transport
-
Artursson P, Palm K, Luthman K. 1996. Caco-2 monolayers in experimental and theoretical predictions of drug transport. Adv Drug Deliv Rev 22:67-84.
-
(1996)
Adv Drug Deliv Rev
, vol.22
, pp. 67-84
-
-
Artursson, P.1
Palm, K.2
Luthman, K.3
-
111
-
-
20044371666
-
The Caco-2 cell line as a model of the intestinal barrier: Influence of cell and culture-related factors on Caco-2 cell functional characteristics
-
Sambuy Y, DeAngelis I, Ranaldi G, Scarino ML, Stammati A, Zucco F. 2005. The Caco-2 cell line as a model of the intestinal barrier: Influence of cell and culture-related factors on Caco-2 cell functional characteristics. Cell Biol Toxicol 21:1-26.
-
(2005)
Cell Biol Toxicol
, vol.21
, pp. 1-26
-
-
Sambuy, Y.1
DeAngelis, I.2
Ranaldi, G.3
Scarino, M.L.4
Stammati, A.5
Zucco, F.6
-
112
-
-
13244285816
-
Cell culture in drug discovery: An industrial perspective
-
van de Waterbeen H, Lennernäs H, editors, Weinheim: Wiley-VCH. pp
-
Ungell AL, Karlsson J. 2003. Cell culture in drug discovery: An industrial perspective. In: van de Waterbeen H, Lennernäs H, editors. Drug bioavailability: Estimation of solubility, permeability, absorption and bioavailability. Weinheim: Wiley-VCH. pp 90-131.
-
(2003)
Drug bioavailability: Estimation of solubility, permeability, absorption and bioavailability
, pp. 90-131
-
-
Ungell, A.L.1
Karlsson, J.2
-
113
-
-
0025132942
-
Caco-2 cell monolayers as a model for drug transport across the intestinal mucosa
-
Hilgers AR, Conradi RA, Burton PS. 1990. Caco-2 cell monolayers as a model for drug transport across the intestinal mucosa. Pharm Res 7:902-910.
-
(1990)
Pharm Res
, vol.7
, pp. 902-910
-
-
Hilgers, A.R.1
Conradi, R.A.2
Burton, P.S.3
-
114
-
-
0035524138
-
Assessing the absorption of new pharmaceuticals
-
Hidalgo IJ. 2001. Assessing the absorption of new pharmaceuticals. Curr Top Med Chem 1:385-401.
-
(2001)
Curr Top Med Chem
, vol.1
, pp. 385-401
-
-
Hidalgo, I.J.1
-
115
-
-
0027136654
-
In vitro/in vivo models for peptide oral absorption: Comparison of Caco-2 cell permeability with rat intestinal absorption of renin inhibitory peptides
-
Conradi RA, Wilkinson KF, Rush BD, Hilgers AR, Ruwart MJ, Burton PS. 1993. In vitro/in vivo models for peptide oral absorption: Comparison of Caco-2 cell permeability with rat intestinal absorption of renin inhibitory peptides. Pharm Res 10:1790-1792.
-
(1993)
Pharm Res
, vol.10
, pp. 1790-1792
-
-
Conradi, R.A.1
Wilkinson, K.F.2
Rush, B.D.3
Hilgers, A.R.4
Ruwart, M.J.5
Burton, P.S.6
-
116
-
-
3242753525
-
Validation of cell culture models for the intestine and the blood brain barrier and comparison of drug permeation
-
Bock U, Flötto T, Haltner E. 2004. Validation of cell culture models for the intestine and the blood brain barrier and comparison of drug permeation. ALTEX 21:57-64.
-
(2004)
ALTEX
, vol.21
, pp. 57-64
-
-
Bock, U.1
Flötto, T.2
Haltner, E.3
-
117
-
-
0031013760
-
Selection of development candidates based on in vitro permeability measurements
-
Lee CP, de Vrueh RLA, Philip L, Smith PL. 1997. Selection of development candidates based on in vitro permeability measurements. Adv Drug Deliv Rev 23:47-62.
-
(1997)
Adv Drug Deliv Rev
, vol.23
, pp. 47-62
-
-
Lee, C.P.1
de Vrueh, R.L.A.2
Philip, L.3
Smith, P.L.4
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