Selection of development candidates based on in vitro permeability measurements

Advanced Drug Delivery Reviews

Volumn 23, Issue 1-3, 1997, Pages 47-62

  Lee, Chao Pin ^a   De Vrueh, Remco L A ^b   Smith, Philip L ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

^b LEIDEN UNIVERSITY   (Netherlands)

Author keywords

absorption; acyclovir; apical recycling; bioavailability; intestinal permeability; oligopeptide transporter; transport

Indexed keywords

AMINO ACIDS; BIOSYNTHESIS; CELL MEMBRANES; CELLS; DRUG THERAPY; HYDROLYSIS; MOLECULES;

ACYCLOVIR; APICAL RECYCLING; BIOAVAILABILITY; IN VITRO PERMEABILITY MEASUREMENT; INTESTINAL PERMEABILITY; OLIGOPEPTIDE TRANSPORTER; ORALLY ACTIVE DRUG CANDIDATES;

DRUG PRODUCTS;

ACICLOVIR; AMINO ACID; ATENOLOL; CEFACLOR; CEFADROXIL; CEFALEXIN; CEFRADINE; CYCLOSPORIN A; DIAZEPAM; ENALAPRIL; FLUNITRAZEPAM; FLUOROURACIL; MANNITOL; METOPROLOL; NAPROXEN; NITRAZEPAM; NORDAZEPAM; OXAZEPAM; PARACETAMOL; PENICILLIN G; PHENAZONE; PRODRUG; ROPINIROLE; TERBUTALINE; UNINDEXED DRUG; VERAPAMIL; VINBLASTINE;

APICAL MEMBRANE; BASOLATERAL MEMBRANE; DRUG BIOAVAILABILITY; DRUG DEVELOPMENT; DRUG FORMULATION; DRUG METABOLISM; DRUG SCREENING; DRUG SOLUBILITY; DRUG TRANSPORT; GASTROINTESTINAL TRACT; HUMAN; HYDROLYSIS; INTESTINE ABSORPTION; MEMBRANE PERMEABILITY; NONHUMAN; PRIORITY JOURNAL; REVIEW;

EID: 0031013760     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-409X(96)00425-5     Document Type: Review

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