The use of the intestinal epithelial cell culture model, Caco-2, in pharmaceutical development

Advanced Drug Delivery Reviews

Volumn 22, Issue 1-2, 1996, Pages 85-103

  Bailey, Carole A ^a   Bryla, Piotr ^a,b   Malick, A Waseem ^a  

^a HOFFMANN LA ROCHE INC   (United States)

^b BAYER CORPORATION   (United States)

Author keywords

Caco 2; formulation development; partition coefficient; peptide transporters; permeability; tissue culture

Indexed keywords

AMINO ACIDS; DRUG PRODUCTS; DRUG THERAPY; PHARMACOKINETICS; TISSUE CULTURE;

CEPHALOSPORIN; FORMULATION DEVELOPMENT; INTESTINAL EPITHELIAL CELL CULTURE MODEL; ORAL ABSORPTION; PARTITION COEFFICIENT; PEPTIDE TRANSPORTERS;

MATHEMATICAL MODELS;

4,4' DIISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; 5 (N,N DIMETHYL)AMILORIDE; ATENOLOL; BUMETANIDE; CARBONYL CYANIDE 4 (TRIFLUOROMETHOXY)PHENYLHYDRAZONE; CEFACLOR; CEFIXIME; CEFUROXIME; CEFUROXIME AXETIL; CEPHALOSPORIN DERIVATIVE; COLCHICINE; DEXAMETHASONE; DEXTRAN; MACROGOL; MANNITOL; N ETHYLMALEIMIDE; OCTANOL; OUABAIN; PEPTIDE; PROPRANOLOL; SALAZOSULFAPYRIDINE; SALICYLIC ACID; UNINDEXED DRUG; VALINOMYCIN; VASOPRESSIN; VERAPAMIL; WATER;

CELL CULTURE; CELL STRAIN CACO 2; DRUG BIOAVAILABILITY; DRUG DEVELOPMENT; DRUG FORMULATION; HUMAN; HUMAN CELL; INTESTINE ABSORPTION; INTESTINE EPITHELIUM CELL; MEMBRANE TRANSPORT; MODEL; PARTITION COEFFICIENT; PHARMACEUTICS; PRIORITY JOURNAL; REVIEW; TISSUE CULTURE;

EID: 0030588644     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-409X(96)00416-4     Document Type: Review

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